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Brain Edema X pp 123–125Cite as

Intracranial Pressure in a Modified Experimental Model of Closed Head Injury

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Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 70))

Summary

Intracranial pressure (ICP) was studied in a modified experimental model of closed head injury, in which the dynamic process of impact versus impulse loading was separately controlled. In this model, mortality of Wistar rats was considerably higher as compared to Sprague-Dawley rats subjected to similar traumatic conditions. Therefore Sprague-Dawley rats were used for all further experiments. Twenty-four rats, divided into 4 groups, underwent either sham or gradually increasing impact-acceleration trauma. Four hours after closed head injury, ICP measurements showed a significant correlation between the severity of the traumatic challenge and the resultant pressure rise (r2 = 0.731; p < 0.001). At the moment of impact there was a momentary blood pressure peak immediately followed by a transient period of hypotension. ICP measurements following directly to an impact-acceleration trauma, revealed an abrupt rise in ICP reaching pathological levels within 5 minutes. In conclusion, this modified model of closed head injury produces a predictable and reproducible pathologic ICP in Sprague-Dawley rats.

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References

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Antwerp, Wilrijkstraat 10, B-2650, Edegem, Belgium

    Koen Engelborghs M.D., J. Verlooy & M. Borgers

  2. Department of Life Sciences, Janssen Research Foundation, Beerse, Belgium

    B. Van Deuren & J. Van Reempts

Authors
  1. Koen Engelborghs M.D.
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  2. J. Verlooy
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  3. B. Van Deuren
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  4. J. Van Reempts
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  5. M. Borgers
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Editor information

Editors and Affiliations

  1. Pediatric Neurosurgery, San Diego, CA, USA

    Hector E. James M.D.

  2. Division of Neurological Surgery, San Diego Medical Center, University of California, San Diego, CA, USA

    Lawrence F. Marshall M.D.

  3. Institut für Neurochirurgie, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Germany

    Hans J. Raulen (Prof. Dr.) (Prof. Dr.)

  4. Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Germany

    Alexander Baethmann (Prof. Dr.) (Prof. Dr.)

  5. Neurological Surgery, Virginia Commonwealth University, Richmond, VA, USA

    Anthony Marmarou Ph.D.

  6. Department of Neurosurgery, Musashino Red Cross Hospital, Tokyo, Japan

    Umeo Ito M.D.

  7. Taubmann Health Care Center, The University of Michigan, Ann Arbor, MI, USA

    Julian T. Hoff M.D.

  8. Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa M.D.

  9. Department of Neurosurgery Medical Resarch Center, Polish Academy of Sciences, Warsaw, Poland

    Zbigniew Czernicki M.D., Ph.D.

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© 1997 Springer-Verlag

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Cite this paper

Engelborghs, K., Verlooy, J., Van Deuren, B., Van Reempts, J., Borgers, M. (1997). Intracranial Pressure in a Modified Experimental Model of Closed Head Injury. In: James, H.E., et al. Brain Edema X. Acta Neurochirurgica Supplements, vol 70. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6837-0_38

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  • DOI: https://doi.org/10.1007/978-3-7091-6837-0_38

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7418-0

  • Online ISBN: 978-3-7091-6837-0

  • eBook Packages: Springer Book Archive

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