Summary
Analysis of 8 autopsied cases with permanent 125I implantation demonstrates that interstitial irradiation of CNS neoplasms causes extensive focal tumour necroses. In some cases, complete tumour regression resulted, with no viable neoplastic cells detectable at autopsy. In large gliomas of the cerebral hemispheres and basal ganglia, central radiation-induced necroses were present, but peripheral tumour masses progressed and ultimately determined the clinical outcome. In patients with tumours located in basal midline structures, interstitial 125I produced areas of delayed radionecrosis extending into the adjacent normal brain tissue. All of these patients were treated with external radiation in addition to interstitial implantation, indicating cumulative radiation toxicity.
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Kiessling, M., Kleihues, P., Gessaga, E., Mundinger, F., Ostertag, C.B., Weigel, K. (1984). Morphology of Intracranial Tumours and Adjacent Brain Structures Following Interstitial Iodine-125 Radiotherapy. In: Gybels, J., Hitchcock, E.R., Ostertag, C., Rossi, G.F., Siegfried, J., Szikla, G. (eds) Advances in Stereotactic and Functional Neurosurgery 6. Acta Neurochirurgica, vol 33. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8726-5_45
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DOI: https://doi.org/10.1007/978-3-7091-8726-5_45
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