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Benzodiazepin-Hypnotika

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Neuro-Psychopharmaka Ein Therapie-Handbuch

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Zusammenfassung

Wie bereits im Abschnitt 2.1.1 ausgeführt, sind die sedativ-hypnotischen und anxiolytischen Wirkungen der Benzodiazepine schwer voneinander zu trennen. Trotzdem werden einige Derivate bevorzugt als Schlafmittel eingesetzt, die im folgenden besprochen werden sollen. Was allgemeine pharmakokinetische Bemerkungen anbetrifft, sei auf Kapitel 2.1.1 verwiesen (Ochs 1983, Greenblatt et al. 1983). Neben der bioverfügbaren Dosis (F x D) und der individuellen systemischen Clearance (CL) spielt für Wirkintensität und -dauer auch das Verhältnis von Dosierungsintervall (τ) zu Eliminationshalbwertzeit (t1/2) eine wichtige Rolle (s. Scite 16). Da bei Hypnotika t = 24 Stunden ist, wird ein Benzodiazepin mit t1/2 = 12 h oder 48 Stunden beispielsweise um den Faktor 1,33 bzw. 3,44 bei mehrmaliger Gabe kumulieren (siehe Abb. 3.1.1.1).

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Authors and Affiliations

  1. Psychiatrische Universitätsklinik, Würzburg, Bundesrepublik Deutschland

    Prof. Dr. Peter Riederer

  2. Psychiatrische Universitätsklinik, Bonn, Bundesrepublik Deutschland

    Prof. Dr. Gerd Laux

  3. Wien, Österreich

    Prof. Dr. Walter Pöldinger

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  1. Prof. Dr. Peter Riederer
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  2. Prof. Dr. Gerd Laux
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  3. Prof. Dr. Walter Pöldinger
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Editors and Affiliations

  1. Psychiatrische Universitätsklinik, Würzburg, Bundesrepublik Deutschland

    Peter Riederer

  2. Psychiatrische Universitätsklinik, Bonn, Bundesrepublik Deutschland

    Gerd Laux

  3. Wien, Österreich

    Walter Pöldinger

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© 1995 Springer-Verlag Wien

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Riederer, P., Laux, G., Pöldinger, W. (1995). Benzodiazepin-Hypnotika. In: Riederer, P., Laux, G., Pöldinger, W. (eds) Neuro-Psychopharmaka Ein Therapie-Handbuch. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6593-5_3

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  • DOI: https://doi.org/10.1007/978-3-7091-6593-5_3

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7357-2

  • Online ISBN: 978-3-7091-6593-5

  • eBook Packages: Springer Book Archive

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