Pain pp 80-81 | Cite as

Spinal Infusion of Opiates and Somatostatin

  • Joachim Chrubasik
Conference paper
Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA, volume 38)


Since the introduction in 1979 of spinal (epidural/intrathecal) administration of opiates in pain treatment, spinal bolus injections have been investigated and employed more and more. Yet, more recent studies have shown that intermittent bolus injections should be replaced when possible by continuous, on-demand spinal infusions by means of externally worn or implantable infusion devices in treatment of acute1 and chronic2 pain. Because of the possibility of individualized treatment of pain, continuous-plus-on- demand epidural infusion of opiates is particularly recommendable in treatment of postoperative pain3, especially when the catheter has been placed for epidural anaesthesia. Pharmacokinetic4 and animal5 investigations have proved that the risk of side-effects is lower with continuous-plus-on-demand epidural infusion than with intermittent bolus epidural injections. A reduction of the injection volume does not result in any loss of analgesic efficacy6. The advantages of continuous, on-demand spinal infusions of opiates include constant analgesia, individualized pain treatment, convenience for patient and staff, and a lower risk of catheter complications.


Pain Treatment Epidural Morphine Epidural Infusion Infusion Device Gastric Mucosal Cell 
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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Joachim Chrubasik
    • 1
  1. 1.Abteilung für Anästhesie der UniversitätsklinikDüsseldorfFederal Republic of Germany

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