Möglichkeit einer TSH-Screening-Methode zur Entdeckung der Hypothyreose bei Neugeborenen
Possibility of a TSH-Screening Method for Detection of Hypothyroidism in the Newborn
In congenital hypothyroidism the TSH level reaches at age 5 days values about 100-times of the normal. Due to this fact, and having a good RIA-method for TSH in the own lab at hand, the possibility of TSH-determination in dried whole-blood on a filter-paper was examined. Control studies with normal blood-samples proved that the values of dried-blood samples had sufficient accuracy. On the 5th day of life the normal TSH-values were below 20 μU/ml while values above 100 μU/ml were suspicious for hypothyroidism. In 1200 newborns the TSH-screening was performed in combination with the routine Guthrie-test. Among them one child with a value above 100 μU/ml proved to have hypothyroidism. The results show that the determination of TSH in dried blood is possible, and that the method described is a useful tool for the early diagnosis of primary hypothyroidism.
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- 9.Dutau, G., Augier, D., Bayard, F., Rochiccioli, F.: Dosage radioimmunologique de la thyroxine dans l’eluat de sang sèche prélevé sur papier buvard. Arch. Franç. Ped. 32, 957 (1975).Google Scholar
- 13.Zabransky, S.: Neugeborenen-Screening auf angeborene Hypothyreose. München: Urban and Schwarzenberg (in Druck).Google Scholar