Zusammenfassung
Die theoretische und klinische Entwicklung der Antidepressiva nahm ihren Ausgang von den Entdeckungen der antidepressiven Wirkung von Imipramin durch Kuhn [187] und von Iproniazid durch Kline [176]. Der „ersten Generation “ von zahlreichen trizyklischen Antidepressiva bzw. Monoaminoxidase (MAO)-Hemmern folgte die Entwicklung der „zweiten Generation“, d. h. antidepressiv wirksame Substanzen, die strukturchemisch und teilweise auch pharmakologisch keine Verwandtschaft mit den „klassischen“ Antidepressiva aufweisen.
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Paioni, R., Waldmeier, P., Delini-Stula, A., Langer, G., Schönbeck, G., Beckmann, H. (1983). Antidepressiva: Grundlagen und Therapie. In: Langer, G., Heimann, H. (eds) Psychopharmaka. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7645-0_4
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