Summary
Following traumatic brain injury catecholamines are routinely applied to increase cerebral perfusion. To date, it remains controversial if infusion of catecholamines is associated with diminished cerebral perfusion due to catecholamine-mediated vasoconstriction. The aims of the present study were to investigate the effects of norepinephrine and dopamine on cortical perfusion and brain edema following controlled cortical impact injury (CCII) in rats.
Four hours after CCII, rats (n = 22) received either norepinephrine or dopamine with the aim of increasing MABP to 120 mm Hg for 90 minutes. Control rats were given NaCl. Cortical perfusion was measured before, during, and after catecholamine infusion using Laser Doppler flowmetry. Brain swelling was determined directly after the study period (8 hrs after CCII).
Following CCII cortical perfusion was reduced by 40% compared to pre-trauma values in all rats. Parallel to the increases in MABP, cortical perfusion was significantly elevated under norepinephrine and dopamine, respectively (p < 0.05). Despite similar MABP values this increase was mostly sustained under norepinephrine. In control rats cortical perfusion remained diminished. Brain swelling was similar in all groups.
Both norepinephrine and dopamine significantly increased cortical perfusion following CCII. Norepinephrine, however, was superior to dopamine in CBF. Based on increased CBF and unchanged brain swelling catecholamine-mediated vasoconstriction does not seem to occur under the present study design.
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References
Altura BM, Gebrewold A, Lassoff S (1980) Biphasic responsiveness of rat pial arterioles to dopamine: direct observations on the microcirculation. Br J Pharmacol 69: 543–544
Baskaya MK, Rao AM, Dogan A, Donaldson D, Dempsey RJ (1997) The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neurosci Lett 226: 33–36
Cherian L, Chacko G, Goodman JC, Robertson CS (1999) Cerebral hemodynamic effects of phenylephrine and L-arginine after cortical impact injury. Crit Care Med 27: 2512–2517
Kroppenstedt SN, Kern M, Thomale UW, Schneider GH, Lanksch WR, Unterberg AW (1999) Effect of cerebral perfusion pressure on contusion volume following impact injury. J Neurosurg 90: 520–526
Kroppenstedt SN, Stroop R, Kern M, Thomale UW, Schneider GH, Unterberg AW (1999) Lubeluzole following traumatic brain injury in the rat. J Neurotrauma 16: 629–637
Talmor D, Roytblat L, Artru AA, Yuri O, Koyfman L, Katchko L, Shapira Y (1998) Phenylephrine-induced hypertension does not improve outcome after closed head trauma in rats. Anesth Analg 87: 574–578
von Essen C, Kistler JP, Lees RS, Zervas NT (1981) Cerebral blood flow and intracranial pressure in the dog during intravenous infusion of nitroglycerin alone and in combination with dopamine. Stroke 12: 331–338
von Essen C, Zervas NT, Brown DR, Koltun WA, Pickren KS (1980) Local cerebral blood flow in the dog during intravenous infusion of dopamine. Surg Neurol 13: 181–188
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© 2002 Springer-Verlag
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Kroppenstedt, SN., Sakowitz, O.W., Thomale, UW., Unterberg, A.W., Stover, J.F. (2002). Norepinephrine is Superior to Dopamine in Increasing Cortical Perfusion Following Controlled Cortical Impact Injury in Rats. In: Czosnyka, M., Pickard, J.D., Kirkpatrick, P.J., Smielewski, P., Hutchinson, P. (eds) Intracranial Pressure and Brain Biochemical Monitoring. Acta Neurochirurgica Supplements, vol 81. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6738-0_58
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DOI: https://doi.org/10.1007/978-3-7091-6738-0_58
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