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Malignant Brain Tumors in Children

  • Chapter
Therapy of Malignant Brain Tumors

Abstract

Among all children suffering from malignant disease brain tumors take the 2nd place: 12–24% after leukemia (31–42%). They are followed by lymphoma (7–13%), neuroblastoma and Wilm’s tumor (8–10% each), and tumors of the bones and the gastrointestinal tract (4–5% each)223, 281, 435.451. Brain tumor incidence shows no differences between white and colored children451.

This review is dedicated to Prof. Dr. O. Hövels, former head of the Department of General Pediatrics, on the occasion of his 65th birthday.

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Abbreviations

AICA:

anterior inferior cerebellar artery

ARAC:

cytosin-arabinoside

ASCY:

astrocytoma

BAER:

brain stem acustic evoked responses

BBB:

blood-brain barrier

CCA:

choriocarcinoma

CCSG:

Childrens’ Cancer Study Group

CEA:

carcinoma embryonic antigen

CHT:

chemotherapy

CN:

cranial nerve

CNS:

central nervous system

CP:

cyclophosphamide

CPL:

cisplatinum

CSF:

cerebrospinal fluid

CT:

computerized tomography

CVF:

citrovorum factor

ECA:

embryonal carcinoma

EEG:

electroencephalogram

EPDY:

ependymoma

EST:

endodermal sinus tumor (yolk sac tumor)

GHRF:

growth hormone releasing factor

GLB:

glioblastoma multiforme

GPO:

German pediatric oncologists

HCG:

human chorionic gonadotropin

HGH:

hypophyseal growth hormone

ICP:

intracranial pressure

IT:

infratentorial

IV:

intravenous

LTH:

luteinizing hormone

ME:

melatonin

MBL:

medulloblastoma

ML:

medial lemniscus

MTX:

methotrexate

MTX-HD:

high-dose methotrexate

MTX-MHD:

middle high-dose MTX

NMR:

nuclear magnetic resonance tomography

OLG:

oligodendroglioma

PBL:

pineoblastoma

PCY:

pineocytoma

PEG:

pneumencephalography

PF:

posterior fossa

PICA:

posterior inferior cerebellar artery

PIF:

prolactin inhibiting factor

PLP:

choroid plexus papilloma

PNET:

primitive neuro-ectodermal tumor

RT:

radiation therapy

SIOP:

Société Internationale d’Oncologie Pédiatrique

ST:

supratentorial

VCR:

vincristine

VECP:

visual evoked cortical potentials

VM:

VUMON® (VM26, teniposide)

References

  1. Abay EO, Laws ER, Grado GL, Bruckman JE, Forbes GS, Gomez MR, Scott M (1981) Pineal tumors in children and adolescents. Treatment by CSF shunting and radiotherapy. J Neurosurg 55: 889–895

    Google Scholar 

  2. Abramson DH, Ronner HJ, Ellsworth RM (1979) Second tumors in nonradiated retinoblastoma. Am J Ophthalmol 87: 624–627

    PubMed  CAS  Google Scholar 

  3. Afra D, Müller W, Slowik F, Wilcke O, Budka H, Turoczy L (1983) Supratentorial lobar ependymomas; reports on the grading and survival periods in 80 cases, including 46 recurrences. Acta Neurochir (Wien) 69: 243–251

    CAS  Google Scholar 

  4. Aguila LA, Chou SM, Bay JW (1984) Primary intracranial germinoma presenting as lower cranial nerve involvement: case report and review of the literature. Neurosurgery 14: 475–479

    PubMed  CAS  Google Scholar 

  5. Ahagon A, Yoshida Y, Kosuno K, Uno T (1983) Suprasellar germinoma in association with Klinefelter’s syndrome. Case report. J Neurosurg 58: 136–138

    Google Scholar 

  6. Aicardi J, Praud E, Bancaud J, Mises J, Chevrie JJ (1970) Épilepsies cliniquement primitives et tumeurs cérébrales chez l’enfant. Arch Franç Pédiat 27: 1041–1055

    PubMed  CAS  Google Scholar 

  7. Albright AL, James HE (1985) Neurosurgical staging of midline intra-axial (nuclear) tumors. Cancer 56: 1786–1788

    PubMed  CAS  Google Scholar 

  8. Allen JC (1978) The effects of cancer therapy on the nervous system. J Pediatrics 93: 903–909

    CAS  Google Scholar 

  9. Allen JC, Nisselbaum J, Epstein F, Rosen G, Schwartz MK (1979) Alpha-fetoprotein and human chorionic gonadotropin determination in cerebrospinal fluid. An aid to the diagnosis and management of intracranial germ-cell tumors. J Neurosurg 51: 368–374

    Google Scholar 

  10. Allen JC, Helson L (1981) High-dose cyclophosphamide chemotherapy for recurrent CNS tumors in children. J Neurosurg 55: 749–756

    PubMed  CAS  Google Scholar 

  11. Allen JC (1981) Neurotoxic potential of methotrexate and vincristine. In: Hanefeld F, Rating D (Hrsg) Aktuelle Neuropädiatrie II. Hippokrates, Stuttgart, S 105–112

    Google Scholar 

  12. Allen JC, Walker R, Kim JH (1985) Preradiation chemotherapy for newly diagnosed central nervous system germinoma—an attempt to reduce the radiotherapy dose while increasing survival (abstr). Ann Neurol 18: 404–405

    Google Scholar 

  13. Alvord EC (1976) Why do gliomas not metastasize? Arch Neurol 33: 73–75

    Google Scholar 

  14. Andler W, Roosen K, Clar HE (1982) Endocrinological investigations in 68 children with brain tumors. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 415–419

    Google Scholar 

  15. Araki C, Matsumoto S (1969) Statistical reevaluation of pinealoma and related tumors in Japan. J Neurosurg 30: 146–149

    PubMed  CAS  Google Scholar 

  16. Arnold H, Franke HD, Langendorf G, Olotu R, Grosch-Wörner J (1982) Medulloblastoma. Relationship of histologic type to survival. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 404–409

    Google Scholar 

  17. Arnstein LH, Boldrey E, Nafziger HC (1951) A case report and survey of brain tumors during the neonatal period. J Neurosurg 8: 315–319

    PubMed  CAS  Google Scholar 

  18. Aron BS (1971) Medulloblastoma in children. Am J Dis Child 121: 314–317

    PubMed  CAS  Google Scholar 

  19. Arseni C, Ciurea AV (1981) Statistical survey of 276 cases of medulloblastoma (1935–1978). Acta Neurochir (Wien) 57: 159–162

    CAS  Google Scholar 

  20. Artiles GN (1968) Tumores de la fossa posterior. Arch Pediatria (Barcelona) 19: 240242

    Google Scholar 

  21. Ashley JB (1969) The two “Hit” and multiple “Hit” theories of carcinogenesis. Br J Cancer 23: 313–328

    PubMed  CAS  Google Scholar 

  22. Atac MS, Blaauw G (1979) Radiotherapy in brain-stem gliomas in children. Clin Neurol Neurosurg 81: 281–290

    PubMed  CAS  Google Scholar 

  23. Attanasio A, Borelli P, di Rocco E, Marini R, Cappa M, Cambiaso P, Crino A, Gupta D (1985) Clinical significance of melatonin in children. In: Gupta D (ed) Pediatric neuroendocrinology. Croom Helm, London Sydney, pp 203–219

    Google Scholar 

  24. Auff E, Schuster H (1980) Konnatales Riesengliom. Neuropädiatrie 11: 91–95

    PubMed  CAS  Google Scholar 

  25. Aur R, Hustu HD, Simone J (1976) Leukoencephalopathy in children with acute lymphocytic leukemia receiving preventive central nervous system therapy. Proc Am Soc Clin Oncol 17: 97

    Google Scholar 

  26. Axelrod L (1977) Endocrine dysfunction in patients with tumors of the pineal region. In: Schmidek HH (ed) Pineal tumors. Masson, New York, pp 61–77

    Google Scholar 

  27. Backus RE, Millichap JG (1962) The seizures as a manifestation of intracranial tumor in childhood. Pediatrics 29: 978–984

    PubMed  CAS  Google Scholar 

  28. Bader JL, Miller RW, Meadows AT, Zimmerman LE, Champion LAA, Voute PA (1980) Trilateral retinoblastoma. Lancet ii: 582–583

    Google Scholar 

  29. Balhuizen JC, Bots GTA, Schaberg A, Bosman FT (1978) Value of cerebrospinal fluid cytology for the diagnosis of malignancies in the central nervous system. J Neurosurg 48: 747–753

    PubMed  CAS  Google Scholar 

  30. Bamberg M, Sauerwein W, Scherer F (1982) Methoden and Ergebnisse der Strahlentherapie beim Medulloblastom. Strahlentherapie 158: 71–75

    PubMed  CAS  Google Scholar 

  31. Bamberg M, Metz K, Alberti W, Heckemann R, Schulz U (1984) Endodermal sinus tumor of the pineal region. Metastases through a ventriculoperitoneal shunt. Cancer 54: 903–906

    Google Scholar 

  32. Barber SG, Smith JA Cove DH, Smith SCH, London DR (1978) Marker for pineal tumors? Lancet ii: 372–373

    Google Scholar 

  33. Barber SG, Smith JA, Hughes RD (1982) Melatonin as a tumor marker in a patient with pineal tumour. Br Med J 3: 328

    Google Scholar 

  34. Barnett HJ, Hyland HH (1952) Tumours involving the brain-stem. A study of 90 cases arising in the brain-stem, fourth ventricle, and pineal tissue. Quart J Med 21: 265–284

    PubMed  CAS  Google Scholar 

  35. Barone BM, Elvidge AR (1970) Ependymomas. A clinical survey. J Neurosurg 33: 428438

    Google Scholar 

  36. Batnitzky S, Segall HD, Cohen ME (1985) Radiologie guidelines in assessing children with intracranial tumors. Cancer 56: 1756–1762

    PubMed  CAS  Google Scholar 

  37. Belemaric J, Chau AS (1969) Medulloblastoma in newborn sisters. J Neurosurg 30: 7679

    Google Scholar 

  38. Berry MP, Jenkin DT, Keen CW, Nair BD, Simpson WJ (1981) Radiation treatment of medulloblastoma. A 21 year review. J Neurosurg 55: 43–51

    PubMed  CAS  Google Scholar 

  39. Berthold R, Janka G, Lampert F (1981) Kleinhirnmedulloblastom — retrospektive Untersuchung der Wertigkeit von Diagnostik and Therapie. Klin Pädiatr 193: 189–197

    PubMed  CAS  Google Scholar 

  40. Bettendorf U (1975) Ein ungewöhnlicher Hirntumor im frühen Säuglingsalter. Monatsschr Kinderheilk 123: 780–786

    CAS  Google Scholar 

  41. Bickerstaff ER, Connolly RC, Woolf AL (1967) Cerebellar medulloblastoma occurring in brothers. Acta Neuropathol (Berl) 8: 104–107

    CAS  Google Scholar 

  42. Bilaniuk LT, Zimmerman RA, Littman P. Gallo E, Rorke LB, Bruce DA, Schut L (1980) Computed tomography of brain stem gliomas in children. Radiology 134: 89–95

    CAS  Google Scholar 

  43. Bleyer WA, Drake JC, Chabner BA (1973) Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in meningeal leukemia. New Engl J Med 289: 770773

    Google Scholar 

  44. Bleyer WA, Milstein J, Balis F (1983) “8 drugs in 1 day” chemotherapy for brain tumors: a new approach and rationale for preradiation chemotherapy. Med Pediatr Oncol 11: 213

    Google Scholar 

  45. Bloom HJG, Wallace ENK, Henk JM (1969) The treatment and prognosis of medulloblastoma in children—a study of 82 verified cases. Am J Roentgenol 105: 4362

    Google Scholar 

  46. Bloom HJG (1975) Combined modality therapy for intracranial tumors. Cancer 35: 111–120

    PubMed  CAS  Google Scholar 

  47. Bloom HJG (1982) Intracranial tumors: response and resistance to therapeutic endeavors, 1970–1980. Int J Radiat Oncol Biol Phys 8: 1083–1113

    PubMed  CAS  Google Scholar 

  48. Bloom HJG, Glees JP (1985) Chemotherapy of gliomas in adults and of medulloblastoma in children. In: Voth D, Krauseneck P (eds) Chemotherapy of gliomas. De Gruyter, Berlin New York, pp 331–339

    Google Scholar 

  49. Blume WT, Girvin JP, Kaufmann JCE (1982) Childhood brain tumors presenting as chronic uncontrolled focal seizure disorders. Ann Neurol 12: 538–541

    PubMed  CAS  Google Scholar 

  50. Bode U (1982) Nebenwirkungen antineoplastischer Therapie auf das kindliche Nervensystem. Klin Pädiatr 194: 351–358

    PubMed  CAS  Google Scholar 

  51. Bodechtel G, Marguth F, Kollmannsberger A, Kazner E (1974) Hirntumoren, kaudaler Hirnstamm. In: Bodechtel G (Hrsg) Differentialdiagnose neurologischer Krankheitsbilder, 3. Aufl. Thieme, Stuttgart, S 408–410

    Google Scholar 

  52. Bogdahn U, Rupniak HTR, Ali-Osman F, Rosenblum ML (1985) Characterization of human malignant brain tumor cells in vitro and comparison of three different in vitro assays to determine their sensitivity to BCNU. In: Voth D, Krauseneck P (eds) Chemotherapy of gliomas. De Gruyter, Berlin New York, pp 321–328

    Google Scholar 

  53. Bolande RP (1974) The neurocristopathies. A unifying concept of disease arising in neural crest maldevelopment. Hum Pathol 5: 409–429

    Google Scholar 

  54. Boldrey E, Sheline G (1966) Delayed transitory clinical manifestations after radiation treatment of intracranial tumors. Acta Radiol (Ther) 5: 5–10

    CAS  Google Scholar 

  55. Bongartz EB, Bamberg M, Nau HE, Schmitt G, Bayindir C (1979) Optimal therapy in medulloblastoma. Acta Neurochir (Wien) 50: 117–125

    CAS  Google Scholar 

  56. Bonnin JM, Rubinstein LJ, Palmer NF, Beckwith JB (1984) The association of embryonal tumors originating in the kidney and in the brain. A report of seven cases. Cancer 54: 2137–2146

    Google Scholar 

  57. Borck WF, Rönnis W (1955) Zur Differentialdiagnose infratentorieller Geschwülste. Die Bedeutung von Vorgeschichte and Untersuchungsbefund für die Erkennung and Unterscheidung der Kleinhirntumoren. Bericht über 480 raumfordernde Prozesse. Neurol Psychiatr (Bucur) 23: 123–166

    Google Scholar 

  58. Borit A, Blackwood W, Mair WGP (1980) The separation of pineocytoma from pineoblastoma. Cancer 45: 1408–1418

    PubMed  CAS  Google Scholar 

  59. Borit A, Richardson EP (1982) The biological and clinical behaviour of pilocytic astrocytomas of the optic pathways. Brain 105: 161–187

    PubMed  CAS  Google Scholar 

  60. Bray PF, Carter S, Taveras JM (1958) Brain stem tumors in children. Neurology 8: 117

    Google Scholar 

  61. Bresnan MJ, Gilles FH, Lorenzo AV, Watters GV, Barlow CF (1972) Leukoencephalopathy following combined irradiation and intraventricular methotrexate therapy of brain tumors in childhood. Trans Am Neurol Assoc NY 97: 204–206

    Google Scholar 

  62. Broadbent VA, Barnes ND, Wheeler TK (1981) Medulloblastoma in childhood: longterm results of treatment. Cancer 48: 26–30

    PubMed  CAS  Google Scholar 

  63. Brown JR (1967) Cerebellar tumors in Cildren. Mayo Clin Proc 42: 511–516

    Google Scholar 

  64. Bruce DA, Allen JC (1985) Tumor staging for pineal region tumors of childhood. Cancer 56: 1792–1794

    PubMed  CAS  Google Scholar 

  65. Brutschin P, Culver GJ (1973) Extracranial metastases from medulloblastoma. Radiology 107: 359–362

    PubMed  CAS  Google Scholar 

  66. Butti G, Knerich R, Tanghetti B, Adinolfi D, Gaetani P, Buoncristiani P, Paolelli P (1984) Perioperative Carmustine chemotherapy for malignant brain tumors. Cancer Treat Rep 68: 1505–1506

    PubMed  CAS  Google Scholar 

  67. Caincross RG, Rexman JHW, Rathborne MP, del Maestro RF (1984) An analysis of post-operative enhancement and other CT artifacts in brain tumor patients. J Neuroloncol 2: 273

    Google Scholar 

  68. Camins MB, Mount LA (1974) Primary suprasellar atypical teratoma. Brain 97: 447456

    Google Scholar 

  69. Castro-Vita H, Salazar OM, Cova M, Rubin P (1978) Cerebellar medulloblastoma: spread and failure patterns following irradiation. Int J Radiat Oncol Biol Phys [Suppl] 2: 211–212

    Google Scholar 

  70. Chang CH, Housepian EM, Herbert C (1969) An operative staging system and a megavoltage radiotherapeutic technic for cerebellar medulloblastoma. Radiology 93: 1351–1359

    PubMed  CAS  Google Scholar 

  71. Chapman PH, Linggood RM (1980) The management of pineal area tumors. A recent reappraisal. Cancer 46: 1253–1257

    Google Scholar 

  72. Chatty E, Earle KM (1971) Medulloblastoma. A report of 201 cases on the relationship of histologic variants and survival. Cancer 28: 977–983

    PubMed  CAS  Google Scholar 

  73. Chatta AS, Delong GR (1975) Sylvian aqueduct syndrome as a sign of acute obstructive hydrocephalus in children. J Neurol Neurosurg Psychiat 38: 288–296

    Google Scholar 

  74. Chen HP (1958) Intracranial teratoma of a newborn. Report of an unusual case. J Neuropathol Exp Neurol 17: 599–603

    PubMed  CAS  Google Scholar 

  75. Choux M, Lena G (1982) Le médulloblastome. Neurochirurgie [Suppl] 28: 1–229. Masson, Paris

    Google Scholar 

  76. Chowdhury C, Roy S, Mahapatra AK, Bhatia R (1985) Medullomyoblastoma. A teratoma. Cancer 55: 1495–1500

    Google Scholar 

  77. Chutorian AM, Schwartz JF, Carter S (1964) Optic glioma in children. Neurology 14: 83–95

    PubMed  CAS  Google Scholar 

  78. Clar E, Reinhardt V, Gerhard L, Hensell V (1979) Clinical and morphological studies of pineal tumours. Acta Neurochir (Wien) 46: 59–76

    CAS  Google Scholar 

  79. Cohen ME, Duffner PK (1984) Brain tumors in children. Principles of diagnosis and treatment. Raven, New York

    Google Scholar 

  80. Cohen ME, Duffner PK, Heffner RR, Lacey DN, Brecher M (1985) Long-term survivors of brainstem gliomas (abstr). Ann Neurol 18: 395

    Google Scholar 

  81. Cook BR, Gutkelch AN (1983) Modern approaches to the treatment of medulloblastoma. Dev Med Child Neurol 25: 245–247

    PubMed  CAS  Google Scholar 

  82. Cooper PR, Budzilovich GN, Bergczeller PH, Lieberman A, Battista A (1974) Metastatic glioma associated with hypercalcemia. J Neurosurg 39: 255–259

    Google Scholar 

  83. Corboz R (1958) Die Psychiatrie der Hirntumoren bei Kindern. Acta Neurochir (Wien) [Suppl] 5: 1–100

    Google Scholar 

  84. Coulon RA, Till K (1977) Intracranial ependymomas in children. A review of 43 cases. Child’s Brain 3: 154–168

    PubMed  CAS  Google Scholar 

  85. Crafts DC, Levin VA, Edwards MS, Pischer TL, Wilson CB (1978) Chemotherapy of recurrent medulloblastoma with combined procarbazine, CCNU, and vincristine. J Neurosurg 49: 589–592

    Google Scholar 

  86. Crist WM, Ragab AH, Vietti TJ, Ducos R, Chu JY (1976) Chemotherapy of childhood medulloblastoma. Am J Dis Child 130: 639–642

    PubMed  CAS  Google Scholar 

  87. Crocker EF, Zimmerman RA, Phelps ME, Kuhl DE (1976) The effects of steroids on the extravascular distribution of radiographic contrast material and technitium pertechnetate in brain tumors as determined by computed tomography. Radiology 119: 471–474

    PubMed  CAS  Google Scholar 

  88. Cumberlin RL, Luk KH, Wara WM, Sheline GE, Wilson CB (1979) Medulloblastoma. Treatment results and effect on normal tissues. Cancer 43: 1014–1020

    Google Scholar 

  89. Danoff BF, Cowchocks FS, Marquette C. Mulgrew L, Kramer S (1982) Assessment of the long-term effects of primary radiation therapy for brain tumors in children. Cancer 49: 1580–1586

    CAS  Google Scholar 

  90. Dayan AD, Marshall AHE, Miller AA, Pick FJ, Bankin NE (1966) Atypical teratomas of the pineal and hypothalamus. J Pathol Bacteriol 92: 1–28

    PubMed  CAS  Google Scholar 

  91. De Girolami U, Schmidek H (1973) Clinicopathological study of 53 tumor of the pineal region. J Neurosurg 39: 455–462

    Google Scholar 

  92. De Girolami U (1977) Pathology of the tumors of the pineal region. In: Schmidek HH (ed) Pineal tumors. Masson, New York, pp 1–19

    Google Scholar 

  93. De Lena M, Guzzon A, Montardini S (1972) Clinical, radiologic, and histopathologic studies on pulmonary toxicity induced by treatment with bleomycin. Cancer Chemother Rep 56: 343–356

    PubMed  Google Scholar 

  94. Deutsch M, Reigel DH (1980) The value of myelography in the management of childhood medulloblastoma. Cancer 45: 2194–2197

    PubMed  CAS  Google Scholar 

  95. Deutsch M, Laurent JP, Cohen ME (1985) Myelography for staging medulloblastoma. Cancer 56: 1763–1766

    PubMed  CAS  Google Scholar 

  96. Diksic M, Sako KK Feindet W, Kato A, Yamamoto YL, Farrokhzad S, Thompson C (1984) Pharmacokinetics of positron labelled 1,3-bis(2-chloroethyl)nitrosurea in human brain tumors using positron emission tomography. Cancer Res 44: 3120–3125

    PubMed  CAS  Google Scholar 

  97. Dohrmann GJ, Farwell JR, Flannery JT (1976) Glioblastoma multiforme in children. J Neurosurg 44: 442–448

    PubMed  CAS  Google Scholar 

  98. Dohrmann GJ, Farwell JR, Flannery JT (1976) Ependymomas and ependyinoblastomas in children. J Neurosurg 45: 273–283

    PubMed  CAS  Google Scholar 

  99. Dohrmann GJ, Rarwell JR, Flannery JT (1978) Oligodendroglioma in children. Surg Neurol 10: 21–25

    PubMed  CAS  Google Scholar 

  100. Dorwart RA, Wara WM, Norman D, Levin VA (1981) Complete myelographic evaluation of spinal metastases from medulloblastoma. Radiology 139: 403–408

    PubMed  CAS  Google Scholar 

  101. Drachman DA, Winter TS, Karon M (1963) Medulloblastoma with extracranial metastases. Arch Neurol 9: 518–530

    PubMed  CAS  Google Scholar 

  102. Duckett S, Claireaux AE (1963) Cerebral teratoma associated with epignathus in a newborn infant. J Neuropath Exp Neurol 20: 888–891

    CAS  Google Scholar 

  103. Duckett S, Wilson RR (1964) Fetal spongioblastoma. J Neuropath Exp Neurol 23: 560–564

    PubMed  CAS  Google Scholar 

  104. Duffner PK, Cohen ME, Thomas PRM, Sinks LF, Freeman AI (1979) Combination chemotherapy in recurrent medulloblastoma. Cancer 43: 41–45

    PubMed  CAS  Google Scholar 

  105. Duffner PK, Cohen ME, Heffner RR, Freeman AI (1981) Primitive neuroectodermal tumors of childhood. An approach to therapy.. J Neurosurg 55: 376–381

    Google Scholar 

  106. Duffner PK, Cohen ME (1981) Extraneural metastases in childhood brain tumors. Ann Neurol 10: 261–265

    PubMed  CAS  Google Scholar 

  107. Duffner PK, Cohen ME, Thomas P (1983) Late effects of treatment on the intelligence of children with posterior fossa turmors. Cancer 51: 233–237

    PubMed  CAS  Google Scholar 

  108. Duffner PK, Cohen ME, Parker MS (1985) Prospective intellectual testing in children with brain tumors (abstr). Ann Neurol 18: 405

    Google Scholar 

  109. Duffner PK, Cohen ME, Thomas PRM, Lansky SB (1985) The long-term effects of cranial irradiation on the central nervous system. Cancer 56: 1841–1846

    PubMed  CAS  Google Scholar 

  110. Dummermuth G (1958) EEG-Befunde bei Hirntumoren im Kindesalter. Arch Psychiat Zschr Ges Neurol 197: 594–618

    Google Scholar 

  111. Dupont MG, Gérard JM, Flament-Durand J, Baleriaux-Waha D, Mortelmans LL (1977) Pathognomonic aspects of germinoma on CT scan. Neuroradiology 14: 209–211

    PubMed  CAS  Google Scholar 

  112. Eade 0E, Urich H (1971) Metastasizing gliomas in young subjects. J Pathol 103: 245256

    Google Scholar 

  113. Edwards MSB, Davis RL, Laurent JP (1985) Tumor markers and cytologic features of cerebrospinal fluid. Cancer 56: 1773–1777

    PubMed  CAS  Google Scholar 

  114. Eiser C (1978) Intellectual abilities among survivors of childhood leukemia as a function of CNS irradiation. Arch Dis Childh 53: 391–395

    PubMed  CAS  Google Scholar 

  115. Ende N (1955) Congenital brain tumor in one of identical twins. Cancer 8: 1057–1059

    PubMed  CAS  Google Scholar 

  116. Enzman DR, Norman D, Levin V, Wilson C. Newton T (1978) Computed tomography in the follow-up of medulloblastomas and ependymomas. Radiology 128: 57–63

    Google Scholar 

  117. Epstein F (1985) A staging system for brain stem gliomas. Cancer 56: 1804–1806

    PubMed  CAS  Google Scholar 

  118. Erlich SS, Davis RL (1978) Spinal subarachnoid metastasis from primary intracranial glioblastoma multiforme. Cancer 42: 2854–2864

    PubMed  CAS  Google Scholar 

  119. Ethelberg S (1950) Symptomatic “cataplexy” or chalastic fits in cortical lesions of the frontal lobe. Brain 73: 499–512

    PubMed  CAS  Google Scholar 

  120. Farwell JR, Dohrmann GJ, Flannery JT (1977) Central nervous system tumors in children. Cancer 40: 3123–3132

    PubMed  CAS  Google Scholar 

  121. Farwell JR, Dohrmann GJ, Flannery JT (1978) Intracranial neoplasms in infants. Arch Neurol 35: 533–537

    PubMed  CAS  Google Scholar 

  122. Farwell JR, Flannery JT (1984) Cancer in relatives of children with central nervous-system neoplasms. New Engl J Med 311: 749–753

    PubMed  CAS  Google Scholar 

  123. Felgenhauer K, Nekic M, Jacobi C, Reiber HO, Frowein RA (1984) Tumormarker im Liquor cerebrospinalis. In: Heyden HW von, Krauseneck P (Hrsg) Hirnmetastasen. Pathophysiologie, Diagnostik, Therapie. Zuckschwerdt, München, S 107–117

    Google Scholar 

  124. Fessard C (1968) Cerebral tumors in infancy. 66 clinicoanatomical case studies. Am J Dis Child 115: 302–308

    PubMed  CAS  Google Scholar 

  125. Fischer AQ, McLean WT (1982) Intractable hiccups as presenting symptom of brainstem tumor in children. Child’s Brain 9: 60–63

    PubMed  CAS  Google Scholar 

  126. Fisher M (1956) An unusual variant of acute idiopathic polyneuritis (syndrome of ophthalmoplegia, ataxia, and areflexia). New Engl J Med 255: 57–65

    PubMed  CAS  Google Scholar 

  127. Foerster O, Gagel O, Mahoney W (1939) Die encephalen Tumoren des verlängerten Markes, der Brücke and des Mittelhirns. Arch Psychiat Nervenkr 110: 1–74

    Google Scholar 

  128. Fokes EC, Earle KM (1969) Ependymomas: clinical and pathological aspects. J Neurosurg 30: 585–594

    PubMed  Google Scholar 

  129. Frederick P, Cassady JR, Jaffe N (1975) Risk of second tumors in survivors of childhood cancer. Cancer 35: 1230–1235

    Google Scholar 

  130. Freeman JE, Johnston PGB, Voke JM (1973) Somnolence after prophylactic cranial irradiation in children with acute lymphoblastic leukemia. Br Med J 4: 525–526

    Google Scholar 

  131. Fresh CB, Takei Y, O’Brien MS (1976) Cerebellar glioblastoma in childhood. J Neurosurg 45: 705–708

    PubMed  CAS  Google Scholar 

  132. Fujii T, Itakura T, Hayashi S. Komai N, Nakamine H, Saito K (1981) Primary pineal choriocarcinoma with hemorrhage monitored by computerized tomography. Case report. J Neurosurg 55: 481 487

    Google Scholar 

  133. Fulton DS, Levin VA, Lubich WP, Wilson CB, Marton LJ (1980) Cerebrospinal fluid polyamines in patients with glioblastoma multiforme and anaplastic astrocytoma. Cancer Res 40: 3293–3296

    PubMed  CAS  Google Scholar 

  134. Fulton DS, Levin VA, Wara WM, Edwards MS, Wilson CB (1981) Chemotherapy of pediatric brain-stem tumors. J Neurosurg 54: 721–725

    PubMed  CAS  Google Scholar 

  135. Futrell NN, Osborn AG, Cheson BD (1981): Pineal region tumors: Computed tomographic-pathologic spectrum. Am J Radiol 137: 951–956

    Google Scholar 

  136. Gagliano RG, Costanzi JJ (1976) Paraplegia following intrathecal methotrexate. Cancer 37: 1663–1668

    PubMed  CAS  Google Scholar 

  137. Galassi E, Tognetti F, Frank F, Gaist G (1984) Extraneural metastases from primary pineal tumors. Review of the literature. Surg Neurol 21: 497–504

    Google Scholar 

  138. Garwicz S, Aronson AS, Elqvist D, Landberg T (1975) Postirradiation syndrome with EEG findings in children with acute lymphoblastic leukemia. Acta Paediat Scand 64: 399–403

    PubMed  CAS  Google Scholar 

  139. Gay JC, Janco RL, Lukens JN (1985) Systemic metastases in primary intracranial germinoma. Cancer 55: 2688–2690

    PubMed  CAS  Google Scholar 

  140. Geissinger JD, Bucy PC (1970) Astrocytomas of the cerebellum in children: Long-term study. Trans Am Neurol Assoc 49: 178–181

    Google Scholar 

  141. Gérard JP (1977) Radiotherapie des Ependymomes. Neurochirurgie (Paris) [Suppl] 1: 39–52

    Google Scholar 

  142. Gerlach H, Jänisch W, Schreiber D (1982) Intracranial and spinal tumors in newborns. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 53–61

    Google Scholar 

  143. Gerlach J, Jensen HP (1959) Zur Differentialdiagnose des Glioblastoma multiforme bei Jugendlichen. Acta Neurochir (Wien) [Suppl] 6: 95–100

    Google Scholar 

  144. Gerlach J, Jensen HP, Koos W, Kraus H (Hrsg) (1967) Pädiatrische Neurochirurgie. Intrakranielle Geschwülste. Thieme, Stuttgart, S 459–645

    Google Scholar 

  145. Ginsberg S, Kirshner J, Reich S, Panasci L, Rinkelstein T, Fandrich S, Fitzpatrick A, Shechtman L, Comis F (1981) Systemic chemotherapy for a primary germ cell tumor of the brain: a pharmacokinetic study. Cancer Treat Rep 65: 477–483

    PubMed  CAS  Google Scholar 

  146. Gjerris F, Klee JG, Klinken L (1976 a) Malignancy grade and long-term survival in brain tumors of infancy and childhood. Acta Neurol Scand (Stockh) 53: 61–71

    Google Scholar 

  147. Gjerris F (1976 b) Clinical aspects and long-term prognosis of intracranial tumours in infancy and childhood. Dev Med Child Neurol 18: 145–159

    Google Scholar 

  148. Gjerris F (1978) Clinical aspects and long-term prognosis in supratentorial tumours of infancy and childhood. Acta Neurol Scand (Stockh) 57: 445–470

    CAS  Google Scholar 

  149. Glasauer FE, Yuan RHP (1963) Intracranial tumors with extracranial metastases. J Neurosurg 20: 474–493

    PubMed  CAS  Google Scholar 

  150. Gonzales-Vitale JC, Hayes DM, Cvitkovic E, Sternberg SS (1977) The renal pathology in clinical trials of cisplatinum ( II)diamedinechloride. Cancer 39: 1362–1371

    Google Scholar 

  151. Goutelle A (1977) Les épendymomes intracraniens sous-tentoriels. Neurochir [Suppl] (23) 1: 53–66

    Google Scholar 

  152. Griepentrog F, Pauly H (1957) Intra- und extrakranielle, frühmanifeste Medulloblastome bei erbgleichen Zwillingen. Zentralbl Neurochir 17: 129–140

    PubMed  CAS  Google Scholar 

  153. Grossman CB, Gonzalez CF (1977) Neuroradiology of the pineal region. In: Schmidek HH (ed) Pineal tumors. Masson, New York, pp 79–98

    Google Scholar 

  154. Grote W, Wappenschmidt J (1965) Großhirngeschwülste im Kindesalter. Zeitschr Kinderchir 2: 153–172

    Google Scholar 

  155. Grote W, Nau HE, Labers B (1982) Operatives Vorgehen beim Medulloblastom. Strahlentherapie 158: 63–70

    PubMed  CAS  Google Scholar 

  156. Gullotta F, Neuman J (1980) Medulloblastome und zerebelläre Sarkome. Eine histologisch-katamnestissche Untersuchung. Neurochirurgie (Stuttgart) 23: 35–40

    Google Scholar 

  157. Gutjahr P, Dieterich E. Walther B (1981) Spätstatus Langzeitüberlebender nach infratentoriellen Tumoren im Kindesalter. In: Hanefeld F. Rating D (Hrsg) Aktuelle Neuropädiatrie II. Hippokrates, Stuttgart, S 94–104

    Google Scholar 

  158. Gutjahr P, Walther B (1982) Late effects after treatment of brain tumours in childhood. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the nervous system in infancy and childhood. Springer. Berlin Heidelberg New York, pp 383–388

    Google Scholar 

  159. Gyepes MT, D’Angio GJ (1966) Extracranial metastases from central nervous system tumors in children and adolescents. Radiology 87: 55–63

    PubMed  CAS  Google Scholar 

  160. Habermalz H, Stephani U, Riehm H, Hanefeld F (1982) Postoperative chemotherapy prior to radiotherapy in the combined treatment of medulloblastoma, ependymoma and tumours of the pineal region. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 338–343

    Google Scholar 

  161. Hanefeld F, Riehm H (1980) Therapy of acute lymphoblastic leukemia in childhood: effects on the nervous system. Neuropediatr 11: 3–16

    CAS  Google Scholar 

  162. Harisiadis L, Chang CH (1977) Medulloblastoma in children: a correlation between staging and results of treatment. Int J Radiat Oncol Biol Phys 2: 833–841

    PubMed  CAS  Google Scholar 

  163. Hart MN, Early KM (1973) Primitive neuroectodermal tumors of the brain children. Cancer 32: 890–897

    PubMed  CAS  Google Scholar 

  164. Hécaen H, de Ajuriaguerra J (1956) Troubles Méntaux au Cours des Tumeurs Intracraniennes. Masson, Paris

    Google Scholar 

  165. Heiskanen 0 (1977) Intracranial tumors of children. Child’s Brain 3: 69–78

    Google Scholar 

  166. Hendin B, Devivo DC, Torak R, Lell ME, Ragab AH, Vietti TJ (1974) Parenchymatous degeneration of the central nervous system in childhood leukemia. Cancer 33: 468–482

    PubMed  CAS  Google Scholar 

  167. Herpers MJHM, Budka H (1985) Primitive neuroectodermal tumors including the medulloblastoma: glial differentiation signaled by immunoreactivity for GFAP is restricted to the pure desmoplastic medulloblastoma (“arachnoid sarcoma of the cerebellum”). Clin Neuropathol 4: 12–18

    PubMed  CAS  Google Scholar 

  168. Herrick MK, Rubinstein LJ (1979) The cytologic differentiating potentials of pineal parenchymal neoplasms (true pinealomas). A clinicopathological study of 28 tumors. Brain 102: 289–320

    PubMed  CAS  Google Scholar 

  169. Herskovic A, Ornitz RD, Shell M, Rogers CC (1982) Treatment experience: glioblastoma multiforme treated with 15 MeV fast neutrons. Cancer 49: 2463–2465

    PubMed  CAS  Google Scholar 

  170. Hess R (1961) Significance of EEG-signs for localization of cerebral tumors. Electroenceph Clin Neurophysiol [Suppl] 19: 75–110

    Google Scholar 

  171. Hirano A. Matsui T (1975) Vascular structure in brain tumors. Human Pathol 6: 61 1621

    Google Scholar 

  172. Hirsch JF, Renier D, Czernichow P, Benveniste L. Pierre-Kahn A (1979) Medulloblastoma in childhood. Survival and functional results. Acta Neurochir (Wien) 48: 1–15

    Google Scholar 

  173. Hochberg F, Parker LM, Takrorian T, Canellos GP, Zervas NT (1981) High-dose BCNU with analogous bone marrow rescue for recurrent glioblastoma multiforme. J Neurosurg 54: 455–460

    PubMed  CAS  Google Scholar 

  174. Hoffmann GR, Thiry S, Achslogh J, Brihaya J, Dereymaeker A (1961) Étude statistique de 202 cas de tumeurs de la fosse postérieur de l’enfance. Neurochirurgie 7: 97–107

    Google Scholar 

  175. Hoffmann HJ, Hendrick EB, Humphreys RP (1976) Metastasis via ventriculoperitoneal shunt in patients with medulloblastoma. J Neurosurg 44: 652–666

    Google Scholar 

  176. Hoffman HJ, Duffner PK (1985) Extraneural metastases of central nervous system tumors. Cancer 56: 1778–1782

    PubMed  CAS  Google Scholar 

  177. Holldack J, Schindler H, Havers W (1985) Neurologische und psychosoziale Störungen bei Kindern mit Hirntumoren. Klin Pädiatr 197: 188–191

    PubMed  CAS  Google Scholar 

  178. Holt JF (1978) Neurofibromatosis in children. Am J Roentgenol 130: 615–639

    CAS  Google Scholar 

  179. Horowitz ME, Kun LE, Mulhern RK, Simmons JC, Sanford RA, Hayes FA, Jacobson M, Igarashi M (1985) Brain tumors in children less than 3 years of age: chemotherapy followed by delayed irradiation. (abstr) Ann Neurol 18: 395–396

    Google Scholar 

  180. Horrax G (1950) Treatment of tumors of the pineal body: experience in a series of 22 cases. Arch Neurol Psychiat (Chic) 64: 227–242

    CAS  Google Scholar 

  181. Hoshino T, Wilson CB (1975) Review of basic concepts of cell kinetics as applied to brain tumors. J Neurosurg 42: 123–131

    PubMed  CAS  Google Scholar 

  182. Hoshino T, Kobayashi S, Townsend JT, Wilson CB (1985) A cell kinetic study on medulloblastoma. Cancer 55: 1711–1713

    PubMed  CAS  Google Scholar 

  183. Jacobi G (1981) Klinik und Diagnostik kindlicher Hirntumoren. In: Hanefeld F, Rating D (Hrsg) Aktuelle Neuropädiatrie II. Hippokrates, Stuttgart, S 54–69

    Google Scholar 

  184. Jacobi G (1982) Intrakranielle Tumoren im Kindesalter. Aktuel Neurol 9: 42–50

    Google Scholar 

  185. Jacobi G (1982) Clinical presentation of space-occupying lesions of the central nervous system. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 72–84

    Google Scholar 

  186. Jacobi G (1984) Infratentorielle Hirntumoren des Kindes. Klinische Untersuchung zur Frage einer Hirnstammbeteiligung. Therapiewoche 34: 1343–1347

    Google Scholar 

  187. James HE, Edwards SB (1985) Systemic staging of supratentorial extra-axial brain tumors in children. Craniopharyngiomas, atypical teratoma and teratoid tumors of the suprasellar region (germinomas), and intracranial teratomas. Cancer 56: 1800–1803

    Google Scholar 

  188. Jänisch W, Schreiber D (1966) Neuroektodermale Hirngeschwülste als Todesursache bei Neugeborenen und Säuglingen. Zentralbl Allg Pathol 109: 170–175

    PubMed  Google Scholar 

  189. Jänisch W, Schreiber D, Gerlach H (1980) Tumoren des Zentralnervensystems bei Feten und Säuglingen. VEB Fischer, Jena

    Google Scholar 

  190. Jautzke G, Iglesias J (1985) Prolactinomas and mixed adenomas with prolactin cells: an immunohistochemical study of the subcellular localization of hormones. In: Auer LM, Leb G, Tscherne G, Urdl W, Walter FG (eds) Prolactinomas. De Gruyter, Berlin New York, pp 15–25

    Google Scholar 

  191. Jellinger K ( 1973 Primary intracranial germ cell tumours. Acta Neuropathol (Berl) 25: 291–306

    CAS  Google Scholar 

  192. Jellinger K, Sunder-Plassmann M (1973) Connatal intracranial tumours. Neuropädiatrie 4: 46–63

    PubMed  CAS  Google Scholar 

  193. Jenkin RD, Simpson WJ, Keen CW (1978) Pineal and suprasellar germinomas. J Neurosurg 48: 99–107

    PubMed  CAS  Google Scholar 

  194. Jereb B, Sundaresan N, Horten B, Reid A, Galicich JH (1981) Supratentorial recurrences in medulloblastoma. Cancer 47: 806–809

    PubMed  CAS  Google Scholar 

  195. Jooma R, Kendall BE (1983) Diagnosis and management of pineal tumors. J Neurosurg 58: 654–665

    PubMed  CAS  Google Scholar 

  196. Jordan RM, Kendall JW, McClung M, Kammer H (1980) Concentration of human chorionic gonadotropin in the cerebrospinal fluid of patients with germinal cell hypothalamic tumors. Pediatrics 65: 121–124

    PubMed  CAS  Google Scholar 

  197. Judisch GF, Patil SR (1981) Concurrent heritable retinoblastoma, pinealoma, and trisomy X. Arch Ophthalmol 99: 1767–1769

    PubMed  CAS  Google Scholar 

  198. Jungmann E, Althoff PH, Hermann J, Schöffling K (1985) Evidence for functional impairment of growth hormone secretion in prolactinoma. In: Auer LM, Leb G, Tscherne G, Urdl W, Walter FG (eds) Prolactinomas. De Gruyter, Berlin New York, pp 147–153

    Google Scholar 

  199. Kadin ME, Rubinstein LE, Nelson JS (1970) Neonatal cerebellar medulloblastoma originating from the fetal exlternal granular layer. J Neuropathol Exp Neurol 29: 583600

    Google Scholar 

  200. Kageyama N, Belsky R (1961) Ectopic pinealoma in the chiasma region. Neurology (Minneap) 11: 318–327

    Google Scholar 

  201. Kahle W (1957) Zum Problem der diffusen Glioblastose. Dtsch Z Nervenheilk 176: 469–499

    CAS  Google Scholar 

  202. Karch SB, Urich H (1972) Medulloepithelioma: definition and entity. J Neuropathol Exp Neurol 31: 27–53

    PubMed  CAS  Google Scholar 

  203. Kay HEM, Knapton PJ, O’Sullivan JP, Harris RF, Innes EM, Stuart J, Schwartz FCM, Thompson EN (1972) Encephalopathy in acute leukemia associated with methotrexate therapy. Arch Dis Childh 47: 344–354

    PubMed  CAS  Google Scholar 

  204. Kazner E, Wende S, Grumme T, Lanksch W, Stochdorph 0 (1981) Computertomographie intrakranieller Tumoren aus klinischer Sicht. Springer, Berlin Heidelberg New York

    Google Scholar 

  205. Kemmerling S, Neumärker KJ (1984) Möglichkeiten mehrdimensionaler Therapie der Medulloblastome und Ependymome im Kindesalter unter Berücksichtigung prognostischer Faktoren. Dtsch Gesundh Wesen 39: 1328–1333

    Google Scholar 

  206. Kernohan JW, Fletcher-Kernohan EM (1937) Ependymomas. A study of 109 cases. Publ Ass Res Nerv Ment Dis 16: 182–209

    Google Scholar 

  207. Keschner M, Bender MB, Strauss I (1937) Mental symptoms in cases of subtentorial tumors. Arch Neurol Psychiatry (Chic) 37: 1–17

    Google Scholar 

  208. Kessinger A (1984) High dose chemotherapy with autologous bone marrow rescue for high grade gliomas of the brain. A potential for improvement in therapeutic results. Neurosurgery 15: 747–750

    PubMed  CAS  Google Scholar 

  209. Kessler LA, Dugan P, Concannon JP (1975) Systemic metastases of medulloblastoma promoted by shunting. Surg Neurol 3: 147–152

    PubMed  CAS  Google Scholar 

  210. Kim YH, Fayos JV (1977) Intracranial ependymomas. Radiology 124: 805–808

    PubMed  CAS  Google Scholar 

  211. King GA, Sagerman RH (1979) Late recurrence in medulloblastoma. Am J Roentgenol 123: 7–12

    Google Scholar 

  212. Kleihues P, Banborschke S, Kiessling M, Wiestler O (1982) Developmental neurooncogenesis in experimental animals. In: Voth D, Gutjahr P, Langmaid C (eds) Tumors of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 19–31

    Google Scholar 

  213. Klein DM, McCulloch DC (1985) Surgical staging of cerebellar astrocytomas in childhood. Cancer 56: 1810–1811

    PubMed  CAS  Google Scholar 

  214. Kleinman GM, Schoene WC, Walshe TM, Richardson EP (1978) Malignant transformation in benign cerebellar astrocytoma. Case report. J Neurosurg 49: 111–118

    Google Scholar 

  215. Kleinman GM, Hochberg FH, Richardson EP (1981) Systemic metastases from medulloblastoma: report of two cases and review of the literature. Cancer 48: 22962309

    Google Scholar 

  216. Klériga E, Hollenberg Sher J, Nallainathan S, Stein SC, Sacher M (1978) Development of cerebellar malignant astrocytoma at site of a medulloblastoma treated 11 years earlier. Case report. J Neurosurg 49: 445–449

    Google Scholar 

  217. Knudson AG (1975) Genetics of human cancer. Genetics 79: 305–316

    PubMed  Google Scholar 

  218. Knudson AG, Meadows AT (1981) Regression of neuroblastoma IV-S: a genetic hypothesis. New Engl J Med 302: 1254–1255

    Google Scholar 

  219. Kobayashi T, Kageyama N, Kida Y, Yoshida J, Shibuya N, Okamura K (1981) Unilateral germinomas involving the basal ganglia and thalamus. J Neurosurg 55: 5562

    Google Scholar 

  220. Koide O, Watanabe Y, Sato K (1980) A pathological survey of intracranial germinoma and pinealoma in Japan. Cancer 45: 2119–2130

    PubMed  CAS  Google Scholar 

  221. Kölmel HW (1977) Atlas of cerebrospinal fluid cells. Springer, Berlin Heidelberg New York

    Google Scholar 

  222. Koos W, Valencak E (1968) Les processus expansifs intracraniens congénitaux présentant l’aspect clinique de l’hydrocéphalie congénitale ou précoce. Neurochirurgie 14: 75–79

    PubMed  CAS  Google Scholar 

  223. Koos WT, Miller MH (1971) Intracranial tumors of infants and children. Thieme, Stuttgart

    Google Scholar 

  224. Kopelson G (1982) Cerebellar glioblastoma. Cancer 50: 308–311

    PubMed  CAS  Google Scholar 

  225. Kopelson G, Linggood RM, Kleinman GM (1983) Medulloblastoma. The identification of prognostic subgroups and implication for multimodality management. Cancer 51: 312–319

    Google Scholar 

  226. Kornhuber B (1982) Cytostatic monotherapy of tumours of the central nervous system in children. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 367–377

    Google Scholar 

  227. Kosnik EJ, Boesel CP, Bay J, Sayers MP (1978) Primitive neuroectodermal tumors of the central nervous system in children. J Neurosurg 48: 741–746

    PubMed  CAS  Google Scholar 

  228. Krauseneck P, Bohndorf W, Bushe KA, Halves E, Mertens HG, Wilms K, Sturm V, Kleihues P (1986) Maligne Tumoren des Gehirns im Erwachsenenalter. Dtsch Ärztebl 83: 686–689

    Google Scholar 

  229. Kricheff II, Becker M, Schneck SA, Taveras JM (1964) Intracranial ependymomas: factors influencing prognosis. J Neurosurg 21: 7–14

    PubMed  CAS  Google Scholar 

  230. Kun LE, d’Souza B, Tefft M (1985) The value of surveillance testing in childhood brain tumors. Cancer 56: 1818–1823

    PubMed  CAS  Google Scholar 

  231. Lacey DJ (1984) Long-term pathologic effects of cancer treatment on the nervous system. In: Cohen ME, Duffner PK (eds) Brain tumors in children. Principles of diagnosis and treatment. Raven Press, New York, pp 328–347

    Google Scholar 

  232. Lapras C, Dechaume JP, Deruty R, Capdeville J (1973) Traitment des tumeurs de la région pinéale. Lyon Chir 69: 196–198

    Google Scholar 

  233. Lapras C, Lepoire J (1967) Traitement de l’hydrocéphalie non tumorale du nourrisson par la dérivation ventriculo-atriale. Neurochirurgie 13: 209–342

    Google Scholar 

  234. Lapras C, Poirier N, Deruty R, Joyeux O (1975) Le cathétérisme de l’aqueduc de Sylvius. Sa place actuelle dans le traitement chirurgical des sténoses des l’aqueduc de Sylvius, des tumeurs de la F.C.P. et de la syringomyélie. Neurochirurgie 21: 101–108

    Google Scholar 

  235. Landberg T, Lindgren ML, Cavallin-Stähl EK, Svahn-Trapper GO, Sundbärg G, Garwicz S, Lagergren JA, Gunnesson VL, Brun AE, Cronqvist SE (1980) Improvements in the radiotherapy of medulloblastoma 1946–1975. Cancer 45: 670–678

    PubMed  CAS  Google Scholar 

  236. Lassiter KRL, Alexander E, Davis CH, Kelly DL (1971) Surgical treatment of brain stem gliomas. J Neurosurg 34: 719–725

    PubMed  CAS  Google Scholar 

  237. Lassman LP, Sarjona VR (1967) Pontine gliomas of childhood. Lancet i: 913–915

    Google Scholar 

  238. Lassman LP (1974) Tumours of the pons and medulla oblongata. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 17. Elsevier, Amsterdam New York, pp 693–706

    Google Scholar 

  239. Latchaw JP, Hahn JF, Moylan DJ, Humphries R, Mealey J (1985) Medulloblastoma. Period of risk reviewed. Cancer 55: 186–189 r

    Google Scholar 

  240. Laurent JP, Chang CH, Cohen ME (1985) A classification system for primitive neuroectodermal tumors (medulloblastoma) of the posterior fossa. Cancer 56: 18071809

    Google Scholar 

  241. Lausberg G (1968) Klinik, Therapie und Prognose des Kleinhirnmedulloblastoms. Zschr Kinderheilk 102: 193–203

    CAS  Google Scholar 

  242. Leavitt F (1928) Cerebellar tumors occurring in identical twins. Arch Neurol Psychiatry (Chic) 19: 617–622

    Google Scholar 

  243. Lee F (1975) Radiation of infratentorial and supratentorial brain-stem tumors. J Neurosurg 43: 65–68

    PubMed  CAS  Google Scholar 

  244. Lee YY, Glass JP, van Eys J, Wallace S (1985) Medulloblastoma in infants and children. Computed tomographic follow-up after treatment. Radiology 154: 677–682

    Google Scholar 

  245. Leedham PW (1972) Primary cerebral rhabdomyosarcoma and the problem of medulloblastoma. J Neurol Neurosurg Psychiat 35: 551–559

    PubMed  CAS  Google Scholar 

  246. Levin VA, Edwards MS, Wara WM, Allen J, Ortega J, Vestnys P (1984a) 1-(2chloroethyl)-3-cyclohexyl-l-nitrourea (CCNU) followed by hydroxurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and Childrens’ Cancer Group. Neurosurgery 14: 679–681

    Google Scholar 

  247. Levin VA, Resser KJ, Grath L, Vestnys P, Nutik S, Wilson CB (1984 b) BCNU Treatment for recurrent malignant glioma. Cancer Treat Rep 68: 969–973

    Google Scholar 

  248. Lewis MB, Nunes LB, Powell DE, Snider BI (1973) Extracranial spread of medulloblastoma. Cancer 31: 1287–1297

    PubMed  CAS  Google Scholar 

  249. Liebner EJ, Pretto JI, Hochhauser M, Kassaraba W (1964) Tumors of the posterior fossa in childhood and adolescence. Radiology 82: 193–201

    PubMed  CAS  Google Scholar 

  250. Lin SR, Crane MD, Lin ZS, Bilaniuk L, Plasche WM, Marshall L, Spataro RF (1978) Characteristics of calcification in the tumors of the pineal gland. Radiology 126: 721726

    Google Scholar 

  251. Littman P, Jarrett P, Bilaniuk LT, Rorke B, Zimmerman RA, Bruce DA, Carabell SC, Schut L (1980) Pediatric brain stem gliomas. Cancer 45: 2787–2792

    PubMed  CAS  Google Scholar 

  252. Liwnicz BH, Rubinstein LJ (1979) The pathways of extraneural spread in metastasizing gliomas. Hum Pathol 10: 453–467

    PubMed  CAS  Google Scholar 

  253. Long DM (1970) Capillary ultrastructure and the blood-brain barrier in human malignant grain tumors. J Neurosurg 32: 127–144

    PubMed  CAS  Google Scholar 

  254. Lorentzen M, Hägerstrand I (1980) Congenital ependymoblastoma. Acta Neuropathol (Berl) 49: 71–74

    CAS  Google Scholar 

  255. Low NL, Correll JW, Hammill JF (1965) Tumors of the cerebral hemispheres in children. Arch Neurol (Chic) 13: 547–554

    CAS  Google Scholar 

  256. Luccarelli G (1980) Glioblastoma multiforme of the cerebellum: description of three cases. Acta Neurochir (Wien) 53: 107–116

    CAS  Google Scholar 

  257. Luddy RE, Gilman PA (1973) Paraplegia following intrathecal methotrexate. J Pediatr 83: 988–992

    PubMed  CAS  Google Scholar 

  258. Luna MA, Bedrossian CW, Lichtiger B (1972) Interstitial pneumonitis associated with bleomycin therapy. Am J Clin Pathol 58: 501–510

    PubMed  CAS  Google Scholar 

  259. Mabon RF, Svien HJ, Kernohan JW, Craig WMK (1949) Ependymomas. Proc Staff Meet Mayo Clin 23: 65–71

    Google Scholar 

  260. Madias NE, Harrington JT (1978) Platinum nephrotoxicity. Am J Med 65: 307–314

    PubMed  CAS  Google Scholar 

  261. Mannoji H, Takeshita I, Fukui M, Ohta M, Kitamura K (1981) Glial fibrillary acid protein in medulloblastoma. Acta Neuropathol (Berl) 55: 63–69

    CAS  Google Scholar 

  262. Mantravadi RVP, Phatak R, Bellur S, Liebner EJ, Haas R (1982) Brain stem gliomas. An autopsy study of 25 cases. Cancer 49: 1294–1296

    PubMed  CAS  Google Scholar 

  263. Markesbery WR, Challa VR (1979) Electron microscopic findings in primitive neuroectodermal tumors of the cerebrum. Cancer 44: 141–147

    PubMed  CAS  Google Scholar 

  264. Maroon JC, Albright L (1977) “Failure to thrive” due to pontine glioma. Arch Neurol (Chic) 34: 295–297

    Google Scholar 

  265. Marsa GW, Probert JC, Rubinstein LJ, Bagshaw MA (1975) Megavoltage irradiation of gliomas of the brain and spinal cord. Cancer 36: 1681–1689

    PubMed  CAS  Google Scholar 

  266. Martinius J, Matthes A, Lombroso CT (1968) Electroencephalographic features in posterior fossa tumors in children. Electroencephal Clin Neurophysiol 25: 128–139

    CAS  Google Scholar 

  267. Marton LJ, Edwards MS, Levin VA, Lubich WP, Wilson CB (1981) CSF polyamines: a new and important means of monitoring patients with medulloblastoma. Cancer 47: 757–760

    PubMed  CAS  Google Scholar 

  268. Matson DD (1964) Intracranial tumors of the first two years of life. West J Surg Obstet Gynecol 72: 117–122

    PubMed  CAS  Google Scholar 

  269. Matson DD, Crigler JF (1969) Management of craniopharyngiomas in childhood. J Neurosurg 30: 377–390

    PubMed  CAS  Google Scholar 

  270. Mazza C, Pasqualin A, da Pian R, Donati E (1981) Treatment of medulloblastoma in children: long-term results following surgery, radiotherapy and chemotherapy. Acta Neurochir (Wien) 57: 163–175

    CAS  Google Scholar 

  271. McComb JG, Davis RL, Isaacs H, Landing BJ (1981) Medulloblastoma presenting as neck tumors in 2 infants. Ann Neurol 7: 113–117

    Google Scholar 

  272. McCulloch DC, Epstein F (1985) Optic pathway tumors. A review with proposals for clinical staging. Cancer 56: 1789–1791

    Google Scholar 

  273. McFarland DR, Horwitz H, Saenger EL, Bahr GK (1969) Medulloblastoma—a review of prognosis and survival. Br J Radiol 42: 198–214

    PubMed  CAS  Google Scholar 

  274. McIntosh N (1979) Medulloblastoma: a changing prognosis. Arch Dis Childh 54: 200203

    Google Scholar 

  275. Meadows AT, Gordon J, Massari DJ, Littman P, Ferguson J, Moss K (1981) Declines in IQ scores and cognitive dysfunction in children with acute cranial irradiation. Lancet ii: 1015–1018

    Google Scholar 

  276. Mealy J, Hall PV (1977) Medulloblastoma in children. Survival and treatment. J Neurosurg 46: 56–64

    Google Scholar 

  277. Mei Liu H, Boggs J, Kidd J (1976) Ependymomas of childhood. I. Histological survey and clinicopathological correlation. Child’s Brain 2: 92–110

    Google Scholar 

  278. Meloche B, Sansregret A, LeBlanc P (1964) Tumeurs cérébrales chez le bébé de moins de deux ans. Union Méd Canada 93: 700–705

    CAS  Google Scholar 

  279. Mercuri S, Russo A, Palma L (1981) Hemispheric supratentorial astrocytomas in children. Long-term results in 29 cases. J Neurosurg 55: 170–173

    PubMed  CAS  Google Scholar 

  280. Milhorat TH (1975) Pontine glioma. J Am Med Assoc 232: 595–596

    Google Scholar 

  281. Milhorat TH (1978) Pediatric neurosurgery. Davis, Philadelphia, pp 228–332

    Google Scholar 

  282. Miller RH, Craig MK, Kernohan JW (1952) Supratentorial tumors among children. Arch Neurol (Chic) 68: 797–814

    CAS  Google Scholar 

  283. Mork SJ, Loken AC (1977) Ependymoma. A follow-up study of 101 cases. Cancer 40: 907–915

    PubMed  CAS  Google Scholar 

  284. Mori K (1985) Anomalies of the nervous system. Neuroradiology and neurosurgery. Thieme, New York Stuttgart, pp 187–212

    Google Scholar 

  285. Müller W, Afra D, Schröder R (1977) Supratentorial recurrences of gliomas. Morphological studies in relation to time intervals with oligodendrogliomas. Acta Neurochir (Wien) 39: 15–25

    Google Scholar 

  286. Müller W, Afra D, Schröder R, Slowik F, Wilcke O, Klug N (1982 a) Medulloblastoma: survey of factors possibly influencing prognosis. Acta Neurochir (Wien) 64: 215224

    Google Scholar 

  287. Müller W, Afra D, Wilcke O, Slowik F, Schröder R, Kordas M ( 1982 b) Data on the biology of medulloblastomas. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 350–353

    Google Scholar 

  288. Murovic JA, Ongley JP, Parker JC, Page LK (1981) Manifestations and therapeutic considerations in pineal yolk-sac tumors. Case report. J Neurosurg 55: 303–307

    Google Scholar 

  289. Neidhardt M, Habermalz HJ, Henze G, Langermann HJ (1982 a) Medulloblastomstudie der Gesellschaft für Pädiatrische Onkologie. Klin Pädiatr 194: 257–261

    Google Scholar 

  290. Neidhardt MK (1982 b) Die Behandlung des Medulloblastoms aus pädiatrischonkologischer Sicht. Strahlentherapie 158: 76–81

    Google Scholar 

  291. Neidhardt M ( 1982 c) Report on the medulloblastoma study of the Society of Pediatric Oncology—present position. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, p 349

    Google Scholar 

  292. Neidhardt MK (1985) Medulloblastom. Dtsch Ärztebl 82: 3270–3274

    Google Scholar 

  293. Neuhäuser G, Schmidt H (1974) Atypischer Krankheitsverlauf beim Medulloblastom. Klin Pädiatr 186: 49–53

    PubMed  Google Scholar 

  294. Neumärker KJ, Neumärker M (1971) Über das psychopathologische Verhalten bei Kindern mit Ponstumoren. Psychiatr Neurol Med Psychol (Leipzig) 23: 509–517

    Google Scholar 

  295. Neuwelt EA, Glasberg M, Frenkel E, Clark K (1979) Malignant pineal region tumors. A clinicopathological study. J Neurosurg 51: 597–607

    Google Scholar 

  296. Norell H, Wilson CB, Slagel DE, Clark DB (1974) Leukoencephalopathy following the administration of methotrexate into the cerebrospinal fluid in the treatment of primary brain tumors. Cancer 33: 923–932

    Google Scholar 

  297. Norgard-Pedersen B, Lindhold J, Albrechtsen R, Arend J, Diemer NH, Rishede J (1978) Alpha-fetoprotein and human chorionic gonadotrophin in a patient with primary intracranial germ cell tumor. Cancer 41: 2315–2320

    Google Scholar 

  298. Oldendorf WH (1974) Blood-brain barrier permeability to drugs. Ann Rev Pharmacol 14: 239–248

    CAS  Google Scholar 

  299. Onoyama Y, Mitsuyuki A, Takahashi M, Yabumoto E, Sakamoto T (1975) Radiation therapy of brain tumors in children. Radiology 115: 687–693

    PubMed  CAS  Google Scholar 

  300. Packer RJ, Allen J, Nielsen S, Petito C, Deck M, Jereb B (1983) Brainstem glioma: clinical manifestations of meningeal gliomatosis. Ann Neurol 14: 177–182

    PubMed  CAS  Google Scholar 

  301. Packer RJ, Sutton LN, Rosenstock JG, Rorke LB, Bilaniuk LT, Zimmerman RA, Littman PA, Bruce DA, Schut L (1984) Pineal region tumors of childhood. Pediatrics 74: 97–102

    PubMed  CAS  Google Scholar 

  302. Packer RJ, Siegel KR, Sutton LN, Littman PA, Bruce DA, Schut L (1985) Leptomeningeal dissemination of primary central nervous system tumors of childhood. Ann Neurol 18: 217–221

    PubMed  CAS  Google Scholar 

  303. Packer RJ, Batnitzky S, Cohen ME (1985) Magnetic resonance imaging in the evaluation of intracranial tumors of childhood. Cancer 56: 1767–1772

    Google Scholar 

  304. Packer RJ, Siegel KR, Sutton LN, Bruce DA, Schut L (1985) Efficacy of combination chemotherapy with lomustine, vincristine, and cisplatin in patients with primitive neuroectodermal tumors medulloblastoma of childhood (abstr). Ann Neurol 18: 394–395

    Google Scholar 

  305. Page LK, Lombroso CT, Matson DD (1969) Childhood epilepsy with late detection of cerebral glioma. J Neurosurg 31: 253–261

    PubMed  CAS  Google Scholar 

  306. Page RB, Plourde PV, Coldwell D, Heald JI, Weinstein J (1983) Intrasellar mixed germ-cell tumor. J Neurosurg 58: 766–770

    PubMed  CAS  Google Scholar 

  307. Palacios E, Azar-Kia B (1975) Malignant metastasizing angioblastic meningiomas. J Neurosurg 42: 185–188

    PubMed  CAS  Google Scholar 

  308. Palmer JO, Kasselberg AG, Netsky MG (1981) Differentiation of medulloblastoma. Studies including immunohistochemical localization of glial fibrillary acid protein. J Neurosurg 55: 161–169

    Google Scholar 

  309. Pampiglione G (1974) Somnolence in children with acute leukemia. Br Med J I: 158

    Google Scholar 

  310. Panitch HS, Berg BO (1970) Brain stem tumors of childhood and adolescence. Am Dis Child 119: 465–472

    CAS  Google Scholar 

  311. Papadakis N, Millan J, Grady DF, Segerberg LH (1971) Medulloblastoma of the neonatal period and early infancy. J Neurosurg 34: 88–91

    PubMed  CAS  Google Scholar 

  312. Pasquier B, Pasquier D, N’Golet A, Panh MH, Couderc P (1980) Extraneural metastases of astrocytomas and glioblastomas. Clinicopathological study of two cases and review of literature. Cancer 45: 112–125

    Google Scholar 

  313. Pasquinucci G, Pardini R, Fedi F (1970) Intrathecal methotrexate. Lancet is 309–310

    Google Scholar 

  314. Parker JC, Mortara RH, McCloskey JJ (1975) Biological behavior of the primitive neuroectodermal tumors: significant supratentorial childhood gliomas. Surg Neurol 4: 383–388

    PubMed  Google Scholar 

  315. Pearl GS, Takei Y (1981) Cerebellar medulloblastoma. Cancer 47: 772–779

    PubMed  CAS  Google Scholar 

  316. Perouthka SJ, Snyders SH (1982) Antiemetics: neurotransmitter receptor binding predicts action. Lancet is 658–659

    Google Scholar 

  317. Phillips TL, Sheline GE, Boldrey EB (1964) Therapeutic considerations in tumors affecting the central nervous system: ependymomas. Radiology 83: 98–105

    PubMed  CAS  Google Scholar 

  318. Pichler E, Kogelnik HD, Reinartz G, Kärcher KH, Zaunbauer F, Jürgenssen OA, Koos W, Kundi M (1981) Ergebnisse der Therapie des Medulloblastoms in den letzten 15 Jahren. Strahlentherapie 157: 508–515

    PubMed  CAS  Google Scholar 

  319. Pierluca P (1977) Les ependymomes de la fosse cérébrale posterieure. Neurochirurgie [Suppl] 23 1: 111–148

    Google Scholar 

  320. Pierre-Kahn A, Hirsch JF, Roux FX, Renier D (1983) Intracranial ependymomas in childhood. Survival and functional results of 47 cases. Child’s Brain 10: 145–156

    PubMed  CAS  Google Scholar 

  321. Plezia PM, Alberts DS, Kessler J, Apro MS, Graham V, Surwit EA (1984) Immediate termination of intractable vomiting induced by cisplatin. Combination of chemotherapy using an intensive five-drug antiemetic regimen. Cancer Treat Rep 68: 1493–1495

    Google Scholar 

  322. Poisson M, Pouillart P, Bataini JP, Mashaly R, Pertuiset BF, Metzger J (1979) Malignant gliomas treated after surgery by combination chemotherapy and delayed irradiation. Part I: Analysis of results. Acta Neurochir (Wien) 51: 15–29

    Google Scholar 

  323. Pomarede R, Czernichow P, Finidori J, Pfister A, Roger M, Kalifa C, Zucker JM, Pierre-Kahn A, Rappaport R (1982) Endocrine aspects and tumoral markers in intracranial germinoma: an attempt to delineate the diagnostic procedure in 14 patients. J Pediatrics 101: 374–378

    CAS  Google Scholar 

  324. Pontz BF, Bohl J, Gutjahr P (1984) Konnatales Astrozytom. Kinderarzt 15: 777–781

    Google Scholar 

  325. Poppen JL, Marino R (1968) Pinealoma and tumors of the posterior part of the third ventricle. J Neurosurg 28: 357–364

    PubMed  CAS  Google Scholar 

  326. Price RA, Jamieson PA (1975) The central nervous system in childhood leukemia. II. subacute leukoencephalopathy. Cancer 35: 306–318

    Google Scholar 

  327. Price RA, Birdwell DA (1978) The central nervous system in childhood leukemia. III. Mineralizing microangiopathy and dystrophic calcification. Cancer 42: 717–728

    Google Scholar 

  328. Probert JC, Parker BR, Kaplan HS (1973) Growth retardation in children after megavoltage irradiation of the spine. Cancer 32/II: 634–639

    Google Scholar 

  329. Quest DO, Brisman R, Antunes JL, Housepian EM (1978) Period of risk for recurrence of medulloblastoma. J Neurosurg 48: 159–163

    PubMed  CAS  Google Scholar 

  330. Raimondi AJ, Tornita R (1979) Advantages of “total” resection of medulloblastoma and disadvantages of full head post-operative radiation therapy. Child’s Brain 5: 550551

    Google Scholar 

  331. Raimondi AJ, Tornita T (1979) Medulloblastoma in childhood. Acta Neurochir (Wien) 50: 127–138

    CAS  Google Scholar 

  332. Raimondi AJ, Cerullo LJ (1980) Pediatric cerebral angiography. A descriptive atlas. Thieme, Stuttgart New York, pp 87–136

    Google Scholar 

  333. Raimondi AJ, Tornita T (1981) Hydrocephalus and infratentorial tumors. Incidence, clinical picture, and treatment. J Neurosurg 55: 174–182

    Google Scholar 

  334. Raimondi AJ, Tomita T (1982) Pineal tumors in childhood. Epidemiology, pathophysiology, and surgical approaches. Child’s Brain 9: 239–266

    Google Scholar 

  335. Rao YTR, Medini E, Haselow RE, Jones TK, Levitt SH (1981) Pineal and ectopic pineal tumors. The role of radiation therapy. Cancer 48: 708–713

    Google Scholar 

  336. Rashkind R, Beigel F (1961) Brain tumors in early infancy probably congenital in origin. J Pediatr 65: 727–732

    Google Scholar 

  337. Reigel DH, Scarff TB, Woodford JE (1979) Biopsy of pediatric brain stem tumors. Child’s Brain 5: 329–340

    PubMed  CAS  Google Scholar 

  338. Reiter RJ, Esquifino AI, Champney TH, Craft CM, Vaugham MK (1985) Pineal melatonin production in relation to sexual development in the male rat. In: Gupta D (ed) Pediatric neuroendocrinology. Croom Helm, London Sidney, pp 190–202

    Google Scholar 

  339. Rich TA, Cassady JR, Strand RD, Winston KR (1985) Radiation therapy for pineal and suprasellar germ cell tumors. Cancer 55: 932–940

    PubMed  CAS  Google Scholar 

  340. Richards GE, Wara WM, Grumbach MM, Kaplan SL, Sheline GE, Conte FA (1976) Delayed onset of hypopituitarism: sequelae of therapeutic irradiation of central nervous system, eye, and middle ear tumors. J Pediatr 89: 553–559

    PubMed  CAS  Google Scholar 

  341. Ringertz N, Reymond A (1949) Ependymomas and choroid plexus papilloms. J Neuropathol Exp Neurol 8: 355–390

    PubMed  CAS  Google Scholar 

  342. Ringertz N, Nordenstam H, Flyger G (1954) Tumors of the pineal region. J Neuropathol Exp Neurol 13: 540–561

    PubMed  CAS  Google Scholar 

  343. Roessmann U, Velasco ME, Gambetti P, Autilio-Gambetti L (1983) Neuronal and astrocytic differentiation in human neuroepithelial neoplasms. An immunohistochemical study. J Neuropathol Exp Neuol 42: 113–121

    Google Scholar 

  344. Roggli VL, Estrada R, Fechner RE (1979) Thyroid neoplasia following irradiation for medulloblastoma. Cancer 43: 2232–2238

    PubMed  CAS  Google Scholar 

  345. Rorke LB (1983) The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropathol Exp Neurol 42: 1–15.

    PubMed  CAS  Google Scholar 

  346. Rosen G, Ghavimi F, Vanucci R, Deck M, Tan C, Murphy L (1974) Pontine glioma. High-dose methotrexate and leucovorin rescue. J Am Med Assoc 230: 1149–1152

    Google Scholar 

  347. Rosen G, Ghavimi F, Nirenberg A, Mosende C, Mehta BP (1977) High-dose methotrexate with citrovorum factor rescue for the treatment of central nervous system tumors in children. Cancer Treat Rep 61: 681–690

    PubMed  CAS  Google Scholar 

  348. Rosenblum ML (1983) Stem cell studies of human malignant brain tumors. J Neurosurg 58: 170

    PubMed  CAS  Google Scholar 

  349. Rossi LN, Vasella F (1976) Hirntumoren im Kindesalter. Heiv Paediatr Acta 31: 21 1220

    Google Scholar 

  350. Röthig HJ (1982) Interferon and antitumour effects. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 42–43

    Google Scholar 

  351. Rothman SJ, Olanow CW (1981) Brain stem glioma in childhood: acute hemiplegic onset. Can J Neurol Sci 8: 63–64

    Google Scholar 

  352. Rozencweig M, von Hoff DD, Slavik M, Muggia FM (1977) Cis-diaminedichloroplatinum. (II): A new anticancer drug. Ann Int Med 86: 803–812

    Google Scholar 

  353. Rubin P, Casarett GW (1972) A direction for clinical radiation pathology. The tolerance dose. Front Radiat Ther Oncol 6: 1–16

    Google Scholar 

  354. Rubinstein U, Northfiled DW (1964) Medulloblastoma and the so-called “arachnoidal cerebellar sarcoma”. Brain 87: 379–412

    PubMed  CAS  Google Scholar 

  355. Rubinstein U (1972) Tumors of the central nervous system. Atlas of tumor pathology. AFIP, Washington DC

    Google Scholar 

  356. Rubinstein U (1972) Cytogenesis and differentiation of primitive neuroepithelial tumors. J Neuropathol Exp Neurol 31: 7–26

    PubMed  CAS  Google Scholar 

  357. Rubinstein U (1974) The cerebellar medulloblastoma: its origin, differentiation, morphologic variants, and biologic behavior. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 18. North-Holland, Amsterdam, pp 167–193

    Google Scholar 

  358. Rubinstein U, Herman MM, Hanbery JW (1974) The relationship between differentiating medulloblastoma and differentiating diffuse astrocytoma. Light, electron microscopic, tissue, and organ culture observations.. Cancer 33: 890–897

    Google Scholar 

  359. Rubinstein L, Herman MM, Long TF, Wilbur JR (1975) Disseminated necrotizing leukoencephalopathy: a complication of treated central nervous system leukemia and lymphoma. Cancer 35: 291–305

    PubMed  CAS  Google Scholar 

  360. Russell A (1951) A diencephalic syndrome of emaciation in infancy and childhood. Arch Dis Childh 26: 274–275

    Google Scholar 

  361. Russell DS, Rubinstein LJ (1977) Pathology of tumors of the central nervous system. London: Arnold

    Google Scholar 

  362. Sacrez R, Juif JG, Friedrich E (1954) Tumeurs cérébrales du nourisson. Arch Franc Pédiatrie 11: 261–263

    CAS  Google Scholar 

  363. Saiki JH, Thompson S, Smith F, Atkinson R (1972) Paraplegia following intrathecal chemotherapy. Cancer 29: 370–374

    PubMed  CAS  Google Scholar 

  364. Salazar OM, Castro-Vita H, Bakos RS, Feldstein ML, Keller B, Rubin P (1979) Radiation therapy for tumors of the pineal region. Int J Radiat Oncol Biol Phys 5: 491499

    Google Scholar 

  365. Salmon S (1980) Clinical correlation of in vitro drug sensitivity. In: Salmon S, Cloning of human tumour stem cells. Alan R Liss, New York

    Google Scholar 

  366. Sanford RA, Laurent JP (1985) Intraventricular tumors of childhood. Cancer 56: 1795–1799

    PubMed  CAS  Google Scholar 

  367. Sano K, Matsutani M (1981) Pinealoma (germinoma) treated by direct surgery and postoperative irradiation. Child’s Brain 8: 81–97

    PubMed  CAS  Google Scholar 

  368. Sayers MP (1978) Treatment of optic pathway gliomas. In: O’Brien MS (ed) Pediatric neurological surgery. Raven Press, New York, pp 51–58

    Google Scholar 

  369. Schäfer M, Lapras C, Ruf H (1978) Catheterization of the aqueduct in certain lesions of the posterior fossa. Adv Neurosurg 5: 216–220

    Google Scholar 

  370. Schatzki PF, Mortati SG, McCain WG (1956) Brain tumor in the newborn infant. New Engl J Med 255: 908–909

    PubMed  Google Scholar 

  371. Scheithauer BW (1978) Symptomatic subependymoma. Report of 21 cases with review of the literature. J Neurosurg 49: 689–696

    PubMed  CAS  Google Scholar 

  372. Schenk K, Solcher H (1970) Diffuse Glioblastose im Kindesalter. Neuropädiatrie 2: 98–106

    Google Scholar 

  373. Schindler E (1985) Die Tumoren der Pinealisregion. Springer, Berlin Heidelberg New York

    Google Scholar 

  374. Schmidek HH (1977) Surgical management of pineal region tumors. Suprasellar germinomas. In: Schmidek HH (ed) Pineal tumors. Masson, New York, pp 99–103 and 115–125

    Google Scholar 

  375. Schmidt RC, Engelhardt P (1981) CT und Liquorzytologie bei massiver meningealer Aussaat eines frisch operierten Medulloblastoms. Aktuel Neurol 8: 82–84

    Google Scholar 

  376. Schmitt HP, Zeisner W (1982) The diffuse brain stem astrocytoma in childhood: morphology, course, and prognosis. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 149–164

    Google Scholar 

  377. Schmitt HP (1983) Rapid anaplastic transformation of gliomas in childhood. Neuropediatrics 14: 137–143

    PubMed  CAS  Google Scholar 

  378. Schold SC, Wasserstrom WR, Fleisher M, Schwartz MK, Posner JB (1980) Cerebrospinal fluid biochemical markers of central nervous system metastases. Ann Neurol 8: 597–604

    PubMed  CAS  Google Scholar 

  379. Schreiber D, Bernstein K, Warzok R (1982) Tumormetastasen im Zentralnervensystem. Eine prospektive Studie. Zbl Allg Pathol Pathol Anat 126: 41–52

    Google Scholar 

  380. Schreiber D, Bernstein K, Schneider J (1982) Tumormetastasen im Zentralnervensystem. Eine prospektive Studie. Zbl Allg Pathol Pathol Anat 126: 64–73

    Google Scholar 

  381. Schreiber D, Jänisch W, Gerlach H (1982) CNS tumours in infancy, childhood, and adolescence. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 62–68

    Google Scholar 

  382. Schulte FJ (1984) Intracranial tumors in childhood—concepts for treatment and prognosis. Neuropediatrics 15: 3–12

    PubMed  CAS  Google Scholar 

  383. Schwarz ES, Wahlen W, Sitzmann FC (1984) Hirntumoren im Kindes-und Jugendalter. Therapiewoche 34: 1336–1346

    Google Scholar 

  384. Segall HD, Batnitzky S, Zee CS, Ahmadi J, Bird CR, Cohen ME (1985) Computed tomography in the diagnosis of intracranial neoplasms in children. Cancer 56: 17481755

    Google Scholar 

  385. Seiler RW (1982) Die undifferenzierten Astrozytome des Großhirns. Eine Übersicht der aktuellen Therapiemöglichkeiten. Springer, Berlin Heidelberg New York (Neurology, ser 22 )

    Google Scholar 

  386. Shalet SM (1982) Growth and hormonal status of children treated for brain tumors. Child’s Brain 9: 284–293

    PubMed  CAS  Google Scholar 

  387. Shapiro WR (1975) Chemotherapy of primary malignant brain tumors in children. Cancer 35: 965–972

    PubMed  CAS  Google Scholar 

  388. Shapiro WR (1982) Treatment of neuroectodermal brain tumors. Ann Neurol 12: 231237

    Google Scholar 

  389. Shaw CM, Sumi SM, Alvord EC, Gerdes AJ, Spence A, Parker RG (1978) Fast neutron irradiation in glioblastoma multiforme. J Neurosurg 39: 1–12

    Google Scholar 

  390. Sheline GE (1975) Radiation therapy of tumors of the central nervous system in childhood. Cancer 35: 957–964

    PubMed  CAS  Google Scholar 

  391. Sheline GE (1975) Conventional radiation therapy of gliomas. Rec Res Cancer Res 51: 125–134

    Google Scholar 

  392. Sheline GE (1983) Radiotherapy of adults primary neoplasms. In: Walker MD (ed) Oncology of the nervous system. M Nijhoff, The Hague, pp 223–245

    Google Scholar 

  393. Shukovsky LJ, Fletcher GH (1972) Retinal and optic nerve complications in high dose irradiation technique of ethmoid sinus and nasal cavity. Radiology 104: 629–634

    PubMed  CAS  Google Scholar 

  394. Shuman RM, Alvord EC, Leech RW (1975) The biology of childhood ependymomas. Arch Neurol (Chic) 32: 731–739

    CAS  Google Scholar 

  395. Sieben RL, Ishii N (1971) Brain stem glioma causing failure to thrive. Pediatrics 47: 451–455

    PubMed  CAS  Google Scholar 

  396. Siegal T, Pfeffer MR, Catane R, Sulkes A, Gomori MJ, Fuks Z (1983) Successful chemotherapy of recurrent intracranial germinoma with spinal metastases. Neurology (Minneap) 33: 631–633

    CAS  Google Scholar 

  397. Silverman CL, Simpson JR (1982) Cerebellar medulloblastoma: the importance of posterior fossa dose to survival and patterns of failure. Int J Radiat Oncol Biol Phys 8: 1869–1876

    PubMed  CAS  Google Scholar 

  398. Simpson DA, Carter RF, Ducru W (1968) Brain tumors of early infancy. Dev Med Child Neurol 10: 190–199

    PubMed  CAS  Google Scholar 

  399. Skullerod K, Halvorsen K (1978) Encephalomyelopathy following intrathecal methotrexate treatment in a child with acute leukemia. Cancer 42: 1211–1215

    Google Scholar 

  400. Smith DR, Hardman JM, Earle KM (1969) Metastasizing neuroectodermal tumors of the central nervous system. J Neurosurg 31: 50–58

    PubMed  CAS  Google Scholar 

  401. Smith RA, Lampe I, Kahn EA (1961) The prognosis of medulloblastoma in children. J Neurosurg 18: 91–97

    Google Scholar 

  402. So SC, Ho J (1980) Multiple primary germinomas (ectopic pinealoma of the brain). Neurochirurgia (Stuttg) 23: 147–150

    CAS  Google Scholar 

  403. Sobin LH (1963) Multiple congenital neoplasms. Arch Pathol 76: 602–608

    PubMed  CAS  Google Scholar 

  404. Solitare GB, Krigman MR (1964) Congenital intracranial neoplasma. A case report and review of the literature. J Neuropathol Exp Neurol 23: 280–292

    Google Scholar 

  405. Spranger J (1982) Brain tumors and genetics. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 132–141

    Google Scholar 

  406. Stachura I, Mendelow H (1980) Endodermal sinus tumor originating in the region of the pineal gland. Cancer 45: 2131–2137

    PubMed  CAS  Google Scholar 

  407. Stefanko SZ, Manschot WA (1979) Pinealoblastoma with retinomatous differentiation. Brain 102: 321–332

    PubMed  CAS  Google Scholar 

  408. Stein BM (1971) The infratentorial supracerebellar approach to pineal lesions. J Neurosurg 35: 197–202

    PubMed  CAS  Google Scholar 

  409. Stein BM (1979) Surgical treatment of pineal tumors. Clin Neurosurg 26: 490–510

    PubMed  CAS  Google Scholar 

  410. Stone JL, Zavala G, Bailey OT (1979) Mixed malignant mesenchymal tumor of the cerebellar vermis. Cancer 44: 2165–2172

    PubMed  CAS  Google Scholar 

  411. Strange P, Wohlert L (1982) Primary brain stem tumors. Acta Neurochir (Wien) 62: 219–232

    CAS  Google Scholar 

  412. Sundaresan N, Gutierrez FA, Larsen MB (1978) Radiation myelopathy in children. Ann Neurol 4: 47–50

    PubMed  CAS  Google Scholar 

  413. Sunder-Plassmann M, Jellinger K (1972) Großhirn-Glioblastom bei einem Säugling. Z Kinderchir 11: 97–103

    Google Scholar 

  414. Sung DI, Harisiadis L, Chang CH (1978) Midline pineal tumors and suprasellar germinomas: highly curable by irradiation. Radiology 128: 745–751

    PubMed  CAS  Google Scholar 

  415. Suzuki J, Iwabuchi T (1965) Surgical removal of pineal tumors (pinealoma and teratoma). J Neurosurg 563–571

    Google Scholar 

  416. Takahashi M, Okudera T, Tanaka M, Kitamura K, Yonemasu Y (1973) Angiographie diagnosis of cerebellar medulloblastomas. Evaluation of pre-and postoperative vertebral angiograms. Am J Roentgenol 118: 622–632

    Google Scholar 

  417. Takei Y, Pearl GS (1981) Ultrastructural study of intracranial yolk sac tumor: with special reference to the oncologie phylogeny of germ cell tumors. Cancer 48: 2038–2048

    PubMed  CAS  Google Scholar 

  418. Takeuchi J, Handa H, Atsuka S, Takebe Y (1979) Neuroradiological aspects of suprasellar germinoma. Neuroradiology 17: 153–159

    PubMed  CAS  Google Scholar 

  419. Tavcar D, Robboy SJ, Chapman P (1980) Endodermal sinus tumor of the pineal region. Cancer 45: 1646–1651

    Google Scholar 

  420. Teilum G (1965) Classification of endodermal sinus tumor (mesoblastoma vitellinum) and so-called “embryonal carcinoma” of the ovary. Acta Pathol Microbiol Scand 64: 407–429

    PubMed  CAS  Google Scholar 

  421. Terheggen HG, Rado M (1978) Cerebrale Komplikationen der Leukämiebehandlung. I. Das Apathiesyndrom. Monatsschr Kinderheilkd 126: 693–695

    Google Scholar 

  422. Terheggen HG (1978) Cerebrale Nebenwirkungen bei der Behandlung akuter Leukämien im Kindesalter. II. Die methotrexatinduzierte Encephalopathie. Monatsschr Kinderheilkd 126: 696–701

    PubMed  CAS  Google Scholar 

  423. Thorbeck R (1981) Hirntumor nach Schädel-Hirn-Trauma. In: Hirt H (Hrsg) Aktuelle Neuropädiatrie III. Thieme, Stuttgart New York, S 192–199

    Google Scholar 

  424. Tibbs PA, Mortara RH (1980) Primary glioblastoma multiforme of the cerebellum. A case report. Acta Neurochir (Wien) 52: 13–18

    Google Scholar 

  425. Tijssen CC, Halprin MR, Endtz U (1982) Familial brain tumours. Nijhoff, The Hague Boston London

    Google Scholar 

  426. Tönnis W, Borck WF (1953) Großhirntumoren des Kindesalters. Zentralbl Neurochir 13: 72–98

    PubMed  Google Scholar 

  427. Ueki K, Tanaka R (1980) Treatment and prognosis of pineal tumors—experience of 110 cases. Neurol Med Chir (Tokyo) 20: 1–26

    CAS  Google Scholar 

  428. Vanucci RC, Baten M (1974) Cerebral metastatic disease in childhood. Neurology (Minneap) 24: 981–985

    Google Scholar 

  429. Vick NA, Khandekar J, Bigner DD (1977) Chemotherapy of brain tumors. The “blood-brain barrier” is not a factor. Arch Neurol 34: 523–526

    Google Scholar 

  430. Villani R, Giani SM, Tomei G (1975) Follow-up study of brain stem tumors in children. Child’s Brain 1: 126–135

    PubMed  CAS  Google Scholar 

  431. Vonofakos D, Marcu H, Hacker H (1979) Oligodendroglioma: CT patterns with emphasis on features indicating malignancy. J Comp Ass Tomogr 3: 783–788

    Google Scholar 

  432. Waggener JD, Beggs JL (1976) Vasculature of natural neoplasms. Adv Neurol 15: 2749

    Google Scholar 

  433. Waldbauer H, Gottschald M, Schmidt G, Neuhäuser G (1976) Medulloblastom des Kleinhirns und Pinealoblastom bei eineiigen Zwillingen. Klin Pädiatr 188: 366–371

    Google Scholar 

  434. Walker MD (1975) Chemotherapy: adjuvant to surgery and radiation therapy. Sem Oncol 2: 69–72

    CAS  Google Scholar 

  435. Walker MD (1976) Diagnosis and treatment of brain tumors. Pediat Clin North Am 23: 131–146

    CAS  Google Scholar 

  436. Wallace S, Charnsangavej C, Carrasco CH, Bechtel W (1984) Infusion-embolization. Cancer 54: 2751–2765

    PubMed  CAS  Google Scholar 

  437. Walther B, Gutjahr P, Beron CCG (1981) Therapiebegleitende und -überdauernde neurologische und neuropsychologische Diagnostik bei akuter lymphoblastischer Leukämie im Kindesalter. Klin Pädiatr 193: 177–183

    PubMed  CAS  Google Scholar 

  438. Walther B, Gutjahr P (1982) Development after treatment of cerebellar medulloblastoma in childhood. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 389–398

    Google Scholar 

  439. Wannemacher M, Knüfermann H (1978) Fortschritte in der Therapie des Medulloblastoms. Onkologie 1: 92–96

    Google Scholar 

  440. Wara WM, Fellows CF, Sheline GE, Wilson CB, Townsend JT (1977) Radiation therapy for pineal tumors and suprasellar germinomas. Radiology 124: 221–223

    PubMed  CAS  Google Scholar 

  441. Wara W, Sheline GE (1978) The role of radiotherapy in the treatment of pediatric brain tumors. In: O’Brien MS (ed) Pediatric neurological surgery. Raven Press, New York, pp 81–86

    Google Scholar 

  442. Wara WM, Jenkin RDT, Evans A, Ertel I, Hittle R, Ortega J, Wilson CB, Hammond D (1979) Tumors of the pineal and suprasellar region: Childrens Cancer Study Group treatment results 1960–1975. A report from Childrens Cancer Study Group. Cancer 43: 698–701

    Google Scholar 

  443. Welte K, Engert A, Siegert M, Gardner H (1979) Verhalten von Gerinnungsproteinen im Liquor cerebìospinalis bei Kindern mit akuter lymphoblastischer Leukämie ( ALL) während der kombinierten Induktionstherapie. Monatsschr Kinderheilkd 127: 262265

    Google Scholar 

  444. West CR, Bruce DA, Duffner PK (1985) Ependymomas. Factors in clinical and diagnostic staging. Cancer 56: 1812–1816

    Google Scholar 

  445. Whyte TB, Colby MJ, Layton DD (1969) Radiation therapy of brain stem tumors. Radiology 93: 413–421

    PubMed  CAS  Google Scholar 

  446. Wilcke 0 (1981) Therapie and Prognose der Medulloblastome im Kindesalter. In: Hanefeld F, Rating D (Hrsg) Aktuelle Neuropädiatrie II. Hippokrates, Stuttgart, S 86–93

    Google Scholar 

  447. Winkelman NW, Cassel C, Schlesinger B (1952) Intracranial tumors with extracranial metastases. J Neuropathol Exp Neurol 11: 149–168

    PubMed  Google Scholar 

  448. Wisiol ES, Handler S, French LA (1962) Extracranial metastases of a glioblastoma multiforme. J Neurosurg 19: 186–194

    PubMed  CAS  Google Scholar 

  449. Wray SH (1977) The neuro-ophthalmic or neurologic manifestations of pinealoma. In: Schmidek HH (ed) Pineal tumors. Masson, New York Paris Barcelona, pp 21–59

    Google Scholar 

  450. Yates AJ, Becker LE, Sachs LA (1979) Brain tumors in childhood. Child’s Brain 5: 3139

    Google Scholar 

  451. Young LJ, Miller RW (1975) Incidence of malignant tumors in U.S. children. J Pediatr 86: 254–258

    PubMed  Google Scholar 

  452. Yung WA, Horten BC, Shapiro WR (1980) Meningeal gliomatosis: a review of 12 cases. Ann Neurol 8: 605–608

    PubMed  CAS  Google Scholar 

  453. Yunis JJ, Ramsay N (1978) Retinoblastoma and subband deletion of chromosome 13. Am J Dis Child 132: 161–163

    PubMed  CAS  Google Scholar 

  454. Zimmerman RA, Bilaniuk LT, Pahlajani H (1978) Spectrum of medulloblastoma demonstrated by computed tomography. Radiology 126: 137–141

    PubMed  CAS  Google Scholar 

  455. Zimmerman RA, Bilaniuk LT, Wood JH, Bruce DA, Schut L (1980) Computed tomography of pineal, parapineal, and histologically related tumors. Radiology 137: 669–677

    PubMed  CAS  Google Scholar 

  456. Zülch KJ (1975) Atlas of gross neurosurgical pathology. Springer, Berlin Heidelberg New York

    Google Scholar 

  457. Zülch KJ (1980) Principles of the new World Health Organization (WHO) classification of brain tumors. Neuroradiology 19: 59–66

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Pediatric Neurology, Zentrum der Kinderheilkunde, Frankfurt am Main, Federal Republic of Germany

    Prof. Dr. G. Jacobi

  2. Division of Pediatric Oncology and Hematology, Zentrum der Kinderheilkunde, Frankfurt am Main, Federal Republic of Germany

    B. Kornhuber

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  1. Prof. Dr. G. Jacobi
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  1. Ludwig Boltzmann Institute of Clinical Neurobiology, Lainz Hospital, Vienna, Austria

    Kurt Jellinger

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Jacobi, G., Kornhuber, B. (1987). Malignant Brain Tumors in Children. In: Jellinger, K. (eds) Therapy of Malignant Brain Tumors. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8876-7_8

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  • DOI: https://doi.org/10.1007/978-3-7091-8876-7_8

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