Summary
In congenital hypothyroidism the TSH level reaches at age 5 days values about 100-times of the normal. Due to this fact, and having a good RIA-method for TSH in the own lab at hand, the possibility of TSH-determination in dried whole-blood on a filter-paper was examined. Control studies with normal blood-samples proved that the values of dried-blood samples had sufficient accuracy. On the 5th day of life the normal TSH-values were below 20 μU/ml while values above 100 μU/ml were suspicious for hypothyroidism. In 1200 newborns the TSH-screening was performed in combination with the routine Guthrie-test. Among them one child with a value above 100 μU/ml proved to have hypothyroidism. The results show that the determination of TSH in dried blood is possible, and that the method described is a useful tool for the early diagnosis of primary hypothyroidism.
Vortrag, gehalten am Symposium über „Aktuelle Probleme der pädiatrischen Endokrinologie“. Wien, 28. 9. 1976.
C. Rodriguez De Vera Roda aus Malaga, Spanien, ist Stipendiatin der Roche-Studienstiftung.
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Illig, R., de Vera Roda, C.R. (1977). Möglichkeit einer TSH-Screening-Methode zur Entdeckung der Hypothyreose bei Neugeborenen. In: Swoboda, W., Zimprich, H. (eds) Aktuelle Probleme der pädiatrischen Endokrinologie. Pädiatrie und Pädologie, vol 5. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8491-2_14
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DOI: https://doi.org/10.1007/978-3-7091-8491-2_14
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