Advances in Down Syndrome Research pp 207-214

Part of the Journal of Neural Transmission Supplement 67 book series (NEURAL SUPPL, volume 67)

Down syndrome and associated congenital malformations

  • B. L. Shapiro

Summary

Congenital malformations are many times more common in individuals with Down syndrome (DS) than in the general population. The scope of these defects is as broad in DS as it is in the general population. A positive correlation exists between the prevalence of these defects in both groups, but the incidence of each is many times greater in DS. Two examples, Brushfield spots and anorectal abnormalities are noted in which racial/ethnic prevalence differences exist. The incidence of each condition in the subpopulation with DS is proportional to but many times greater than the incidence of that condition in the general population from which the subpopulation with DS was derived. Findings presented in this review support the notion that the autosomal trisomic state amplifies expression of exposure to teratogens.

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • B. L. Shapiro
    • 1
    • 2
  1. 1.Department of Oral Sciences and Institute of Human GeneticsUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of Oral Sciences and Institute of Human Genetics17-220 Moos TowerMinneapolisUSA

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