Methods of Developmental Research

  • A. Ünlü
Conference paper
Part of the Acta Neurochirurgica Supplements book series (NEUROCHIRURGICA, volume 83)


Neural tube defects (NTD) caused by abnormal neurulation are the major congenital anomalies which result in fetal or embryonic death, and medical, financial and social problems. The multifactorial events of neurulation have attracted researchers to identify the mechanisms of this disability.

Research focused on NTDs is one of the major topics in developmental experiments. Mammalian, avian, amphibian and computer models are used as fundamental models to discover specific events causing NTDs. There are advantages of working on some models: rats and mice are mammalian models of neurulation; amphibians and avian embryos are simple models and more practical.

Advancement in laboratory techniques has yielded more detailed information about neurulation which will assist in future with prevention and therapy of these defects.


Method neural tube defect neurulation avian embryo 


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Copyright information

© Springer-Verlag/Wien 2002

Authors and Affiliations

  • A. Ünlü
    • 1
    • 2
  1. 1.Neurosurgery DepartmentUniversity of Ankara, School of MedicineAnkaraTurkey
  2. 2.AnkaraTurkey

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