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Abstract

Saponins are complex molecules made up of sugars linked to a triterpenoid or a steroid or a steroidal alkaloid. These natural products are attracting much attention in recent years because of the host of biological activities they exhibit. The diversity of structural features, the challenges of isolation because of their occurrence as complex mixtures, the pharmacological and biological activities still to be discovered, and the prospect of commercialization — these all are driving the study of saponins. Triterpenoid saponins are dominating constituents of this class and occur widely throughout the plant kingdom including some human foods e.g. beans, spinach, tomatoes, and potatoes, and animal feed e.g. alfalfa and clover. Saponins were initially a rather neglected area of research primarily because of great difficulties in their isolation and characterization. With the advent of more sophisticated methods of isolation and structure elucidation through the last two decades, there has been increased interest in these natural products. Besides structure determination, research activities are now moving forward to clarify structure-activity relationships. Our previous reviews on triterpenoid saponins (1, (2) covered literature from 1979 to mid-1989. The literature on triterpenoid saponins up to 1988 has also been covered by two reviews by HILLER et al. (3, 4). This review incorporates newer trends in isolation and structure determination of triterpenoid saponins, new triterpenoid saponins isolated and biological properties of these products reported during the period late 1989–mid 1996.

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References

  1. Mahato, S.B., S.K. Sarkar, and G. Poddar: Triterpenoid Saponins. Phytochemistry, 27, 3037 (1988).

    CAS  Google Scholar 

  2. Mahato, S.B., and A.K. Nandy: Triterpenoid Saponins Discovered between 1987 and 1989. Phytochemistry, 30, 1357 (1991).

    CAS  Google Scholar 

  3. Bader, G., and K. Hiller: Triterpenoid Saponins. Pharmazie, 42, 577 (1987).

    CAS  Google Scholar 

  4. Schöpke, T., and K. Hiller: Triterpenoid Saponins. Pharmazie, 45, 313 (1990).

    Google Scholar 

  5. Jia, Z., K. Koike, T. Ohmoto, and M. Ni: Triterpenoid Saponins from Ardisia crenata. Phytochemistry, 37, 1389 (1994).

    CAS  Google Scholar 

  6. Zhao, W., J. Xu, G. Quin, and R. Zu: New Triterpenoid Saponins from Mussaenda pubescens. J. Nat. Prod., 57, 1613 (1994).

    CAS  Google Scholar 

  7. Massiot, G., C. Lavaud, V. Besson, L.L. Men-Olivier, and G.V. Binst: Saponins from Aerial Parts of Alfalfa (Medicago sativa). J. Agric. Food Chem., 39, 78 (1991).

    CAS  Google Scholar 

  8. Rodriguez, J., R. Castro, and R. Riguera: Holothurinosides: New Antitumour Non Sulphated Triterpenoid Glycosides from the Sea Cucumber Holothuria forskalii. Tetrahedron, 47, 4753 (1991).

    CAS  Google Scholar 

  9. Mahato, S.B.: Saponins with Antifilarial Activity from Acacia auriculiformis. In: Saponins: Chemistry and Biological Activity (G.R. Waller, K. Yamasaki, eds.). New York: Plenum, 1996.

    Google Scholar 

  10. Williams, D.H., C. Bradley, G. Bojesen, S. Santikarn, and L.C.E. Taylor: Fast Atom Bombardment Mass Spectrometry: A Powerful Technique for the Study of Polar Molecules. J. Am. Chem. Soc., 103, 5700 (1981).

    CAS  Google Scholar 

  11. Fenselau, C.: Fast Atom Bombardment and Middle Molecule Mass Spectrometry. J. Nat. Prod., 47, 215 (1984).

    CAS  Google Scholar 

  12. Lattimer, R.P., and H.R. Schulten: Field Ionization and field Desorption Mass Spectrometry: Past, Present and Future. Anal. Chem., 61, 1201A (1989).

    CAS  Google Scholar 

  13. Sundvist, B., P. Roepstorff, J. Fohlman, A. Hedin, P. Hakansson, I. Kamensky, M. Lindberg, M. Salehpoour, and G. Save: Molecular Weight Determination of Proteins by Californium Plasma Desorption Mass Spectrometry. Science, 226, 696 (1984).

    Google Scholar 

  14. Karas, M., and F. Hillenkamp: Laser Desorption Ionization of Proteins with Molecular Masses Exceeding 10,000 Daltons. Anal. Chem., 60, 2299 (1988).

    CAS  Google Scholar 

  15. Covey, T.R., E.C. Huang, and J.D. Henion: Structural Characterization of Protein Tryptic Peptides via Liquid Chromatography/Mass Spectrometry and Collision-Induced Dissociation of their Doubly Charged Molecular Ions. Anal. Chem., 63, 1193 (1991).

    CAS  Google Scholar 

  16. Imoto, T., F.M. Yamamoto, A. Miyasaka, and H. Hatano: High Performance Liquid Chromatography-Atmospheric Pressure Ionization Mass Spectrometry of Gymnemic Acids. J. Chromatography, 557, 383 (1991).

    CAS  Google Scholar 

  17. Castello, C.E.: Application of Tandem Mass Spectral Approaches to Structural Determination of Saponins. Symposium on Saponins: Chemistry and Biological Activity, 210th ACS National Meeting, Chicago, Illinois, August 20–24, 1995.

    Google Scholar 

  18. Lee, M.R., J.S. Lee, J.C. Wang, and G.R. Waller: Structural Determination of Saponins from Mung Bean Sprouts by Tandem Mass Spectrometry. Symposium on Saponins: Chemistry and Biological Activity, 210th ACS National Meeting, Chicago, Illinois, August 20–24, 1995.

    Google Scholar 

  19. Lee, M.K., Y.C. Ling, M. Jurzysta, and G.R. Waller: Saponins from Alfalfa, Clover, and Mungbeans Analyzed by Electrospray Iionization Mass Spectrometry Compared with Positive and Negative FAB Mass Spectrometry. Symposium on Saponins: Chemistry and Biological Activity, 210th ACS National Metting, Chicago, Illinois, August 20–24, 1995.

    Google Scholar 

  20. West, P.R., P.W. Geno, G.R. Waller, W. Oleszek, and M. Jurzysta: Structure Confirmation of Alfalfa Saponins by LS/MS and B/E LS/MS/MS. Symposium on Saponins: Chemistry and Biological Activity, 210th ACS National Meeting, Chicago, Illinois, August 20–24, 1995.

    Google Scholar 

  21. Arao, T., J. Kinjo, T. Nohara, and R. Isobe: Oleanene-type Triterpene Glycosides from Puerariae Radix II. Isolation of Saponins and the Application of Tandem Mass Spectrometry to their Structure Determination. Chem. Pharm. Bull., 43, 1176 (1995).

    CAS  Google Scholar 

  22. Schöpke, T., C. Al-Tawaha, V. Wray, M. Nimtz, A. Meyer, and K. Hiller: Triterpenoid Saponins from the Aerial Parts of Aster bellidiastrum. Phytochemistry, 40, 1489 (1995).

    Google Scholar 

  23. Perera, P., R. Andersson, L. Bohlin, C. Andersson, D. Li, N.L. Owen, R. Dunkel, C.L. Mayne, R.J. Rugmire, D.M. Grant, and P.A. Cox: Structure Determination of a New Saponin from the Plant Alphitonia zizyphoides by NMR Spectroscopy. Magn. Res. Chem., 31, 472 (1993).

    CAS  Google Scholar 

  24. Garai, S., S.B. Mahato, K. Ohtani, and K. Yamasaki: Dammarane-Type Triterpenoid Saponins from Bacopa monniera. Phytochemistry, 42, 815 (1993).

    Google Scholar 

  25. Waltho, J.P., D.H. Williams, S.B. Mahato, B.C. Pal, and J.C.J. Barna: Structure Elucidation of Two Triterpenoid Tetrasaccharides from Androsace saxifragifolia. J. Chem. Soc. Perkin Trans. 1, 1517 (1986).

    Google Scholar 

  26. Bader, G., T. Danzandarjaa, K. Hiller, G. Renicek, J. Jurenitsch, M. Golly, H. Schröder, M. Schubert-Zsilaveez, and E. Haslinger: A New Triterpene Saponin from Heteropappus biennis with an Unusual Carbohydrate Chain. Helv. Chim. Acta, 77, 1861 (1994).

    CAS  Google Scholar 

  27. Shao, Y., B. Zhou, L. Lin, and G.A. Cordell: Triterpenoid Saponins from Aster batangensis. Phytochemistry, 38, 927 (1995).

    CAS  Google Scholar 

  28. Bader, G., Y. Kulhanek, and H. Ziegler-Boehme: Antifungal Action of Glycosides of Polygalacic Acid. Pharmazie, 45, 618 (1990).

    CAS  Google Scholar 

  29. Takechi, M., and Y. Tanaka: Structure-Activity Relationships of the Saponin α-Hederin. Phytochemistry, 29, 451 (1990).

    CAS  Google Scholar 

  30. Shimoyamada, M., M. Suzuki, H. Sonta, M. Muruama, and K. Okubo: Antifungal Activity of the Saponin Fraction from Asparagus officinalis L. and its Active Principle. Agric. Biol. Chem., 54, 2553 (1990).

    CAS  Google Scholar 

  31. Lalitha, T., and L.V. Venkataraman: Antifungal Activity and Mode of Action of Saponins from Madhuca butyraceae Macb. Indian J. Chem., 29, 558 (1991).

    CAS  Google Scholar 

  32. Zehavi, U., O. Ziv-Fecht, M. Levy, M. Naim, R. Evron, and I. Polachek: Synthesis and Antifungal Activity of Medicagenic Acid Saponins on Plant Pathogens: Modification of the Saccharide Moiety and the 23α-Substitution. Carbohydr. Res., 244, 161161 (1993).

    Google Scholar 

  33. Bower, P., B.R. Clarke, P. Lunnes, M.J. Daniels, and A.E. Osbourn: Host Range of a Plant Pathogenic Fungus Determined by Saponin Detoxifying Enzyme. Science, 267, 371 (1995).

    Google Scholar 

  34. Favel, A., M.D. Steinmetz, P. Regli, E. Vidal-Ollivier, R. Elias, and G. Balansard: In Vitro Antifungal Activity of Triterpenoid Saponins. Planta Med., 60, 50 (1994).

    CAS  Google Scholar 

  35. Dalsgaard, K.: A Study of the Isolation and Characterization of the Saponin Quil A: Evaluation of its Adjuvant Activity with Special Reference to the Application in the Vaccination of Cattle Against Foot and Mouth Disease. Acta Vei. Scand., 695, 1 (1978).

    Google Scholar 

  36. Wu, J.Y., B.H. Gardner, C.I. Murphy, J.R. Seals, C.R. Kensil, J. Recchia, G.A. Beltz, G.W. Newman, and M.J. Newman: Saponins Adjuvant Enhancement of Antigen-Specific Immune Responses to an Experimental HIV-1 Vaccine. J. Immunol., 148, 1519 (1992).

    CAS  Google Scholar 

  37. White, A.C., P. Cloutier, and R.T. Coughlin: A Purified Saponin Acts as an Adjuvant for a T-Independent Antigen. Adv. Exp. Med. Biol., 303, 207 (1991).

    CAS  Google Scholar 

  38. Newman, M.J., J.Y. Wu, B.H. Gardner, and K.J. Munroe: Saponin Adjuvant Induction of Ovalbumin-Specific CD8+ Cytotoxic T Lymphocyte Responses. J. Immunol., 148, 2357 (1992).

    CAS  Google Scholar 

  39. Kirkley, J.E., P.H. Naylor, D.J. Marciani, C.R. Kensil, M. Newman, and A.L. Goldstein: QS-21 Augments the Antibody Response to a Synthetic Peptide Vaccine Compared to Alum. Comb. Ther. [Proc. Int. Symp.] 1st 1991 (A.L. Goldstein, Garaci, eds.). New York: Plenum. 1992.

    Google Scholar 

  40. Bomford, R., M. Stapleton, S. Winsor, J.E. Beesley, E.A. Jssup, K.R. Price, and G.R. Fenwick: Adjuvanticity and ISCOM Formation by Structurally Diverse Saponins. Vaccine, 10, 572 (1992).

    CAS  Google Scholar 

  41. Newman, M.J., J.Y. Wu, R.T. Coughlin, C.I. Murphy, J.R. Seals, M.S. Wyand, and C.R. Kensil: Immunogenicity and Toxicity Testing of an Experimental HIV-1 Vaccine in Nonhuman Primates. AIDS Res. Hum. Retroviruses, 8, 1413 (1992).

    CAS  Google Scholar 

  42. Newman, M.J., K.J. Munroe, C.A. Anderson, C.I. Murphy, D.L. Panicali, J.R. Seals, J.Y. Wu, M.S. Wyano, and C.R. Kensil: Induction of Antigen-Specific Killer T Lymphocyte Responses Using Subunit SIV mac 251 gag and enV Vaccines Containing QS-21 Saponin Adjuvant — Immunochemistry. AIDS Res. Hum. Retroviruses, 10, 853 (1994).

    CAS  Google Scholar 

  43. Yang, C., and G. Yang: Immunologic Effect of Panaxquinquefolium Saponin in vitro and in vivo. Zhongguo Mianyixue Zazhi, 8, 188 (1992).

    CAS  Google Scholar 

  44. He, G., J. Zhang, X. Xue, and J. Want: Immune Function Stimulatory and Regulatory Action of Ginseng Saponins on Chronic Pulmonary Heart Diseases. Baiqiuen Yike Daxue Xuebao, 19, 50 (1993).

    Google Scholar 

  45. Ronnberg, B., M. Fekadli, and B. Morein: Adjuvant Activity of Nontoxic Quillaja Saponaria molina Components for Use in ISCOM Matrix. Vaccine, 13, 1375 (1995).

    CAS  Google Scholar 

  46. Takeda, O., S. Tanaka, K. Yamasaki, H. Khoda, Y. Ywanaga, and M. Tsuji: Screening for Molluscicidal Activity in Crude Drugs. Chem. Pharm. Bull., 37, 1090 (1989).

    CAS  Google Scholar 

  47. Thiilborg, S.T., S.B. Christenseen, C. Cornett, C.E. Olsen, and E. Lemmich: Molluscicidal Saponins from Phytolacca dodecandra. Phytochemistry, 32, 1167 (1993).

    CAS  Google Scholar 

  48. Ndama, J., E. Lemmich, and P. Moelgaard: Release of Molluscicidal Saponins from Phytolacca dodecandra Aqueous Berry Extracts as Influenced by the Male Plant and the Extraction Procedure. Biochem. Syst. Ecol., 22, 249 (1994).

    Google Scholar 

  49. Hamburger, M., I. Slacanin, K. Hostettmann, W. Dyatmiko, and S. Jadi: Acetylated Saponins with Molluscicidal Activity from Sapindus rarak: Unambiguous Structure Determination by PMR and Quantitative Analysis. Phytochem. Anal., 3, 231 (1992).

    CAS  Google Scholar 

  50. Lemmich, E., C. Cornett, P. Furu, C.L. Jorstian, A.D. Knudsen, and C.E. Olsen: Molluscicidal Saponins from Catunaregam nilotica. Phytochemistry, 39, 63 (1995).

    CAS  Google Scholar 

  51. Pakrashi, A., H. Ray, B.C. Pal, and S.B. Mahato: Sperm Immobilizing Effect of Triterpene Saponins from Acacia auriculiformis. Contraception, 43, 475 (1991).

    CAS  Google Scholar 

  52. Garg, S., G. Dancel, S. Chabra, S.N. Upadhyay, and G.P. Talwar: Synergistic Spermicidal Activity of Neem Seed Extract Reetha Saponins and Quinine Hydrochloride. Contraception, 50, 185 (1994).

    CAS  Google Scholar 

  53. Rajasekaran, M., A.G.R. Nair, W.J.G. Hellstron, and S.C. Sikka: Spermicidal Activity of an Antifungal Saponin Obtained from the Tropical Herb Mollugo pentaphylla. Contraception, 47, 401 (1993).

    CAS  Google Scholar 

  54. Mahato, S.B.: Bioactive Gymnemic Acids and Congeners from Gymnema sylvestre. In: Studies in Natural Products Chemistry (A. Rahman, ed.), Vol. 18, pp. 649–676. Amsterdam: Elsevier 1996.

    Google Scholar 

  55. Kang, J.S., H. Koh, and T.K. Suh: Effect of Gymnemic Acid on the Elevation of Blood Glucose Concentration Induced with Oral Sucrose in Strepto-zotocin-Diabetic Rats. Hanyang Vidae Haksulchi, 10, 587 (1990).

    CAS  Google Scholar 

  56. Harms, S.D., Z. Lu, S. Li, and Y. Cai: Hypoglycemic Effect of Saponin Isolated from Leaves of Acanthopanax senticosus (Rupr. et Maxim.). Zhongguo Zhongyao Zazhi, 19, 683 (1994).

    Google Scholar 

  57. Jod, C.N., and J.Y. Kim: Hypoglycemic Action of Ginseng Saponins on Streptozotocin-Induced Diabetes in Rats (II). Koryo Insam Hakhoechi, 16, 198 (1992).

    Google Scholar 

  58. Wang, D., H. Yu, S. Hu, P. Qiu, and H.W. Leng: Hypoglycemic Effect of Total Saponins of Aralia decaisneana in Rat and Mice Models. Zhongguo Yaoxue Zazhi, 30, 407 (1995).

    CAS  Google Scholar 

  59. Tokuda, H., T. Konoshima, M. Kuzuka, and T. Kimura: Inhibition of 12-O-Tetra-decanoylphorbol-13-acetate-promoted Mouse Skin Papilloma by Saponins. Oncology, 48, 77 (1991).

    CAS  Google Scholar 

  60. Kim, W., and N.P. Jung: Effects of a Ginseng Saponin Fraction on the Tumoricidal Activity of Murine Macrophage against K562 Cells. Koryo Insam Hakhoechi, 13, 24 (1989).

    CAS  Google Scholar 

  61. Hesegawa, H., S. Matsumiya, M. Uchiyama, T. Kurokawa, Y. Inouye, R. Kasai, S. Ishibashi, and K. Yamasaki: Inhibitory Effect of Some Triterpenoid Saponins on Glucose Transport in Tumor Cells and its Application to in vitro Cytotoxic and Antiviral Activities. Planta Med., 60, 240 (1994).

    Google Scholar 

  62. Rao, A.V., and M.K. Sung: Saponins as Anticarcinogens. J. Nutr., 125, 7175 (1995).

    Google Scholar 

  63. Sung, M.K., C.W.C. Kendall, M.M. Koo, and A.V. Rao: Effect of Soybean Saponins and Gypsophila Saponins on Growth and Viability of Colon Carcinoma Cells in Culture. Nutr. Cancer, 23, 259 (1995).

    CAS  Google Scholar 

  64. Amarowicz, R., M. Shimoyamad, and K. Okubo: Hypocholesterolemic Effects of Saponins. Rocz. Panstw. Zakl. Hig., 45, 125 (1994).

    CAS  Google Scholar 

  65. Xu, Q., Y. Zhao, and G. Cheng: Blood Lipid-decreasing Action of Total Saponins of Panax notoginseng (Bark). F.H. Chen. Zhongguo Zhongyao Zazhi, 18, 367 (1993).

    CAS  Google Scholar 

  66. Li, J., Z. Lu, and Y Lu: Effects of Panax quinquefolium Saponin on Serum Lipoprotein-Cholesterol and Its Anti-peroxidation in Hyperlipidemic Rats. Zhongguo Yaoxue Zazhi, 28, 355 (1993).

    CAS  Google Scholar 

  67. Yamamoto, M., and S. Kameda (MARUZEN SEIYAKU KK): Feed Additives Containing Quillaja Saponins and/or Yucca Saponins for Poultry Egg Production with the Saponins and Low-Cholesterol Eggs Produced by the Poultry. Japanese patent JP 0507, 462 (1993).

    Google Scholar 

  68. Wu, C., Q. Yu, W. Liu, Y. Guo, and G. Zhang: A Study on the Antiaging Effect of Ginseng Stem and Leaf Saponin in Terms of the Free Radical Theory of Aging. Shenyang Yaoxueyuan Xuebao, 9, 37 (1992).

    CAS  Google Scholar 

  69. Pan, H., L. Huang, Z. Zhou, G. Liang, X. Hong, and Z. Huan: Experimental Studies on Anti-Aging Effect of Total Saponin from Stalk and Leaf of Sanchi (Panax notoginseng). Zhongcaoyao, 24, 581 (1993).

    CAS  Google Scholar 

  70. Ma, C., Z. Lu, and Y. Jiang: Antioxidative Effect of Panax quinquefolium Saponin on the Myocardium Injury Induced by Dexorubicin in Rats. Zhongguo Yaolixue Yu Dulixue Zazhi, 7, 267 (1993).

    CAS  Google Scholar 

  71. Yang, S., J. Qu, G. Zhong, and W. Zhang: Protective Effects of PQS on Oxidative Damage of Cultured Rat Cardiac Cells. Zhongguo Zhongyao Zazhi, 17, 555 (1992).

    CAS  Google Scholar 

  72. Wang, S., Y. Jiang, G. Zhang, and X. Sun: Anti-Free-Radical Damaging Action of PDS, PTS on the Myocardial Contractibility of the Isolated Rat Working Heart. Zhongguo Zhongyao Zazhi, 18, 113 (1993).

    CAS  Google Scholar 

  73. Wang, S., R. Sun, S. Li, Y. Wang, X. Xiao, L. Hao, and X. Ma: Anti-Aging Effects of Rhodosin and Ginseng Stem-Leaf Saponins. Baiqien Yike Daxue Xuebao, 20, 329 (1994).

    CAS  Google Scholar 

  74. Li, H., and L. Shi: Effects of Total Saponinsfrom Panax notogenseng on Calcium Influx into Myocardial Cells. Zhongguo Yaote Xuebao, 11, 213 (1990).

    CAS  Google Scholar 

  75. Zhang, K., Y. Zou, and C. Zhou: Preventive Effects of Crude Saponins of Glabrous Greenbrier (Smilax glabra) on the cholesterol-Fed Atherosclerosis of Quails. Zhon-caoyao, 22, 411 (1991).

    CAS  Google Scholar 

  76. Huang, C., T. Gu, Y. Guean, and J. Wang: Effects of Panax notoginseng Saponins on Myocardial Ischemia and Reprefusion Injury in Conscious Rabbit. Zhongguo Yaolixue Tongbao, 7, 190 (1991).

    CAS  Google Scholar 

  77. Li, L., Z. Wang, Z. Huang, Y. Zhang, and J. Wei: Effects of Panax notoginseng Saponins on Acute Cerebral Ischemia. Zhonguo Yoolixue Tonbao, 1, 56 (1991).

    Google Scholar 

  78. Gao, B.Y., X.J. Li, L. Liu, and B.H. Zhang: Effect of Panaxatriol Saponins (PTS) Isolated from Panax notoginseng on Myocardial Ischemic Arrhythmia in Mice and Rats. Yaoxue Xuebao, 27, 641 (1992).

    CAS  Google Scholar 

  79. Wu, J., and J. Sun: Comparative Effects of Panax notoginseng Saponins, Verapamil, and Norepinephrine on Cerebral Circulation in Anesthetized Rats and Rabbits. Zhongguo Yaoli Xuebao, 13, 520 (1992).

    CAS  Google Scholar 

  80. Zhong, S. J., H. Li, W.J. Zheg, C.W. Sun, X.K. Ma, and L. Wang: Block Effect of PQS on Calcium Channel on Culture Rat Myocardiocyte. Zhongguo Yaoxue Zazhi, 29, 525 (1994).

    Google Scholar 

  81. Hang, H., X. Lin, Q. Wang, J. Wei, and Y. Chen: Protective Effects of Panax notoginseng saponins (PNS), Panax Japonicus Saponins (PJS) and Gypenosides (GP) on Myocardial Ischemia and Reperfusion Injury. Zhongguo Bingli Shengli Zazhi, 10, 128 (1994).

    Google Scholar 

  82. Lu, C., H. Jin, W. Lu, and Y. Chen: Effects of Astragalus saponins on Dog Cardiac Functions in vivo. Baiquen Yike Daxue Xuebao, 20, 326 (1994).

    Google Scholar 

  83. Jiang, Y., G. Zhong, C. Shao, and G. Yue: Calcium Channel Blocking Effect of Panaxadiol Saponins and Panaxatriol Saponins on Cultured Cardiac Cells. Zhongguo Zhongyao Zazhi, 17, 172 (1992).

    CAS  Google Scholar 

  84. Sui, D., Z. Lu, L. Ma, and Z. Fan: Effects of Saponins of Acanthopanax senticosus (Rupr. et. Maxim) Harms. On Myocardial Infarct Size in Acute Ischemic Dogs. Zhongguo Zhongyao Zazhi, 19, 746 (1994).

    CAS  Google Scholar 

  85. Li, J., X. Wang, and H. Zhang: Protective Effect of Saponin of Chinese and American inseng Stem and Leaf on Cells Infected by HSV-1. Zhongcaoyao, 23, 249 (1992).

    CAS  Google Scholar 

  86. Maria, L., and C. Pizza: Structure and in vitro Antiviral Activity of Triterpenoid Saponins from Calendula arvensis. Planta Med., 57, 250 (1991).

    Google Scholar 

  87. Lin, X., Y. Cai, and P. Xiao: Inhibition of SIV in vitro by Cimicifuga dahurica Saponin and Its Action Mechanism. Huaxi Yaoxue Zazhi, 9, 221 (1994).

    CAS  Google Scholar 

  88. Yoshikawa, K., N. Shimono, and S. Arihara: Antisweet Substances, Jujuba saponins I–III from Zizyphus jujuba. Revised Structure of Ziziphin. Tetrahedron Lett., 32, 7059 (1991).

    CAS  Google Scholar 

  89. Yoshikawa, K., S. Arihara, and K. Matsuura: A New Type of Antisweet Principles occurring in Gymnema sylvestre. Tetrahedron Lett., 32, 789 (1991).

    CAS  Google Scholar 

  90. Yoshikawa, K., S. Tumura, K. Yamada, and S. Arihara: Antisweet Natural Products. VII Hodulosides I, II, III, IV and V from the Leaves of Hovenia dulcis Thunb. Chem. Pharm. Bull., 40, 2287 (1992).

    CAS  Google Scholar 

  91. Imoto, T.: Sugar Discriminations and Plant Originated Glycosides and Gymnemic Acids. Seibatsi Butsuri, 30, 146 (1990).

    CAS  Google Scholar 

  92. Kim, H.S., S.H. Kim, M.K. Lee, K.J. Choi, and S.C. Kim: Effects of Ginseng Leaf Saponins on the Development of Morphine Tolerance and Dependence in Mice. Koryo Insam Hakoechi, 13, 8 (1989).

    CAS  Google Scholar 

  93. Kim, H.S., J.G. Kang, H.M. Rheu, D.H. Cho, and K.W. Oh: Blockade by Ginseng Total Saponin of the Development of Methamphetamine Reverse Tolerance and Dopamine Receptor Supersensitivity in Mice. Planta Med., 61, 22 (1995).

    CAS  Google Scholar 

  94. Kim, H.S., J.G. Kang, Y.H. Seong, K.Y. Nam, and K.W. Oh: Blockade by Ginseng Total Saponin of the Development of Cocaine Induced Reverse Tolerance and Dopamine Receptor Supersensitivity in Mice. Pharmacol. Biochem. Behav., 50, 23 (1995).

    CAS  Google Scholar 

  95. Kim, H.S., K.W. Oh, and Y.H. Seong: The Role of Ginseng Total Saponins in the Inhibition of the Development of Analgesic Tolerance to Morphine. Koryo Insam Hokhoechi, 15, 179 (1991).

    CAS  Google Scholar 

  96. Majester-Savornin, B., R. Elias, A.M. Diaz-Lanza, G. Balansard, M. Gasquet, and F. Delmas: Saponins of Ivy Plant, Hedera helix, and their Leishmanicidic Activity. Planta Med., 57, 260 (1991).

    CAS  Google Scholar 

  97. Ghosh, M., S.P. Sinha Babu, N.C. Sukul, and S.B. Mahato: Antifilarial Effect of Two Triterpenoid Saponins Isolated from Acacia auriculiformis. Indian J. Exp. Biol., 31, 604 (1993).

    CAS  Google Scholar 

  98. Waller, G.R., M. Jurzysta, and R.L.Z. Thorne: Allelopathic Activity of Root Saponin from Alfalfa (Medicago sativa L.) on Weeds and Wheat. Bot. Bull. Acad. Sin., 34, 1 (1993).

    CAS  Google Scholar 

  99. Oleszek, W.: Allelopathic Potentials of Alfalfa (Medicago sativa) Saponins: Their Relation to Antifungal and Hemolytic Activities. J. Chem. Ecol., 19, 1063 (1993).

    CAS  Google Scholar 

  100. Hiji, Y.: Gymnemic Acid for Prevention of Dental Caries. US Patent, US4, 912, 089, 27 Mar 1990.

    Google Scholar 

  101. Kato, T., N. Nagata, and S. Watabe (Rohto Pharmaceutical Co. Ltd.): Ethanol-Absorption Inhibitors Containing Saponins. Japanese patent JP 04,145,028, 19 May 1992.

    Google Scholar 

  102. Kennelly, E.J., L. Cai, N.C. Kim, and A.D. Kinghorn: Abrusoside E, a Further Sweet-Tasting Cycloartane glycoside from the Leaves of Abrus precatorius. Phytochemistry, 41, 1381 (1993).

    Google Scholar 

  103. Pauthe-Dayde, D., M. Rochd, and M. Henry: Triterpenoid Saponins Production in Callus and Multiple Shoot Cultures of Gypsophila spp. Phytochemistry, 29, 483 (1990).

    CAS  Google Scholar 

  104. Besson, V., C. Lavaud, G. Massiot, L.E. Men-Olivier, S. Bianchi, P. Flament, and Y. Dattee: Medicagenic Acid and Saponins in Callus and Suspension Cultures of Alfalfa. Phytochemistry, 28, 1379 (1989).

    CAS  Google Scholar 

  105. Yu, X.: Preliminary Study on Saponin Content in Callus of Five Leaf Gynostemma (Gynostemma pentaphyllum). Zhongcaoyao, 22, 468 (1991).

    CAS  Google Scholar 

  106. Katakura, M., and T. Kimura: Production of Saikosaponins by Tissue Culture of Bupleurum falcatum L. Endo. I. Eng., 7, 97 (1991).

    CAS  Google Scholar 

  107. Kubo, Y., and M. Murakami: Tissue Culture of Panax japonicus. III. Saponin Production in Adventitious Root Cultures. Toyama-ken Yakuji Kenkyusho Nenpo 18, 60 (1990).

    CAS  Google Scholar 

  108. Zhou, L.G., G.Z. Zheng, F.Y. Gan, S.L. Wang, C.R. Yang, and C. Xu: Separation and Identification of Main Medicinal Saponin Components from Cell Cultures of Panax notoginseng. F.H. Chem. Yaoxue Xuebao, 26, 876 (1991).

    CAS  Google Scholar 

  109. Ionkova, I.: Producing Triterpene Saponins by Conventional and Genetically-Transformed Cultures of Astragalus hamosus L. Probl. Farmakol. Farm., 5, 32 (1991).

    CAS  Google Scholar 

  110. Choi, K.T., and J.C. Park: Production of Ginseng Saponin in Tissue Culture of Ginseng (Panax ginseng C.A. Meyer). Fiziol. Rast., 41, 891 (1994).

    CAS  Google Scholar 

  111. Zhou, Y., M. Hirotani, H. Rui, and T. Furuya: TWO Triglycosidic Triterpene Astragalosides from Hairy Root Cultures of Astragalus membranaceus. Phytochemistry, 38, 1407 (1995).

    CAS  Google Scholar 

  112. Mahato, S.B.: Glycosides, Saponins and Sapogenins. In: Second Supplement to the 2nd Edition of Rodd’s Chemistry of Carbon Compounds, Vol. II B (Partial) and E (M. Sainsbury, ed.) pp. 509–554. Amsterdam: Elsevier, 1994.

    Google Scholar 

  113. Sakai, Y., T. Takeshita, J. Kinjo, Y. Ito, and T. Nohara: Leguminous Plants 17. Two New Triterpenoid Sapogenals and a New Saponin from Abrus cantoniensis (II). Chem. Pharm. Bull., 38, 824 (1990).

    CAS  Google Scholar 

  114. Choi, Y.H., R.A. Hussain, J.M. Pezzuto, A.D. Kinghorn, and J.F. Morton: Abrusosides A-D, Four Novel Sweet-tasting Triterpene Glycosides from the Leaves of Abrus precatorius. J. Nat. Prod., 52, 1118 (1989).

    CAS  Google Scholar 

  115. Mahato, S.B., B.C. Pal, and A.K. Nandy: Structure Elucidation of Two Acylated Triterpenoid Bisglycosides from Acacia auriculiformis Cunn. Tetrahedron, 48, 6717 (1992).

    CAS  Google Scholar 

  116. Kohda, H., S. Tanaka, and Y. Yamaoko: Saponins from Leaves of Acantho-panax hypoleucus Makino. Chem. Pharm. Bull., 38, 3380 (1990).

    CAS  Google Scholar 

  117. Sawada, H., M. Miyakoshi, S. Isoda, Y. Ida, and J. Shoji: Saponins from Leaves of Acanthopanax siebodianus. Phytochemistry, 34, 1117 (1993).

    CAS  Google Scholar 

  118. Miyakoshi, M., Y. Ida, S. Isoda, and J. Shoji: 3α-Hydroxy-oleanane-type Triterpene Glycosyl Esters from Leaves of Acanthopanax spinosus. Phytochemistry, 34, 1599 (1993).

    CAS  Google Scholar 

  119. Miyakoshi, M., Y. Ida, S. Isoda, and J. Shoji: 3 Epi-oleanane Type Triterpene Glycosyl Esters from Leaves of Acanthopanax spinosus. Phytochemistry, 33, 891 (1993).

    CAS  Google Scholar 

  120. Lacaille-Dubois, M.A., B. Hanquet, A. Rustaiyan, and H. Wagner: Squarroside A, a Biologically Active Triterpene Saponin from Acanthophyllum squarrosum. Phytochemistry, 34, 489 (1993).

    CAS  Google Scholar 

  121. Ida, Y., Y. Satoh, M. Katoh, M. Katsumata, M. Nagasao, K. Yamaguchi, H. Kamei, and J. Shoji: Achyranthosides A and B, Novel Cytotoxic Saponins from Achyranthes fauriei Root. Tetrahedron Lett., 35, 6887 (1994).

    CAS  Google Scholar 

  122. Ida, Y., Y. Satoh, M. Katsumata, M. Nagasao, and J. Shoji: Achyranthosides C and D, Novel Glucuronide Saponins from Achyranthes fauriei Root. Chem. Pharm. Bull., 43, 896 (1995).

    CAS  Google Scholar 

  123. Faini, E., M. Castillo, R. Torres, G. Delle Monache, and E. Gacs-Baitz: Malabaricane Triterpene Glucosides from Adesmia aconcaquensis. Phytochemistry, 40, 885 (1995).

    CAS  Google Scholar 

  124. Fang, S., Z. He, J. Gao, and P. WANG: Triterpenoid Glycosides from Adina rubella. Phytochemistry, 39, 1241 (1995).

    CAS  Google Scholar 

  125. Ikuta, A., and H. Itokawa: 30-Noroleanane Saponins from Callus Tissues of Akebia quinata. Phytochemistry, 28, 2663 (1989).

    CAS  Google Scholar 

  126. Ikuta, A.: Saponins and Triterpenes from Callus Tissues of Akebia trifoliata and Comparison with the Constituents of Other Lardizabalaceous Callus Tissues. J. Nat. Prod., 58, 1378 (1995).

    CAS  Google Scholar 

  127. Pal, B.C., B. Achari, K. Yoshikawa, and S. Arihara: Saponins from Albizia lebbeck. Phytochemistry, 38, 1287 (1995).

    CAS  Google Scholar 

  128. Orsini, F., F. Pelizzoni, and L. Verotta: Saponins from Albizzia lucida. Phytochemistry, 30, 4111 (1991).

    CAS  Google Scholar 

  129. Li, D., N.L. Owen, P. Perera, C. Andersson, L. Bohlin, P.A. Cox, R.J. Pugmire, C.L. Mayne, and D.M. Grant: Structure Elucidation of Three Triterpenoid Saponins from Alphitonia zizypleoides Using 2D NMR Techniques. J. Nat. Prod., 59, 218 (1994).

    Google Scholar 

  130. Rastrelli, L., C. Pizza, P. Saturnino, O. Schettino, and A. Dim: Studies on the Constituents of Amaranthus caudatus (Kiwicha) Se eds. Isolation and Characterization of Seven New Triterpene Saponins. J. Agric. Food Chem., 43, 904 (1995).

    CAS  Google Scholar 

  131. Kohda, H., S. Tanaka, Y. Yamoka, and Y. Ohhara: Saponins from Amaranthus hypochodriacus. Chem. Pharm. Bull., 39, 2609 (1991).

    CAS  Google Scholar 

  132. Brandao, M.G.L., M.A. Lacailee-Dubois, M.A. Teixeira, and H. Wagner: Triterpene Saponins from the Roots of Ampelozizphus amaronicus. Phytochemistry, 31, 352 (1992).

    CAS  Google Scholar 

  133. Brandao, M.G.L., M.A. Lacaille-Dubois, M.A. Teixeira, and H. Wagner: A Dammarane-Type Saponin from the Roots of Ampelozizyphus amaronicus. Phytochemistry, 34, 1123 (1993).

    CAS  Google Scholar 

  134. Shoji, N., A. Umeyama, K. Yoshikawa, and S. Arihara: Structures of Anagallosa-ponins I-V and Their Companion Substances from Anagallis arvensis L. Chem. Pharm. Bull., 42, 1874 (1994).

    Google Scholar 

  135. Shoji, N., A. Umeyama, K. Yoshikawa, and S. Arihara: Triterpenoid Glycosides from Anagallis arvensis. Phytochemistry, 37, 1397 (1994).

    CAS  Google Scholar 

  136. Mahato, S.B., N.P. Sahu, S.K. Roy, and S. Sen: Structure Elucidation of Four New Triterpenoid Oligoglycosides from Anagallis arvensis. Tetrahedron, 47, 5215 (1991).

    CAS  Google Scholar 

  137. Li, X., C. Yang, Y. Liu, R. Kasai, K. Ohtani, and K. Yamasaki: Triterpenoid Glycosides from Anemocleama glaucifolium. Phytochemistry, 39, 1175 (1995).

    CAS  Google Scholar 

  138. Wang, M., F. Wu, and Y. Chen: Triterpenoid Saponins from Anemone hupehensis. Phytochemistry, 34, 1395 (1993).

    CAS  Google Scholar 

  139. Duoux, M.G., C. Lavaud, G. Massiot, L. Lemenoliver, and D.M. Sheeley: A Saponin from Leaves of Aphloia madagascariensis. Phytochemistry, 34, 497 (1993).

    Google Scholar 

  140. Hu, M., K. Ogawa, Y. Sashida, and P. Xiao: Triterpenoid Glucurono-saponins from Root Bark of Aralia armata. Phytochemistry, 39, 179 (1995).

    CAS  Google Scholar 

  141. Miyase, T., N. Sutoh, D.M. Zhang, and A. Ueno: Araliasaponins XII-XVIII, Triterpene Saponins from the Roots of Aralia chinensis. Phytochemistry, 42, 1123 (1993).

    Google Scholar 

  142. Kawai, H., M. Nishida, Y. Tashiro, M. Kuroyanagi, A. Ueno, and M. Satake: Studies on the Structures of Udosaponins A, B, C, D, E and F from Aralia cordates Thumb. Chem. Pharm. Bull., 37, 2318 (1989).

    CAS  Google Scholar 

  143. Miyase, T., K. Shiokawa, D.M. Zhang, and A. Ueno: Araliasaponins I-XI, Triterpene Saponins from the Roots of Aralia decaisneana. Phytochemistry, 41, 1411 (1993).

    Google Scholar 

  144. Saito, S., S. Sumita, N. Tamura, Y. Nagamura, K. Nishida, M. Ito, and I. Ishiguro: Saponins from the Leaves of Aralia elata Seem (Araliaceae). Chem. Pharm. Bull., 38, 411 (1990).

    CAS  Google Scholar 

  145. Jiang, Y., S. Xu, X. Yao, and Y. Chen: Chemical Constituents and Pharmacological Activities of Aralia elata. Shenyang Yaoxueynan Xuebao, 8, 290 (1991).

    CAS  Google Scholar 

  146. Sakai, S., M. Katsumato, Y. Satoh, M. Nagasao, M. Miyakoshi, Y. Ida, and J. Shoji: Oleanolic Acid Saponins from Root Bark of Aralia elata. Phytochemistry, 35, 1319 (1994).

    CAS  Google Scholar 

  147. Satoh, Y., S. Sakai, M. Katsumato, M. Nagasao, M. Miyakoshi, Y. Ida, and J. Shoji: Oleanolic acid Saponins from Root Bark of Aralia elata. Phytochemistry, 36, 147 (1994).

    CAS  Google Scholar 

  148. Yu, S., D. Yu, and X. Liang: Triterpenoid Saponins from the Roots of Aralia spinifolia. J. Nat. Prod., 57, 978 (1994).

    CAS  Google Scholar 

  149. Jia, Z., K. Koike, T. Nikaido, T. Ohmoto, and M. Ni: Triterpenoid Saponins from Ardisia crenata and their Inhibitory Activity on CAMP Phosphodiesterase. Chem. Pharm. Bull., 42, 2309 (1994).

    CAS  Google Scholar 

  150. Jia, Z., K. Koike, T. Nikaido, and T. Ohmoto: TWO Novel Triterpenoid Pentasaccharides with an Unusual Glycosylglycerol Side Chain from Ardisia crenata, Tetrahedron, 50, 11853 (1994).

    CAS  Google Scholar 

  151. Wang, M., X. Guan, X. Han, and S. Hong: A New Triterpenoid Saponin from Ardisia crenata. Planta Med., 58, 205 (1992).

    CAS  Google Scholar 

  152. De Tommasi, N., S. Piacente, F. Desimone, C. Pizza, and Z.L. Zhou: Characterization of Three New Triterpenoid Saponins from Ardisia japonica. J. Nat. Prod., 56, 1669 (1993).

    Google Scholar 

  153. Charrouf, Z., J.M. Wieruszeski, S. Fkih-Tetouani, Y Leroy, M. Charrouf, and B. Fournet: Triterpenoid Saponnins from Argania spinosa. Phytochemistry, 31, 2079 (1992).

    CAS  Google Scholar 

  154. Shao, Y., B. Zhou, K. Ma, and H. Wu: New Triterpenoid Saponins, Asterbatanoside D and E from Aster batangensis. Planta Med., 61, 246 (1995).

    CAS  Google Scholar 

  155. Shao, Y., B. Zhou, K. Ma, H. Wu, L. Lin, and G. A. Cordell: Medicagenic Acid Saponins from Aster batangensis. Phytochemistry, 39, 875 (1995).

    CAS  Google Scholar 

  156. Nagao, T., R. Tanaka, Y. Iwase, and H. OKABE: Studies on the Constituents of Aster scaber Thunb. IV. Structure of Four Echinocystic acid Glycosides Isolated from the Herb. Chem. Pharm. Bull., 41, 659 (1993).

    CAS  Google Scholar 

  157. Nagao, T., Y. Iwase, and H. OKABE: Studies on the Constituents of Aster scaber Thumb. V. Structures of Six New Echinocystic Acid Glycosides Isolated from the Herb. Chem. Pharm. Bull., 41, 1562 (1993).

    CAS  Google Scholar 

  158. Tanaka, R., T. Nagao, H. Okabe, and T. YAMAUCHI: Studies on the Constituents of Aster tataricus L.f.I.V. Structures of Aster Saponins Isolated from the Herb. Chem. Pharm. Bull., 38, 1153 (1992).

    Google Scholar 

  159. Cheng, D., and Y. Shao: Terpenoid Glycosides from the Roots of Aster tataricus. Phytochemistry, 35, 173 (1994).

    CAS  Google Scholar 

  160. Nagao, T., H. Okabe, and T. Yamauchi: Studies on the Constituents of Aster tataricus L.f.III. Structures of Aster Saponins E and F Isolated from the Root. Chem. Pharm. Bull., 38, 783 (1990).

    CAS  Google Scholar 

  161. Shao, Y., B. Zhou, K. Ma, and H. Wu: Echinocystic Acid Saponins from Aster Yunnanensis. J. Nat. Prod., 58, 837 (1995).

    CAS  Google Scholar 

  162. Shao, Y., B. Zhou, L. Lin, and G.A. Cordell: Triterpene Saponins from Aster yunnanensis. Phytochemistry, 38, 1487 (1995).

    CAS  Google Scholar 

  163. Shao, Y., B. Zhou, J. Gao, L. Lin, and G.A. Cordell: Glycosides from Aster yunnanensis. Phytochemistry, 38, 675 (1995).

    CAS  Google Scholar 

  164. Espada, A., C. Jimenez, J. Rodriguez, P. Crews, and R. Riguera: Sarasinosides D-G Four New Triterpenoid Saponins from the Sponge Asteropus sarasinosum. Tetrahedron, 48, 8685 (1992).

    CAS  Google Scholar 

  165. Orsini, F., L. Verotta, L. Barboni, N.A. El-Sebakhy, A.M. Asaad, R.M. Abdallah, and S.M. Toaima: Cycloaratane Triterpene Glycosides from Astragalus alexandrinus. Phytochemistry, 35, 745 (1994).

    CAS  Google Scholar 

  166. Wang, H.K., K. He, L. Ji, Y. Tezuka, and K.I. Tohru: Asernestioside C, a New Saponin from the Roots of Astragalus ernestii Comb; First Example of Negative Nuclear Overhauser Effect in the Saponins. Chem. Pharm. Bull., 37, 2041 (1989).

    CAS  Google Scholar 

  167. Zhu, Y.Z., S. Lu, Y. Okada, M. Takata, and T. Okuyama: TWO New Cycloartane-type Glycosides Mongholicoside I and II from Aerial Part of Astragalus mongholicus Bungi. Chem. Pharm. Bull., 40, 2230 (1992).

    CAS  Google Scholar 

  168. El-Sebakhy, N.A., F.M. Hadraz, R.M. Abdallah, A.M. Asaad, F. Orsini, F. Pelizzoni, G. Sello, and L. Verotta: Cycloartane Triterpene Glycosides from Egyptian Astragalus Species. Phytochemistry, 29, 3271 (1990).

    CAS  Google Scholar 

  169. Gariboldi, P., F. Pelizzoni, M. Tato, L. Verotta, N. El-Sebakhy, A.M. Asaad, R.M. Abdallah, and S.N. Toaima: Cycloartane Triterpene Glycosides from Astragalus trigonus. Phytochemistry, 40, 1755 (1995).

    CAS  Google Scholar 

  170. Hiller, K., M. Leska, E. Gruendemann, G. Dube, A. Karwatzki, and P. Franke: Structure of Bisdesmosidic Saponins from Astrantia major L. Pharmazie, 45, 615 (1990).

    CAS  Google Scholar 

  171. Jain, P., and D.K. Kulshreshtha: Bacoside A1, a Minor Saponin from Bacopa monniera. Phytochemistry, 33, 449 (1993).

    CAS  Google Scholar 

  172. Rastogi, S., R. Pal, and D.K. Kulshreshtha: Bacoside A3, a Triterpenoid Saponin from Bacopa monniera. Phytochemistry, 36, 133 (1994).

    CAS  Google Scholar 

  173. Garai, S., S.B. Mahato, K. Ohtani, and K. Yamasaki: Bacopasaponin D-A Pseudo-jujubogenin Glycosides from Bacopa monniera. Phytochemistry, 43, 447 (1993).

    Google Scholar 

  174. Pal, B.C., T. Chaudhuri, K. Yoshikawa, and S. Arihara: Saponins from Barringtonia acutangula. Phytochemistry, 35, 1315 (1994).

    CAS  Google Scholar 

  175. Pal, B.C., B. Achari, and K.R. Price: A Triterpenoid Glucoside from Barringtonia acutangula. Phytochemistry, 30, 4177 (1991).

    CAS  Google Scholar 

  176. Schöpke, T., V. Wray, B. Rzazewska, and K. Hiller: Bellissaponins BA1 and BA2, Acylated Saponins from Bellis perennis. Phytochemistry, 30, 627 (1991).

    Google Scholar 

  177. Schöpke, T., V. Wray, A. Kunath, and K. Hiller: Bayogenin and Asterogenic Acid Glycosides from Bellis perennis. Phytochemistry, 31, 2555 (1992).

    Google Scholar 

  178. Schöpke, T., K. Hiller, V. Wray, K.D. Koppel, K. Yamasaki, and R. Kasai: Triterpenoid Saponins from Bellis sylvestris, I. Structures of the Major Deacyl Saponins. J. Nat. Prod., 57, 1279 (1994).

    Google Scholar 

  179. Schöpke, T., M.I.H. Agha, V. Wray, and K. Hiller: Triterpenoid Saponins from Bellium bellidioides. Phytochemistry, 36, 449 (1994).

    Google Scholar 

  180. Schöpke, T., V. Wray, M. Nimtz, and K. Hiller: Triterpenoid saponins from Bellium bellidioides. Structure of the Minor Deacylsaponins. Phytochemistry, 41, 1399 (1993).

    Google Scholar 

  181. Ridout, C.L. K.R. Price, G. Parkin, M.G. Dijoux, and C. Lavaud: Saponins from Sugar Beet and the Floc Problem. J. Agric. Food. Chem., 42, 279 (1994).

    CAS  Google Scholar 

  182. Fuchino, H., T. Satoh, and N. Tanaka: Chemical Evaluation of Betula Species in Japan. I. Constituents of Betula ermanii. Chem. Pharm. Bull., 43, 1937 (1995).

    CAS  Google Scholar 

  183. Ohashi, K., H. Kojima, T. Tanikawa, Y. Okumura, K. Kawazoe, N. Tatara, H. Shibuya, and I. Kitagawa: Indonesian Medicinal Plants. IX. Chemical Structures of Gongganosides A, B and C, Three New Quinovic Acid Glycosides from the Bark of Bhesa paniculata (Celastraceae). Chem. Pharm. Bull., 42, 1596 (1994).

    CAS  Google Scholar 

  184. Espada, A., J. Rodriguez, M.C. Villaverde, and R. Riguera: Boussingoside D1, a New Triterpenoid Saponin from Boussingaultia baselloides. Liebigs Ann. Chem., 3, 291 (1991).

    Google Scholar 

  185. Espada, A., J. Rodriguez, M.C. Villaverde, and R. Riguera: Hypoglycemic Triterpenoid Saponins from Boussingaultia baselloides. Can. J. Chem., 68, 2039 (1990).

    CAS  Google Scholar 

  186. Oobyyashi, K., K. Yoshikawa, and S. Arihara: Structural Revision of Bryonoside and Structure Elucidation of Minor Saponins from Bryonia dioica. Phytochemistry, 31, 943 (1992).

    Google Scholar 

  187. Ebata, N., K. Nakajima, H. Taguchi, and H. Mitsuhashi: Isolation of New Saponins from the Root of Bupleurum falcatum L. Chem. Pharm. Bull., 38, 1432 (1990).

    CAS  Google Scholar 

  188. Pistelli, L., A. Cammilli, A. Manunta, A. Marsili, and I. Morelli: Triterpenoid Saponins and Flavonoid Glycosides from Bupleurum falcatum subsp. cirnuum. Phytochemistry, 33, 1537 (1993).

    CAS  Google Scholar 

  189. Ebata, N., K. Nakajima, K. Hayashi, M. Okada, and M. Maruno: Saponins from the Root of Bupleurum falcatum. Phytochemistry, 41, 895 (1993).

    Google Scholar 

  190. Guinea, M.C., J. Parellada, M.A. Lacaille-Dubois, and H. Wagner: Biologically Active Triterpene Saponins from Bupleurum fruticosum. Planta Med., 60, 163 (1994).

    CAS  Google Scholar 

  191. Pistelli, L., A.R. Bilia, A. Marsili, N. De Tommasi, and A. Manunta: Triterpenoid Saponins from Bupleurum fruticosum. J. Nat. Prod., 56, 233 (1993).

    CAS  Google Scholar 

  192. Zhang, R.Y., X.K. Chen, X.B. Yang, W.Y. He, and L. Tan: Structures of Saikosaponin M and N from Bupleurum smithi. Yaoxue Xuebao, 29, 684 (1994).

    CAS  Google Scholar 

  193. Luo, H.S., Y.Y. Zhao, L.B. Ma, Y.Z. Jin, J.R. Peng, and R.Y. Zhang: Isolation and Identification of Saikogenin Q and Saikosaponin Q from Bupleurum smithi. Yaoxue Xuebao, 30, 435 (1995).

    CAS  Google Scholar 

  194. Takeda, T., T. Nakamura, S. Takashima, O. Yano, and Y. Ogihara: Studies on the Constituents of Calliandra anomala (Kunth) Macbr. I. Structure Elucidation of Two Acylated Triterpenoidal Saponins. Chem. Pharm. Bull., 41, 2132 (1993).

    CAS  Google Scholar 

  195. Nakamura, T., T. Takeda, and Y. Ogihara: Studies on the Constituents of Calliandra anomala (Kunth) Macbr. II. Structure Elucidation of Four Acylated Triterpenoidal Saponins. Chem. Pharm. Bull., 42, 1111 (1994).

    CAS  Google Scholar 

  196. Yoshikawa, M., E. Harada, T. Murakami, H. Matsudo, J. Yamahara, and N. Murakami: Camellia Saponins B1 B2, C1 and C2, New Type Inhibitors of Ethanol Absorption in Rats from the Seeds of Camellia japonica L. Chem. Pharm. Bull., 42, 742 (1994).

    CAS  Google Scholar 

  197. Ahmad, W., K. Usmanghani, I. Ahmad, V.U. Ahmad, and T. Miyase: Isolation and Characterization of Saponins from Castanospermum australe Cunn. et. Fraster. Chem. Pharm. Bull., 42, 314 (1994).

    Google Scholar 

  198. Ahmad, V.U., W. Ahmad, and K. Usmanghani: Triterpenoid Saponins from Leaves of Castanospermum australe. Phytochemistry, 31, 2805 (1992).

    CAS  Google Scholar 

  199. Sahu, N.P., S.K. Roy, and S.B. Mahato: Spectroscopic Determination of Structures of Triterpenoid Trisaccharides from Centella asiatica. Phytochemistry, 28, 2852 (1989).

    CAS  Google Scholar 

  200. Gupta, D., and J. Singh: Triterpenoid Saponins from Centipeda minima. Phytochemistry, 28, 1197 (1989).

    CAS  Google Scholar 

  201. Caliskan, O.A., H. Anil, and G.R. Stephenson: Cephalaria Saponin A, a New Bidesmosidic Triterpene Saponin from Cephalaria transylvanica. J. Nat. Prod., 57, 1001 (1994).

    CAS  Google Scholar 

  202. Alankus-Caliskan, O., and H. Anil: A Bidesmosidic Triterpene Saponin from Cephalaria transylvanica. Phytochemistry, 38, 1493 (1995).

    CAS  Google Scholar 

  203. Kirmizigul, S., and H. Anil: An Acidic Triterpene Glycoside from Cephalaria transsylyvanica. Phytochemistry, 36, 1555 (1994).

    CAS  Google Scholar 

  204. Kirmizigul, S., H. Anil, and M.E. Rose: Triterpenoid Glycosides from Cephalaria transsylvanica. Phytochemistry, 39, 1171 (1995).

    CAS  Google Scholar 

  205. Mizui, F., R. Kasai, K. Ohtani, and O. Tanaka: Saponins from Bran of Quinoa, Chenopodium quinoa Wild. II. Chem Pharm. Bull., 38, 375 (1990).

    CAS  Google Scholar 

  206. Kusano, A., K. Shimizu, M. Idoji, M. Shibano, K. Minoura, and G. Kusano: Studies on the Constituents of Cimicifuga species. XVI. Three New Cycloartane Xylosides from the Aerial Parts of Cimicifuga simplex. Chem. Pharm. Bull., 43, 279 (1995).

    CAS  Google Scholar 

  207. Shao, B., G. Qin, R. Xu, H. Wu, and K. Ma: Triterpenoid Saponins from Cleamatis chinensis. Phytochemistry, 38, 1473 (1995).

    CAS  Google Scholar 

  208. Bahuguna, R.P., J.S. Jangwan, T. Kaiya, and J. Sakakibara: Clemontanoside A, a Bisglycoside from Clematis montana. Phytochemistry 28, 2511 (1989).

    CAS  Google Scholar 

  209. Thapliyal, R.P. and R.P. Bahuguna: Clemontanoside E, an New Saponin from Clematis montana. Int. J. Pharmacogn., 32, 373 (1994).

    CAS  Google Scholar 

  210. Whang, W.: Aromatic Compounds and Triterpenoidal Saponins from Clematis koreana var. umbrosa. Arch. Pharmacol. Res., 17, 5 (1994).

    CAS  Google Scholar 

  211. Kuntze, O., S.R. Xue, J.Q. Liu, G. Wang, J.Q. Shi, Q.J. Wu, and S.Z. Hu: Triterpenoid Saponin of Clinopodium chinense (Benth.) O. Yaoxue Xuebao, 27, 207 (1992).

    Google Scholar 

  212. Liu, Z., Z. Jia, R.G. Cates, D. Li, and N.L. Owen: Triterpenoid Saponins from Clinopodium chinensis. J. Nat. Prod., 58, 184 (1995).

    CAS  Google Scholar 

  213. Liu, Z., D. Li, N.L. Owen, D.M. Grant, R.G. Cates, and Z. Jia: Oleanane Triterpene Saponins from the Chinese Medicinal herb Clinopodium chinensis. J. Nat. Prod., 58, 1600 (1995).

    CAS  Google Scholar 

  214. Mori, F., T. Miyase, and A. Ueno: Oleanane-Triterpene Saponins from Clinopodium Chinese var. Parviflovrum Phytochemistry, 36, 1485 (1994).

    CAS  Google Scholar 

  215. Yamamoto, A., T. Miyase, A. Ueno, and T. Maeda: Clinoposaponins I-V, New Oleanane Triterpene Saponins from Clinopodium gracile. O. Kuntze Chem. Pharm. Bull., 41, 1270 (1993).

    CAS  Google Scholar 

  216. Yamamoto, A., H. Suzuki, T. Miyase, A. Ueno, and T. Maeda: Clinoposaponins VI and VIII, Two Oleanane-Triterpene Saponins from Clinopodium micranthum. Phytochemistry, 34, 485 (1993).

    CAS  Google Scholar 

  217. Xue, S., J. Liu, and G. Wang: Triterpenoid Saponins from Clinopodium polycephalum. Phytochemistry, 31, 1049 (1992).

    CAS  Google Scholar 

  218. Joshi, B.S., K.M. Moore, S.W. Pelletier, M.S. Puar, and B.N. Pramanik: Saponins from Collinsonia canadensis. J. Nat. Prod., 55, 1468 (1992).

    CAS  Google Scholar 

  219. Seaforth, C.E., S. Mohammed, A. Maxwell, W.F. Tinto, and W.F. Reynolds: Mabioside A, New Saponin from Coluhrina elliptica. Tetrahedron Lett., 33, 4111 (1992).

    CAS  Google Scholar 

  220. Tinto, W., W.F. Reynolds, C.E. Seaforth, S. Mohammed, and A. Maxwell: New Bitter Saponins from the Bark of Coluhrina elliptica: Proton and Carbon-13 Assignments by 2D NMR Spectroscopy. Magn. Reson. Chem., 31, 859 (1993).

    CAS  Google Scholar 

  221. Oulad-Ali, A., D. Guillaume, B. Weniger, Y. Jiang, and R. Anton: Mabiosides C-E: Triterpenoid Saponins from the Bark of Coluhrina elliptica. Phytochemistry, 36, 445 (1994).

    CAS  Google Scholar 

  222. Abdul Quader, M., A.I. Gray, P.G. Waterman, C. Lavaud, G. Massiot, C.M. Hasan, and M.D. Ahmad: Capsugenin-25-30-O-β-D-diglucopyranoside: a New Glycoside from the Leaves of Corchorus capsularies. J. Nat. Prod., 53, 527 (1990).

    CAS  Google Scholar 

  223. Asada, Y., T. Ueoka, and T. Furuya: Novel Acylated Saponins from Montbretia (Crocosmia crocosmiiflora). Isolation of Saponins and the Structures of Crocosmiosides A, B and H. Chem. Pharm. Bull., 37, 2139 (1989).

    CAS  Google Scholar 

  224. Asada, Y., T. Ueoka, and T. Furuya: Novel Acylated Saponins from Montbretica (Crocosmia crocosmiiflora). II. The Structures of Crocosmiosides C, D, E, F, G and I. Chem. Pharm. Bull., 38, 142 (1990).

    CAS  Google Scholar 

  225. Asada, Y., M. Ikeno, and T. Furuya: Acylated Saponins, Masonosides A-C, from the Corms of Crocosmia masoniorum. Phytochemistry, 35, 757 (1994).

    CAS  Google Scholar 

  226. Asada, Y., M. Ikeno, T. Ueoka, T. Furuya: Desacylsaponins, Desacylmasonosides 1, 2 and 3 from the Corns of Crocosmia masonorum. Chem. Pharm. Bull., 37, 2747 (1989).

    CAS  Google Scholar 

  227. Asada, Y., M. Ikeno, and T. Furuya: Minor Desacylsaponins from the Corms of Crocosmia masoniorum. Phytochemistry, 36, 455 (1994).

    CAS  Google Scholar 

  228. Gariboldi, P., L. Verotta, and B. Gobetta: Saponins from Crossopteryx febrifuga. Phytochemistry, 29, 2629 (1990).

    CAS  Google Scholar 

  229. Ding, Y., J. Kinjo, C. Yang, and T. Nohara: Studies of the Constituents of Leguminous Plants. Part XX. Oleanane Glycosides from Crotalaria albida. Chem. Pharm. Bull., 39, 496 (1991).

    CAS  Google Scholar 

  230. Reznicek, G., J. Jorenitsch, W. Robien, and W. Kubelka: Saponins in Cyclamen Species: Configuration of Cyclamiretin C and Structure of Isocyclamin. Phytochemistry, 28, 825 (1989).

    CAS  Google Scholar 

  231. Pambou, T.H., B. Koudogbo, J.C. Tabet, and E. Casadevall: A Triterpene Saponin from Cylicodiscus gabunensis. Phytochemistry, 29, 2723 (1990).

    Google Scholar 

  232. Tchivounda, H.P., B. Koudogbo, Y. Besace, and E. Casadevall: Triterpene Saponins from Cylicodiscus gabunensis. Phytochemistry, 30, 2711 (1991).

    CAS  Google Scholar 

  233. Kong, J., X. Li, B. Wei, and C. Yang: Triterpenoid Glycosides from Decaisnea fargesii. Phytochemistry, 33, 427 (1993).

    CAS  Google Scholar 

  234. Kubo, T., S. Hamada, T. Nohara, Z.H. Wang, H. Hirayama, K. Ikegami, K. Yasukawa, and M. Takido: Leguminous Plants. XIV. Study on the Constituents of Desmodium styracifolium. Chem. Pharm. Bull., 37, 2229 (1989).

    CAS  Google Scholar 

  235. Malaviya, N., R. Pal, and N.M. Khanna: Saponins from Deutzia corymbosa. Phytochemistry, 30, 2798 (1991).

    CAS  Google Scholar 

  236. Tagawa, N.T., Y. Inatomi, M. Nishi, H. Murata, A. Inada, and S. Aibara: TWO New Hopane-Triterpene Glycosides from a Fern Diplazium subsinuatum (Wall. ex. Hook et Grev.). Chem. Pharm. Bull., 43, 2256 (1995).

    Google Scholar 

  237. Li, H.Y., K. Koike, T. Ohmoto, and K. IKEDA: Dianchinenosides A and B, two New Saponins from Dianthus chinensis. J. Nat. Prod., 56, 1065 (1993).

    CAS  Google Scholar 

  238. Li, H.Y., K. Koike, and T. Ohmoto: Triterpenoid Saponins from Dianthus chinensis. Phytochemistry, 35, 751 (1994).

    CAS  Google Scholar 

  239. Koike, K. H. Li, Z. Jia, H. Muraoka, S. Fukui, M. Inoue, and T. Ohmoto: Triterpenoid Saponins from Dianthus chinensis. Tetrahedron, 50, 1281 (1994).

    Google Scholar 

  240. Komertelidze, E.P., L.N. Gvazava, M.D. Alaniya, V.S. Kikoladze, and V.G. Tsitsishvili: Digitoside, a Novel Triterpene Glycoside from Digitalis ciliata. J. Nat. Prod., 55, 217 (1992).

    Google Scholar 

  241. Jayasinghe, U.L.B., G.P. Wannigama, and J.K. MacLeod: Saponins of Diploclisia glaucescens. Nat. Prod. Lett., 2, 249 (1993).

    CAS  Google Scholar 

  242. Bandara, B.M.R., L. Jayasinghe, V. Karunaratne, G.P. Wannigama, W. Kraus, M. Bokel, and S. Sotheeswaran: Diploclisin, a Bidesmosicid Triterpenoid Saponin from Diploclisia glaucescens. Phytochemistry, 28, 2783 (1989).

    CAS  Google Scholar 

  243. Jung, K.Y., J.C. Do, and K.H. Son: Triterpenoid Glycosides from the Roots of Dipsacus asper. J. Nat. Prod., 56, 1912 (1993).

    CAS  Google Scholar 

  244. Kouno, I., A. Tsuboi, M. Nanri and N. Kawano: Acylated Triterpene Glycoside from Roots of Dipsacus asper. Phytochemistry, 29, 338 (1990).

    CAS  Google Scholar 

  245. Wei, F., Z.C. Lou, Y.M. Liu, and Z.C. Miao: Application of New Techniques of NMR in the Structure Elucidation of Two New Saponins, Asperosaponin F and H1, and Spectral Rules Involved. Yaoxue Xuebao, 29, 511 (1994).

    CAS  Google Scholar 

  246. Yoshiki, Y., J.H. Kim, K. Okubo, I. Nagoya, T. Sakabe, and N. Tamura: A Saponin Conjugated with 2,3,-Dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one from Dolichos lablab. Phytochemistry 38, 229 (1995).

    CAS  Google Scholar 

  247. Kinjo, J., K. Suyama, and T. Nohara: Triterpenoidal Saponins from Dumasia truncata. Phytochemistry, 40, 1765 (1995).

    CAS  Google Scholar 

  248. Segiet-Kujawa, E., and M. Kaluga: Triterpenoid Saponins of Eleuthero-coccus senticosus Roots. J. Nat. Prod., 54, 1044 (1991).

    CAS  Google Scholar 

  249. Rasoanaivo, P., G. Multar, E. Federici, and C. Galeffi: Triterpenoid Diglucoside of Enterospermum pruinosum. Phytochemistry, 39, 251 (1995).

    CAS  Google Scholar 

  250. Miyase, T., F.R. Melek, O.D. El-Gindi, S.M. Abdel-Khalik, M.R. El-Gindi, M.Y. Haggag and S.H. Hilal: Saponins from Fagonia arabica. Phytochemistry 41, 1175 (1996).

    Google Scholar 

  251. Melek, F.R., T. Miyase, O.D. El-Gindi, S.M. Abdel-Khalik, and M.Y. Haggag: Saponins from Fagonia Mollis. Phytochemistry 42, 1405 (1993).

    Google Scholar 

  252. Cai, L.N., R.V. Zhang, Z.L. Zhang, B. Wang, L. Qiao, L.R. Huang, and J.R. Cheng: The Structure of Glyeurysaponin. Yaoxue Xuebao, 29, 447 (1991).

    Google Scholar 

  253. Kitagawa, I., K. Hori, M. Sakagami, F. Hashiuchi, M. Yoshikawa, and J. Ren: Saponin and Sapogenol. XLIX. On The constituents of the Roots of Glycyrrhiza inflata Batalin from Xinjiang, China; Characterization of Two Sweet Oleanane-type Triterpene Oligoglycosides, Apioglycyrrhizin And Arabogycyrrhizin. Chem. Pharm. Bull., 41, 1350 (1993).

    CAS  Google Scholar 

  254. Kitagawa, I., K. Hori, T. Taniyama, J.L. Zhou, and M. Yoshikawa: Saponin and Sapogenol. XLVII. On the Constituents of the Roots of Glycyrrhiza uralensis Fischer From Northeastern China. (1) Licorice-Saponins A3, B2, and C2. Chem. Pharm. Bull., 43 (1993).

    Google Scholar 

  255. Kitagawa, I., K. Hori, M. Sakagami, J.L. Zhou, and M. Yoshikawa: Saponin and Sapogenol. XLVIII. On the Constituents of the Roots of Glycyrrhiza uralensis Fischer from Northeastern China. (2) Licorice-Saponins D3, E2, F3, G2, H2, J2 and K2. Chem. Pharm. Bull., 41, 1337 (1993).

    CAS  Google Scholar 

  256. Kitagawa, I., J. Zhou, M. Sakagami, E. Uchida, and M. Yoshikawa: Licorice-Saponins F3, G2, H2, J2 and K2, Five New Oleanane-Triterpene Oligoglycosides fromthe Root of Glycyrrhiza uralensis. Chem. Pharm. Bull., 39, 244 (1991).

    CAS  Google Scholar 

  257. Kitagawa, I., K. Hori, E. Uchida, W.Z. Chen, M. Yoshikawa, and J. Ren: Saponin and Sapogenol. L. On the Constituents of the Roots of Glycyrrhiza uralensis Fischer from Xinjiang, China. Chemical Structures of Licorice-Saponin L3 and Isoliquiritin Apioside. Chem. Pharm. Bull., 41, 1567 (1993).

    CAS  Google Scholar 

  258. Gao, D., R. Zhang, and B. Yao: Structure Identification of Yunnangly-saponin A and B. J. Chin. Pharm. Sci., 3, 1 (1994).

    CAS  Google Scholar 

  259. Ohtani, K., K. Ogawa, R. Kasai, C. Yang, K. Yamasaki, J. Zhou, and O. Tanaka: Studies on the Constituents of Glycyrrhiza yunnanensis. Part 1. Oleanane Glycosides from Glycyrrhiza yunnanensis Roots. Phytochemistry 31, 1747 (1992).

    CAS  Google Scholar 

  260. Zang, L., R.Y. Zhang, D. Wang, J.H. Pang, Z.L. Zhang, C.Y. Gao, and Z.C. Lou: Glyyunnanprosapogenin and Glyyunnsapogenin from the Roots of Glycyrrhiza yunnanensis. Yaoxue Xuebao, 25, 750 (1991).

    Google Scholar 

  261. Ahmad, V.U., S. Perveen, and S. Bano: Guaiacin A and B from the Leaves of Guaiacum officinale. Planta Med., 55, 307 (1989).

    CAS  Google Scholar 

  262. Ahmad, V.U., N. Bano, S. Uddin, S. Perveen, and I. Fatima: Structure of Guaianin C from Guaiacum officinale. Fitoterapia, 60, 255 (1989).

    CAS  Google Scholar 

  263. Ahmad, V.U., S. Perveen, and S. Bano: Saponins from the Leaves of Guaiacum officinale. Phytochemistry, 29, 3287 (1990).

    CAS  Google Scholar 

  264. Ahmad, V.U., S. Uddin, and S. Bano: Isolation and Structure Elucidation of Saponins from the Fruit of Guaiacum officinale. J. Nat. Prod., 53, 1168 (1990).

    CAS  Google Scholar 

  265. Ahmad, V.U., N. Saba and S. Perveen: Structure of Guaianin M from Guaiacum officinale. Fitoterapia, 63, 226 (1992).

    CAS  Google Scholar 

  266. Yoshikawa, K., S. Arihara, K. Matsuura, and T. Miyase: Dammarane Saponins from Gymnema sylvestre. Phytochemistry, 31, 237 (1992).

    CAS  Google Scholar 

  267. Yoshikawa, K., K. Amimoto, S. Arihara, and K. Matsuura: Gymnemic Acid V, VI and VII from Gur-Ma, the Leaves of Gymnema sylvestre R. Br. Chem. Pharm. Bull., 37, 852 (1989).

    CAS  Google Scholar 

  268. Kiuchi, F., H.M. Liu, and Y. Tsuda: TWO New Gymnemic acid Congeners Containing a Hexulopyranoside Moiety. Chem. Pharm. Bull., 38, 2326 (1990).

    CAS  Google Scholar 

  269. Sahu, N.P., S.B. Mahato, S.K. Sarkar, and G. Poddar: Triterpenoid Saponins from Gymnema sylvestre. Phytochemistry, 41, 1181 (1993).

    Google Scholar 

  270. Yoshikawa, K., M. Nakagawa, R. Yamamoto, S. Arihara, and K. Matsuura: Antisweet Natural Products. V Structures of Gymnemic Acids VIII-XII from Gymnema sylvestre R. Br. Chem. Pharm. Bull., 40, 1779 (1992).

    CAS  Google Scholar 

  271. Yoshikawa, K., Y. Kondo, S. Arihara, and K. Matsuura: Antisweet Natural Products. IX. Structures of Gymnemic Acids XV-XVIII from Gymnema sylvestre R.Br.V. Chem. Pharm. Bull., 41, 1730 (1993).

    CAS  Google Scholar 

  272. Ding, S., and Z. Zhu: Gycomoside I: A New Dammarane Saponin from Gynostemma compressum. Planta Med., 59, 373 (1993).

    CAS  Google Scholar 

  273. Zhang, X., H. Zhang, W. Sun, and Z. Shan: Studies on the Saponin Constituents of Gynostemma longipes. Chin. Chem. Lett., 2, 221 (1991).

    CAS  Google Scholar 

  274. Piacente, S., C. Pizza, T.N. De, and S.F. De: New Dammarane-Type Glycosides from Gynostemma pentaphyllum. J. Nat. Prod., 58, 512 (1995).

    CAS  Google Scholar 

  275. Kuwahara, M., F. Kawanishi, T. Komiya, and H. Oshio: Dammarane Saponins of Gynostemma pentaphyllum Makino and Isolation of Malonylginsenosides-Rb1,-Rd, and Malonylgypenoside V. Chem. Pharm. Bull., 37, 135 (1989).

    CAS  Google Scholar 

  276. Elgamal, M.H.A., H.S.M. Soliman, M.S. Karawya, B. Mikhova, and H. Duddeck: Isolation of Triterpene Saponins from Gypsophila capillaris. Phytochemistry, 38, 1481 (1995).

    CAS  Google Scholar 

  277. Liu, Z., D. Li, N. Owen, D.M. Grant, R.G. Cates, and Z. Jia: Triterpenoid Saponins from Gypsophila oldhamiana. J. Nat. Prod., 58, 1632 (1995).

    CAS  Google Scholar 

  278. Frechet, D., B. Christ, B.M. Dusorbier, H. Fischer, and M. Vuilhorgne: Four Triterpenoid Saponins from Dried Roots of Gypsophila Species. Phytochemistry 30, 927 (1991).

    CAS  Google Scholar 

  279. Elias, R., A.M. Diaz-Lanza, E. Vidai-Ollivier, G. Balansard, R. Faure, and A. Babadjamian: Triterpenoid Saponins from the Leaves of Hedera helix. J. Nat. Prod., 54, 98 (1991).

    CAS  Google Scholar 

  280. Grishkovets, V.I., A.A. Loloiko, A.S. Shashkov, and V.Y. Chirva: Triterpene Glycosides of Hedera taurica. V. Structure of Hederosides C and E1 from Crimean Ivy Berries. Khim. Prir. Soedin., 230 (1990).

    Google Scholar 

  281. Babady-Bila, W.C., S. Toppet, A. Kilonda, and G. Hoornaert: TWO Triterpenoid Saponins from Heinsia crinata. Phytochemistry, 36, 1489 (1994).

    CAS  Google Scholar 

  282. Bader, G., M. Zieschang, K. Wagner, E. Gruendemann, and K. Hiller: New Triterpenoid Saponins from Helianthus annuus. Planta. Med., 57, 471 (1991).

    CAS  Google Scholar 

  283. Kasai, R., T. Tanaka, R.L. Nie, M. Miyakoshi, J. Zhou, and O. Tanaka: Saponins from Chinese Medicinal plant, Hemsleya graciliflora (Cucurbitaceae). Chem. Pharm. Bull., 38, 1320 (1990).

    CAS  Google Scholar 

  284. Schroeder, H., M. Schubert-Zsilavecz, G. Reznicek, J. Cart, J. Jurenitsch, and E. Haslinger: A Triterpene Saponin from Herniaria glabra. Phytochemistry, 34, 1609 (1993).

    CAS  Google Scholar 

  285. Tamamsch, B.G., D. Tuia, V. Wray, and K. Hiller: New Triterpenoid Saponins from Heteropappus altaicus (Willd.) Novopokr. and Heteropappus biennis (Ldb.) Tarn. Pharmazie, 49, 209 (1994).

    Google Scholar 

  286. Yoshikawa, K., Y. Nagai, M. Yoshida, and S. Arihara: Antisweet Natural Products. VIII. Structures of Hodulosides VII-X from Hovenia dulcis Thunb. Chem. Pharm. Bull., 41, 1722 (1993).

    CAS  Google Scholar 

  287. Dellagreca, M., A. Fiorentino, P. Monaco, and L. Previtera: Oleanane Glycosides from Hydrocotyle ranunculoids. Phytochemistry, 36, 1479 (1994).

    CAS  Google Scholar 

  288. Kakuno, T., K. Yoshikawa, and S. Arihara: Saponin from Ilex spp. Part 3. Triterpene Saponins from Fruit of Ilex crenata. Phytochemistry, 31, 2809 (1992).

    CAS  Google Scholar 

  289. Kakuno, T., K. Yoshikawa, and S. Arihara: Triterpenoid Saponins from Ilex crenata. Phytochemistry 31, 3553 (1992).

    CAS  Google Scholar 

  290. Hata, C., M. Kakuno, K. Yoshikawa, and S. Arihara: Triterpenoid Saponins of Aquifoliaceous Plants. V. Ilexosides XV-XIX from the Bark of Ilex crenata. Chem. Pharm. Bull., 40, 1990 (1992).

    CAS  Google Scholar 

  291. Kakuno, T., K. Yoshikawa, S. Arihara, M. Takei, and K. Endo: Ilexo-sides E, F, G, H and I, Novel 18,19-Seco-ursane Glycosides from Fruit of Ilex crenata. Tetrahedron, 47, 7219 (1991).

    CAS  Google Scholar 

  292. Heinzmann, B.M., and E.P. Schenkel: Saponins from Ilex dumosa. J. Nat. Prod., 58, 1419 (1995).

    CAS  Google Scholar 

  293. Yano, I., C. Nishizumi, K. Yoshikawa, and S. Arihara: Triterpenoid Saponins of Aquifoliaceous Plants. Part VII. Triterpenoid Saponins from Ilex integra. Phytochemistry, 32, 417 (1993).

    CAS  Google Scholar 

  294. Ouyang, M., C.R. Yang., Z. Chen, and H. Wang: Triterpenes and Triterpenoid Glycosides from the Leaves of Ilex kudincha. Phytochemistry, 41, 871 (1993).

    Google Scholar 

  295. Gosmann, G., D. Guilliaume, A.T.C. Taketa, E.P. Schenkel: Triterpenoid Saponins from Ilex paraguariensis. J. Nat. Prod., 58, 438 (1995).

    CAS  Google Scholar 

  296. Kraemer, K.H., A.T.C. Taketa, E.P. Schenkel, G. Gosmann, and D. Guilliaume: Matesaponin 5, a Highly Polar Saponin from Ilex paraguariensis. Phytochemistry, 42, 1119 (1993).

    Google Scholar 

  297. Amimoto, K., K. Yoshikawa, and S. Arihara: Triterpenoid Saponins of Aquifoliaceous plants. VIII. Ilexosides XXIX-XXXII from the Leaves of Ilex rotunda Thunb. Chem. Pharm. Bull., 40, 3138 (1992).

    CAS  Google Scholar 

  298. Amimoto, K., K. Yoshikawa, and S. Arihara: Triterpenoid Saponins of Aquifoliaceous Plants. XL Ilexosides XLI-XLV from the Leaves of Ilex rotunda Thunb. Chem. Pharm. Bull., 41, 39 (1993).

    CAS  Google Scholar 

  299. Amimoto, K., K. Yoshikawa, and S. Arihara: Triterpenoid Saponins of Aquifoliaceous Plants. XII. Ilexosides XLVI-LI from the Leaves of Ilex rotunda Thunb. Chem. Pharm. Bull., 41, 77 (1993).

    CAS  Google Scholar 

  300. Rumbero-Sanchez, A., and P. Vazquez: A Nor-triterpene Glycoside from Isertia haenkeana and A-13C NMR study of Cincholic Acid. Phytochemistry, 30, 623 (1991).

    CAS  Google Scholar 

  301. Della, G.M., A.J. Fiorentino, P. Monaco, and L. Previtera: Juncoside I, a New Cycloartane Lactone Glycoside from Juncus effusus. Nat. Prod. Lett., 4, 183 (1994).

    Google Scholar 

  302. Shao, C., R. Kasai, K. Ohtani, O. Tanaka, and H. Kohda: Saponins from Leaves of Kalopanax pictus (Thunb.). Nakai, Harigiri: Structures of Kalopanaxsaponins JLa and JLb. Chem. Pharm. Bull., 38, 1087 (1990).

    CAS  Google Scholar 

  303. Shao, C., R. Kasai, J.D. Xu, and O. Tanaka: Saponins from Roots of Kalopanax septemlobus (Thunb.). Koidz: Structures of Kalopanax saponins C, D, E and F. Chem. Pharm. Bull., 37, 311 (1989).

    CAS  Google Scholar 

  304. Shao, C., R. Kasai, K. Ohtani, J. Su, O. Tanaka: Saponins from leaves of Kalopanax septemlobus (Thunb.) Koidz. Structures of Kalopanax Saponins La, Lb and Lc. Chem. Pharm. Bull., 37, 3251 (1989).

    CAS  Google Scholar 

  305. Elujoba, A., F. Fell, P.A. Linley, and D.J. Maitland: Triterpenoid Saponins from Fruits of Legenaria breviflora. Phytochemistry, 29, 3281 (1990).

    CAS  Google Scholar 

  306. Mao, Q., and X.S. Jia: Chemical Constituents of Lonicera fulvotomentosa Hsu et S.C. Cheng. Yaoxue Xuebao, 24, 269 (1989).

    CAS  Google Scholar 

  307. Son, K.H., K.Y. Jung, H.W. Chang, H.P. Kim, and S.S. Kang: Triterpenoid Saponins from the Aerial Parts of Lonicera japonica. Phytochemistry, 35, 1005 (1994).

    CAS  Google Scholar 

  308. Hasan, M., D.K. Burdi, and V.U. Ahmad: Leucasin, a Triterpene Saponin from Leucas nutans. Phytochemistry, 30, 4181 (1991).

    CAS  Google Scholar 

  309. Nagao, T., R. Tanaka, Y. Iwase, H. Hanazono, and H. Okabe: Studies on the Constituents of Luffa acutangula Roxb.I. Structures of Acutosides A-G, Oleanane-type Triterpene Saponins Isolated from the Herb. Chem. Pharm. Bull., 39, 599 (1991).

    CAS  Google Scholar 

  310. Nagao, T., R. Tanaka, and H. Okabe: Studies on the Constituents of Luffa acutangula Roxb.II. Structures of Acutosides H and I, Oleanolic Acid Saponins isolated from the Seed. Chem. Pharm. Bull., 39, 889 (1991).

    CAS  Google Scholar 

  311. Yoshikawa, K., S. Arihara, J. Wang, T. Narui, and T. Okuyamo: Structures of Two New Fibrinolytic Saponins from the Seed of Luffa cylindrica Roem. Chem. Pharm. Bull., 39, 1185 (1991).

    Google Scholar 

  312. Kohda, H., O. Takeda, and S. Tanaka: Molluscicidal Triterpenoidal Saponin from Lysimachia sikokiana. Chem. Pharm. Bull., 37, 3304 (1989).

    CAS  Google Scholar 

  313. Nigam, S.K., X. Li, D. Wang, G. Misra, and C. Yng: Triterpenoid Saponins from Madhuca butyracea. Phytochemistry, 31, 3169 (1992).

    CAS  Google Scholar 

  314. Li, X., Y. Liu, D. Wang, C. Yang, S.K. Nigam, and G. Misra: Triterpenoid Saponins from Madhuca butyracea. Phytochemistry, 37, 827 (1994).

    CAS  Google Scholar 

  315. Sindambiwe, J.B., A.M. Balde, O. Bruyne, L. Pieters, H. Van Den Heuvel, M. Claeys, D.A. Van Den Berghe, and A.J. Vlietinck: Triterpenoid Saponins from Maesa lanceolata. Phytochemistry 41, 269 (1993).

    Google Scholar 

  316. Khan, M.N.I., S.S. Nizami, M.A. Khan, and Z. Ahmad: New Saponins from Mangifera indica. J. Nat. Prod., 56, 767 (1993).

    CAS  Google Scholar 

  317. De Tommasi, N.D., L. Rastrelli, J. Cumanda, G. Speranza, and C. Pizza: Aryl and Triterpenic Glycosides from Margyricarpus setosus. Phytochemistry, 42, 163 (1993).

    Google Scholar 

  318. Yaguchi, E., T. Miyase, and A. Ueno: Mazusaponins I-IV, Triterpene Saponins from Mazus miquelii. Phytochemistry, 39, 185 (1995).

    CAS  Google Scholar 

  319. Mahato, S.B.: Triterpenoid Saponins from Medicago hispida. Phytochemistry, 30, 3389 (1991).

    CAS  Google Scholar 

  320. Kinjo, J., H. Uemura, M. Nakamura, and T. Nohara: Leguminous Plants. XL. Two New Triterpenoidal Glycosides from Medicago polymorphe L. Chem. Pharm. Bull., 42, 1339 (1994).

    CAS  Google Scholar 

  321. Timbekova, A.E., A.L. Vereshchagin, A.A. Semenov, N.K. Abubakirov: Triterpene Glycosides of Alfalfa. VI. Medicoside L. Khim. Prir. Soedin. 221 (1990).

    Google Scholar 

  322. Oleszek, W., M. Jurzysta, M. Ploszynski, I.J. Colquhoun, K.R. Price, and G.R. Fenwick: Zahnic Acid Tridesmoside and Other Dominant Saponins from Alfalfa (Medicago sativa L.) Aerial Parts. J. Agric. Food. Chem., 40, 191 (1992).

    CAS  Google Scholar 

  323. Janeczko, Z., J. Sendra, K. Kmiec, and C.H. Brieskorn: A Triterpenoid Glycoside from Menyanthes trifoliata. Phytochemistry, 29, 3885 (1990).

    CAS  Google Scholar 

  324. Jiang, Y., G. Massiot, C. Lavaud, J.-M. Teulon, C. Guéchot, M. Haag-Berrurier, and R. Anton: Triterpenoid Glycosides from the Bark of Mimosa tenuiflora. Phytochemisty, 30, 2357 (1991).

    CAS  Google Scholar 

  325. Jiang, Y., M. Haag-Berrurier, R. Anton, G. Massiot, C. Lavaud, J.M. Teulon, and C. Guéchot: Structure of a New saponin from the Bark of Mimosa tenuiflora. J. Nat. Prod., 54, 1247 (1991).

    CAS  Google Scholar 

  326. Sahu, N.P., K. Koike, Z. Jia, and T. Nikaido: Novel Triterpenoid Saponins from Mimusops elengi. Tetrahedron, 51, 13435 (1995).

    CAS  Google Scholar 

  327. Sahu, N.P.: Triterpenoid Saponins of Mimusops elengi. Phytochemistry, 41, 883 (1993).

    Google Scholar 

  328. Lavaud, C., G. Massiot, M. Becchi, G. Misra, and S.K. Nigam: Saponins from Three Species of Mimusops. Phytochemistry, 41, 887 (1993).

    Google Scholar 

  329. Xu, J., R. Xu, Z. Luo, and J. Dong: New Triterpenoidal Saponins from Folk Contraceptive Medicine, Mussaenda pubescens. Huaxue Xuebao, 49, 621 (1991).

    CAS  Google Scholar 

  330. Zhao, W., J. Xu, G. Qin, R. Xu, H. Wu, and G. Weng: New Triterpenoid Saponins from Mussaenda pubescens. J. Nat. Prod., 57, 1613 (1994).

    CAS  Google Scholar 

  331. Zhao, W., J. Xu, G. Qin, and R. Xu: Saponins from Mussaenda pubescens. Phytochemistry, 39, 191 (1995).

    CAS  Google Scholar 

  332. Zhao, W., R. Xu, G. Qin, T. Vaisar and M.S. Lee: Saponins from Mussaenda pubescens. Phytochemistry 42, 1131 (1993).

    Google Scholar 

  333. Bloor, S.J., and L. Qi: Cytotoxic Saponins from New Zealand Myrsine Species. J. Nat. Prod., 57, 1354 (1994).

    CAS  Google Scholar 

  334. Lamidi, M., E. Ollivier, R. Faure, L. Debrauwer, L. Nze-Ekekang, and G. Balansard: Quinovic Acid Glycosides from Nauclea diderrichii. Phytochemistry, 38, 209 (1995).

    CAS  Google Scholar 

  335. Fujita, S., R. Kasai, K. Ohtani, K. Yamasaki, M. Chiu, R. Nie, and O. Tanaka: Dammarane Glycosides from Aerial Parts of Neoalsomitra integrifoliola. Phytochemistry, 38, 465 (1995).

    CAS  Google Scholar 

  336. Fujita, S., R. Kasai, K. Ohtani, K. Yamasaki, M. Chiu, R. Nie, and O. Tanaka: Dammarane Glycosides from Aerial Part of Neoalsomitra integrifoliola. Phytochemistry, 39, 591 (1995).

    CAS  Google Scholar 

  337. Chiu, M., R. Nie, H. Nagasawa, A. Isogai, J. Zhou, and A. Suzuki: A Dammarane Saponin from Neoalsomitra integrifoliola. Phytochemistry, 31, 2451 (1992).

    CAS  Google Scholar 

  338. Yu, S., Z. Xiao, P. Cai, T. Jiang, and J.K. Snyder: A new Triterpenoid Saponin from the Chinese Traditional Medicine Nothopanax davidii Harms (Araliaceae). Tetrahedron, 50, 11601 (1994).

    CAS  Google Scholar 

  339. Yu, S.S., D.Q. Yu, and X.T. Liang: Triterpenoid Saponins from the Bark of Nothopanax davidii. Phytochemistry, 38, 695 (1995).

    CAS  Google Scholar 

  340. Crespin, F., E. Ollivier, C. Lavaud, A. Babadjamian, R. Faure, L. Debrauwer, G. Balansard, and G. Boudon: Triterpenoid Saponins from Opilia celtidifolia. Phytochemistry 33, 657 (1993).

    CAS  Google Scholar 

  341. Sun, R., and Z. Jia: A Triterpenoid Saponin from Oxytropis bicolor. Phytochemistry, 30, 3480 (1991).

    CAS  Google Scholar 

  342. Sun, R., and Z. Jia: Saponins from Oxytropis glabra. Phytochemistry, 29, 2032 (1990).

    CAS  Google Scholar 

  343. Sun, R., Z. Jia, and Z. Zhu: Chemical Constituents of Oxytropis glabra. Chin. Sci. Bull., 34, 609 (1989).

    CAS  Google Scholar 

  344. Sun, R., Z. Jia, and D. Cheng: Three Saponins from Oxytropis Species. Phytochemistry, 30, 2707 (1991).

    CAS  Google Scholar 

  345. Lee, S.S., W.C. Su, and K.C. Liu: Two New Triterpene Glucosides from Paliurus ramosissimus. J. Nat. Prod., 54, 615 (1991).

    CAS  Google Scholar 

  346. Zhao, Y.Q., L.J. Wu, C.L. Yuan, X. Li, and Y.J. Chen: A New Triterpene Saponin from the Stems and Leaves of Panax ginseng. Chin. Chem. Lett., 3, 887 (1992).

    CAS  Google Scholar 

  347. Kim, D., Y. Cheng, U. Zedk, P. Zhao, Y Liu, and . Yang: Dammarane Saponins from Panax ginseng. Phytochemistry, 40, 1493 (1995).

    CAS  Google Scholar 

  348. Zhao, P., Y. Liu, and C. Yang: Minor Constituents from the Roots of Panax notoginseng. Yunnan Zhiwu Yanjiu, 15, 409 (1993).

    CAS  Google Scholar 

  349. Zhao, P., Y.Q. Liu, and C. Yang: Minor Dammarane saponins from Panax notoginseng. Phytochemistry, 41, 1419 (1993).

    Google Scholar 

  350. Kohda, H., S. Tanaka, Y. Yamaoka, H. Izumi, M. Nuno, S. Isoda, K. Gotoh, T. Watanabe, S. Katsuki, and M. Satake: Chikusetsusaponin. VI. A New Saponin from the Rhizome of Panax pseudo-ginseng var. angustatus. Chem. Pharm. Bull., 39, 1588 (1991).

    CAS  Google Scholar 

  351. Shukla, Y.N., and R.S. Thakur: Studies on Indian ginseng. Part 9. A Triterpenoid Saponin from Panax pseudoginseng subsp. hemalaicus var. angustifolium. Phytochemistry, 29, 239 (1990).

    CAS  Google Scholar 

  352. Shukla, Y.N., R.S. Thakur, and P. Pachaly: Studies on Indian Ginseng. Part 13. A Bidesmosidic Oleanolic Acid Saponin from Panax pseudo-ginseng. Phytochemistry, 31, 1046 (1992).

    CAS  Google Scholar 

  353. Nguyen, M.D., T.N. Nguyen, R. Kasai, A. Ito, K. Yamasaki, and O. Tanaka: Saponins from Vietnamese Ginseng Panax vietnamensis Ha et Grushv. Collected in Central Vietnam. I. Chem. Pharm. Bull., 41, 2010 (1993).

    CAS  Google Scholar 

  354. Nguyen, M.D., R. Kasai, K. Ohtani, A. Ito, T.N. Nguyen, K. Yamasaki, and O. Tanaka: Saponins from Vietnamese Ginseng Panax vietnamensis Ha et Grushv. Collected in Central Vietnam. II. Chem. Pharm. Bull., 42, 115 (1994).

    CAS  Google Scholar 

  355. Nguyen, M.D., R. Kasai, K. Ohtani, A. Ito, T. Nguyen, K. Yamasaki, and O. Tanaka: Saponins from Vietanamese Ginseng Panax vietnamensis Ha et Grushv. Collected in Central Vietnam. III. Chem. Pharm. Bull., 42, 634 (1994).

    Google Scholar 

  356. Ikeda, Y., M. Sugiura, C. Fukaya, K. Yokoyama, Y. Hashimoto, K. Kawa-Nishi, and M. Moriyasu: Poriandradulcins A,B and C: Phosphodiesterase Inhibitors from Periandra dulcis Mart. Chem. Pharm. Bull., 39, 566 (1991).

    CAS  Google Scholar 

  357. Massiot, G., X.-F. Chen, C. Lavaud, L. Le Men-Olivier, C. Delaude, A. Viari, P. Vigny, and J. Duval: Saponins from Stem Bark of Petersianthus macrocarpus. Phytochemistry, 31, 3571 (1992).

    CAS  Google Scholar 

  358. Jain, D.C., P.K. Agrawal, and R.S. Thakur: Phaseoluside-A, a New Soyasapogenol B Triglucoside from Phaseolus vulgaris Seeds. Planta Med., 57, 94 (1991).

    CAS  Google Scholar 

  359. Yoshiki, Y., J. Kim, and K. Okubo: Saponins Conjugated with 2,3,-Dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one from Phaseolus cocineus. Phytochemistry, 36, 1009 (1994).

    CAS  Google Scholar 

  360. Spengel, S., and W. Schaffner: Esculentoside S, a New Saponin from the Leaves of Phytolacca acinosa. Nat. Prod. Lett., 2, 243 (1993).

    CAS  Google Scholar 

  361. Nielsen, S.E., U. Anthoni, C. Christophersen, and C. Cornett: Triterpenoid Saponins from Phytolacca rivinoides and Phytolacca bogotensis: Phytochemistry, 39, 625 (1995).

    CAS  Google Scholar 

  362. Thiiborg, S.T., S. Broegger Christensen, C. Cornett, C.E. Olsen, and E. Lemmich: Molluscicidal Saponins from a Zimbabwean Strain of Phytolacca dodecandra. Phytochemistry 36, 753 (1994).

    Google Scholar 

  363. Yi, Y: A Triterpenoid Saponin from Phytolacca esculenta. Phytochemistry, 31, 2552 (1992).

    CAS  Google Scholar 

  364. Yi, Y: Two New Saponins from the Roots of Phytolacca esculenta. Planta Med., 58, 99 (1992).

    CAS  Google Scholar 

  365. Yi, Y., and F. Dai: A New Triterpenoid and Its Glycoside from Phytolacca esculenta. Planta. Med., 57, 162 (1991).

    CAS  Google Scholar 

  366. Yi, Y.: Esculentoside L and K: Two New Saponins from Phytolacca esculenta. Planta. Med., 56, 301 (1990).

    CAS  Google Scholar 

  367. Yi, Y.H., and X. Huang: Isolation and Identification of Three New Saponins from Shanglu (Phytolacca esculenta). Yaoxue Xuebao, 25, 745 (1991).

    CAS  Google Scholar 

  368. Seiji, T., T. Takagi, and T. Hashimoto: A γ-Pyronyl-triterpenoid Saponin from Pisum sativum. Phytochemistry, 31, 2435 (1992).

    Google Scholar 

  369. Reznicek, G., H. Schroeder, M. Schubert-Zsilavecz, T.H. Schöpke, S. Lehrkinder, E. Haslinger, K. Hiller, J. Jurenitsch, and W. Kubelka: Polemonium caeruleum L.; the Main Saponins of Lower Polarity. Pharmazie, 49, 58 (1994).

    CAS  Google Scholar 

  370. Bhandari, S.P.S., P.K. Agarwal, and H.S. Garg: A Triterpenoid Saponin from Polycarpone Loeflingiae. Phytochemistry, 29, 3889 (1990).

    CAS  Google Scholar 

  371. Zhang, D., T. Miyase, M. Kuroyanagi, K. Umehara, and A. Ueno: Studies on the Constituents of Polygala japonica Houtt. I. Structures of Polygalasaponins I-X. Chem. Pharm. Bull., 43, 115 (1995).

    CAS  Google Scholar 

  372. Zhang, D., T. Miyase, M. Kuroyanago, K. Umehara, and A. Ueno: Studies on the Constituents of Polygala japonica. Houtt.II. Structures of Polygalasaponins XI-XIX. Chem. Pharm. Bull., 43, 966 (1995).

    CAS  Google Scholar 

  373. Miyase, T., H. Saitoh, K. Shiokawa, and A. Ueno: Six New Presenegenin Glycosides, Reiniosides A-F, from Polygala reini Root. Chem. Pharm. Bull., 43, 466 (1995).

    CAS  Google Scholar 

  374. Gopal Samy, N., J. Gueho, H.R. Julien, A.W. Owadally, and K. HOSTETTMANN: Molluscicidal Saponins of Polyscias dichroostachya. Phytochemistry, 29, 793 (1990).

    CAS  Google Scholar 

  375. Paphassarang, S., J. Raynaud, M. Lussignol, and M. Becchi: Triterpenic Glycosides from Polyscias Scutellaria. Phytochemistry 28, 1539 (1989).

    CAS  Google Scholar 

  376. Paphassarang, S., J. Raynaud, M. Lussignol, and M. Becchi: Triterpenoid Saponins from Polyscias Scutellaria. J. Nat. Prod., 52, 239 (1989).

    CAS  Google Scholar 

  377. Bilia, A.R., E. Palme, S. Catalano, G. Flamine, and I. Morelli: New Triterpenoid Saponins from the Roots of Potentilla tormentilla. J. Nat. Prod., 57, 333 (1994).

    CAS  Google Scholar 

  378. Ahmad, V.U., V. Sultana, and Q.N. Saqib: Triterpenoid Saponins from Primula denticulata. Planta. Med., 56, 94 (1990).

    CAS  Google Scholar 

  379. Ahmad, V. U., M.G. Shah, F.V. Mohammad, and F.T. Baqai: Macrophyllicin, a Saponin from Primula macrophylla. Phytochemistry, 32, 1543 (1993).

    CAS  Google Scholar 

  380. Ahmad, V.U., and M.G. Shah: Macrophyllicinin, a Saponin from Primula macrophylla. J. Nat. Prod., 56, 1580 (1993).

    CAS  Google Scholar 

  381. Calis, I., A. Yuruker, H. Ruegger, A.D. Wright, and O. Sticher: Triterpene Saponins from Primula veris subsp. macrocalyx and Primula elatior subsp. meyeri. J. Nat. Prod., 55, 1299 (1992).

    CAS  Google Scholar 

  382. Tian, J., F. Wu, M. Qiu, and R. NIE: TWO Triterpenoid Saponins from Pterocephalus bretschneidri. Phytochemistry, 32, 1539 (1993).

    CAS  Google Scholar 

  383. Tian, J., F. Wu, M. Qiu, and R. Nie: Triterpenoid Saponins from Pterocephalus hookeri. Phytochemistry, 32, 1535 (1993).

    CAS  Google Scholar 

  384. Kang, S.S.: Saponin from the Roots of Pulsatilla koreana. Arch. Pharmacol. Res., 12, 42 (1989).

    CAS  Google Scholar 

  385. Sotheesawaran, S., M. Bokel, and W. Kraus: A Hemolytic Saponin, Randianin, from Randia dumetorum. Phytochemistry, 28, 1544 (1989).

    Google Scholar 

  386. Dubois, M.A., S. Benze, and H. Wagner: New Biologically Active Triterpene Saponins from Randia dumetorum. Planta. Med., 56, 451 (1990).

    CAS  Google Scholar 

  387. Ohtani, K., C. Miyajima, T. Takahasi, R. Kasai, O. Tanaka, D.R. Hahn, and N. Naruhashi: A Dimeric Triterpene Glycoside from Rubus coreanus. Phytochemistry, 29, 3275 (1990).

    CAS  Google Scholar 

  388. Kinjo, J., F. Kishida, K. Watanabe, F. Hashimoto, and T. Nohara. Leguminous plants. XLII. Five New Triterpene Glycosides from Russell Lupine. Chem. Pharm. Bull., 42, 1874 (1994).

    CAS  Google Scholar 

  389. Jia, Z., X. Liu, and Z. Liu: Triterpenoids from Sanguisorba alpina. Phytochemistry, 32, 155 (1993).

    Google Scholar 

  390. Pancharoen, O., P. Tuntiwachwuttikul, W.C. Taylor, and K. Picker: Triterpenoid Glycosides from Schefflera lucantha. Phytochemistry, 35, 987 (1994).

    CAS  Google Scholar 

  391. Maeda, C., K. Ohtani, R. Kasai, K. Yamasaki, N.M. Due, N.T. Nham, and G.K.Q. Cu: Oleanane and Ursane Glycosides from Schefflera octophylla. Phytochemistry, 37, 1131 (1994).

    CAS  Google Scholar 

  392. Sung, T.V., C. Lavaud, A. Porzel, W. Steglich, and G. Adam: Triterpenoids and their Glycosides from the Bark of Schefflera octophylla. Phytochemistry, 31, 227 (1992).

    CAS  Google Scholar 

  393. Sung, T.V., W. Steglich, and G. Adam: Triterpene Glycosides from Schefflera octophylla. Phytochemistry, 30, 2349 (1991).

    CAS  Google Scholar 

  394. Sung, T.V., and G. Adam: A Sulfated Triterpenoid Saponin from Schefflera octophylla. Phytochemistry, 30, 2717 (1991).

    CAS  Google Scholar 

  395. Sung, T.V., J. Peter-Katalinic, and G. Adam: A Bidesmosidic Triterpenoid Saponin from Schefflera octophylla. Phytochemistry, 30, 3717 (1991).

    CAS  Google Scholar 

  396. Tran, V.S., and G. Adam: An Acetylated Bidesmosidic Saponin from Schefflera octophylla. J. Nat. Prod., 55, 503 (1992).

    CAS  Google Scholar 

  397. Purohit, M.C., G. Pant, and M.S.M. Rawat: A Betulinic Acid Glycoside from Schefflera venulosa. Phytochemistry, 30, 2419 (1991).

    CAS  Google Scholar 

  398. Calis, I., M. Zor, A.A. Basaran, A.D. Wright, and O. Sticher: Ilwensisaponins A, B, C and D: Triterpene Saponins from Scrophularia ilwensis. Helv. Chim. Acta., 76, 1352 (1993).

    CAS  Google Scholar 

  399. Bhandari, S.P.S., R. Roy, P.K. Agrawal, and H.S. Garg: Scrokoelziside A, a Triterpene Glycoside from Scrophularia koelzii. Phytochemistry, 41, 879 (1993).

    Google Scholar 

  400. Potterat, O., K. Hostettmann, H. Stoeckli-Evang, and M. Saadou: Saponins with an Unusual Secoursene Skeleton from Sesamum alatum Thonn. Helv. Chim. Acta, 75, 883 (1992).

    Google Scholar 

  401. Jiang, Y., A.O. Ali, D. Guillaume, B. Weniger, and R. Anton: Triterpenoid Saponins from the Root of Sideroxylon cubense. Phytochemistry, 35, 1013 (1994).

    CAS  Google Scholar 

  402. Nicolas, G., A. Ouland-Ali, D. Guillaume, A. Lobstein, B. Weniger, and R. Anton: Triterpenoid Saponins from the Root of Sideroxylon foetidissimum. Phytochemistry, 38, 225 (1995).

    CAS  Google Scholar 

  403. Lacille-Dubois, M., B. Hanquet, Z. Cui, Z. Lou, and H. Wagner: Acylated Triterpene Saponins from Silene jenisseensis. Phytochemistry, 40, 509 (1995).

    Google Scholar 

  404. Reznicek, G., J. Jurenitsch, M. Plasun, S. Korhammer, E. Haslinger, K. Hiller, and W. Kubelka: Four Major Saponins from Solidago canadensis. Phytochemistry, 30, 1629 (1991).

    CAS  Google Scholar 

  405. Reznicek, G., W. Kubelka, J. Jurenitsch, G. Michl, and E. Haslinger: Structure elucidation of a Saponin from Solidago gigantea. Bull. Magn. Reson., 11, 402 (1989).

    CAS  Google Scholar 

  406. Reznicek, G., J. Jurenitsch, G. Michl, and E. Haslinger: The First Structurally Confirmed Saponin from Solidago gigantea. Structure Elucidation by Modern NMR Techniques. Tetrahedron Lett., 30, 4097 (1989).

    CAS  Google Scholar 

  407. Bader, G., V. Wray, and K. Hiller: Virgaureasaponin 3, a 3,28-Bisdesmosidic Triterpenoid Saponin from Salidago virgaurea. Phytochemistry, 31, 621 (1992).

    CAS  Google Scholar 

  408. Inose, Y., T. Miyase, and A. Ueno: Studies on the Constituents of Solidago virgaaurea L. II. Structures of Solidagosaponins X-XX. Chem. Pharm. Bull., 40, 946 (1992).

    CAS  Google Scholar 

  409. Miyase, T., Y. Inose, and A. Ueno: Studies on the Constituents of Solidago Virgaurea L. III. Structures of Solidagosaponins XXI-XXIX. Chem. Pharm. Bull., 42, 617 (1994).

    CAS  Google Scholar 

  410. Ding, Y., R. Tian, J. Kinjo, T. Nohara, and I. Kitagawa: Constituents of Leguminous Plants. XXXIII. Three New Oleanene Glycosides from Sophora flavescens. Chem. Pharm. Bull., 40, 2990 (1992).

    CAS  Google Scholar 

  411. Bilia, A.R., F. Flamini, G. Flamini, I. Morelli, and A. Marsili: Flavonoids and a Saponin from Apartium junceum. Phytochemistry, 34, 847 (1993).

    CAS  Google Scholar 

  412. Yamamoto, R., T. Miyase, and A. Ueno: Stachyssaponins I-VIII, New Oleanane-type Triterpene Saponins from Stachys riederichamisso. Chem. Pharm. Bull., 42, 1291 (1994).

    CAS  Google Scholar 

  413. Wang, H.B., D.Q. Yu, and X. Liang: Yemuoside I, a New Nor-triterpenoid glycoside from Stauntonia chinensis. J. Nat. Prod., 54, 1097 (1991).

    CAS  Google Scholar 

  414. Wang, H., D. Yu, X. Liang, N. Watanabe, M. Tamai, and S. Omura: Yemuoside YM7, YM11, YM13 and YM14: Four Nortriterpenoid Saponins from Stauntonia chinensis. Planta. Med., 55, 303 (1989).

    CAS  Google Scholar 

  415. Wang, H., D. Yu, X. Liang, N. Watanabe, M. Tamai, and S. Omura: Structures of Two Nortriterpenoid Saponins from Stauntonia chinensis. J. Nat. Prod., 53, 313 (1990).

    CAS  Google Scholar 

  416. Wang, H.B., D.Q. Yu, X.T. Liang, N. Watanabe, M. Tamai, and S. Omura: The Structures of Yamuoside YM10 and YM12 from Stauntonia chinensis. Yaoxue Xuebao, 24, 444 (1989).

    CAS  Google Scholar 

  417. Wang, H.B., R. Mayer, and G. Ruecker: Triterpenoid Glycosides from Stauntonia hexaphylla. Phytochemistry, 33, 1496 (1993).

    Google Scholar 

  418. Wang, H.B., R. Mayer, and G. Ruecker: Triterpenoid Glycosides from Stauntonia hexaphylla. Phytochemistry, 34, 1389 (1993).

    CAS  Google Scholar 

  419. Lavaud, C., G. Massiot, L. Le Men-Olivier, A. Viari, P. Vigny, and C. Delaude: Saponins from Steganotaenia araliacea. Phytochemistry, 31, 3177 (1992).

    CAS  Google Scholar 

  420. Yoshikawa, K., H. Taninaka, Y. Kan, and S. Arihara: Antisweet Natural Products. X. Structures of Sitakisoside I-V from Stephanotis lutchuensis Koidz, var. japonica. Chem. Pharm. Bull., 42, 2023 (1994).

    CAS  Google Scholar 

  421. Ahmad, V.U., M. Noorwala, F.V. Mohammad, B. Sener, A.H. Gilani, and K. Aftab: Symphytoxide A, a Triterpenoid Saponin from the Roots of Symphytum officinale. Phytochemistry, 32, 10003 (1993).

    Google Scholar 

  422. Mohammad, F.V., M. Noorwala, V.U. Ahmad, and B. Sener: A Bidesmosidic Hederagenin Hexasaccharide from the Roots of Symphytum officinale. Phytochemistry, 40, 213 (1995).

    CAS  Google Scholar 

  423. Ahmad, V.U., M. Noorwala, F.V. Mohammad, and B. Sener: A New Triterpene Glycoside from the Roots of Symphytum officinale. J. Nat. Prod., 56, 329 (1993).

    CAS  Google Scholar 

  424. Noorwala, M., F.V. Mohammad, V.U. Ahmad, and B. Sener: A Bidesmosidic Triterpene Glycoside from the Roots of Symphytum officinale. Phytochemistry, 36, 439 (1994).

    CAS  Google Scholar 

  425. Ahmad, V.U., F.V. Mohammad, M. Noorwala, and B. Sener: A New Bidesmosidic Triterpenoidal Saponin from the Roots of Symphytum officinale. Planta Med., 59, 461 (1993).

    CAS  Google Scholar 

  426. Mahato, S.B., A.K. Nandy, and A.P. Kundu: Pentacyclic Triterpenoid Sapogenols and Their Glycosides from Terminalia bellerica. Tetrahedron, 48, 2483 (1992).

    CAS  Google Scholar 

  427. Nandy, A.K., G. Podder, N.P. Sahu, and S.B. Mahato: Triterpenoids and Their Glucosides from Terminalia bellerica. Phytochemistry, 28, 2769 (1989).

    CAS  Google Scholar 

  428. Kundu, A.P., and S.B. Mahato: Triterpenoids and Their Glycosides from Terminalia chebula. Phytochemistry, 32, 999 (1993).

    CAS  Google Scholar 

  429. Maillard, M., C.O. Adewunmi, and K. Hostettmann: A Triterpene Glycoside from the Fruits of Tetrapleura tetraptera. Phytochemistry, 31, 1321 (1992).

    CAS  Google Scholar 

  430. Yoshimitsu, H., K. Hayashi, M. Kumabe, and T. Nohara: Cycloartane Type Glycosides from Thalictri herba. Phytochemistry, 38, 939 (1995).

    CAS  Google Scholar 

  431. Yi, Y., and Z. Wu: A New Triterpene Glycoside of Thalictrum foeniculaceum. Zhongguo Yaoxue Daxue Xuebao, 22, 270 (1991).

    CAS  Google Scholar 

  432. Yoshimitsu, H., K. Hayashi, K. Shingu, J. Kinjo, S. Yahara, K. Nakano, K. Murakami, T. Tomimatsu, and T. Nohara: TWO New Cycloartane Glycosides, Thalictoside A and C from Thalictrum thunbergii D.C. Chem. Pharm. Bull., 40, 2465 (1992).

    CAS  Google Scholar 

  433. Schenkel, E.P., W. Werner, and K.E. Schulte: Saponins from Thinouia coriaceae. Planta. Med., 57, 463 (1991).

    CAS  Google Scholar 

  434. Nagao, T., H. Okabe, K. Mihashi, and T. Yamauchi: Studies on the Constituents of Thladiantha dubia Bunge. I. The Structures of Dubiosides A, B and C, the Quillaic Acid Glucuronide Saponins Isolated From the Tuber. Chem. Pharm. Bull., 37, 925 (1989).

    CAS  Google Scholar 

  435. Nagao, T., R. Tanaka, H. Okabe, and T. Yamauchi: Studies on the Constituents of Thladiantha dubia Bunge. II. Structures of Dubiosides D, E, and F, Neutral Saponins of Quillaic acid Isolated from the Tuber. Chem. Pharm. Bull., 38, 378 (1990).

    CAS  Google Scholar 

  436. Nie, R., T. Tanaka, M. Miyakoshi, R. Kasai, T. Morita, J. Zhou, and O. Tanaka: A Triterpenoid Saponin from Thladiantha hookeri var. pentadactyla. Phytochemistry, 28, 1711 (1989).

    CAS  Google Scholar 

  437. Miyase, T., H. Kohsaka, and A. Ueno: Tragopogonosides A-I, Oleanane Saponins from Tragopogon pratensis. Phytochemistry, 31, 2087 (1992).

    CAS  Google Scholar 

  438. Massiot, G., C. Lavaud, C. Delaude, G. Van Binst, S.P.F. Miller, and H.M. Fales: Saponins from Tridesmostemon claessenssi. Phytochemistry, 29, 3291 (1990).

    CAS  Google Scholar 

  439. Mohamed, K.M., K. Ohtani, R. Kasai, and K. Yamasaki: Oleanene Glycosides from Seeds of Trifolium alexandrium. Phytochemistry, 40, 1237 (1995).

    CAS  Google Scholar 

  440. Sakamoto, S., S. Kofuji, M. Kuroyanagi, A. Ueno, and S. Sekita: Saponins from Trifolium repens. Phytochemistry, 31, 1773 (1992).

    CAS  Google Scholar 

  441. Ma, W., D. Wang, Y. Zeng, and C. Yang: Three Triterpenoid Saponins from Triplostegia grandiflora. Phytochemistry, 30, 3401 (1991).

    CAS  Google Scholar 

  442. Yepez P.A.M., O.L. De Ugaz, C.M. Alvarez A, V. De Feo, R. Aquino, F. De Simone, and C. Pizza: Quinovic Acid Glycosides from Uncaria guianensis. Phytochemistry, 30, 1635 (1991).

    CAS  Google Scholar 

  443. Klimek, B., C. Lavaud, and G. Massiot: Saponins from Verbascum nigrum. Phytochemistry, 31, 4368 (1992).

    CAS  Google Scholar 

  444. Seiferi, K., A. Preiss, S. Johne, N.T. Juergen Lien, C. Lavaud, and G. Massiot: Triterpene Saponins from Verbascum songaricum. Phytochemistry, 30, 3395 (1991).

    Google Scholar 

  445. Hartleb, I., and K. Seifert: Songarosaponin D — a Triterpenoid Saponin from Verbascum songaricum. Phytochemistry, 35, 1009 (1994).

    CAS  Google Scholar 

  446. Hartleb, I., and K. Seifert: Triterpenoid Saponins from Verbascum songaricum. Phytochemistry, 38, 221 (1995).

    CAS  Google Scholar 

  447. Vasanth, S., A.B. Kundu, S.K. Panda, and A. Patra: Vicoside A, a 28-Nortriterpenoid Glucoside from Vicoa indica. Phytochemistry, 30, 3053 (1991).

    CAS  Google Scholar 

  448. Govindachari, T.R., and M.S. Premila: Triterpenoid Saponins from Wedelia calendulaceae Less. Indian J. Chem. Sect. B., 30B, 466 (1991).

    CAS  Google Scholar 

  449. Konoshima, T., M. Kozuka, M. Haruna, K. Ito, T. Kimura, and H. Tokuda: Studies on the Constituents of Leguminous Plants XII. The Structures of New Triterpenoid Saponins from Wistaria brachybotrys Sieb. et Zucc. Chem. Pharm. Bull., 37, 2731 (1989).

    CAS  Google Scholar 

  450. Kinjo, J., Y. Fujishima, K. Saino, R. Tian, and T. Nohara: Leguminous Plants. XLV. Five New Triterpene Glycosides from Wistaria brachybotrys (Leguminosae). Chem. Pharm. Bull., 43, 636 (1995).

    CAS  Google Scholar 

  451. Konoshima, T., M. Kozuka, M. Haruna, and K. Ito: Constituents of Leguminous Plants, XIII. New Triterpenoid Saponins from Wistaria brachybotrys. J. Nat. Prod., 54, 830 (1991).

    CAS  Google Scholar 

  452. Yoshikawa, K., N. Shimono, and S. Arihara: Antisweet Natural Products, VI. Jujubasaponins IV, V and VI from Zizyphus jujuba Mill. Chem. Pharm. Bull., 40, 2275 (1992).

    CAS  Google Scholar 

  453. Hassanean, H.A., M.M.A. El-Hamouly, S.A. El-Moghazy, and D.W. Bishay: 14-Decarboxyquinovic and Quinovic Acid Glycosides from Zygophyllum album. Phytochemistry, 33, 667 (1993).

    CAS  Google Scholar 

  454. Hassanean, H.H., E.K. Desoky, and M.M.A. El-Hamouly: Quinovic Acid Glycosides from Zygophyllum album. Phytochemistry, 33, 663 (1993).

    CAS  Google Scholar 

  455. Elgamal, M.H.A., K.H. Shaker, K. Poellmann, and K. Seifert: Triterpenoid Saponins from Zygophyllum Species. Phytochemistry, 40, 1233 (1995).

    CAS  Google Scholar 

  456. Ahmad, V.U., U.S. Ghazala, and S. Bano: Saponins from Zygophyllum propinquum. J. Nat. Prod., 53, 1193 (1990).

    CAS  Google Scholar 

  457. Ahmad, V.U., and U.S. Ghazala: A Triterpenoid Saponin from Zygophyllum propinquum. Phytochemistry, 31, 1051 (1992).

    CAS  Google Scholar 

  458. Ahmad, V.U., U.S. Ghazala, and S.M. Aki: Saponins from Zygophyllum propinquum. Phytochemistry, 33, 453 (1993).

    CAS  Google Scholar 

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Mahato, S.B., Garai, S. (1998). Triterpenoid Saponins. In: Herz, W., Kirby, G.W., Moore, R.E., Steglich, W., Tamm, C. (eds) Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 74. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6496-9_1

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