Response of Gonadotropins to Stimulation With Luteinizing Hormone — Releasing Hormone (LH-RH) in Children With Precocious Puberty Before, During and Following Therapy With Cyproterone Acetate or an Ethisterone Derivate

Conference paper
Part of the Pädiatrie und Pädologie book series (PÄD SUPPL, volume 5)


9 children with precocious puberty were treated over a period of 6 months to 6\(6 \frac{\hbox{$\scriptstyle 3$}}{\hbox{$\scriptstyle {12}$}}\) years with Cyproteron acetate or an Ethisterone derivate. LH-RH tests with radioimmunological estimations of LH and FSH were performed before therapy was begun, during and after completion of treatment. In children with untreated precocious puberty the mean basal LH levels were the same as in normal prepubertal children but the increase and the peak values after i. v. LH-RH were found to be considerably greater than in normals. In the treated patients this stimulatable LH release was suppressed; after completion of therapy it was again elevated.

The basal FSH levels in untreated children were elevated; however the increase and the peak values were comparable to the collective norm. Results were not altered considerably by therapy; however these parameters were again elevated after completion of therapy.

Despite the marked suppression of stimulatable LH by therapy acceleration of bone age is practically not affected. After completion of therapy this drug-induced suppression of gonadotropines is promptly reversible.


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  1. 1.
    Bremner, W., Paulsen, C. A.: Two Pools of Luteinizing Hormone in the Human Pituitary: Evidence From Constant Administration of LH-RH. J. Clin. Endocrin. Metab. 39, 811–815 (1974).CrossRefGoogle Scholar
  2. 2.
    Butenandt, O., Souvatzoglu, A.: Luteinisierendes Hormon im Serum gesunder Kinder und bei Pubertas praecox. Mschr. Kinderheilk. 121, 473–474 (1973).PubMedGoogle Scholar
  3. 3.
    Dickermann, Z., Prager, R., Laron, Z.: Response of Plasma LH and FSH to Synthetic LH-RH in Children at Various Pubertal Stages. Amer. J. Dis. Child. 130, 634–638 (1976).Google Scholar
  4. 4.
    Donald, R. A., Espiner, E. A., Cowles, R. J., Fazackerley, J. E.: The Effect of Cyproterone Acetate on the Plasma Gonadotrophin Response to Gonadotrophin Releasing Hormone. Acta Endocr. 81, 680–684 (1976).PubMedGoogle Scholar
  5. 5.
    Franchimont, P.: Le dosage radioimmunologique des gonadotrophins. Ann. Endocr. (Paris) 29, 403 (1968).Google Scholar
  6. 6.
    Friedrich, F.: Klinik der Gelbkörperfunktion. Wien-München-Bern: Wilhelm-Maudrich-Verlag 1975.Google Scholar
  7. 7.
    Frisch, H.: Treatment of Idiopathic Precocious Puberty in Four Girls With an Antiandrogene. XIV Int. Congress of Pediatrics, Abstract p. 111. Buenos Aires (1974).Google Scholar
  8. 8.
    Greulich, W. W., Pyle, S. I.: Radiographic Atlas of the Skeletal Development of the Hand and Wrist. Ed. 2. Stanford: Stanford Univ. Press 1959.Google Scholar
  9. 9.
    Kemeter, P., Friedrich, F.: Funktionsteste bei Amenorrhoe. 7. Fortbildungskurs der II. Universitäts-Frauenklinik, Wien, 3. bis 8. 2. 1975 (Hrsg. H. Husslein, A. Schaller), Abstrakt S. 43 (1975).Google Scholar
  10. 10.
    Kemeter, P.: Die Endokrinologie der Pubertät. 8. Fortbildungskurs der II. Universitäts-Frauenklinik, Wien, 2. bis 7. 2. 1976 (Hrsg. H. Husslein, A. Schaller), Abstrakt S. 17 (1976).Google Scholar
  11. 11.
    Martini, L.: Central Nervous Influences on Gonadal Functions. Acta Endocr. 155 (Suppl.), 44 (1974).Google Scholar
  12. 12.
    Reiter, E. O., Kaplan, S. L., Conte, F. A., Grumbach, M. M.: Responsibility of Pituitary Gonadotropes to Luteinizing Hormone-Releasing Factor in Idiopathic Precocious Puberty, Precocious Thelarche, Precocious Adrenarche, and in Patients Treated With Medroxyprogesteron Acetate. Pediat. Res. 9, 111–116 (1975).PubMedGoogle Scholar
  13. 13.
    Roth, J. C., Grumbach, M. M., Kaplan, S. L.: Effect of Synthetic Luteinizing Hormone-Releasing Factor on Serum Testosterone and Gonadotropin in Pubertal and Adults Males. J. Clin. Endocr. Metab. 37, 680 (1973).PubMedCrossRefGoogle Scholar
  14. 14.
    Roth, J. C., Kelch, R. D., Kaplan, S. L., Grumbach, M. M.: FSH and LH Response to Luteinizing Hormone Releasing Factor in Prepubertal and Pubertal Children, Adult Males and Patients With Hypogonadotropic and Hypergonadotropic Hypogonadism. J. Clin. Endocr. Metab. 35, 926 (1972).PubMedCrossRefGoogle Scholar
  15. 15.
    Schreiner, W. E.: In: Klinik der inneren Sekretion (Hrsg. A. Labhart). BerlinHeidelberg—New York: Springer 1971.Google Scholar
  16. 16.
    Solbach, H. G., Wiegelmann, W., Kley, H. K., Zimmermann, H., Krüskemper, H. L.: Die diagnostische Bedeutung des synthetischen LH-RH für die Oberprüfung der gonadotropen Funktion des Hypophysenvorderlappens. Dtsch. med. Wschr. 98, 2114–2119 (1973).Google Scholar
  17. 17.
    Tanner, J. M.: Growth at Adolescence. 2nd Ed. Oxford: Blackwell Sci. Publ. 1962.Google Scholar
  18. 18.
    Winter, J. S. D.: Analysis of Clinical Studies With LH-RH in Children and Adolescents. Amer. J. Dis. Child. 130, 590–592 (1976).PubMedGoogle Scholar
  19. 19.
    Yen, S. S. C., Lasley, B. L., Wang, C. F., Leblanc, H., Siler, T. M.: The Operating Characterstics of the Hypothalamic-Pituitary System During the Menstrual Cycle and Observations of Biological Action of Somatostatin. Rec. Prog. Horm. Res. 31, 321 (1975).PubMedGoogle Scholar
  20. 20.
    Yen, S. S. C.: Hypothalamic Control and Ovarian Modulation of Gonadotropin Release by the Adenohypophysis. Serono Symposia Firenze 7. to 9. 10. 1975, Abstract by Serono.Google Scholar

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© Springer-Verlag/Wien 1977

Authors and Affiliations

  1. 1.Universitäts-KinderklinikÖsterreich
  2. 2.II. Universitäts-FrauenklinikViennaÖsterreich
  3. 3.Universitäts-KinderklinikWienAustria

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