Summary
This is an update on aspects of structure, function and pathology of the primary sensory unit in man, emphasizing concepts which form the basis for understanding a) rationales of new physiological clinical tests and b) the nature of neuropathic sensory syndromes of recent recognition.
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References
Asbury AK, Porte D, Genuth SM, Griffin J, Halter JB, Kimura J, Kuller LH, McLeod JG, Ochoa JL, Ward JD (1988) Report and recommendations of the San Antonio conference on diabetic neuropathy. Diabetes Care 11: 592–597
Assal JP, Lindblom U (1989) Letter to the Editor on “Consensus Conference on Diabetic Peripheral Neuropathy”. Muscle and Nerve 12/3: 246
Bini G, Gruccu G, Hagbarth K-E, Schady W, Torebjörk E (1984) Analgesic effect of vibration and cooling on pain induced by intraneural electrical stimulation. Pain 18: 239–248
Blumberg H, Jänig W (1984) Discharge pattern of afferent fibers from a neuroma. Pain 20: 335–353
Brown MJ, Martin JR, Asbury AK (1976) Painful diabetic neuropathy. Arch Neurol 33: 164–171
Campbell JN, Raja SN, Meyer RA, MacKinnon (1988) Myelinated afferents signal the hyperalgesia associated with nerve injury. Pain 32: 89–94
Cline M, Ochoa J (1986) Chronically sensitized C-nociceptors in skin. Patient with hyperalgesia, hyperpathia, and spontaneous pain. Soc Neurosci Abstracts 12/1: 331
Cline M, Ochoa J, Torebjörk H-E (1989) Chronic hyperalgesia and skin warming caused by sensitized C nociceptors. Brain 112: 621–647
Collins WF, Nulsen FE, Randt CT (1960) Relation of peripheral nerve fiber size and sensation in man. Arch Neurol 3: 381–385
Culp WJ, Ochoa J, Cline M, Dotson R (1989) Heat and mechanical hyperalgesia induced by Capsaicin. Cross modality threshold modulation in human C-nociceptors. Brain 112: 1317–1331
DeCastro F (1930) Recherches sur la degeneration et la regeneration du systeme nerveux sympathique. Quelques observations sur la constitution des synapses dans les ganglions. Trabajos de Laboratorio de investigaciones biologicas de la Universidad de Madrid 26: 357–456
Devor M (1983) Nerve pathophysiology and mechanisms of pain in causalgia. J Auton Nerv Syst 7: 371–384
Dyck PJ, Lambert EH (1969) Dissociated sensation in amyloidosis. Arch Neurol 20: 490–507
Dyck PJ, Lambert EH, Nichols PC (1972) Quantitative measurement of sensation related to compound action potential and number and sizes of myelinated and unmyelinated fibers of sural nerve in health, Friedreich’s ataxia, hereditary sensory neuropathy, and tabes dorsalis. In: Cobb WA (ed) Handbook of electroencephalography and clinical neurophysiology, vol 9. Elsevier: Amsterdam
Fruhstorfer H, Lindblom U, Schmidt WG (1976) Method for quantitative estimation of thermal thresholds in patients. J Neurol Neurosurg Psychiatry 39: 1071–1075
Head H (1920) Sensation and the cerebral cortex. Studies in Neurology 9: 741
Lewis T (1936) Vascular disorders of the limbs, described for practitioners and students. MacMillan: New York
Lindblom U, Ochoa J (1986) Somatosensory function and dysfunction. In: Asbury AK, McKhann GM, McDonald WI (eds) Disease of the nervous system, vol I. Ardmore Medical Books: Philadelphia, an imprint of W. B. Sanders, William Heinemann Medical Books: London, pp 283–298
Melzack R, Wall PD (1965) Pain mechanisms: a new theory. Science 150: 971–979
Meyer RA, Campbell JN, Raja SN (1985) Peripheral neural mechanisms of cutaneous hyperalgesia. In: Fields HL, Dubner R, Cervero F (eds) Proceedings of the Fourth World Congress on Pain, Seattle. Advances in pain research and therapy, vol 9. Raven Press: New York, pp 53–71
Nielsen VK (1984) Pathophysiology of hemifacial spasm: I. Ephaptic transmission and ectopic excitations. Neurology (Minneap) 34: 418–426
Noordenbos W (1959) Pain. Problems pertaining to the transmission of nerve impulses which give pain. Elsevier: Amsterdam
Nordin M, Nystrom B, Wallin U, Hagbarth K-E (1984) Ectopic sensory discharges and paresthesiae in patients with disorders of peripheral nerves, dorsal roots and dorsal columns. Pain 20: 231–245
Ochoa J, Mair WGP (1969a) The normal sural nerve in man. I. Ultrastructure and numbers of fibres and cells. Acta Neuropathologica 13: 197–216
Ochoa J, Mair WGP (1969b) The normal sural nerve in man. II. Changes in the axons and Schwann cells due to ageing. Acta Neuropathologica 13: 217–239
Ochoa J (1970a) Isoniazid neuropathy in man — quantitative electron microscope study. Brain 93: 831–850
Ochoa J (1970b) The structure of developing and adult sural nerve in man and the changes which occur in some diseases. A light and electron microscopic study. PhD Thesis, University of London
Ochoa J (1978) Recognition of unmyelinated fiber disease: morphologic criteria. Muscle Nerve 1: 375–387
Ochoa JL, Noordenbos W (1979) Pathology and disordered sensation in local nerve lesions: an attempt at correlation. In: Bonica JJ, Liebeskind JC, Albe-Fessard DG (eds) Advance in pain research and therapy. Raven Press: New York, pp 67–90
Ochoa J, Torebjörk HE (1980) Paraesthesiae from ectopic impulse generation in human sensory nerves. Brain 103: 835–853
Ochoa J (1982) Pain in local nerve lesions. In: Culp WJ, Ochoa J (eds) Abnormal nerves and muscles as impulse generators. Oxford University Press: New York Oxford, pp 568–587
Ochoa J (1986a) Unmyelinated fibers, microneurography, thermography and pain. American Assoc of Electromyography and Electrodiagnosis, Ninth Annual Continuing Education Course, Boston
Ochoa J (1986b) The newly recognized painful ABC syndrome: thermographic aspects. Thermology 2: 65–107
Ochoa J, Cline M, Dotson R, Marchettini P (1987) Pain and paresthesias provoked mechanically in human cervical root entrapment (sign of spurling). Single sensory unit antidromic recording of ectopic, bursting, propagated nerve impulse activity. In: Pubols LM, Sessle BJ (eds) Effects of injury on trigeminal and spinal somatosensory systems. Alan R. Liss: New York, pp 389–397
Ochoa J, Torebjörk E (1989) Sensations evoked by intraneural microstimulation of identified C nociceptor fibres in human skin nerves. J Physiol 415: 583–599
Ochoa JL (1989) “Hot” and “cold” neuropathic pain patients. Abstracts of 9th International Meeting of Peripheral Nerve Study Group, Padova, Italy
Ochoa J, Roberts WJ, Cline MA, Dotson R, Yarnitsky D (1989) Two mechanical hyperalgesias in human neuropathy. Soc Neurosci Abstracts 15/1: 472
Ochoa J, Yarnitsky D (1994) The triple cold (‘CCC’) syndrome: cold hyperalgesia, cold hypoesthesia and cold skin in peripheral nerve disease. Brain 117: 185–197
Perl ER (1976) Sensitization of nociceptors and its relation to sensation. In: Bonica JJ, Albe-Fessard D (eds) Advances in pain research and therapy, vol 1. Raven Press: New York, pp 17–28
Ranson SW (1915) Unmyelinated nerve-fibers as conductors of protopathic sensations. Brain 38: 381–389
Rowbotham MC, Fields HL (1989) Post-herpetic neuralgia: the relation of pain, complaint, sensory disturbance, and skin temperature. Pain 39: 129–144
Sanders DB (1989) Ephaptic transmission in hemifacial spasm: a single-fiber EMG study. Muscle and Nerve 12: 690–694
Scadding JW (1982) Ectopic impulse generation in experimental neuromas: behavioral, physiological and anatomical correlates. In: Culp WJ, Ochoa J (eds) Abnormal nerves and muscles as impulse generators. Oxford University Press: Oxford, pp 533–552
Seltzer Z, Devor M (1979) Ephaptic transmission in chronically damaged peripheral nerves. Neurology 29: 1061
Thomas PK (1982) Pain in peripheral neuropathy: clinical and morphological aspects. In: Culp WJ, Ochoa J (eds) Abnormal nerves and muscles as impulse generators. Oxford University Press: Oxford
Torebjörk HE, Hallin RG (1970) C-fibre units recorded from human sensory nerve fascicles in situ. Acta Societatis Medicorum Uppsaliensis 75: 81–84
Torebjörk HE, Hallin RG (1973) Perceptual changes accompanying controlled preferential blocking of A and C fibre responses in intact human skin nerves. Exp Brain Res 16: 321
Torebjörk HE (1974) Afferent C units responding to mechanical, thermal and chemical stimuli in human non-glabrous skin. Acta Physiologica Scandinavica 92: 374–390
Torebjörk HE, Ochoa JL (1995) Receptor characteristics and sensory attributes of nociceptors with myelinated (A) fibres innervating the glabrous skin of the human hand. Brain Research (submitted)
Wahren LK, Torebjörk E, Jørum E (1989) Central suppression of cold-induced C fibre pain by myelinated fibre input. Pain 38: 313–319
Wall PD, Gutnick M (1974) Properties of afferent nerve impulses originating from a neuroma. Nature 248: 740–743
Wall PD (1984) The hyperpathic syndrome: a challenge to specificity theory. In: Euler C v, Franzen O, Lindblom U, Ottoson D (eds) Somatosensory mechanisms, vol 41. Wenner-Gren International Symposium. MacMillan Press: London, pp 327–337
Wallin G, Torebjörk E, Hallin R (1976) Preliminary observations on the pathophysiology of hyperalgesia in the causalgic pain syndrome. In: Zotterman Y (ed) Sensory functions of the skin in primates, with special reference to man. Wenner-Gren Center. Pergamon Press: Stockholm
Yarnitsky D, Ochoa JL (1990) Release of cold-induced burning pain by block of cold specific afferent input. Brain 113: 893
Zotterman Y (1933) Studies in the peripheral nervous mechanism of pain. Acta Medica Scandinavica 80: 185–242
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Ochoa, J. (1995). The human sensory unit — new concepts and syndromes. In: Asbury, A.K., Budka, H., Sluga, E. (eds) Sensory Neuropathies. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6595-9_1
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DOI: https://doi.org/10.1007/978-3-7091-6595-9_1
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82642-3
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