Pathology of Human Intracranial Neoplasia

  • K. Jellinger


Intracranial neoplasms (ICN) are divided into primary growths derived from the central nervous system (CNS) and other structures within the cranial cavity, and secondary or metastatic tumors. Although ultimately classified according to the cell of origin, primary intracranial growths can be broadly subdivided into a) neuroectodermal neoplasms arising from the CNS tissue and b) those tumors derived from other structures within the cranial cavity. The natural history of ICN is not only related to their cytology, anatomical pattern, extent and growth behavior, but also to their location or site within the cranial cavity, and the reaction of the host with respect to increased intracranial pressure, cerebral barrier functions, blood flow, and immunological response.


Brain Tumor Anaplastic Astrocytoma Pilocytic Astrocytoma Granular Cell Tumor Anaplastic Glioma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Adams JH, Graham DI, Doyle D (1981) Brain biopsy—the smear technique for neurosurgical biopsies. Chapman and Hall, LondonGoogle Scholar
  2. 2.
    Afra D, Müller W, Slowik F, Wilcke O, Budka H, Turoczy L (1983) Supratentorial lobar ependymomas; reports on the grading and survival periods in 80 cases, including 40 recurrences. Acta Neurochir (Wien) 69: 243–251Google Scholar
  3. 3.
    Ahyal A, Zimmermann A, Spaar FW (1983) Flow fluorescence-cytometry DNA in meningiomas; stud ies on surgically removed tumor specimens compared with their cells in primary tissue cultures. Surg Neurol 20: 195 - 205Google Scholar
  4. 4.
    Aichner F, Schuler G (1982) Primary leptomeningeal melanoma: Diagnosis by ultrastructural cytology of cerebrospinal fluid and cranial computed tomography. Cancer 50: 1751–1756PubMedGoogle Scholar
  5. 5.
    Allen JC, Nisselbaum J, Epstein F, Rosen G, Schwartz MK (1980) Alphafetoprotein and human chorionic gonadotropin determination in cerebrospinal fluid. An aid in the diagnosis and management of intracranial germ-cell tumors. J Neurosurg 51: 369–374Google Scholar
  6. 6.
    Ambier M, Pogacar S, Sidman R (1969) Lhermitte-Duclos disease (granule cell hypertrophy of the cerebellum): Pathological analysis of the first familial cases. J Neuropathol Exp Neurol 28: 622–647Google Scholar
  7. 7.
    Anderson WR, Cameron JD, Tsai SH (1980) Primary intracranial leiomyosarcoma. J Neurosurg 53: 401–405PubMedGoogle Scholar
  8. 8.
    Ansell J, Bhawan J, Cohen S, Sullivan J, Sherman D (1982) Histiocytic lymphoma and malignant angioendotheliomatosis. One disease or two? Cancer 50: 1506–1512PubMedGoogle Scholar
  9. 9.
    Arendt A (1975) Ependymomas. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 18. Elsevier, Amsterdam New York, pp 105–150Google Scholar
  10. 10.
    Arendt A (1977) Histologisch-diagnostischer Atlas der Geschwülste des Zentralnervensystems und seiner Anhangsgebilde. Fischer, JenaGoogle Scholar
  11. 11.
    Arendt A (1982) Histopathologie von Gliomrezidiven. Zbl allg Path pathol Anat 126: 499–504Google Scholar
  12. 12.
    Artigas J, Cervos-Navarro J, Iglesias JR, Ebhardt G (1985) Gliomatosis cerebri: clinical and histological findings. Clin Neuropathol 4: 135–148PubMedGoogle Scholar
  13. 13.
    Auer RN, Becker LE (1983) Cerebral medulloepithelioma with bone, cartilage and striated muscle. J Neuropathol Exp Neurol 42: 256–267PubMedGoogle Scholar
  14. 14.
    Auer RN, Rice GPA, Hinton GG, Amacher AL, Gilbert JJ (1981) Cerebellar astrocytoma with benign histology and malignant clinical course. J Neurosurg 54: 128–132PubMedGoogle Scholar
  15. 15.
    Azzarelli B, Richards DE, Anton AH, Roesmann U (1977) Central neuroblastomaElectron-microscopic observations and catecholamine determinations. J Neuropathol Exp Neurol 36: 384–397PubMedGoogle Scholar
  16. 16.
    Bagshawe KD (1976) Risk and prognostic factors in trophoblastic neoplasia. Cancer 58: 1375–1378Google Scholar
  17. 17.
    Bailey P, Cushing H (1926) Classification of tumors of the glioma group on a histogenetic basis with a correlated study of prognosis. Lippincott, PhiladelphiaGoogle Scholar
  18. 18.
    Bamborschke S, Ebhardt G, Szelies-Stock B, Dreesbach HA, Heiss WD (1985) Review and case report: Primary melanoblastosis of the leptomeninges. Clin Neuropathol 4: 47–55PubMedGoogle Scholar
  19. 19.
    Barnard RO (1982) The classification of tumors of the central nervous system. Neuropathol Appl Neurobiol 8: 1–10PubMedGoogle Scholar
  20. 20.
    Barnard RO (1986) The pathology of brain tumours. In: Bleehen NM (ed) Tumours of the brain. Springer, Berlin Heidelberg New York Tokyo, pp 1–18Google Scholar
  21. 21.
    Barnard RO, Bradford R, Scott T, Thomas DCT (1986) Gliomyosarcoma: Report of a case of rhabdomyosarcoma arising in a malignant glioma. Acta Neuropathol (Berl) 69: 23–27Google Scholar
  22. 22.
    Barnard RO, Logue V, Reaves PS (1976): An atlas of tumours involving the central nervous system. Baillière and Tindall, LondonGoogle Scholar
  23. 23.
    Bartkowski HM (1984) Peritumoral edema. Prog Exp Tumor Res 27: 179–190PubMedGoogle Scholar
  24. 24.
    Battista AF, Bloom W, Koffman H, Feigin I (1961) Autotransplantation of anaplastic astrocytomas into the subcutaneous tissue of man. Neurology 11: 977–981PubMedGoogle Scholar
  25. 25.
    Batzdorf U, Malamud N (1963) The problem of multicentric gliomas. J Neurosurg 20: 122–136PubMedGoogle Scholar
  26. 26.
    Becker LE (1985) An appraisal of the World Health Organization classification of tumors of the central nervous system. Cancer 56: 1858–1864PubMedGoogle Scholar
  27. 27.
    Becker LE, Hinton D (1983) Primitive neuroectodermal tumors of the central nervous system. Hum Pathol 14: 538–550PubMedGoogle Scholar
  28. 28.
    Bennett JP, Rubinstein LJ (1984) The biological behavior of primary cerebral neuroblastoma: A reappraisal of the clinical course in a series of 70 cases. Ann Neurol 16: 21–27PubMedGoogle Scholar
  29. 29.
    Berger MS, Edwards MSB, Wara WM, Levis VY, Wilson CB (1983) Primary cerebral neuroblastoma. Long-term follow-up and therapeutic guidelines. J Neurosurg 59: 418–423PubMedGoogle Scholar
  30. 30.
    Bernell WR, Kepes JJ, Seitz EP (1972) Malignant recurrence of childhood cerebellar astrocytoma. J Neurosurg 37: 470–475PubMedGoogle Scholar
  31. 31.
    Bernstein U, Schreiber D, Schweider J (1982) Tumormetastasen im Zentralnervensystem. Eine prospektive Studie. Zbl Allg Pathol Anat 126: 53–63Google Scholar
  32. 32.
    Berry MP, Jenkin RDT (1981) Parameningeal rhabdomyosarcoma in the young. Cancer 48: 281–288PubMedGoogle Scholar
  33. 33.
    Biggs PJ, Powers JM (1984) Neuroblastic medulloblastoma with abundant cytoplasmic actin filaments. Arch Pathol Lab Med 108: 326–329PubMedGoogle Scholar
  34. 34.
    Bilzer TH, Stavrou D (1985) Cell-mediated immune response during progressive glioma growth. In: Voth D, Krauseneck P (eds) Chemotherapy of gliomas. de Gruyter, Berlin New YorkGoogle Scholar
  35. 35.
    Bloom HJG (1982) Intracranial tumor: Response and resistance to therapeutic endeavors. Int J Rad Oncol Biol Phys 8: 1083–111Google Scholar
  36. 36.
    Bloom HJG (1986) Treatment of brain gliomas in children. In: Bleehan NM (ed) Tumours of the brain. Springer, Berlin Heidelberg New York, pp 121–140Google Scholar
  37. 37.
    Bloom HJG, Richardson WW, Field JG (1970) Host resistance and survival in carcinoma of the breast: A study of 104 cases of medullary carcinoma in a series of 1,411 cases of breast cancer followed for 20 years. Brit Med J 3: 181–188PubMedGoogle Scholar
  38. 38.
    Böck P, Jellinger K (1981) Detection of glycosaminoglycans in human gliomas by histochemical methods. Acta Neuropathol (Berl) Suppl 7: 81–84Google Scholar
  39. 39.
    Böker DK (1982) Lymphocytic infiltration in human intracranial tumors. Morphologic evidence for a host-immune reaction and comparison with the leukocyte migration test. Clin Neuropathol 1: 113–120PubMedGoogle Scholar
  40. 40.
    Böker DK, Gullotta F (1985) Mononuclear infiltrates in human brain tumours: possible morphological equivalence of an immunological defence reaction. In Voth D, Krauseneck P (eds) Chemotherapy of gliomas. De Gruyter, Berlin, pp 87–92Google Scholar
  41. 41.
    Böker DK, Ka1ff R, Gullotta F, Weekes-Seifert S, Möhrer S (1984) Mononuclear infiltrates in human intracranial tumors as a prognostic factor. Influence of preoperative steroid treatment. I. Glioblastoma. Clin Neuropathol 3: 143–147PubMedGoogle Scholar
  42. 42.
    Boekstegers A, Grundmann E (1985) What a new in natural killer cells? Path Res Pract 180: 536–552PubMedGoogle Scholar
  43. 43.
    Boesel CP, Suhan JP, Sayers MP (1978) Melanotic medulloblastoma. Report of a case with ultrastructural findings. J Neuropathol Exp Neurol 37: 531–543PubMedGoogle Scholar
  44. 44.
    Bonnin JM, Pena CE, Rubinstein LJ (1983) Mixed capillary hemangioblastoma and glioma. Redefinition of the “angioglioma”. J Neuropathol Exp Neurol 42: 504–516PubMedGoogle Scholar
  45. 45.
    Bonnin JM, Rubinstein U (1984) Immunocytochemistry of central nervous system tumors: Its contribution to neurosurgical diagnosis. J Neurosurg 60: 1121–1133PubMedGoogle Scholar
  46. 46.
    Bonnin JM, Rubinstein LJ, Papasozomenos SCH, Marangos PJ (1984) Subependymal glial cell astrocytoma. Significance and possible cytogenetic implications of an immunohistochemical study. Acta Neuropathol (Berl) 62: 185–193Google Scholar
  47. 47.
    Bont A, Blackwood W, Mair WGP (1980) The separation of pineocytoma from pineoblastoma. Cancer 45: 1408–1418Google Scholar
  48. 48.
    Bradford R, Crockard HA, Isaacson PG (1985) Primary rhabdomyosarcoma of the CNS (case report). Neurosurg 17: 101–104Google Scholar
  49. 49.
    Broder AC (1926) Carcinoma. Grading and practical application. Arch Path (Chic) 2: 376Google Scholar
  50. 50.
    Brooks JJ, LiVolsi VA, Trojanowski JQ (1986) Does chondroid chordoma exist? Acta Neuropathol (Berl )Google Scholar
  51. 51.
    Brooks WH, Markesberry WR, Gupta GD, Roszman TL (1978) Relationship of lymphocyte invasion and survival of brain tumor patients. Ann Neurol 4: 219–224PubMedGoogle Scholar
  52. 52.
    Brooks WH, Roszmal TL (1980) Cellular immune responsitiveness of patients with primary intracranial tumours. In: Thomas DGT, Graham DI (eds) Brain tumours. Butterworth, London Boston, pp 121–132Google Scholar
  53. 53.
    Bruno LA, Rorke LB, Norris DG (1981) Primary neuroectodermal tumors of infancy and childhood. In: Humphrey GB, Dehner LP (eds) Pediatric oncolocy, I. M Nijhoff, The Hague Boston, pp 265–267Google Scholar
  54. 54.
    Budka H (1974) Intracranial lipomatous hamartoma (“intracranial lipomas”). Acta Neuropathol (Berl) 28: 205–222Google Scholar
  55. 55.
    Budka H (1975) Partially resected and irradiated cerebellar astrocytoma of childhood: malignant evolution after 28 years. Acta Neurochir (Wien) 32: 139–146Google Scholar
  56. 56.
    Budka H (1984) Tumoren des Zentralnervensystems. In: Österr Ges Pathol (Hrsg) Histologische Tumorklassifikation. Springer, Wien New York, S 140–146Google Scholar
  57. 57.
    Budka H, Jellinger K, Lassmann H, Weiser G (1974) Tumoren des peripheren Nervengewebes. In: Österr Ges Pathol (Hrsg) Histologische Tumorklassifikation. Springer, Wien New York, S 147–149Google Scholar
  58. 58.
    Budka H, Majdic O, Knapp W (1985) Cross-reactivity between human hemopoietic cells and brain tumors as defined by monoclonal antibodies. J Neuro-Oncol 3: 173–179Google Scholar
  59. 59.
    Budka H, Pilz P, Guseo A (1975) Primary leptomeningeal sarcomatosis. Clinico-pathological report of six cases. J Neurol 211: 77–93PubMedGoogle Scholar
  60. 60.
    Budka H, Podreka I, Reisner TH, Zeiler K (1980) Diagnostic and pathomorphological aspects in glioma multiplicity. Neurosurg Rev 3: 233–241PubMedGoogle Scholar
  61. 61.
    Budka H, Podreka I, Zaunbauer F (1979) Overgrowth of a primitive cell population in operated recurrent gliomas: The possible cell population and radiotherapy. In: Paoletti P, Walker MD, et al. (eds): Multidisciplinary aspects of brain tumor therapy. Elsevier/North-Holland, Amsterdam New York, pp 357–362Google Scholar
  62. 62.
    Burger PC (1985) The “ideal” classification of pediatric central nervous system neoplasms. Cancer 56: 1865–1868PubMedGoogle Scholar
  63. 63.
    Burger PC, Dubois PJ, Schold SC Jr, Smith KR Jr, Odom GL, Crafts DC, Giangasparo F (1983) Computed tomographic and pathologic studies of the untreated, quiescent, and recurrent glioblastoma multiforme. J Neurosurg 58: 159–169PubMedGoogle Scholar
  64. 64.
    Burger PC, Grahmann F, Bliestle A, Kleihues P (1986) Differentiation in the medulloblastoma—an immunohistochemical study (abstr). Clin Neuropathol 5: 110Google Scholar
  65. 65.
    Burger PC, Mahaley MS, Dudka L, Vogel FS (1979) The morphologic effects of radiation administered therapeutically for intracranial gliomas: A postmortem study of 25 cases. Cancer 44: 1256–1272PubMedGoogle Scholar
  66. 66.
    Burger PC, Makek M, Kleihues P (1986) Tissue polypeptide antigen ( TPA) staining of the chondroma and notochordal remnants. Acta Neuropathol (Berl) 70: 269–272Google Scholar
  67. 66a.
    Burger PC, Shibata T, Kleihues P (1986) The use of monoclonal antibody Ki-67 in the identification of proliferating cells. Application to surgical neuropathology. Amer J Surg Pathol 10: 611–617Google Scholar
  68. 67.
    Burger PC, Vogel SF (1982) Surgical pathology of the nervous system and its coverings, 2nd edn. J Wiley, New YorkGoogle Scholar
  69. 68.
    Burger PC, Vogel SF, Green SB, Strike TA (1985) Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications. Cancer 56: 1106–1111PubMedGoogle Scholar
  70. 69.
    Burger PC, Vollmer R (1980) Histologic factors of prognostic significance in the glioblastoma multiforme. Cancer 46: 1179–1186PubMedGoogle Scholar
  71. 70.
    Cairncross JG, Pexman JHW, Rathbone MP, del Maestro RF (1985) Postoperative contrast enhancement in patients with brain tumor. Ann Neurol 17: 570–572PubMedGoogle Scholar
  72. 71.
    Campbell AN, Chan HS, Becker LE, Aneman A, Park TS, Hoffmann HJ (1984) Extracranial metastases in childhood primary intracranial tumors. Cancer 53: 979–981Google Scholar
  73. 72.
    Camins MB, Cravioto HM, Epstein F, Ransohoff J (1980) Medulloblastoma: An ultrastructural study. Evidence for astrocytic and neuronal differentiation. Neurosurg 6: 398–411Google Scholar
  74. 73.
    Cancer statistics 1983. CA Cancer Clin 33: 9–25Google Scholar
  75. 74.
    Casentini L, Gullotta F, Möhrer U (1981) Clinical and morphological investigations on ependymomas and their tissue cultures. Neurochir (Stuttg) 24: 51–56Google Scholar
  76. 75.
    Chatty EM, Earle KM (1971) Medulloblastoma: A report on 201 cases with emphasis on the relationship of histologic variants to survival. Cancer 28: 977–983PubMedGoogle Scholar
  77. 76.
    Chaudry AP, Haar JG, Koul A, Nickerson PA (1978) Olfactory neuroblastoma (esthesioneuroblastoma). A light and ultrastructural study of two cases. Cancer 44: 564–579Google Scholar
  78. 77.
    Chaudry AP, Montes M, Cohn GA (1980) Ultrastructure of cerebellar hemangioblastoma. Cancer 42: 1834–1850Google Scholar
  79. 78.
    Chin HW, Maruyama Y, Tibbs P, Markesberry W, Young B (1984) Cerebellar glioblastoma in childhood. J Neuro-Oncol 2: 79–84Google Scholar
  80. 79.
    Choi HSH, Anderson PJ (1984) Immunohistochemical diagnosis of olfactory neuro-blastoma. J Neuropathol Exp Neurol 44: 18–31Google Scholar
  81. 80.
    Chowdmury C, Roy S, Mahapara AK, Bhatia R (1985) Medullomyoblastoma, a teratoma. Cancer 55: 1495–1500Google Scholar
  82. 81.
    Coakham HB, Garson JA, Brownell B, Kemshead JT (1985) Diagnosis of cerebral neoplasms using monoclonal antibodies. In: Rose FS, Fields WS (eds), Neuro-Oncology. Karger, BaselGoogle Scholar
  83. 82.
    Codd MB, Kurland LT (1985) Descriptive epidemiology of primary intracranial neoplasms. In: Rose FS, Fields WS (eds) Neuro-Oncology. Karger, BaselGoogle Scholar
  84. 83.
    Coffin CM, Mukai K, Dehner LP (1983) Glial differentiation in medulloblastomas; Histogenetic insight, glial reaction, or invasion of the brain? Amer J Surg Pathol 7: 555–565Google Scholar
  85. 83a.
    Coffin CM, Wick MR, Brain JTT, Dehner LP (1986) Choroid plexus neuroplasms. Clinicopathologic and immunohistochemical studies. Amer J Surg Pathol 10: 394–404Google Scholar
  86. 84.
    Cohen MF, Duffner PK (eds) (1984) Brain tumors in children. Principles in diagnosis and treatment. Raven Press, New YorkGoogle Scholar
  87. 85.
    Cohandon F, Aouad N, Rougier A, Vital C, Rivel J, Dartigues JF (1985) Histologic and non-histologic factors correlated with survival time in supratentorial astrocytic tumors. J Neuro-Oncol 3: 105–111Google Scholar
  88. 86.
    Conley FK, Rubinstein U, Spence AM (1976) Studies on experimental malignant nerve sheath tumors maintained in tissue and organ culture systems. II. Electron microscopy observations. Acta Neuropathol (Berl) 34: 293–310Google Scholar
  89. 87.
    Cosatto JO, Font RL (1982) Hemangiopericytoma of the orbit. Human Pathol 13: 210–218Google Scholar
  90. 88.
    Curtis JL, Rubinstein LI (1982) Pigmented olfactory neuroblastoma. A new example of melanotic neuroepithelial neoplasm. Cancer 49: 2136–2143PubMedGoogle Scholar
  91. 89.
    Cybolski GR, Russell EJ, D Angelo CM, Bailey OT (1985) Falcine chondrosarcoma: Case report and literature review. Neurosurgery 16: 412–416Google Scholar
  92. 90.
    De Abrera VSE, Burke W, Bleasel KR, Bader L (1973) Carcinomas of the pituitary gland. J Pathol 109: 335–343PubMedGoogle Scholar
  93. 91.
    Dastur DK (1983) Cerebral ganglioglio-neuroblastoma: an unusual brain tumor of the neuron series. J Neurol Neurosurg Psych 45: 139–142Google Scholar
  94. 92.
    Deane BD, Lantos PL (1981) The vasculature of experimental brain tumors, Part 1 and 2. J Neurol Sci 49: 55–66PubMedGoogle Scholar
  95. 92a.
    Deane BD, Lantos PL (1981) The vasculature of experimental brain tumors, Part 1 and 2. J Neurol Sci 49: 67–77PubMedGoogle Scholar
  96. 93.
    De Armond SJ, Eng LF (1984) Immunohistochemistry: Techniques and application to neurooncology. Progr exp Tumor Res 27: 92–117PubMedGoogle Scholar
  97. 94.
    De Jong ASH (1984) Myosin and myoglobin as tumor markers in the diagnosis of rhabdomyosarcoma. Amer J Surg Pathol 8: 521–528Google Scholar
  98. 95.
    De Ridder LI, Laerum OD, Mork SV, Bigner DD (1986) Invasiveness of human glioma cell lines in vitro: Relation to tumorigenicity in atypic mice. Acta Neuropathol (Berl) 71.Google Scholar
  99. 96.
    Dick SJ, Macchi B, Papazoglou S, Oldfield EH, Kornblith PL, et al. (1983) Lymphoid cell-glioma cell interaction enhances cell coat production by human gliomas; Novel suppressor mechanisms. Science 220: 739–741PubMedGoogle Scholar
  100. 97.
    Dickson DW, Hart MN, Menezes A, Cancilla PA (1983) Medulloblastoma with glial and rhabdomyoblastic differentiation. J Neuropathol Exp Neurol 42: 639–647PubMedGoogle Scholar
  101. 97a.
    Dickson DW, Suzuki KI, Kanner R, Weitz S, Horoupian DS (1986) Cerebral granular cell tumor: Immunohistochemical and electron microscopic study. J Neuropathol Exp Neurol 45: 304–314PubMedGoogle Scholar
  102. 98.
    Dolman CL (1984) Ultrastructure of Brain Tumors and Biopsies. A diagnostic atlas. Praeger, New York PhiladelphiaGoogle Scholar
  103. 99.
    Dohrmann GJ, Farwell JR, Flannery JT (1978) Oligodendrogliomas in children. Surg Neurol 10: 21–25PubMedGoogle Scholar
  104. 100.
    Drut R, Jones MC (1983) Melanotic medulloblastoma of infancy: A case report with immunohistochemical study and literature review. Morf Norm Patol 7: 53–62Google Scholar
  105. 101.
    Duffy PE (1983) Astrocytes: Normal, reactive, and neoplastic. Raven Press, New YorkGoogle Scholar
  106. 102.
    Duffy PE, Huang Y, Rapport MM, Graf L (1980) Glial fibrillary acidic protein in giant cell tumors of brain and other gliomas. Acta Neuropathol (Berl) 52: 51Google Scholar
  107. 103.
    Duhaime AC, Schut L, Rorke LB, Bruce DA, Sutton LN (1984) The MEAN disease. Karger, Basel, pp 154–164 (Concepts in pediatric neurosurgery, vol V )Google Scholar
  108. 104.
    El-Gindi S, Salama M, El-Heaway M, Farag S (1973) Metastases of glioblastoma multiforme to cervical lymph nodes. J Neurosurg 38: 631–634PubMedGoogle Scholar
  109. 105.
    Elkon D, Hightower SI, Lim MI, Cantrell RW, Constable WC (1979) Esthesioneuroblastoma. Cancer 44: 1087–1994PubMedGoogle Scholar
  110. 106.
    Eazinger FM, Weiss SW (1983) Soft tissue tumors. Mosby, St Louis Toronto LondonGoogle Scholar
  111. 107.
    Epstein JI, White CL, Mendelsohn G (1984) Factor VIII related antigen and glial fibrillary acidic protein immunoreactivity in the differential diagnosis of central nervous system hemangioglastomas. Am J Clin Pathol 81: 285–292PubMedGoogle Scholar
  112. 108.
    Erlandson RA, Woodruff JM (1982) Peripheral nerve sheath tumors: An electron-microscopic study of 43 cases. Cancer 49: 273–287PubMedGoogle Scholar
  113. 109.
    Erlich SS, Davis RL (1978) Spinal subarachnoid metastases from primary intracranial glioblastoma multiforme. Cancer 42: 2854–2864PubMedGoogle Scholar
  114. 110.
    Esiri MM, Adams CBI, Burke C, Umberdown R (1983) Pituitary adenomas: Immunohistology and ultrastructural analysis of 118 tumors. Acta Neuropathol (Berl) 62: 1–14Google Scholar
  115. 111.
    Ezrin C, Kovacs, Horvath E (1982) Pathology of the adenohypophysis. In: Bloodworth JMB (ed) Endocrine pathology: general and surgical, 2nd edn. William and Wilkins, Baltimore, pp 100–132Google Scholar
  116. 112.
    Ezrin-Waters C, Klein M, Deck J, Lang AE (1984) Diagnostic importance of immunological markers in lymphoma involving the central nervous system. Ann Neurol 16: 668–672PubMedGoogle Scholar
  117. 113.
    Fallace WJ, Okawara SH, McDonald JV (1984) Neurocutaneous melanosis with extensive intracerebral and spinal cord involvement. Report of two cases. J Neurosurg 61: 782–785Google Scholar
  118. 114.
    Fan KJ, Pezeshkpour F (1986) Immunoperoxidase study of primary central nervous system lymphomas. Acta Neuropathol (Berl)Google Scholar
  119. 115.
    Farwell JR, Dohrmann GJ, Flannery JT (1984) Medulloblastoma in childhood: an epidermiological study. J Neurosurg 61: 657–664PubMedGoogle Scholar
  120. 116.
    Feichter G, Schwechheimer K, Goertler K (1983) Assistierte impulszytometrische Beurteilung bei der Routine-Diagnostik von Meningeomen und Gliomen. Pathologe 4: 294–302PubMedGoogle Scholar
  121. 117.
    Feigin I, Epstein F, Mangiardi J (1983) Extensive advanced maturation of medulloblastoma to astrocytoma and ependymoma. J Neuro-Oncol 1: 95–108Google Scholar
  122. 118.
    Fialkow PJ (1979) Clonal origin of human tumors. Rev Med 30: 135–143Google Scholar
  123. 119.
    Firsching R, Schröder R, Köning W. Frowein RA (1985) Spinale Abtropfmetastase beim cerebralen Glioblastom/Gliosarkom. Nervenarzt 56: 629–634PubMedGoogle Scholar
  124. 120.
    Fleischer AS, Reagan T, Ransohoff J (1972) Primary carcinomas of the pituitary gland with metastasis to the brain stem. J Neurosurg 36: 781–784PubMedGoogle Scholar
  125. 121.
    Fogelholm R, Uutela T, Murros K (1984) Epidemiology of central nervous system neoplasms. A regional survey in Central Finland. Acta Neurol Scand 69: 129–136PubMedGoogle Scholar
  126. 122.
    Folkman J (1984) What is the role of endothelial cells in angiogenesis? Lab Invest 51: 601–604PubMedGoogle Scholar
  127. 123.
    Folkman J (1985) Tumor angiogenesis. In: Klein G, Weinhouse S (eds) Advances in cancer research, vol 43. Academic Press, New York, pp 175–203Google Scholar
  128. 124.
    Foerster O, Gagel O (1938) Das umschriebene Arachnoidalsarkom des Kleinhirns. Z Ges Neurol Psych 164: 565Google Scholar
  129. 125.
    Fould L (1969) Neoplastic development, vol 1. Academic Press, London New YorkGoogle Scholar
  130. 126.
    Freedman AS, Byod AW, Anderson KC, Fisher DC, Pinkus GS, Schlossman-SF, Nadler-LM (1985) Immunologic heterogeneity of diffuse large cell lymphomas. Blood 65: 630–637Google Scholar
  131. 127.
    Friede RL (1978) Gliofibroma: A peculiar neoplasia of collagen forming glia-like cells. J Neuropathol Exp Neurol 38: 300–313Google Scholar
  132. 128.
    Friede R, Pollak A (1978) The cytogenetic basis for classifying ependymomas. J Neuropathol Exp Neurol 37: 103–118PubMedGoogle Scholar
  133. 129.
    Frydl Y (1985) Intrakranielle Lipome und Xanthome. Med Welt 36: 375–381Google Scholar
  134. 129a.
    Fukui M, Iwaki T, Sawa H, Inoue T, Takeshita I, Kitamura K (1986) Proliferative activity of meningiomas as evaluated by bromodeoxyuridine uptake examination. Acta Neurochir (Wien) 81: 135–141Google Scholar
  135. 130.
    Fulling KH, Garcia DM (1985) Anaplastic astrocytoma of the adult cerebrum: Prognostic value of histologic features. Cancer 55: 928–931PubMedGoogle Scholar
  136. 131.
    Fulling KH, Gersell DJ (1983) Neoplastic angioendotheliosis. Histologic, immunohistochemical, and ultrastructural findings in two cases. Cancer 51: 1107–1118PubMedGoogle Scholar
  137. 132.
    Gaffney CC, Sloane JP, Bradley NJ, Bloom HJG (1985) Primitive neuroectodermal tumours of the cerebrum. Pathology and treatment. J Neuro-Oncol 3: 23–33Google Scholar
  138. 133.
    Gallassi E, Tognetti F, Frank F, Gaist G (1984) Extraneural metastases from primary pineal tumors. Review of the literature. Surg Neurol 21: 497–504Google Scholar
  139. 134.
    Gambarelli D, Hassoun J, Choux M, Toga M (1982) Complex cerebral tumor with evidence of neuronal, glial and Schwann cell differentiation: A histologic, immunocytochemical and ultrastructural study. Cancer 49: 1420–1428PubMedGoogle Scholar
  140. 135.
    Garcia DM, Fulling KH (1985) Juvenile pilocytic astrocytoma of the cerebrum in adults. A distinctive neoplasm with favorable prognosis. J Neurosurg 63: 382–386PubMedGoogle Scholar
  141. 136.
    Gately MK, Glaser M, Carron RM, Dick SJ, Dick MD, Mettetal RW, Kornblith PL (1982) Mechanisms by which human gliomas may escape cellular immune attack. Acta Neurochir (Wien) 64: 175–197Google Scholar
  142. 137.
    Gerstner L, Jellinger K, Heiss WD, Wöber G (1976) Morphological changes in anaplastic gliomas treatet with radiation and chemotherapy. Acta Neurochir (Wien) 36: 117–138Google Scholar
  143. 138.
    Ghatak NR, McWhorter JM (1976) Ultrastructural evidence for CSF production by a choroid plexus papilloma. J Neurosurg 45: 409–415PubMedGoogle Scholar
  144. 139.
    Gherardi R, Baudrimont M, Nguyen JP, Gaston A, Cesaro P, et al. (1986): Monstrocellular heavily lipidized malignant glioma. Acta Neuropathol (Berl) 67: 28–32Google Scholar
  145. 140.
    Gherardi R, Lacombe MJ, Poirier J, Roucayrol AM, Wechsler J (1984) Asymptomatic encephalic intraparenchymatous neuroepithelial cysts. Acta Neuropathol (Berl) 63: 264–268Google Scholar
  146. 141.
    Giangasparo F, Burger PC (1983) Correlations between cytologic composition and biologic behavior in the glioblastoma multiforme. A postmortem study of 50 cases. Cancer 52: 2320–2333Google Scholar
  147. 142.
    Gill PS, Levine AM, Meyer PR, Boswell WD, et al. (1985) Primary CNS lymphoma in homosexual men: Clinical, immunologic and pathologic features. Amer J Med 78: 742–748PubMedGoogle Scholar
  148. 143.
    Gilles FH (1985) Classification of childhood brain tumors. Cancer 56: 1857–1859Google Scholar
  149. 144.
    Gilles FH, Leviton A, Hedley-Whyte ET, Jasnow M (1983) Childhood brain tumors update. Human Pathol 14: 834–845Google Scholar
  150. 145.
    Giordana MT, Bertelotto A, Migheli A, Pezzotta S, et al. (1982) Glycosaminoglycans in human cerebral tumors. Acta Neuropathol (Berl) 57: 299–305Google Scholar
  151. 146.
    Gjerris F, Harman A, Klinken L, Reske-Nielsen E (1978) Incidence and long-term survival of children with intracranial tumours treated in Denmark 1935–1959. Brit J Cancer 38: 442–451PubMedGoogle Scholar
  152. 147.
    Gjerris F, Klinken L (1978) Long-term prognosis in children with benign cerebellar astrocytoma. J Neurosurg 24: 125–135Google Scholar
  153. 148.
    Goldenberg DM, Pavia RA (1982) In vivo horizontal oncogenesis by a human tumor in nude mice. Proc Natl Acad Sei USA 79: 2389–2392Google Scholar
  154. 149.
    Gomez JG, Garcia JH, Colon LE (1985) A variant of cerebral glioma called pleomorphic xanthoastrocytoma. Neurosurg 16: 703–706Google Scholar
  155. 150.
    Grant JW, Jones DB (1984) Immunohistochemistry of lymphomas affecting the nervous system. Neuropathol Appl Neurobiol 10: 310Google Scholar
  156. 151.
    Groothuis DR, Molnar P, Blasberg RG (1984) Regional blood flow and blood-totissue transport in five brain tumor models. Implications for chemotherapy. Prog Exp Tumor Res 27: 132–153PubMedGoogle Scholar
  157. 152.
    Gullotta F (1981) Morphological and biological basis for the classification of brain tumors, with a comment on the WHO-classification 1979. In: Krayenbühl H (ed) Advances and technical standards in neurosurgery, vol 8. Springer, Wien New York, pp 123–165Google Scholar
  158. 153.
    Gullotta F, de Melo AS (1979) Das Karzinom des Plexus chorioideus. Neurochir (Stuttg) 22: 1–9Google Scholar
  159. 154.
    Gullotta F, Schindler F, Schmutzler R, Weeks-Seifert A (1965) GFAP in brain tumor diagnosis: possibilities and limitations. Path Res Pract 180: 54–60Google Scholar
  160. 154a.
    Halper J, Scheithauer BW, Okazaki H, Laws ER, Jr (1986) Meningio-angiomatosis. A report of six cases with special reference to the occurrence of neurofibrilary tangles. J Neuropathol Exp Neurol 45: 426–446PubMedGoogle Scholar
  161. 155.
    Hanak H, Radaszkiewicz T (1984) Tumoren des lymphatischen Systems. In: Österr Ges Pathol (Hrsg) Histologische Tumorklassifikation. Springer, Wien New York, pp 133–135Google Scholar
  162. 156.
    Hara M, Kawachi S, Hirano A (1981) Lipoma of the superior medullary velum with Schwann cells. Acta Path Jpn 31: 825–833Google Scholar
  163. 157.
    Hart MN, Earle KM (1973) Primitive neuroectodermal tumors of the brain in children. Cancer 32: 890–897PubMedGoogle Scholar
  164. 158.
    Hassoun J, Gambarelli D, Grisou F, Pellet W, Salomon G, Pellissier JF, Toga M (1982) Central neurocytoma. An electron microscopic study of two cases. Acta Neuropathol (Berl) 56: 151–156Google Scholar
  165. 159.
    Hassoun J, Gambarelli D, Pellissier JF, Henin D, Toga M (1981) Germinomas of the brain. Light and electron microscopic study. Acta Neuropathol (Berl) 37: 105–108Google Scholar
  166. 160.
    Hegedus K (1984) Burkitt-type lymphoma and reticulum cell sarcoma, an unusual mixed form of two intracranial primary malignant lymphomas. Surg Neurol 21: 23–29PubMedGoogle Scholar
  167. 161.
    Hegedus K, Molnar P (1983) Primary cerebellar glioblastoma multiforme with an unusual long survival. J Neurosurg 58: 589–592PubMedGoogle Scholar
  168. 162.
    Helle TL, Britt RH, Colgy TU (1984) Primary lymphoma of the central nervous system. J Neurosurg 60: 94–103PubMedGoogle Scholar
  169. 163.
    Heppner GH, Shapiro WR, Rankin JK (1981) Tumor heterogeneity. In: Humphrey GB, et al. (eds) Pediatric oncology, vol 1. Nijhoff, The Hague Boston LondonGoogle Scholar
  170. 164.
    Herman MM, Rubinstein LJ (1984) Divergent glial and neuronal differentiation in a cerebellar medulloblastoma in an organ culture system. Acta Neuropathol (Berl) 65: 10–24Google Scholar
  171. 165.
    Herpers MJHM, Budka H (1984) Glial fibrillary acidic protein (GFAP) in oligodendroglial tumors: gliofibrillary oligodendroglioma and transitional oligoastrocytomas as subtypes of oligodendrogliomas. Acta Neuropathol (Berl) 64: 265–272Google Scholar
  172. 166.
    Herpers MJHM, Budka H (1985) Primitive neuroectodermal tumors including the medulloblastoma: glial differentiation signaled by immunoreactivity for GFAP is restricted to the pure desmoplastic’medulloblastoma (“arachnoidal sarcoma of the cerebellum”). Clin Neuropathol 4: 12–18PubMedGoogle Scholar
  173. 167.
    Herrick K, Rubinstein LJ (1979) The cytological differentiating potential of pineal parenchymal neoplasms (true pinealomas). Brain 102: 289–320PubMedGoogle Scholar
  174. 168.
    Hinton DR, Halliday WD (1984) Primary rhabdomyosarcoma of the cerebellum. A light, electron microscopic, and immunohistochemical study. J Neuropathol Exp Neurol 43: 439–449PubMedGoogle Scholar
  175. 169.
    Hirakawa K, Suzuki K, Ueda S, Handa J (1986) Fetal origin of medulloblastomas as manifested by growth analyses. Acta Neuropathol (Berl) 70: 227–234Google Scholar
  176. 170.
    Hirano A, Ghatak NR (1974) The fine structure of colloid cysts of the third ventricle. J Neuropathol Exp Neurol 33: 333–341PubMedGoogle Scholar
  177. 171.
    Hirano A, Ghatak NR, Zimmerman HM (1973) The fine structure of ependymoblastoma. J Neuropathol Exp Neurol 32: 144–152PubMedGoogle Scholar
  178. 172.
    Hirano A, Matsui T (1975) Vascular structures in brain tumors. Human Pathol 6: 611–621Google Scholar
  179. 173.
    Hirano T, Aida T, Moriyama M, Asano G, Suzuki I, Yuge K (1985) Primary neuroblastoma of the nasal cavity and review of literature. Acta Pathol Jpn 35: 183–191PubMedGoogle Scholar
  180. 174.
    Hirose T, Sano T, Hizawa K (1986) Ultrastructural localization of S-100 protein in neurofibroma. Acta Neuropathol (Berl) 69: 103–110Google Scholar
  181. 175.
    Ho KL (1984) Ultrastructure of cerebellar capillary hemangioblastoma I. WeibelPalade bodies and stroma cell histogenesis. J Neuropathol Exp Neurol 43: 592–608PubMedGoogle Scholar
  182. 176.
    Ho KL (1985) Ecchordosis physaliphora and chordoma; a comparative ultrastructural study. Clin Neuropathol 4: 77–86PubMedGoogle Scholar
  183. 177.
    Hoffman HJ, Duffner KP (1985) Extraneural metastases of central nervous system tumors. Cancer 56: 1778–1782PubMedGoogle Scholar
  184. 178.
    Hojo S, Hirano A (1982) Pathology of metastases effecting the Central nervous system. In: Takakura K, Sano K, Hojo S, Hirano A (eds) Metastatic tumors of the central nervous system. Igaku-Shoin, Tokyo New YorkGoogle Scholar
  185. 179.
    Horten BC, Rubinstein LJ (1976) Primary cerebral neuroblastoma. Brain 99: 735–756PubMedGoogle Scholar
  186. 180.
    Horten BC, Urich H, Rubinstein LJ, Montague S (1977) Malignant meningiomas and hemangiopericytomas. J Neurol Sci 31: 387–410PubMedGoogle Scholar
  187. 181.
    Horten BC, Urich H, Stefoski D (1979) Meningiomas with conspicuous plasma celllymphocytic components. Report of five cases. Cancer 41: 258–264Google Scholar
  188. 182.
    Hoshino T (1981) Cellular aspects of human brain tumors (gliomas). In: Fedoroff, Hertz. (eds) Advances in cellular neurobiology, vol 2. Academic Press, New York, pp 167–209Google Scholar
  189. 183.
    Hoshino T (1984) A commentary on the biology and growth kinetics of low-grade and high-grade gliomas. J Neurosurg 61: 895–600PubMedGoogle Scholar
  190. 184.
    Hoshino T, Kobayashi S, Townswend JJ, Wilson CB (1985) A cell kinetic study on medulloblastoma. Cancer 55: 1711–1713PubMedGoogle Scholar
  191. 185.
    Hoshino T, Wilson CB (1979) Cell kinetic analyses of human malignant brain tumors (gliomas). Cancer 44: 956–962PubMedGoogle Scholar
  192. 186.
    Hoshino T, Wilson CB, Ellis WG (1975) Gemistocytic astrocytes in gliomas: An autoradiographic study. J. Neuropathol Exp Neurol 34: 263–281PubMedGoogle Scholar
  193. 187.
    Hoshino T, Wilson CB, Muraoka I (1979) The stathmokinetic (mitostatic) effect of vincristine and vinblastine in human gliomas. Acta Neuropathol (Berl) 47: 21–25Google Scholar
  194. 188.
    Houtteville JP, Lechavalier B, Lecog PJ, Wesley C, Escourolle R (1976) Pituicytome à cellules granulaires (choristome) de la tige pituitaire Rev Neurol (Paris) 137: 589–604Google Scholar
  195. 189.
    Hulbanni S, Goodma PA (1976) Glioblastoma multiforme with extraneural metastases in absence of previous surgery. Cancer 37: 1577–1583PubMedGoogle Scholar
  196. 190.
    Iglesias JR, Kazner E, Aruffo C, Esparza J (1985) CT diagnosis of brain tumours: Semiautomatical type-specific diagnosis with the help of a personal computer. In: Lamke HU, Rhodes ML, et al. (eds) Computer assisted radiology. Springer, Berlin Heidelberg New York Tokyo, pp 443–448Google Scholar
  197. 191.
    Iglesias JR, Sanchez MJ, Sendra A, Mohnhaupt A (1983) Computer model of archive and diagnosis of brain tumours based on the WHO classification. EDV in Medizin and Biologie 14: 40–44Google Scholar
  198. 191a.
    Iglesias JR, Pfannkuch F, Aruffo C, Kazner E, Cervos-Navarro J (1986) Histopathologic diagnosis of brain tumors with the help of a computer: Mathematical fundaments and practical application. Acta Neuropathol (Berl) 71: 130–135Google Scholar
  199. 192.
    Ilgren EB, Stiller CA, Hughes HT (1984) Ependymomas: A clinic and pathological study. Part II. Survival features. Clin Neuropathol 3: 122–127PubMedGoogle Scholar
  200. 193.
    Ironside JW, Jefferson AA, Timperley WR (1986) Growth hormone-secreting pituitary adenoma of mixed cell type: a histological, ultrastructural and immunocytochemical study. Clin Neuropathol 5: 28–33PubMedGoogle Scholar
  201. 194.
    Jacob W, Scheida D, Wingert F (eds) (1978) ZNS-Tumor-Histologie-Schlüssel DA. International International classification of diseases for oncology. Springer, Berlin Heidelberg New YorkGoogle Scholar
  202. 195.
    Jänisch W, Güthert H, Schreiber D (1976) Pathologie der Tumoren des Zentralnervensystems. VEB Fischer, JenaGoogle Scholar
  203. 196.
    Jänisch W, Fennwarth B, Lagemann G (1967) Zur Epidemiologie der Geschwülste des Zentralnervensystems. Dtsch Z Nervenheilk 191: 80–90Google Scholar
  204. 197.
    Janzer RC, Kleihues P (1985) Primitive neuroectodermal tumor with choroid plexus differentiation. Acta Neuropathol (Berl) 4: 93–98Google Scholar
  205. 198.
    Jellinger K (1972) Cerebral medulloepithelioma. Acta Neuropathol (Berl) 22: 95–101Google Scholar
  206. 199.
    Jellinger K (1973) Primary intracranial germ cell tumors. Acta Neuropathol (Berl) 25 291–306Google Scholar
  207. 200.
    Jellinger K (1977) Zur Histopathologie von Hirntumorrezidiven. Zbl Neurochir 38: 307–324Google Scholar
  208. 201.
    Jellinger K (1977) Human central nervous system lesions following radiation therapy. Zbl Neurochir 38: 199–220Google Scholar
  209. 202.
    Jellinger K (1978) Pathology of brain tumours with relation to prognosis. Zbl Neurochir 39: 285–300Google Scholar
  210. 203.
    Jellinger K (1978) Glioblastoma multiforme. Acta Neurochir (Wien) 42: 5–32Google Scholar
  211. 204.
    Jellinger K (1983) Primäre und sekundäre Lymphome des ZNS. In: Seitz D, Vogl P (Hrsg) Verh Dtsch Ges Neurol, vol 2. Berlin Heidelberg New York, S 14–48Google Scholar
  212. 205.
    Jellinger K (1983): Histologische Klassifikation und therapie-bedingte Veränderungen. In: Krauseneck P, Mertens HG (Hrsg) Therapie maligner Neoplasien des Gehirns. Perimed, Erlangen, S 15–24Google Scholar
  213. 206.
    Jellinger K (1983) Maligne Lymphome und Leukämien im Zentralnervensystem. Verh Dtsch Ges Path 67: 556–573Google Scholar
  214. 207.
    Jellinger K (1984) Häufigkeit und Charakteristik der zerebralen Karzinommetastasen. In: v Heyden HW, Krauseneck P (Hrsg) Hirnmetastasen. Zuckschwerdt, München Bern Wien, S 49–79Google Scholar
  215. 208.
    Jellinger K (1985) Therapy-induced changes in anaplastic gliomas and brain tissue. In: Voth D, Krauseneck P (eds) Chemotherapy of gliomas. De Gruyter, Berlin New York, pp 151–176Google Scholar
  216. 209.
    Jellinger K (1986) Primary non-Hodgkin’s lymphoma of the CNS. J Neuro-OncolGoogle Scholar
  217. 210.
    Jellinger K (1986) Present limits of conventional treatment of malignant brain tumors. In: Hatanaka H (ed) Boron neutron capture therapy of tumors. Nishimura-Elsevier, Tokyo Amsterdam New York, pp 309–347Google Scholar
  218. 211.
    Jellinger K, Grisold W, Weiss R (1986) Zytologische Differenzierung von Malignomzellen des Liquor cerebrospinalis. In: Kölmel W, Dommasch H (Hrsg) Liquorzytologie. Edition Medizin, Weinheim S 137–175Google Scholar
  219. 212.
    Jellinger K, Machacek E (1982) Rare intracranial tumours in infancy and childhood. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 44–52Google Scholar
  220. 213.
    Jellinger K, Schuster H (1977) Extraneurale Metastasierung anaplastischer Gliome. Zbl Allg Path Pathol Anat 121: 526–534Google Scholar
  221. 214.
    Jellinger K, Slowik F (1975) Histological subtypes and prognostic problems in meningiomas. J Neurol 208: 279–298PubMedGoogle Scholar
  222. 215.
    Jellinger K, Vole D, Grisold W, Flament H, Weiss R (1983) Kombinationsbehandlung maligner Gliome. Wien Klin Wschr 95: 407–415PubMedGoogle Scholar
  223. 216.
    Jennings MT, Gelman R, Hochberg F (1985) Intracranial germ-cell tumors, Natural history and pathogenesis. J Neurosurg 63: 155–167PubMedGoogle Scholar
  224. 217.
    Johannsson JH, Rekate HL, Roessmann U (1981) Gangliogliomas pathological and clinical correlation. J Neurosurg 54: 58–63PubMedGoogle Scholar
  225. 218.
    Jones TR, Ruoslahti E, Schold SC, Bigner DD (1982) Fibronectin and glial fibrillary acidic protein expression in normal human brain and anaplastic human gliomas. Cancer Res 42: 168–177PubMedGoogle Scholar
  226. 219.
    Jooma R, Torrens MJ, Bradshaw J, Brownell B (1985) Subependymomas of the 4th ventricle. Surgical treatment in 12 cases. J Neurosurg 62: 508–512PubMedGoogle Scholar
  227. 220.
    Jordan RM, Kendall JW, McClung M, Kammer H (1980) Concentration of human choriostic gonadotrophies in the cerebrospinal fluid of patients with germinal cell hypothalamic tumors. Pediatrics 65: 121–124PubMedGoogle Scholar
  228. 221.
    Karch SB, Urich H (1972) Medulloepithelioma: Definition of an entity. J Neuropathol Exp Neurol 31: 27–53PubMedGoogle Scholar
  229. 222.
    Katenkamp D, Stiller D, Holzhausen HJ (1983) Morphologie des Neuroblastoms. Zbl Allg Path Anat 127: 207–218Google Scholar
  230. 223.
    Kawano N, Yada K, Aikara M, Yagishita S (1983) Oligodendroglioma-like (clear cells) in ependymoma. Acta Neuropathol (Berl) 62: 141–144Google Scholar
  231. 224.
    Kay HEM (1983) Immunsuppression and the risk of brain lymphoma. New Engl J Med 308: 109Google Scholar
  232. 225.
    Kazner E, Wende S, Grumme TH, Lanksch W, Stochdorph D (1981) Computertomographie intrakranieller Tumoren aus klinischer Sicht. Springer, Berlin Heidelberg New YorkGoogle Scholar
  233. 226.
    Kepes JJ (1982) Meningiomas: biology, pathology and differential diagnosis. Masson, New YorkGoogle Scholar
  234. 227.
    Kepes JJ, Rubinstein LJ (1981) Malignant gliomas with heavily lipidized (foamy) tumor cells: a report of three cases and report with immunoperoxidase study. Cancer 47: 2451–2459PubMedGoogle Scholar
  235. 228.
    Kepes JJ, Rubinstein LJ. Laurence F (1979) Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with relatively favourable prognosis. Cancer 44: 1839–1852PubMedGoogle Scholar
  236. 229.
    Kernohan JW, Mahon RF, Svien HJ, Adson AW (1949) A simplified classification of the gliomas. Proc Mayo Clin 24: 71–74PubMedGoogle Scholar
  237. 230.
    Kernohan JW, Sayre GP (1952) Tumors of the central nervous system. In: Atlas of tumor pathology, fase 35. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
  238. 231.
    Kersting G (1973) Tissue culture of recurrent gliomas. In: Modern aspects of neurosurgery, vol 3. Excerpta Medica, pp 122–124Google Scholar
  239. 232.
    Kikuchi K, Neuwelt EA (1983) Presence of immunosuppressive factors in brain tumor cyst fluid. J Neurosurg 59: 790–799PubMedGoogle Scholar
  240. 233.
    Klatzo I (1967) Neuropathological aspects of brain edema. J Neuropathol Exp Neurol 26: 1–14PubMedGoogle Scholar
  241. 234.
    Klee GC, Go VLW (1982) Serum tumor markers. Mayo Clin Proc 57: 129–132PubMedGoogle Scholar
  242. 235.
    Kleihues P, Rajewsky MF (1984) Chemical neuro-oncogenesis: Role of structural DNA modification, DNA repair and neural target cell population. Prog Exp Tumor Res 27: 1–16PubMedGoogle Scholar
  243. 236.
    Kleinmann GM, Schoene WC, Walshe TM III, Richardson EP (1978) Malignant transformation of benign cerebellar astrocytoma. J Neurosurg 52: 414–418Google Scholar
  244. 237.
    Klinken LH, Diemer NH, Gjerris F (1984) Automatized image analysis, histologic malignancy grading, and survival in patients with astrocytic gliomas. Clin. Neuropathol 3: 107–112Google Scholar
  245. 238.
    Kobayashi H, Sano T, Li K, Hizawa K (1984) Primary Burkitt type lymphoma of the CNS. Acta Neuropathol (Berl) 64: 12–14Google Scholar
  246. 239.
    Koide C, Watanabe Y, Sato K (1980) A pathologic survey of intracranial germinoma and pinealoma in Japan. Cancer 45: 2119–2130PubMedGoogle Scholar
  247. 240.
    Koos WT, Miller M (1971) Intracranial tumors of infants and children. Mosby, St LouisGoogle Scholar
  248. 241.
    Kopelsen G, Linggood RM, Kleinman GM (1983) Medulloblastoma: the identification of prognostic subgroups and implications for management. Cancer 51: 312–319Google Scholar
  249. 241a.
    Kornfeld M (1986) Granular cell glioblastoma: A malignant granular cell neoplasm of astrocytic origin. J Neuropathol Exp Neurol 45: 447–462PubMedGoogle Scholar
  250. 242.
    Kovacs K (1984) Light and electron microscopic pathology of pituitary tumors: Immunohistochemistry. In: McBlack P, et al. (eds) Secretory tumors of the pituitary gland. Raven Press, New York, pp 365–375Google Scholar
  251. 243.
    Kovacs K, Horvath E, Ryan N (1981) Immunocytology of the human pituitary. In DeLellis RA (ed) Diagnostic immunocytochemistry. Masson, New York, pp 17–35Google Scholar
  252. 244.
    Kretschmer H (1974) Die extrakranielle Metastasierung intrakranieller Geschwülste. Zbl Neurochir 35: 81–112Google Scholar
  253. 245.
    Kristoferitsch W, Jellinger K (1986) Multifocal spinal angiosarcoma after chordotomy. Acta Neurochir (Wien) 79: 145–153Google Scholar
  254. 246.
    Krücke W (1974) Pathologie der peripheren Nerven. In: Olivecrona H, Tönnis W, Krenkel W (Hrsg) Handbuch der Neurochirurgie, vol 7, Teil 3. Springer, Berlin Heidelberg New YorkGoogle Scholar
  255. 247.
    Kubota T, Hirano A, Sato K, Yamamota S (1985) The fine structure of astroblastoma. Cancer 55: 745–750PubMedGoogle Scholar
  256. 248.
    Kuhlendahi H, Miltz H, Wüllenweber R (1973) Die Astrozytome des Großhirns. Acta Neurochir (Wien) 29: 151–162Google Scholar
  257. 249.
    Kuhlendahi H, Stochdorph O, Hübner G (1975) Zur nosologischen Stellung und histologischen Herleitung des sogenannten Kleinhirnastrozytoms. Acta Neurochir (Wien) 32: 235–245Google Scholar
  258. 250.
    Kumimashi T, Washiyama K, Saito T (1986) Primary malignant lymphoma of the brain; An immunhistochemical study of 8 cases using a panel of monoclonal and heterologous antibodies. Acta Neuropathol (Berl) 71: 190–196Google Scholar
  259. 251.
    Kuminashi T, Washiyama K, Watanabe K, Sekiguchi K (1985) Glial fibrillary acidic protein in medulloblastomas. Acta Neuropathol (Berl) 67: 1–5Google Scholar
  260. 252.
    Lack EE, Cubilla AL, Woodruff JM (1979) Paragangliomas of the head and neck region: A pathological study of tumors from 71 patients. Human Pathol 10: 191–218Google Scholar
  261. 253.
    Laerum OD, Bjerkvig R, Steinsvag SK, de Ridder L (1984) Invasiveness of primary brain tumors. Cancer Metastasis Rev 3: 223–236Google Scholar
  262. 254.
    Lalitha VS, Rubinstein LJ (1979) Reactive glioma in intracranial sarcoma: a form of mixed sarcoma and glioma (sarcoglioma). Cancer 43: 246–257PubMedGoogle Scholar
  263. 254a.
    Lang C, Möbius H-J, Schlote W (1986) The growth fraction of human gliomas as determined by the Ki-67 mouse monoclonal anti-proliferation antibody (abstr). 10 Int Congr Neuropath, Stockholm, 869, p 431Google Scholar
  264. 254b.
    Langford LA (1986) The ultrastructure of the ependymoblastoma Acta Neuropathol (Berl) 71: 136–141Google Scholar
  265. 255.
    Lantos PL (1980) Chemical induction of tumors in the nervous system. In: Thomas DGT, Graham DI (eds) Brain tumours. Butterworth, London Boston Sidney, pp 85–108Google Scholar
  266. 256.
    Lassmann H, Jurecka W, Lassmann G, Gebhart W, Matras H, Watzek G (1977) Different types of benign nerve sheath tumors. Light microscopy, electron microscopy and autoradiography. Virchows Arch (Pathol Anat) 375: 197–210Google Scholar
  267. 257.
    Laurence KM (1979) The biology of choroid plexus papilloma in infancy and childhood. Acta Neurochir (Wien) 50: 79–90Google Scholar
  268. 258.
    Laurent JP, Chang CH, Cohen ME (1985) A classification system for primitive neuroectodermal tumors (medulloblastoma) of the posterior fossa. Cancer 56: 1807–1809PubMedGoogle Scholar
  269. 259.
    Leech RE, Olafson RA (1977) Epithelial cysts of the neuaxis. Arch Path Lab Med 101: 196–202PubMedGoogle Scholar
  270. 260.
    Lennert K (1981) Histopathologie der Non-Hodgkin-Lymphome (nach der Kiel-Klassifikation). Springer, Berlin Heidelberg New YorkGoogle Scholar
  271. 261.
    Letendre L, Banks PH, Reese DF, Miller RN, Scanlon PW, Kiely JM (1982) Primary lymphoma of the central nervous system. Cancer 49: 939–943PubMedGoogle Scholar
  272. 262.
    Leviton A (1984) Principles of epidemiology. In: Cohen ME, Duffner PK (eds) Brain tumors in children. Raven Press, New York, pp 22–45Google Scholar
  273. 263.
    Lewy RM, Bredesen DE, Rosenblum ML (1985) Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): Experience at UCSF and review of the literature. J Neurosurg 62: 475–495Google Scholar
  274. 264.
    Lhermitte J, Ducclos (1920) Sur un ganglioneurome diffuse du cortex du cervelet. Bull Ass Franç Etude Cancer 9: 99–106Google Scholar
  275. 265.
    Lilja A, Bergstrom K, Spannare B, Olsson Y (1981) Reliability of computed tomography in assessing histopathological features of malignant supratentorial gliomas. J Comput Assist Tomogr 5: 625–636PubMedGoogle Scholar
  276. 266.
    Limas C, Tio FO (1972) Meningeal melanocytoma (“melanotic meningiomas”). Its melanocytic origin as revealed by electron microscopy. Cancer 30: 1286–1294PubMedGoogle Scholar
  277. 267.
    Liwnicz BH, Rubinstein LJ (1979) The pathways of extraneural spread in metastasizing gliomas. A report of three cases and critical review of the literature. Hum Pathol 10: 453–467PubMedGoogle Scholar
  278. 268.
    Llena JF (1983) Paraganglioma in the cerebrospinal axis. In: Zimmerman HM (ed) Progress in neuropathology, vol 5. Raven Press, New York, pp 261–276Google Scholar
  279. 269.
    Long DM (1970) Capillary ultrastructure and the blood-brain barrier in human malignant brain tumors. J Neurosurg 32: 127–144PubMedGoogle Scholar
  280. 269a.
    Ludwig CL, Smith MT, Godfrey AD, Armbrustmacher VW (1986) A clinico-pathological study of 323 patients with oligodendrogliomas. Ann Neurol 19: 15–21PubMedGoogle Scholar
  281. 270.
    Mackintosh FR, Colby TV, Podolsky WJ, et al. (1982) Central nervous system involvement in non-Hodkin’s lymphomas: Analysis of 105 cases. Cancer 49: 586–595PubMedGoogle Scholar
  282. 271.
    Mantravani RVP, Phatak R, Bellur S, Liebner EJ, Haas R (1982) Brain stem gliomasan autopsy study of 25 cases. Cancer 49: 1294–1296Google Scholar
  283. 272.
    Manual for staging of cancer (1977) American joint committee on cancer staging and end results reporting. Amer J Cancer 10: 167–172Google Scholar
  284. 273.
    Manual of tumor nomenclature and coding (1968) American Cancer Society, New YorkGoogle Scholar
  285. 274.
    Marsh WL, Stevenson OR, Long HJM (1983) Primary leptomeningeal presentation of T-cell lymphoma. Cancer 51: 1125–1131PubMedGoogle Scholar
  286. 275.
    Martin H, Voss K, Hufhagl P, Frölkich K (1984) Automated image analysis of gliomas. An objective and reproducible method for tumor grading. Acta Neuropathol (Berl) 63: 160–169Google Scholar
  287. 276.
    Martinez AJ, Lee A, Moossy J, Maroon JC (1980) Pituitary adenomas: Cytopathological and immunohistochemical study. Ann Neurol 7: 24–36PubMedGoogle Scholar
  288. 277.
    Massie AP (1979) A granular pituicytoma of the neurohypophysis. J Path 129: 53–56PubMedGoogle Scholar
  289. 278.
    Masuzawa T, Sato F (1983) The enzyme histochemistry of the choroid plexus. Brain 106: 55–99PubMedGoogle Scholar
  290. 279.
    Matsushima T (1983) Choroid plexus papillomas and human choroid plexus. A light and electron microscopic study. J Neurosurg 59: 1054–1064PubMedGoogle Scholar
  291. 280.
    Mauney M, Sciotto CG (1983) Primary malignant lymphoma of the cauda equina. Amer J Surg Pathol 7: 185–190Google Scholar
  292. 281.
    Maunoury R, Vedrenne C, Constans JP (1975) Infiltrations lymphocytaires dans les gliomes humains. Acta Neuropathol (Berl) 21: 213–222Google Scholar
  293. 282.
    McComb JG (1984) Recent research into the nature of cerebrospinal fluid formation and absorption. J Neurosurg 59: 369–383Google Scholar
  294. 283.
    McComb RD, Bigner DD (1984) The biology of malignant gliomas—a comprehensive survey. Clin Neuropathol 3: 93–106PubMedGoogle Scholar
  295. 284.
    McComb RD, Burger PC (1983) Choroid plexus carcinoma. Report of a case with immunohistochemical and ultrastructural observations. Cancer 51: 470–475PubMedGoogle Scholar
  296. 285.
    McGravan WL, Sypert GW, Ballinger WE (1978) Melanotic schwannoma. Neurosurgery 2: 47–51Google Scholar
  297. 286.
    Mena H, Garcia JH (1978) Primary brain sarcomas. Light and electron microscopic features. Cancer 42: 1298–1307PubMedGoogle Scholar
  298. 287.
    Mendenhall NP, Thar TL, Agee OF, Harty-Golder B, Barringer WE III, Million RR (1983) Primary lymphoma of the central nervous system. Cancer 52: 1993–2000PubMedGoogle Scholar
  299. 288.
    Mennel HD (1985) Classification of supratentorial gliomas. In: Voth D, Krauseneck P (eds) Chemotherapy of gliomas. De Gruyter, Berlin New York, pp 3–17Google Scholar
  300. 289.
    Mennel HD, Invankovis S (1975) Experimentelle Erzeugung von Tumoren des Nervensystems. In: Handbuch der allgemeinen Pathologie, vol 6/7. Springer, Berlin Heidelberg New York, S 33–122Google Scholar
  301. 290.
    Miettinen M, Lehto VL, Dahl D, Virtanen I (1983) Differential diagnosis of chordome, chondroid, and ependymal tumors as aided by anti-intermediate filament antibodies. Amer J Pathol 112: 160–169Google Scholar
  302. 291.
    Milhorat TH, Hammock MK, Davis DA, Fenstermacher JD (1976) Choroid plexus papilloma. II. Ultrastructure. Child’s Brain 2: 290–303PubMedGoogle Scholar
  303. 292.
    Miller DC, Goodman ML, Pilch BZ, Shi SR, Dickersin GR, Halpern H, Norris CM Jr (1984) Mixed olfactory neuroblastoma and carcinoma. A report of two cases. Cancer 43: 2019–2028Google Scholar
  304. 292a.
    Möbius HJ, Lang C, Schlote W (1986) Zellproliferation in Meningeomen und Neurinomen. Quantitative immunhistochemischc Untersuchungen (abstr). 31th Ann Meet Germ Assn Neuropath, Mainz, October 8–10, 1986. Zbl allg Path Path AnatGoogle Scholar
  305. 293.
    Mohan J, Brownell B, Oppenheimer DR (1976) Malignant spread of haemanglioblastorna: Report of two cases. J Neurol Neurosurg Psychiat 39: 515–525PubMedGoogle Scholar
  306. 294.
    Morant RA, Feigin I, Ransohoff J (1976) Gliosarcoma: a clinical and pathological survey of 24 cases. J Neurosurg 45: 398Google Scholar
  307. 295.
    Morild I, Bang G, Mörk S (1984) Hemangiopericytic meningioma with extracranial spread to multiple sites without intracranial recurrence. Clin Neuropathol 3: 128–130PubMedGoogle Scholar
  308. 296.
    Mork SJ, Halvorsen TB, Lindegaard KK, Eide GE (1986) Oligodendroglioma. Histologic evaluation and prognosis. J Neuropathol Exp Neurol 45: 65–78PubMedGoogle Scholar
  309. 296a.
    Mork SJ, Lindegaard KF, Halvorsen TB, Lehmann EH, et al. (1985) Oligodendroglioma: incidence and biological behavior in a defined population. J Neurosurg 63: 881–889PubMedGoogle Scholar
  310. 297.
    Mork SJ, Nyland H, Matre R, Ganz J (1985) Characterization of host mononuclear cells in gliomas (abstr). J Neuropathol Exp Neurol 44: 317Google Scholar
  311. 298.
    Mork SJ, Rubinstein LJ (1985) Ependymoblastoma. A reappraisal of a rate embryonal tumor. Cancer 55: 1536–1542PubMedGoogle Scholar
  312. 299.
    Moss TH (1986) Tumours of the nervous system. An ultrastructural atlas. Springer, London Berlin Heidelberg New York Paris TokyoGoogle Scholar
  313. 300.
    Mostofi FK, Sobin LH (1977) Histologic typing of testicular tumours. World Health Organization, GenevaGoogle Scholar
  314. 301.
    Mukai M (1983) Immunohistochemical localization of S-100 protein and peripheral nerve myelin proteins (P 2 protein, P 0 protein) in granular cell tumors. Am J Pathol 112: 139–146PubMedGoogle Scholar
  315. 302.
    Muller W, Schröder R (1968) Zur Diagnostik der Gliome. Neurochir (Stuttg)11: 30–36Google Scholar
  316. 303.
    Nagashima M, Yasui K, Kimura J, Washizu M, Yamaguchi K, Mori W (1984) Induction of brain tumors by a newly isolated JC virus. Amer J Pathol 116: 455–463Google Scholar
  317. 303a.
    Nagashima T, DeArmond SJ, Murovic J, Hoshino T (1985) Immunocytochemical demonstration of S-phase cells by anti-bromo-deoxyuridine monoclonal antibody in human brain tumor tissues. Acta Neuropathol (Berl) 67: 155–159Google Scholar
  318. 304.
    Nakamura V, Becker LE (1983) Subependymal giant cell tumor: Astrocytic or neuronal? Acta Neuropathol (Berl) 60: 287–299Google Scholar
  319. 305.
    Nakamura Y, Becker LE, Mancer K, Gillespie R (1982) Peripheral medulloepithelioma. Acta Neuropathol (Berl) 57: 137–142Google Scholar
  320. 306.
    Nakamura Y, Becker LE, Marks A (1983) Distribution of immunoreactive S-100 protein in pediatric brain tumors. J Neuropathol Exp Neurol 42: 136–145PubMedGoogle Scholar
  321. 307.
    Nakazato Y, Ishizeki J, Takahashi K, Yamaguchi H (1982) Immunohistochemical localization of S-100 protein in granular cell myoblastoma. Cancer 49: 1624–1628PubMedGoogle Scholar
  322. 308.
    Nelson DF, Nelson JS, Davis DR, Chang CH, Griffin TW, Pajak TF (1985) Survival and prognosis of patients with astrocytoma with atypical or anaplastic features. J Neuro-Oncol 3: 99–103Google Scholar
  323. 309.
    Nelson JS, Tsukada Y, Schoenfeld D, Fulling K, Lamarche J, Peress N (1983) Necrosis as a prognostic criterion in malignant supratentorial astrocytic gliomas. Cancer 52: 550–554PubMedGoogle Scholar
  324. 310.
    Netsky MG, Shuangshoti S(1975) The choroid plexus in health and disease. University Press of Virginia, CharlottesvilleGoogle Scholar
  325. 311.
    Neumann J (1985) Zur Frage der prognostischen Bedeutung perivasaler Rundzellinfiltrate bei Oligodendrogliomen. Neurochir (Stuttg) 28: 17–19Google Scholar
  326. 312.
    Neumann J, Kimpel I, Gullotta F (1978) Das Oligodendrogliom. Klinischer Verlauf in Bezug zum histologischen Grading. Neurochir (Stuttg) 21: 35–42Google Scholar
  327. 313.
    Neuwelt EA (1984) Therapeutic potential for blood-brain barrier modification in malignant brain tumors. Prag Exp Tumor Res 28: 51–66Google Scholar
  328. 314.
    Neuwelt EA, Kikuchi K, Hill S, Lipsky P, Frcnkel EP (1983) Immune response in patients with brain tumors. Cancer 51: 248–255PubMedGoogle Scholar
  329. 315.
    Neuwelt EY, Smith RG (1979) Presence of lymphocysts surface markers on “small cells” in a pineal germinoma. Ann Neurol 6: 133–136PubMedGoogle Scholar
  330. 316.
    Norris HJ, Liskin JJ, Benson WL (1976) Immature malignant teratoma of the ovary. A clinical and pathologic study. Cancer 37: 2359–2372PubMedGoogle Scholar
  331. 317.
    Nunnery EW, Kahn LB, Reddick RL, Lipper S (1981) Hemangiopericytoma. A light microscopic and ultrastructural study. Cancer 47: 906–914PubMedGoogle Scholar
  332. 318.
    Oehmichen M (1971) Extracerebrale Gliome im Gesichtsbereich. Acta Neuropathol (Berl) 17: 321–330Google Scholar
  333. 319.
    Ojeda VJ (1982) Neoplastic angioendotheliosis of the spinal cord. Acta Neuropathol (Berl) 62: 164–166Google Scholar
  334. 320.
    Ojeda VJ, Stokes BAR, Lee MA, Thomas GW, et al. (1986) Primary cerebral neuroblastomas. A clinico-pathological study of one adolescent and five adult patients. Pathology 18: 41–49PubMedGoogle Scholar
  335. 321.
    Okeda R, Mochizuki T, Terao E, Matsutani M (1980) The origin of intracranial fibrosarcoma. Acta Neuropathol (Berl) 52: 223–230Google Scholar
  336. 322.
    Okeda R, Song SJ, Nakajima T, Matsutani M (1984) Pineocytoma. Observation of an autopsy cases by electron microscopy and cell markers. Acta Pathol Jpn 34: 911–918PubMedGoogle Scholar
  337. 323.
    Olson JJ, Menezes AH, Godersky JC, Laborsky JM, Hart M (1985) Primary intracranial rhabdomyosarcoma. Neurosurgery 17: 25–34PubMedGoogle Scholar
  338. 324.
    Packer JR, Siegel KR, Sutton LN, Litmann P, Bruce DA, Schut L (1985) Leptomeningeal dissemination of primary central nervous system tumors of childhood. Ann Neurol 18: 217–221PubMedGoogle Scholar
  339. 325.
    Packer RJ, Sutton LN, Rorke LB, Zimmermann RA, Littman P, et al. (1985) Oligodendroglioma of the posterior fossa in childhood. Cancer 56: 195–199PubMedGoogle Scholar
  340. 326.
    Packer RJ, Sutton LN, Rosenstock JG, Rorke, et al. (1984) Pineal region tumors of childhood. Pediatrics 74: 97–102PubMedGoogle Scholar
  341. 327.
    Page RB, Plourde PV, Coldwell D, Heald JI, Weinstein J (1983) Intrasellar mixed germ-cell tumor. J Neurosurg 58: 766–770PubMedGoogle Scholar
  342. 328.
    Palma L, di Lorenzo N, Guidetti B (1978) Lymphocytic infiltrates in primary glioblastomas and redivius gliomas: Incidence, fate, and relevance to prognosis in 228 operated cases. J Neurosurg 49: 854–861PubMedGoogle Scholar
  343. 329.
    Palma L, Russo A, Mercuri S (1983) Cystic cerebral astrocytoma in infancy and childhood. Long term results. Child’s Brain 10: 79–91PubMedGoogle Scholar
  344. 330.
    Palmer JO, Kasselberg AG, Netsky MG (1981) Differentiation of medulloblastoma. J Neurosurg 55: 161–169PubMedGoogle Scholar
  345. 331.
    Pasquier B, Couderc P, Pasquier D, Panh MH, N’Golet A (1978) Sarcoma arising in oligodendroglioma of the brain: A case with intramedullary and subarachnoid spinal metastases. Cancer 42: 2753–2758PubMedGoogle Scholar
  346. 332.
    Pasquier B, Kojder I, Labat F, Keddar E, Pasquier D, et al. (1985) Pleomorphic xanthoastrocytoma of young subjects. A report of 2 cases with discordant course and review of literature. Ann Pathol (Paris) 5: 29–44Google Scholar
  347. 333.
    Pasquier B, Lachard A, Pasquier D, Couderc P, Delpech B, Courel MN (1983) Protéine gliofibrillaire acide (GFA) et tumeurs nerveuses centrales. Etude immunohistochimique d’une série de 107 cas. Ann Pathol (Paris) 3: 203–211Google Scholar
  348. 334.
    Pasquier BV, Pasquier D, Colet A, Panh MH, Couderc P (1980) Extraneural metastases of astrocytomas and glioblastomas: Clinicopathological study of two cases and review of literature. Cancer 45: 112–125PubMedGoogle Scholar
  349. 335.
    Payan MJ, Gambarelli D, Keller P, Lacherd A, Garcin M, Vigouroux C, Toga M (1986) Melanotic neurofibroma. A case report with ultrastructural study. Acta Neuropathol (Berl) 148–152Google Scholar
  350. 336.
    Payne DG, Simpson WJ, Keen C, Plattis ME (1982) Malignant astrocytoma: Hyperfractionated and standard radiotherapy with chemotherapy in a randomized prospective clinical trial. Cancer 50: 2301–2306PubMedGoogle Scholar
  351. 337.
    Pearl GS, Chan WC, Bakay RAE, Wood JH (1985) Primary lymphoma of the central nervous system diagnosed by computerized scan-directed needle-biopsy with a frozen section immunoperoxidase techniques. Neurosurgery 16: 1–4PubMedGoogle Scholar
  352. 338.
    Pearl GS, Takei Y (1981) Cerebellar “neuroblastoma”. Nosology as it relates to medulloblastoma. Cancer 47: 772–779PubMedGoogle Scholar
  353. 339.
    Pfeifer J (1984) Tumoren des Nervensystems. In: Remmele W (Hrsg) Pathologie, vol 4. Springer, Berlin Heidelberg New York Tokyo, S 247–287Google Scholar
  354. 340.
    Perentes E, Rubinstein LJ (1986) Immunohistochemical recognition of human neuroepithelial tumors by anti-Leu 7 (HNK-1) monoclonal antibody. Acta Neuropathol (Berl) 69: 227–233Google Scholar
  355. 341.
    Phillips JP, Eremin O, Anderson JR (1982) Lymphoreticular infiltrates in human brain tumors and in normal brain. Brit J Cancer 45: 61–69PubMedGoogle Scholar
  356. 342.
    Pitkethly DT, Hardman JM, Kempe LG, Earle KM (1970) Angioblastic meningiomas: Clinicopathologic study of 81 cases. J Neurosurg 32: 539–544PubMedGoogle Scholar
  357. 343.
    Pitts OM, Powers JM, Hoffman PM (1983) Vascular neoplasms induced in rodent central nervous system by murine sarcoma viruses. Lab Invest 49: 171–182PubMedGoogle Scholar
  358. 344.
    Pollak A, Friede RL (1977) Fine structure of medulloepithelioma. Neuropathol Exp Neurol 36: 712–725Google Scholar
  359. 345.
    Poon TP, Hirano A, Zimmerman H (1971) Electron microscopic atlas of brain tumors. Grune and Stratton, New YorkGoogle Scholar
  360. 346.
    Porwit-Ksiazek A, Christensson B, Lindemalm C, Mellstedt M, etal. (1983) Characterization of malignant and non-neoplastic cell phenotypes in highly malignant non-Hodgkin’s lymphomas. Int J Cancer 32: 667–674Google Scholar
  361. 347.
    Priest J, Dehner LP, Sung JH, Nesbit ME (1981) Primitive neuroectodermal tumors (embryonal gliomas) of childhood. In: Humphrey GB, et al. (eds) Pediatric oncology, vol I. Nijhoff, The Hague Boston London, pp 247–264Google Scholar
  362. 348.
    Pulciani S, Santos E, Lauver AF, Long LK, Barbacid M (1982) Oncogenesis in human tumor cell lines: molecular cloning of a transforming gene from human blander carcinoma cells. Proc Natl Acad Sci USA 79: 2846–2849Google Scholar
  363. 349.
    Rea GL, Akerson RD, Rockswald GL, Smith SA (1983) Subependymoma 2’ /z years old boy. J Neurosurg 59: 1088–1091PubMedGoogle Scholar
  364. 350.
    Reinhardt V, Nahser NCH (1984) Gliofibroma originating from temporoparietal hamartoma-like lesions. Clin Neuropathol 3: 131–138PubMedGoogle Scholar
  365. 351.
    Richman AV, Balis GA, Moniscalco JE (1980) Primary intracerebral tumor with mixed chondrosarcoma and glioblastoma: Gliosarcoma or sarcoglioma? J Neuropathol Exp Neurol 39: 329–335PubMedGoogle Scholar
  366. 352.
    Ridley A, Cavanagh JB (1971) Lymphocytic infiltration in gliomas: Evidence of possible host resistance. Brain 94: 117–124PubMedGoogle Scholar
  367. 353.
    Ringertz N (1950) Grading of gliomas. Acta Path Microbiol Scand 27: 54–64Google Scholar
  368. 354.
    Robertson AJ, Anderson JM, Brown RA, Slidders W, Beck JS (1978) Grading of astrocytomas using a Quantimet 720 image-analyse computer. J Neurol Neurosurg Psychiat 31: 469–474Google Scholar
  369. 355.
    Roessmann U, Velasco ME, Gambetti P, Autilio-Gambetti L (1983) Neuronal and astrocytic differentiation in human neuroepithelial neoplasm. An immunohistochemical study. J Neuropathol Exp Neurol 42: 113–121PubMedGoogle Scholar
  370. 355a.
    Roggendorf W, Schuster Th, Peiffer J (1986) Immunhistologische Untersuchungen zum Proliferationsverhalten nicht glialer Hirntumoren (abstr). 31th Ann Meet Germ Assn Neuropath, Mainz, October 8–10, 1986. Zbl Allg Path Path AnatGoogle Scholar
  371. 356.
    Rorke LB (1983) The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropathol Exp Neurol 42: 1–15PubMedGoogle Scholar
  372. 357.
    Rorke LB, Gilles F, Davis RL, Becker LE (1985) Revision of the World Health Organization Classification of brain tumors for childhood brain tumors. Cancer 56: 1869–1985PubMedGoogle Scholar
  373. 358.
    Rosenblum ML, Gerosa MA, Bodell WJ, Talcott RL (1984) Tumor cell resistance. Prog exp Tumor Res 27: 191–214PubMedGoogle Scholar
  374. 359.
    Rosenblum ML, Wilson CB (eds) (1984) Brain tumor biology. Karger, Basel (Prog exp tumor res, vol 27 )Google Scholar
  375. 359a.
    Royds JA, Ironside W, Taylor CB, Graham DI, Timperley WR (1986) An immunohistochemical study of glial and neuronal markers in primary neoplasms of the central nervous system. Acta Neuropathol (Berl) 70: 320–326Google Scholar
  376. 360.
    Rubinstein LJ (1970) The definition of ependymoblastoma. Arch Path (Chic) 90: 35–45Google Scholar
  377. 361.
    Rubinstein LJ (1974) The cerebellar medulloblastoma. Its origin, differentiation, morphological variants, and biological behavior. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 18. North-Holland, Amsterdam, pp 167–193Google Scholar
  378. 362.
    Rubinstein LJ (1979) Tumors of the central nervous system. Atlas of tumor pathology, 2nd series, fase 6. Armed Forces Institute of Pathology, WashingtonGoogle Scholar
  379. 363.
    Rubinstein LJ (1981) Cytogenesis and differentiation of pineal neoplasms. Human Pathol 12: 441–448Google Scholar
  380. 364.
    Rubinstein LJ (1985) Embryonal central neuroepithelial tumors and their differentiating potential. A cytogenetic view of a complex neurooncological problem. J Neurosurg 62: 795–805PubMedGoogle Scholar
  381. 365.
    Rubinstein LJ, Brucher JM (1981) Focal ependymal differentiation in choroid plexus papilloma. Acta Neuropathol (Berl) 53: 29–33Google Scholar
  382. 366.
    Rubinstein LJ, Herman MM (1979) Recent advances in human brain neurooncology. In: Smith WT, Cavanagh JB (eds) Recent advances in neuropathology, vol 1. Churchill-Livingstone, Edinburgh London New York, pp 179–223Google Scholar
  383. 367.
    Rubinstein LJ, Herman MM, Hanbery (1974) The relationship between differentiating medulloblastoma and dedifferentiating diffuse cerebellar astrocytoma. Cancer 33: 675–690Google Scholar
  384. 368.
    Rubinstein LJ, Herman MM, Vanden Berg SR (1984) Differentiation and anaplasia in central neuroepithelial tumors. Prog Exp Tumor Res 27: 32–48PubMedGoogle Scholar
  385. 369.
    Rubinstein LJ, Northfield DWC (1964) The medulloblastoma and the so-called arachnoidal cerebellar sarcoma. A critical reexamination of a nosological problem. Brain 87: 379–412PubMedGoogle Scholar
  386. 370.
    Russell DS, Rubinstein LJ, (1977): Pathology of tumours of the nervous system, 4th edn. Arnold, LondonGoogle Scholar
  387. 371.
    Saeger W (1981) Die Hypophyse. In: Doerr W, Uehlinger E, Seifert G (Hrsg) Spezielle pathologische Anatomie. Springer, Berlin Heidelberg New YorkGoogle Scholar
  388. 372.
    Sakaki S, Mori Y, Motozaki T, Nakagawa K, Matsuoka K (1981) A cerebral neuroblastoma with extracranial metastases. Surg Neurol 16: 53–59PubMedGoogle Scholar
  389. 373.
    Salacar OM (1983) A better understanding of CSF seeding and a brighter outlook of postoperatively irradiated patients with ependymomas. Int J Rad Oncol Biol Phys 9: 1231–1234Google Scholar
  390. 374.
    Salcman M (1980) Survival in glioblastoma: Historical perspective. Neurosurg 7: 435–439Google Scholar
  391. 375.
    Schaumburg HH, Plack CR, Adams RD (1972) The reticulum cell sarcomamicroglioma group of brain tumors. Brain 95: 199–212PubMedGoogle Scholar
  392. 376.
    Scheithauer BW (1978) Symptomatic subependymoma. J Neurosurg 49: 689–696PubMedGoogle Scholar
  393. 377.
    Scheithauer BW, Kovacs K, Randall RY, Horvath E, Okazaki H, Laws ER (1983) Hypothalamic neural hamartoma and adenohypophyseal neuronal choristoma: Their association with growth hormone adenoma of the pituitary gland. J Neuropathol Exp Neurol 42: 648–663PubMedGoogle Scholar
  394. 378.
    Scheithauer BW, Rubinstein W (1978) Meningeal and mesenchymal chondrosarcoma: Report of eight cases with review of the literature. Cancer 42: 2744–2752PubMedGoogle Scholar
  395. 379.
    Scheithauer BW, Rubinstein LJ (1979) Cerebral medulloepithelioma. Childs Brain 5: 62–71PubMedGoogle Scholar
  396. 380.
    Schelper RL, Kagan-Hallet KS, Huntington HW (1986) Brainstem subarachnoid respiratory epithelial cysts: Report of two cases and review of the literature. Hum Pathol 17: 417–422PubMedGoogle Scholar
  397. 381.
    Scherer JH (1940). The forms of growth in gliomas and their practical significance. Brain 63: 1–35Google Scholar
  398. 382.
    Schiffer D, Cavicchioli D, Giordana MT, Palmucci L, Piazza A (1979) Analysis of some factors affecting survival in malignant gliomas. Tumori 65: 119–125PubMedGoogle Scholar
  399. 383.
    Schiffer D, Giordana MT, Mauro A, Migheli A (1984) GFAP, F VIII/RAg, laminin, in gliosarcomas: an immunohistochemical study. Acta Neuropathol (Berl) 63: 108–116Google Scholar
  400. 384.
    Schiffer D, Giordana MT, Paoletti P, Soffietti R, Rarenzi L (1980) Pathology of human malignant gliomas after radiation and chemotherapy Acta Neurochir (Wien) 53: 205–216Google Scholar
  401. 385.
    Schiffer D, Giordana MT, Soffietti R, Sciolla R, Sannazzari GL, Vasario E (1984) Effects of radiotherapy on the astrocytomatous areas of malignant gliomas. J NeuroOncol 2: 167–175PubMedGoogle Scholar
  402. 386.
    Schindler E (1985) Die Tumoren der Pinealisregion. Springer, Berlin Heidelberg New YorkGoogle Scholar
  403. 387.
    Schmitt HP (1983) Rapid anaplastic transformation in gliomas of adulthood. “Selection” in neuro-oncogenesis. Path Res Pract 176: 313–323PubMedGoogle Scholar
  404. 388.
    Schoenberg BS (1983) The epidemiology of central nervous system tumors. In: Walker EA (ed) Oncology of the nervous system. Nijhoff, Boston Hague, pp 1–29Google Scholar
  405. 389.
    Schold SC Jr, Bullard DR, Bigner SH, Jones TR, Bigner DD (1983) Growth, morphology, and serial transplantation of anaplastic human gliomas in athymic mice. J Neuro-Oncol 1: 5–14Google Scholar
  406. 390.
    Schreiber D, Warzok R, Güthert H, Schneier J (1980) Tumoren des ZNS im Biopsie-und Autopsiegut. 4. Glioblastoma. Zbl Allg Pathol Pathol Anat 124: 416–423Google Scholar
  407. 391.
    Schröder R, Müller N, Bonis G, Vorreith M (1970) Statistische Beiträge zum Grading der Gliome. III. Astrozytome and Oligodendrogliome. Acta Neurochir (Wien) 18: 186–200Google Scholar
  408. 392.
    Schuier F (1976) Is there an anaplastic oligodendroglioma? J Neurol 213: 263–267PubMedGoogle Scholar
  409. 393.
    Scully RE (1979) Tumors of the ovary and maldeveloped gonads. Atlas of Tumor Pathology. Fascicle 16, series 2. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
  410. 394.
    Seiler RW (1982) Die undifferenzierten Astrozytome des Großhirns. Springer, Berlin Heidelberg New YorkGoogle Scholar
  411. 395.
    Seyama S, Ohta M, Nishio S, Matsushima T, Kitamura K (1982) Cells constitutin cerebellar hemangioblastomas. Ultrastructural study. Acta Pathol Jpn 32: 399–413PubMedGoogle Scholar
  412. 396.
    Shapiro WR, Byrne TH (1983) Chemotherapy of brain tumors basic concepts. In: Walker MD (ed) Oncology of the nervous system. Nijhoff, Boston Hague, pp 223–245Google Scholar
  413. 397.
    Shapiro JR, Shapiro WR (1984) Clonal tumor cell heterogeneity. Prog Exp Tumor Res 27: 49–66PubMedGoogle Scholar
  414. 398.
    Sheline GE (1983) Radiotherapy of adult primary cerebral neoplasm. In: Walker MD (ed) Oncology of the nervous system. Nijhoff, Boston Hague, pp 223–245Google Scholar
  415. 399.
    Sheline GE (1986) Normal tissue tolerance and radiation therapy of gliomas of the adult brain. In: Bleehan NM (ed) Tumours of the brain. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  416. 400.
    Shimada H (1982) Transmission and scanning electron microscopic studies on the tumors of neuroblastoma group. Acta Pathol Jpn 32: 415–426PubMedGoogle Scholar
  417. 401.
    Shimura T, Hirano A, Llena JF (1985) Ultrastructure of cerebellar hemangioblastoma. Some new observations on the stromal cell. Acta Neuropathol (Berl) 67: 6–12Google Scholar
  418. 402.
    Shokry A, Janzer RC, von Hochstetter AR, Yasargil MG, Hedinger C (1985) Primary intracranial germ-cell tumors. J Neurosurg 62: 826–830PubMedGoogle Scholar
  419. 403.
    Suangshoti S, O’Charoen (1983) Cerebellar neoplasm of mixed mesenchymal and neuroepithelial origin. J Neurosurg 59: 337–343Google Scholar
  420. 404.
    Slaughter JC, Dardman JM, Kempe LG, Earle KM (1969) Neurocutaneous melanosis and leptomeningeal melanomatosis in children. Arch Pathol 88: 298–304PubMedGoogle Scholar
  421. 405.
    Slowik F, Jellinger K, Gaszó L, Fischer J (1985) Gliosarcomas. Histological, immunohistochemical, ultrastructural, and tissue culture studies. Acta Neuropathol (Berl) 67: 201–210Google Scholar
  422. 406.
    Smith DA, Lantos PL (1985) Immunocytochemistry of cerebellar astrocytomas: with a special note on Rosenthal fibres. Acta Neuropathol (Berl) 66: 155–159Google Scholar
  423. 407.
    Smith MT, Armbrustmacher VM, Violett TW (1981) Diffuse meningeal rhabdomyosarcoma. Cancer 47: 2081–1086PubMedGoogle Scholar
  424. 408.
    Smith MT, Ludwig CL, Godfrey AD, Armbrustmacher VW (1983) Grading of oligodendrogliomas. Cancer 52: 2107–2144PubMedGoogle Scholar
  425. 409.
    Smith TW, Bhawan J (1980) Tactile-like structures in neurofibromas. An ultra-structural study. Acta Neuropathol (Berl) 50: 233–236Google Scholar
  426. 410.
    Smith TW, Davidson RI (1984) Medulloblastoma. A histologic, immunohistochemical and ultrastructural study. Cancer 54: 323–332PubMedGoogle Scholar
  427. 411.
    Snider WD, Simpson DM, Nielsen S, Gold JWM, Metroka CR, Posner JB (1983) Neurological complications of acquired immune deficiency syndrome: Analysis of 50 patients. Ann Neurol 14: 403–418PubMedGoogle Scholar
  428. 412.
    Sobel HJ, Markquet E, Schwarz R (1973) Is schwannoma related to granular cell myoblastoma? Arch Pathol (Chic) 95: 396–401Google Scholar
  429. 413.
    Sobel RA, Trice JE, Nielson SL, Ellis WG (1981) Pineoblastoma with ganglionic and glial differentiation. Acta Neuropathol (Berl) 55: 243–246Google Scholar
  430. 414.
    Sommeland PR, Scheithauer BW, Onofrio BM (1985) Myxopapillary ependymoma. A clinico-pathologic and immunocytochemical study of 77 cases. Cancer 56: 883–893Google Scholar
  431. 415.
    Sonoda H, Matsukado Y, Uemura S, Kaku M (1984) Tissue polypeptide antigen as a tumor marker of brain tumors. Neurol Med Chir 24: 655–662Google Scholar
  432. 416.
    Spaar FW, Blech M, Ahyal A (1986) DNA-flow fluorescence-cytometry of ependymomas. Acta Neuropathol (Berl) 69: 153–160Google Scholar
  433. 417.
    Spence AM, Rubinstein U, Conley FK, Herman MM (1976) Studies on experimental malignant nerve sheath tumors maintained in tissue and organ culture systems. Acta Neuropathol (Berl) 35: 27–45Google Scholar
  434. 418.
    Spencer GD, Weiss RB, van Eys J, Cohen P, Edwards B (1984) Medulloblastoma metastatic to the marrow. J Neuro-Oncol 2: 223–235Google Scholar
  435. 419.
    Stahlberger R, Friede RL (1977) Fine structure of medullomyoblastoma. Acta Neuropathol (Berl) 37: 43–48Google Scholar
  436. 420.
    Stavrou D, Anzil AP, Weidenbach W, Rodt H (1977) Immunofluorescence study of lymphocytic infiltration in gliomas. J Neurol Sci 33: 275–282PubMedGoogle Scholar
  437. 421.
    Steel GG (1980) Growth kinetics of brain tumors. In: Thomas DGT, Graham DI (eds) Brain tumours. Butterworth, London Boston, pp 10–20Google Scholar
  438. 422.
    Stefanko SZ, Manschot WA (1979) Pinealoblastoma with retinoblastomatous differentiation. Brain 102: 321–332PubMedGoogle Scholar
  439. 423.
    Stefanko SZ, Talerman A, Mackay WM, Vuzevski VD (1979) Infundibular germi-noma. Acta Neurochir (Wien) 50: 71–78Google Scholar
  440. 424.
    Stefansson K, Wollmann R, Jerkovic M (1982) S-100 protein in soft-tissue tumors derived from Schwann cells and melanocytes. Am J Pathol 106: 261–268PubMedGoogle Scholar
  441. 425.
    Stewart PA, Hayakawa K, Hayakawa E, Farrell CL, de l’Maest RF (1985) A quantitative study of blood-brain barrier permeability. Ultrastructure in a new rat glioma model. Acta Neuropathol (Berl) 67: 96–102Google Scholar
  442. 426.
    Stochdorph O (1979) How to handle brain tumor classification. Adv Neurosurg 7: 381–384Google Scholar
  443. 427.
    Stout AP, Murray MR (1942) Neuroepithelioma of the radial nerve with a study of its behaviour in vitro. Rev Can Biol 1: 651–659Google Scholar
  444. 428.
    Sung JH, Mastri AR, Segal EL (1973) Melanotic medulloblastoma of the cerebellum. J Neuropathol Exp Neurol 32: 437–445PubMedGoogle Scholar
  445. 429.
    Sunohara N, Mukoyama M, Satoyoshi E (1984) Neoplastic angioendotheliosis of the central nervous system. J Neurol 231: 14–19PubMedGoogle Scholar
  446. 430.
    Sweet DL, Hendler FH, Hanlon K, Hekmatpanah J, et al. (1979) Treatment of grade III and IV astrocytomas with BCNU alone and in combination with VM-26 following surgery and radiation therapy. Cancer Treatm Rep 63: 1707–1711Google Scholar
  447. 431.
    Systematized nomenclature of medicine (1976) College of the American Pathologists, ChicagoGoogle Scholar
  448. 432.
    Takeda N, Tanaka R, Yamazaki K (1980) Correlation of computed tomography with post-mortem histopathology of cerebral malignant glioma. Neuro Med Chir (Tokyo) 20: 603–611Google Scholar
  449. 433.
    Takeuchi J, Barnard RO (1976) Perivascular cuffing in astrocytomas. Acta Neuropathol (Berl) 35: 265–271Google Scholar
  450. 434.
    Takeuchi J, Handa H (1979) Spontaneous extracranial metastases of cerebral neuroblastoma. Surg Neurol 12: 337–339PubMedGoogle Scholar
  451. 435.
    Takeuchi K, Hoshino K (1977) Statistical analysis of factors affecting survival after glioblastomas multiforme. Acta Neurochir (Wien) 37: 57–73Google Scholar
  452. 436.
    Taratuto AL, Molina HA, Diez B, Zuccaro G, Monges J (1985) Primary rhabdomyosarcoma of brain and cerebellum. Report of four cases in infants: An immunohistochemical study. Acta Neuropathol (Berl) 66: 98–104Google Scholar
  453. 437.
    Taratuto M, Molina H, Menges J (1983) Choroid plexus tumors in infancy and childhood. Focal ependymal differentiation. Acta Neuropath (Berl) 59: 304–308Google Scholar
  454. 438.
    Tavcar D, Robboy SJ, Chapmann P (1980) Endodermal sinus tumor of the pineal region. Cancer 45: 2646–2651PubMedGoogle Scholar
  455. 439.
    Taylor CR, Russell R, Lukes RJ, Davis RL (1978) An immunohistochemical study of immunoglobulin content of primary central nervous system lymphomas. Cancer 34: 1293–1302Google Scholar
  456. 440.
    Thomas DGT, Graham DT (eds) (1980) Brain tumours: Scientific basis, clinical investigation and current therapy. Butterworth, London BostonGoogle Scholar
  457. 441.
    Tiberin P, Maor E, Zaizov R, Cohen Ij, et al. (1984) Brain sarcomas of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia. J Neurosurg 61: 772–776PubMedGoogle Scholar
  458. 442.
    Torres LF, Grant N, Harding BN, Scaravelli F (1985) Intracerebral neuroblastoma: Report of a case with neuronal maturation and long survival. Acta Neuropathol (Berl) 68: 110–114Google Scholar
  459. 443.
    Touraine A (1949) Les mélanoses neuro-cutanées. Ann Dermatol Venerol 9: 489–524Google Scholar
  460. 443a.
    Townsend JJ, Seaman JP (1986) Central neurocytoma. A rare benign intraventricular tumor. Acta Neuropathol (Berl) 71: 167–170Google Scholar
  461. 444.
    Trojanowski JQ, Lee V, Pillsbury N, Lee S (1982) Neuronal origin of human esthesioneuroblastoma demonstrated with anti-neurofilament monoclonal antibodies. New Engl J Med 307: 159–161PubMedGoogle Scholar
  462. 445.
    Trojanowski JQ, Lee VMY, Schlaepfer WW (1984) An immunohistochemical study of human central and peripheral nervous system tumors, using monoclonal antibodies against neurofilaments and glial filaments. Hum Pathol 15: 248–257PubMedGoogle Scholar
  463. 446.
    Trojanowsky JQ, Tascos NA, Rorke LB (1982) Malignant pineocytoma with prominent papillary features. Cancer 50: 1789–1793Google Scholar
  464. 447.
    Tankos M, Linnolla RI, Chandra RS, Triche TJ (1984) Neuron-specific enolase in the diagnosis of neuroblastoma and other small, round-cell tumors in children. Hum Pathol 15: 575–584Google Scholar
  465. 448.
    Ueki K, Tanaka R (1980) Treatment and prognosis of pineal tumors. Experience of 110 cases. Neurol Med Chir (Tokyo) 20: 1–26Google Scholar
  466. 449.
    Underwood JCE (1974) Lymphoreticular infiltration in human tumours: Prognostic and biological implications. Brit J Cancer 30: 538–548PubMedGoogle Scholar
  467. 450.
    Velasco ME, Dahl B, Roessmann U, Gambetti P (1980) Immunohistochemical localization of glial fibrillary acidic protein in human glial neoplasms. Cancer 45: 484–494PubMedGoogle Scholar
  468. 451.
    Vick NA, Khandekar JD, Bigner DD (1977) Chemotherapy of brain tumors: The “blood-brain barrier” is not a factor. Arch Neurol (Chic) 34: 523–526Google Scholar
  469. 452.
    Vinores SA, Bonnin JM, Rubinstein U, Marangos PJ (1984) Immunohistochemical demonstration of neuron-specific enolase in neoplasms of the CNS and other tissues. Arch Pathol Lab Med 108: 536–540PubMedGoogle Scholar
  470. 453.
    Von Hanwehr RL, Hofman FM, Taylor CR, Apuzzo MU (1984) Mononuclear lymphoid populations infiltrating the microenvironment or primary CNS tumors. Characterization of cell subsets with monoclonals antibodies. J Neurosurg 60: 1138–1147Google Scholar
  471. 454.
    Voth D, Krauseneck P (eds) (1985) Chemotherapy of gliomas. De Gruyter, Berlin New YorkGoogle Scholar
  472. 455.
    Vuia O (1980) Embryonic carcinosarcoma (mixed tumor) of the pineal gland. Neurochir (Stuttg) 23: 47–54Google Scholar
  473. 456.
    Waggener JD, Beggs JL (1966) Vasculature of neural neoplasms. Adv Neurol 15: 27–49Google Scholar
  474. 457.
    Walker EA (ed) (1983) Oncology of the nervous system. Nijhoff, Boston Hague SidneyGoogle Scholar
  475. 458.
    Walter GF, Brucher JM (1979) Ultrastructural study of medullomyoblastoms. Acta Neuropathol (Berl) 48: 211–214Google Scholar
  476. 459.
    Walker EA, Robins M, Weinfeld FD (1985) Epidemiology of brain tumors: The national survey of intracranial neoplasms. Neurology 35: 219–226PubMedGoogle Scholar
  477. 460.
    Waltz TA, Brownell BL (1966) Sarcoma: A possible late result of effective radiation therapy for pituitary adenoma. J Neurosurg 24: 901–907PubMedGoogle Scholar
  478. 461.
    Warren WH, Lee I, Gould VE, Memoli VA, Wellington J (1985) Paragangliomas of the head and neck: Ultrastructural and immunohistochemical studies. Ultrastruct Pathol 8: 333–344PubMedGoogle Scholar
  479. 462.
    Warzok R, Güthert_H (1978) Die Tumoren des Zentralnervensystems im Biopsie-and Autopsiegut. Zbl All Path Path Anat 122: 462–473Google Scholar
  480. 463.
    Warzok R, Jänisch W, Lang C (1983) Morphology and biology of cerebellar neuroblastomas. J Neuro-Oncol 1: 373–379Google Scholar
  481. 464.
    Warzok B, Jänisch W, Schreiber D (1982) Das Gliomedullomyoblastom. Zbl Allg Path Path Anat 126: 5–15Google Scholar
  482. 465.
    Watabe K, Kumanishi T, Ikuta F, Oyake Y (1983) Tactile-like corpuscles in neurofibromas: Immunohistochemical demonstration of S-100 protein. Acta Neuropathol (Berl) 61: 173–177Google Scholar
  483. 466.
    Webb JN (1982) The ultrastructure of melanotic schwannoma of the skin. J Pathol 137: 25–36PubMedGoogle Scholar
  484. 467.
    Weiser G (1978) Neurofibrom and Perineuralzelle. Elektronenoptische Untersuchung an neun Neurofibromen. Virchows Arch Pathol Anat 375: 73–81Google Scholar
  485. 468.
    Weiss SW, Langloss JM, Enzinger FM (1983) Value of S-100 protein in the diagnosis of soft tissue with particular reference to benign and malignant Schwann cell tumors. Lab Invest 49: 299–308PubMedGoogle Scholar
  486. 469.
    Weldon-Linne GM, Victor TA, Groothuis DR, Vick NA (1983) Pleomorphic xanthoastrocytoma. Ultrastructural and immunohistochemical study of a case with a rapidly fatal outcome following surgery. Cancer 52: 2055–2063PubMedGoogle Scholar
  487. 470.
    Weller RO (1986) The immunopathology of brain tumours. In: Bleehan NM (ed) Tumours of the brain. Springer, Berlin Heidelberg New York Tokyo, pp 19–33Google Scholar
  488. 471a.
    Weller RO, Foy M, Cox S (1977) The development and ultrastructure of the microvasculature in malignant gliomas. Neuropathol Appl Neurobiol 397–322Google Scholar
  489. 471b.
    West CR, Bruce DA, Duffner PK (1985) Ependymomas. Factors in clinical and diagnostic staging. Cancer 56: 1812–1816PubMedGoogle Scholar
  490. 472.
    Wick MR, Mills SE, Scheithauer BW, Cooper PH, Davitz MA, Parkinson K (1986) Reassessment of malignant “angioendotheliomatosis”. Evidence in favor of its reclassification as “intravascular lymphomatosis”. Amer J Surg Pathol 10: 112–123Google Scholar
  491. 473.
    Wikstrand CJ, Graham FC, McComb RD, Bigner DD (1985) Antigenic heterogeneity of human anaplastic gliomas and gliomaderived cell lines defined by monoclonal antibodies. J Neuropathol Exp Neurol 44: 229–241PubMedGoogle Scholar
  492. 474.
    Willis K, du Boulay GH, Teather B (1981) Initial findings in the computer-aided diagnosis of cerebral tumors using CT scan results. Brit J Radiol 54: 948–952Google Scholar
  493. 475.
    Willis RA (1967) Pathology of Tumours, 3rd edn. Butterworth, LondonGoogle Scholar
  494. 476.
    Willson N, Duffy PE (1974) Morphologic changes associated with combined BCNU and radiation therapy in glioblastoma multiforme. Neurology (Minneap) 24: 465–471Google Scholar
  495. 477.
    Wöber G, Jellinger K (1977) Diagnostischer Wert der Abtupfzytologie in der Neurochirurgie. Wien Klin Wsch 89: 122–126Google Scholar
  496. 478.
    Wold LE, Laws ER Jr (1983) Cranial chordomas in children and young adults. J Neurosurg 59: 1043–1047PubMedGoogle Scholar
  497. 479.
    Wong SW, Ducker TB, Powers JM (1979) Fulminating parapontine epidermoid carcinoma in a four-year-old boy. Cancer 37: 1525–1531Google Scholar
  498. 480.
    Wood G, Morantz RA (1979) Immunohistologic evaluation of the lymphoreticular infiltrate in human central nervous system tumours. J Nat Cancer Inst 62: 485–491PubMedGoogle Scholar
  499. 481.
    Woodruff JM, Horten BC, Erlandson RA (1983) Pathology of peripheral nerves and paragangliomas. In: Silverberg SG (ed) Principles and practice of surgical pathology. Wiley, New York, pp 1503–1520Google Scholar
  500. 482.
    World Health Organization (1977): Manual of the international statistical classification of diseases, injuries, and causes of death, 1975 revision. World Health Organization, GenevaGoogle Scholar
  501. 483.
    Yagashita S, Itoh Y, Chiba Y, Fujino H (1979) Primary rhabdomyosarcoma of the cerebrum. Acta Neuropathol (Berl) 45: 111–115Google Scholar
  502. 484.
    Yagashita S, Itoh Y, Chiba Y, Kuwano N (1982) Investigations on cerebellar “neuroblastoma” group. Acta Neuropathol (Berl) 56: 22–28Google Scholar
  503. 485.
    Yagishita S, Itah Y, Chiba Y, Yamashita T, Nakazima F, Kuwabara T (1980) Cerebellar neuroblastoma: A light and ultrastructural study. Acta Neuropathol (Berl) 50: 139–142Google Scholar
  504. 486.
    Yamamura Y, Akamizu H, Hirata T, Kito S, Hamada T (1983) Malignant lymphoma presenting with neoplastic angioendotheliosis of the central nervous system. Clin Neuropathol 2: 62–68PubMedGoogle Scholar
  505. 487.
    Yasuda K, Alderson T, Phillips J, Sikora K (1983) Detection of lymphocytes in malignant gliomas by monoclonal antibodies. J Neurol Neurosurg Psychiat 46: 734–737PubMedGoogle Scholar
  506. 488.
    Yates AJ, Decker LE, Sachs LA (1979) Brain tumors in childhood. Child’s Brain 5: 31–39PubMedGoogle Scholar
  507. 489.
    Yung WA, Horten BC, Shapiro WR (1980) Meningcal gliomatosis. A review of 12 cases. Ann Neurol 8: 605–608PubMedGoogle Scholar
  508. 490.
    Zänker KS, Lederer T, Trappe A, Blümel G (1985) Escape phenomena of glioma cells to allogenic lymphocytes and rhythmically altered protein synthesis encoded by signal transfer. In: Voth D, Krauseneck P (eds) Chemotherapy of gliomas. De Gruyter, Berlin New York, pp 71–76Google Scholar
  509. 491.
    Zänker KS, Trappe A, Blümel G (1982) In-vitro resistance of cloned human glioma cells to natural killer activity of allogeneic peripheral lymphocytes. Brit J Cancer 46: 617–624PubMedGoogle Scholar
  510. 492.
    Zeller WJ, Ivankovic S, Habs M, Schmah D (1982) Experimental chemical productions of brain tumors. Amer NY Acad Sci 381: 250–263Google Scholar
  511. 493.
    Zimm S, Wampler GI, Stablein D (1981) Intracerebral metastases in solid tumor patients. Cancer 48: 384–394PubMedGoogle Scholar
  512. 494.
    Zimmerman HM (1969) Brain tumors: Their incidence and classification in man and their experimental reproduction. Ann New York Acad Sci 159: 337–359Google Scholar
  513. 495.
    Zülch KJ (1975) Atlas of gross neurosurgical pathology. Springer, Berlin Heidelberg New YorkGoogle Scholar
  514. 496.
    Zülch KJ (1979) Histological typing of tumours of the central nervous system. World Health Organization, Geneva (Intern histol classification of tumours, no 21 )Google Scholar
  515. 497.
    Zülch KJ (1980) Principles of the New World Health Organization (WHO) classification of brain tumors. Neuroradiol 19: 59–66Google Scholar
  516. 498.
    Zülch KJ (1986) Brain tumors: their biology and pathology, 3rd edn. Springer, New YorkGoogle Scholar
  517. 499.
    Ziilch KJ, Wechsler W (1968) Pathology and classification of gliomas. Basel New York (Progr neurol surg, vol 2, pp 1–84 )Google Scholar
  518. 500.
    Zu Rhein GM, Varakis JN (1979) Prenatal induction of medulloblastomas in syrian golden hamsters by an human polyoma virus ( JC ). Natl Cancer Inst Monogr 51: 205–208PubMedGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1987

Authors and Affiliations

  • K. Jellinger
    • 1
  1. 1.Ludwig Boltzmann Institute of Clinical NeurobiologyLainz HospitalViennaAustria

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