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Androgènes Plasmatiques et Maturation de l’Axe Hypothalamo-Hypophyso-Gonadique Chez le Nourrisson et l’Enfant

Conference paper
Part of the Pädiatrie und Pädologie book series (PÄD SUPPL, volume 5)

Resumé

Les androgènes plasmatiques, testostérone (T) et Δ 4-androstenedione (Δ 4) ont été mesurés par dosages radioimmunologiques spécifiques (RIA) chez 245 nourrissons de moins de 1 an, chez 70 enfants prépubères et chez 250 adolescents en cours de puberté. Lex taux circulants de T et Δ 4 leurs variations selon l’âge, le sexe, et l’un par rapport à l’autre, suggèrent que:
  1. 1.

    à la naissance T et Δ 4 sont produits par le foetus et chez le garçon existe une importante activité endocrine testiculaire;

     
  2. 2.

    après le sexième mois de vie il n’y a plus d’activité sécrétoire testiculaire notable;

     
  3. 3.

    l’activation prépubertaire de la production androgénique (adrénarche) est similaire dans le deux sexes mais leur chronologie en est différente pour chaque androgène: les taux de Δ 4 montent après l’âge de 8 ans, ceux de T seulement après l’âge de 10 ans;

     
  4. 4.

    durant la puberté l’augmentation de T et Δ 4 diffère à nouveau considérablement selon le sexe.

     

Bien que la maturation progressive de la production des hormones stéroïdiennes androgènes signant la “puberté surrénalienne” soit bien documentée, le rôle de ces androgènes dans la maturation de l’axe hypothalamo-hypophyso-gonadique reste encore hypothétique.

Plasma Androgens and Maturation of the Hypothalamo-Pituitary-Gonadal Axis in Infants and Children

Summary

The plasma androgens testosterone (T) and Δ 4-androstenedione (Δ 4) were measured by RIA in 245 children under 1 year of age, in 70 children of prepubertal age, and in 250 adolescents during puberty. The values presented in the tables, and their changing relation to each other, suggest, that
  1. 1.

    at birth T and Δ 4 are of fetal origin demonstrating the important endocrine function of the fetal testis;

     
  2. 2.

    after 6 months of age there is no significant endocrine activity of the gonads any more;

     
  3. 3.

    the prepubertal activation of the adrenal androgens production (adrenarche) is similar in the 2 sexes but their chronology is different for each androgen: an increase is observed after age 8 for Δ 4, after age 10 for T.

     
  4. 4.

    in puberty the increase of T- and Δ 4-values differs markedly according to the two sexes.

     

So, while the gradual prepubertal maturation of androgen steroid production, passing the stage of “adrenal puberty”, could be demonstrated convincingly, the role of the different androgens in the maturation of the “gonadostat” (hypothalamopituitary complex) still remains a matter of hypothesis.

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Copyright information

© Springer-Verlag/Wien 1977

Authors and Affiliations

  1. 1.Unité de Recherches Endocriniennes et Métaboliques chez l’Enfant (INSERM U. 34)Hôpital DebrousseLyonFrance

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