Predictors of outcome in schizophrenia: the concept of time

  • J. A. Lieberman
Conference paper


The ability to predict the treatment response of patients with schizophrenia has been the goal of an extensive number of studies (reviewed in Lieberman and Kane 1986, Lieberman and Sobel 1993, Lieberman and Koreen 1993, Lieberman et al. 1994). Measures that have been examined as potential predictors of treatment outcome can be classified into several categories. These include historical, constitutional, environmental, phenomenologic and biologic variables. The ability of these measures to be predictive of treatment outcome is dependent on in what phase of the illness they are being assessed and when in the course of illness outcome is being assessed. In addition, there are a number of factors that can influence the expression and ability to identify measures that might be predictive of treatment outcome (Table 1).


Good Treatment Outcome Neurologic Soft Sign Island Jewish Medical Primary Negative Sign Antipsychotic Drug Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Crow TJ, MacMillan JF, Johnson AL, Johnstone EC (1986) A randomised controlled trial of prophylactic neuroleptic treatment. Br J Psychiatry 148: 120–127.PubMedCrossRefGoogle Scholar
  2. Lieberman JA, Brown AS, Gorman (1994) Biological markers in schizophrenia. American Psychiatric Press Review of Psychiatry 13: 133–170.Google Scholar
  3. Lieberman JA, Kane JM (eds) (1986) Predictors of relapse in schizophrenia. American Psychiatric Press, Washington DC.Google Scholar
  4. Lieberman JA, Kane JM, Sarantakos S, Gadaleta D, Woerner M, Alvir J, Ramos-Lorenzi J (1987) Prediction of relapse in schizophrenia. Arch Gen Psychiatry 44: 597–603.PubMedCrossRefGoogle Scholar
  5. Lieberman JA, Koreen A (1993) Neurochemistry and neuroendocrinology of schizophrenia. A selective review. Schizophr Bull 19(2): 371–429.PubMedGoogle Scholar
  6. Lieberman JA, Soebel SN (1993) Predictors of treatment response and course of schizophrenia. Curr Opin Psychiatry 6: 63–69.CrossRefGoogle Scholar
  7. Loebel AD, Lieberman JA, Alvir JMJ, Mayerhoff DI, Geisler SH, Szymanski SR (1992) Duration of psychosis and outcome in first episode schizophrenia. Am J Psychiatry 149: 1183–1188.PubMedGoogle Scholar
  8. May PR, Tuma AH, Dixon WJ (1981) Schizophrenia: a follow-up study of the results of five forms of treatment. Arch Gen Psychiatry 38: 776–784.PubMedCrossRefGoogle Scholar
  9. Wyatt RJ (1991) Neuroleptics and the natural course of schizophrenia. Schizophr Bull 17:325–351.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Wien 1994

Authors and Affiliations

  • J. A. Lieberman
    • 1
  1. 1.Department of PsychiatryHillside Hospital, Long Island Jewish Medical CenterGlen OaksUSA

Personalised recommendations