Skip to main content
SpringerLink
Log in

Die Osteoporose

  • Chapter
Internistische Geriatrie

  • 28 Accesses

Zusammenfassung

Unter dem Begriff Osteoporose wird ein proportionaler Rückgang sowohl des Mineralgehaltes wie auch der Matrix des Knochens verstanden. Klinisch wird der Begriff Osteoporose aherdings viel großzügiger gehandhabt und auch für andere Zustände mit reduzierter Knochenmasse verwendet.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Aloia, J. F., Zanzi, I., Vaswani, A., EUis, K., Cohn, S. H.: Combination therapy for osteoporosis with estrogen, fluoride and calcium. J. Am. Geriatr. Soc. 30: 13–17 (1982).

    PubMed  CAS  Google Scholar 

  • Anonymous: Risk factors in postmenopausal osteoporosis. Lancet i: 1370–1372 (1985).

    Google Scholar 

  • Antunes, C. M. F., Stolley, P. D., Rosenshein, N. B., Davies, J. L., Tonascia, J. A., Brown, C., Burnett, L., Rutledge, A., Pokempner, M., Garcia, R.: Endometrial cancer and estrogen use. New Engl. J. Med. 300: 9–13 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Avioh, L. v., McDonald, J. E., Lee, S. W.: The influence of age on the intestmal absorption of in women and its relation to 47Ca absorption in postmenopausal osteoporosis. J. Clin. Invest. 44: 1960–1967 (1965).

    Article  Google Scholar 

  • Baran, D. T., Teitelbaum, S. L., Bergfeld, M. A., Parker, G., Cmvant, E. M., Avioli, L. V.: Effect of alcohol ingestion on bone and mineral metabolism in rats. Am. J. Physiol. 238: 507–510 (1980).

    Google Scholar 

  • Canalis, E. M., Dietrich, J. W., Maina, D. M., Raisz, L. G.: Hormonal control of bone collagen synthesis in vitro. Effects of insulin and glucagon. Endocrinology 100: 668–674 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Canalis, E.: Effect of insulin lüce growth factor I on DNA and protein synthesis in cultured rat calvaria. J. Clin. Invest. 66: 709–714 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Chestnut, C. H., Baylink, D. J., Sisom, K., Nelp, W. B., Roos, B. A.: Basal plasma immuno- reactive calcitonin in postmenopausal osteoporosis. Metabolism 29: 559–562 (1980).

    Article  Google Scholar 

  • Chestnut, C. H., Ivey, J. L., Gmber, H. E., Matthews, M., Nelp, W. B., Sisom, K., Baylink, D. J.: Stanozolol m postmenopausal osteoporosis: therapeutic efficacy and possible mechanisms of action. Metabolism 32: 571–580 (1983).

    Article  Google Scholar 

  • Christiansen, C., Christensen, M. S., Transbol, I.: Bone mass in postmenopausal women after withdrawal of oestrogen/gestagen replacement therapy. Lancet i: 459–461 (1981).

    Article  Google Scholar 

  • Cohen, H. N., Farrah, D., Fogelman, I., Göll, C. C., Beastall, G. H., Mcintosh, W. B., Fletcher, M., Boyle, I. T.: A low dose regime of 1 -alpha-hydroxyvitamin D3 in the management of senile osteoporosis: a püot study. Clin. Endocrinol. 12: 537–542 (1980).

    Article  CAS  Google Scholar 

  • Cohn, S. H., Vaswani, A., Zanzi, L, Ellis, K. J.: Effect of aging on bone mass in adult women. Am. J. Physiol. 230: 143–148 (1976).

    PubMed  CAS  Google Scholar 

  • Compston, J. E., Chada, S., Merrett, A. L.: Osteomalacia developing during treatment of osteoporosis with sodium fluoride and vitamin D. Brit. Med. J. 281: 910–911 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Council on Scientific Affairs: Estrogen replacement in the menopause. J.A.M.A. 249: 359–361 (1983).

    Article  Google Scholar 

  • Crilly, R. G., Jones, M. M., Horsman, A., Nordin, B. E. C.: Rise in plasma alkaline phosphatase at the menopause. Clin. Sci. 58: 341–342 (1980).

    PubMed  CAS  Google Scholar 

  • Dambacher, M. A., Ittner, J., Riiegsegger, P.: Neue Aspekte zur Pathogenese (und Therapie) der Osteoporose. Therapiewoche 35: 1879–1892 (1985).

    Google Scholar 

  • Daniell, H. W.: Osteoporosis of the slender smoker. Arch. Int. Med. 136: 298–304 (1976).

    Article  CAS  Google Scholar 

  • Deftos, L. J., Weisman, M. H., Williams, G. W., Karpf, D. B., Frumar, A. M., Davidson, B. J., Parthemore, J. G., Judd, H. L.: Influence of age and sex on plasma calcitonin in human beings. New Engl. J.Med. 302: 1351–1353 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Dietrich, J. W., Canalis, E. M., Maina, D. M., Raisz, L. G.: Effect of glucocorticoids on fetal rat bone collagen synthesis in vitro. Endocrinology 104: 715–721 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Editorial: Osteoporosis and activity. Lancet i: 1365–1366 (1983).

    Google Scholar 

  • Eilon, G., Raisz, L. G.: Comparison of the effects of stimulators and inhibitors of resorption on the release of lysosomal enzymes and radioactive calcium from fetal bone in organ culture. Endocrinology 103: 1969–1975 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Frumar, A. M., Meldrum, D. R., Geola, F., Shamoniki, I. M., Tataryn, I. V., Deftos, L. J., Judd, H. L.: Relationship of fasting urinary calcium to circulating estrogen and body weight in postmenopausal women. J. Clin. Endocrinol. Metabol. 50: 70–75 (1980).

    Article  CAS  Google Scholar 

  • Gallagher, J. C., Riggs, B. L., Eisman, J., Harmstra, A., Arnaud, S. B., DeLuca, H. F.: Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. J. Clin. Invest. 64: 729–736 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Gallagher, J. C., Riggs, B. L., Jerpbak, C. M., Arnaud, C. D.: The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women. J. Lab. Clin. Med. 95: 373–385 (1980).

    PubMed  CAS  Google Scholar 

  • Goodman, C. E.: Osteoporosis: protective measures of nutrition and exercise. Geriatrics 40/4: 59–70 (1985).

    PubMed  CAS  Google Scholar 

  • Griffith, G. C., Nichols, G., Asher, J. D., Flanagan, B.: Heparin osteoporosis: J.M.A.A. 193: 91–94 (1965).

    CAS  Google Scholar 

  • Heaney, R. P., Recker, R. R., Saville, P. D.: Menopausal changes in bone remodeling. J. Lab. Clin. Med. 92: 964–970 (1978).

    PubMed  CAS  Google Scholar 

  • Hoover, R., Gray, L. A., Cole, P., MacMahon, B.: Menopausal estrogens and breast cancer. New Engl. J. Med. 295: 401–405 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Horsman, A., Marshall, D. H., Nordin, B. E. C., Crilly, R. G., Simpson, M.: The relation between bone mass and calcium balance in women. Clin. Sci. 59: 137–142 (1980).

    PubMed  CAS  Google Scholar 

  • Horsman, A., Jones, M., Francis, R., Nordin, C.: The effect of estrogen dose on postmenopausal bone loss. New Engl. J. Med. 309: 1405–1407 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Hutchinson, T. A., Polansky, S. M., Feinstein, A. R.: Post-menopausal oestrogens protect against fractures of hip and distal radius. Lancet ii: 705–709 (1979).

    Article  Google Scholar 

  • Jaffe, M. D., Willis, P. W.: Multiple fractures associated with long-term sodium heparin therapy. J.A.M.A. 193: 158–150 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Jensen, J. S., Tondesvold, E.: Mortality after hip fractures. Acta Orthop. Scand. 50: 161–166 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Jowsey, J.: Why is mineral nutrition important in osteoporosis? Geriatrics 40/8: 39–48 (1978).

    Google Scholar 

  • Jowsey, J., Riggs, B. L., Kelly, P. J., Hoffman, D. L.: Calcium and salmon calcitonin in treatment of osteoporosis. J. Clin. Endocrinol. Metabol. 47: 633–639 (1978).

    Article  CAS  Google Scholar 

  • Krolner, B., Nielsen, S. P.: Bone mineral content of the lumbar spine in normal and osteoporotic women: cross sectional and longitudinal studies. Clin. Sci. 62: 329–336 (1982).

    PubMed  CAS  Google Scholar 

  • Lane, J. M., Vigorita, V. J., Falls, M.: Osteoporosis: current diagnosis and treatment. Geriatrics 39/4:40–47 (1984).

    PubMed  CAS  Google Scholar 

  • Lewis, A. F.: Fracture of the neck of the femur: changing incidence. Brit. Med. J. 283: 1217–1220 (1981).

    Article  CAS  Google Scholar 

  • Lund, B., Sorensen, O. H., Lund, B., Agner, E.: Serum 1,25-Dihydroxyvitamin D in normal subjects and in patients with postmenopausal osteopenia. Influence of age, renal function and oestrogen therapy. Horm. Metabol. Res. 14: 271–274 (1982).

    Article  CAS  Google Scholar 

  • Marshall, D. H., Crilly, R. G., Nordin, B. E. C.: Plasma androstendione and oestrone levels in normal and osteoporotic postmenopausal women. Brit. Med. J. 2: 1177–1179 (1977).

    Article  PubMed  CAS  Google Scholar 

  • McNair, P., Madsbad, S., Christiansen, C., Christensen, M. S., Faber, O. K., Binder, C., Transbol, I.: Bone loss in diabetes: effects of metabolic state. Diabetologia 17: 283–286 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Morimoto, S., Tsuji, M., Okada, Y., Onishi, T., Kumahara, Y.: The effect of oestrogens on human calcitonin secretion after calcium infusion in elderly female subjects. Chn. Endocrinol. 13: 135–143 (1980).

    Article  CAS  Google Scholar 

  • Mundy, G. R., Cove, D. H., Fisken, R.: Primary hyperparathyroidism: changes in the pattern of clinical presentation. Lancet i: 1317–1320 (1980).

    Article  Google Scholar 

  • Nordin, B. E. C.: Clinical significance and pathogenesis of oestoporosis. Brit. Med. J. 1: 571–576 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Nordin, B. E. C., Horsman, A., CriUy, R. G., Marshall, D. H., Simpson, M.: Treatment of spinal osteoporosis in postmenopausal women. Brit. Med. J. 280: 451–454 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Pfeffer, R. I., Whipple, G. H., Kurosaki, T. T., Chapman, J. M.: Coronary risk and estrogen use in postmenopausal women. Am. J. Epidemiol. 107: 479–487 (1978).

    PubMed  CAS  Google Scholar 

  • Quigley, M. M., Hammond, C. B.: Estrogen replacement therapy — help or hazard? New Engl. J. Med. 301: 646–648 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Raisz, L. G., Canahs, E. M., Dietrich, J. W., Kream, B. E., Gworek, S. C.: Hormonal regulation of bone formation. Recent Progr. Horm. Res. 34: 335–356 (1978).

    PubMed  CAS  Google Scholar 

  • Raisz, L. G., Vanderhoek, J. Y., Simmons, H. A., Kream, B. E., Nicolaon, K. C.: Prostaglandin synthesis by fetal rat bone in vitro: evidence for a role of prostacyclin. Prostaglyndins 17: 905–911 (1979).

    Article  CAS  Google Scholar 

  • Raisz, L. G.: Osteoporosis. J. Am. Geriatr. Soc. 30: 127–138 (1982).

    PubMed  CAS  Google Scholar 

  • Recker, R. R., Saville, P. D., Heaney, R. P.: Effect of estrogens and calcium carbonate on bone loss in postmenopausal women. Ann. Int. Med. 87: 649–655 (1977).

    PubMed  CAS  Google Scholar 

  • Report from the Boston CoUabor. Drug Surveillance Program: Surgically confirmed gaU- bladder disease, venous thromboembohsm, and breast tumors in relation to postmenopausal estrogen therapy. New Engl. J. Med. 290: 15–19 (1974).

    Article  Google Scholar 

  • Riggs, B. L., Seeman, E., Hodgson, S. F., Taves, D. R., O’Fallon, W. M.: Effect of the fluoride/ calcium regimen on vertebral fracture occurrence in postmenopausal women. New Engl. J. Med. 306: 446–450 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Riggs, B. L., Melton, L. J.: Evidence for two distinct syndromes of involutional osteoporosis. Am. J. Med. 75: 899–901 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Slovik, D. M., Adams, J. S., Neer, R. M., Holick, M. F., Potts, J. T.: Deficient production of 1, 25-dihydroxyvitamin D in elderly osteoporotic patients. New Engl. J.Med. 305: 372–374 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Smith, D. M., Nance, W. E., Kang, K. W., Christian, J. C., Johnston, C. C.: Genetic factors in detemuningbone mass. J. Clin. Invest. 52: 2800 2808 (1973).

    Google Scholar 

  • Stevenson, J. C., Abeyasekera, G., Hillyard, C. J., Phang, K. G., Maclntyre, I., Campbell, S., Townsend, P. T., Young, O., Whitehead, M. I.: Calcitonin and the calcium-regulating hormones in postmenopausal women: effect of oestrogens. Lancet i: 693–695 (1981).

    Article  Google Scholar 

  • Stewart, A. F., Adler, M., Byers, C. M., Segre, G. V., Broadus, A. E.: Calcium homeostasis in immobilization: an example of resorptive hypercalciura. NewEngl. J.Med. 306: 1136–1140 (1982).

    Article  CAS  Google Scholar 

  • Tibblin, S., Palsson, N., Rydberg, J.: Hyperparathyroidism in the elderly. Ann. Surg. 197: 135–138 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Tiegs, R. D., Body, J. J., Wahner, H. W., Barta, J., Riggs, B. L., Heath, H.: Calcitonin secretion in postmenopausal osteoporosis. New Engl. J. Med. 312: 1097–1100 (1985).

    Article  PubMed  CAS  Google Scholar 

  • Toh, S. H., Claunch, B. C., Brown, F. H.: Effect of hyperthyroidism and its treatment on bone mineral content. Arch. Int. Med. 145: 883–886 (1985).

    Article  CAS  Google Scholar 

  • Weinstein, M. C.: Estrogen use in postmenopausal women — costs, risks, and benefits. New Engl. J. Med. 303: 308–316 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Wiedeman, E., Schwartz, E., Frantz, A. G.: Acute and chronic estrogen effects upon serum somatomedin activity, growth hormone and prolactin in man. J. Chn. Endocrinol. Metabol. 42:942–952 (1976).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. I. Medizinischen Abteilung, Kaiser-Franz-Joseph-Spitals, Wien, Österreich

    Prof. Dr. Karl Heinz Tragl (Vorstand)

Authors
  1. Prof. Dr. Karl Heinz Tragl
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag/Wien

About this chapter

Cite this chapter

Tragl, K.H. (1986). Die Osteoporose. In: Internistische Geriatrie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8839-2_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-8839-2_11

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-81904-3

  • Online ISBN: 978-3-7091-8839-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation