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The Muscle Satellite Cell and Its Role in Muscle Transplantation (A Short Review)

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Muscle Transplantation

Abstract

Successful free autologous muscle transplantation is highly dependent on the regenerative capacity of skeletal muscle. Because of transient ischemia, only a thin superficial layer of muscle fibres vias found to survive free muscle transplantation, as shown by the Vienna group (Holle et al., 1974; Lischka et al.y 1977) and in more detail by Carlson and Gutmann (1975 a, b), Schiaffino et al. (1975), and Hansen-Smith and Carlson (1979). Even after prior denervation of the transplanted muscle, as first recommended by Thompson (1971), the number of surviving superficial muscle fibres is only moderately increased (Carlson, 1978). Thus, a process of degeneration and regeneration governs the events resulting in the structural and functional recovery of the transplanted muscle. Of course, modern research in muscle transplantation aims to avoid ischemic necrosis as far as possible by immediate reconstitution of the muscle’s vascular supply (Harii et al., 1976), but still under such favorable conditions damage to the transplant will not be avoidable, and a good result will still be dependent on the regenerative capacity of striated muscle.

Supported by the “Fonds zur Förderung der wissenschaftlichen Forschung in Österreich” (Project 2618).

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Authors and Affiliations

  1. Institut für Anatomie (2), Universität Wien, Währinger Strasse 13, A-1090, Wien, Austria

    Prof. Dr. R. Mayr

  2. Department of Anatomy 2, University of Vienna, Austria

    Prof. Dr. R. Mayr

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Editors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, Second Surgical University Clinic of Vienna, Austria

    Gerhard Freilinger  & Jürgen Holle  & 

  2. Department of Anatomy, University of Michigan, Ann Arbor, Michigan, USA

    Bruce Martin Carlson

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Mayr, R. (1981). The Muscle Satellite Cell and Its Role in Muscle Transplantation (A Short Review). In: Freilinger, G., Holle, J., Carlson, B.M. (eds) Muscle Transplantation. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8618-3_2

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  • DOI: https://doi.org/10.1007/978-3-7091-8618-3_2

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  • Print ISBN: 978-3-7091-8620-6

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