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Aging and the nigro-striatal pathway

  • Conference paper
Book cover Dementia in Parkinsonism

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURAL SUPPL,volume 51))

Summary

Aging is associated with a progressive impairment in motor function. This feature, together with the decline in mental function, could be considered as an aging syndrome which may finally compromise the ability of the elderly to maintain an active, independent life-style.

In the present paper a wide variety of morphological aspects, which have been classically related to brain aging and others such as cytoskeletal changes, the role of growth factors and molecular changes, will be reviewed focusing on aging of the nigrostriatal pathway. In addition to sharing features of aging common to other structures, it is likely that the nigrostriatal pathway has specific characteristics derived from its particular molecular characteristics and/or from a selective vulnerability to aging.

To gain further insight into the aging syndrome, the acquisition of rigorous criteria for selecting control cases is paramount. The improvement of methods for the preservation of human tissue is also crucial.

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Authors and Affiliations

  1. Neurological Tissue Bank, Hospital Clinic, University of Barcelona, Spain

    F. F. Cruz-Sánchez M.D, A. Cardozo, C. Castejón, E. Tolosa & M. L. Rossi

Authors
  1. F. F. Cruz-Sánchez M.D
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  2. A. Cardozo
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  3. C. Castejón
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  4. E. Tolosa
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  5. M. L. Rossi
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Editor information

Editors and Affiliations

  1. Parkinson’s Disease Society Brain Research Centre (Brain Bank), Institute of Neurology, London, UK

    S. E. Daniel  & A. J. Lees  & 

  2. Neurological Tissue Bank, Hospital Clinic, University of Barcelona, Spain

    F. F. Cruz-Sánchez

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© 1997 Springer-Verlag/Wien

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Cruz-Sánchez, F.F., Cardozo, A., Castejón, C., Tolosa, E., Rossi, M.L. (1997). Aging and the nigro-striatal pathway. In: Daniel, S.E., Cruz-Sánchez, F.F., Lees, A.J. (eds) Dementia in Parkinsonism. Journal of Neural Transmission. Supplementa, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6846-2_2

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  • DOI: https://doi.org/10.1007/978-3-7091-6846-2_2

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82959-2

  • Online ISBN: 978-3-7091-6846-2

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