Zusammenfassung
Neben den häufig replizierten Befunden zu Erweiterungen der inneren und äußeren Liquorräume bei Schizophrenen stehen heute Untersuchungen an limbischen Strukturen, am Thalamus, zur kortikalen Architektur, an den Basalganglien sowie Befunde einer gestörten kortikalen Strukturasymmetrie im Zentrum des Interesses.
Dieser Beitrag ist ein Ausschnitt eines umfangreicheren Kapitels „Funktionell-neuro-anatomische und neuropathologische Grundlagen psychischer Erkrankungen“, das vom Autor im „Handbuch für Psychiatrie“ (Hrsg. Möller, Laux, Kapfhammer) publiziert wird
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Akbarian S, Kim JJ, Potkin SG, Hetrick WP, Bunney WE, Jones EG (1996) Maldistribution of interstitial neurons in the prefrontal white matter of the brains of schizophrenics. Arch Gen Psychiatry 53: 425–436
Akil M, Lewis DA (1997) Cytoarchitecture of the entorhinal cortex in schizophrenia. Am J Psychiatry 154: 1010–1012
Amato T, Rochet T, Dalery J, Chauchat JH, Martin JP, Marie-Cardine M (1994) Seasonality of birth and ventricular enlargement in chronic schizophrenia. Psychiatry Res (Neuroimaging) 55: 65–73
Arnold SE, Hyman BT, VanHösen GW, Damasio AR (1991) Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry 48: 625–632
Bachus SE, Kleinman JE (1996) The neuropathology of schizophrenia. J Clin Psychiatry 57[Suppl 11]: 72–83
Benes FM, Bird ED (1987) An analysis of the arrangement of neurons in the cingulate cortex of schizophrenic patients. Arch Gen Psychiatry 44: 608–616
Bilder RM, Wu H, Bogerts B, Degreef G, Ashtari M, Alvier JM, Snyder P, Lieberman J (1994) Absence of regional hemispheric volume asymmetries in first episode schizophrenia. Am J Psychiatry 151: 1437–1447
Bogerts B (1991) The neuropathology of schizophrenia: pathophysiological and neuro-developmental implications. In: Mednick SA, Cannon TD, Barr CE (eds) Fetal neural development and adult schizophrenia. Cambridge University Press, pp 153–173
Bogerts B (1993) Recent advances in the neuropathology of schizophrenia. Schizophr Bull 19: 431–445
Bogerts B (1995) Hirnstrukturelle Untersuchungen an schizophrenen Patienten. In: Lieb K, Riemann D, Berger M (Hrsg) Biologisch-psychiatrische Forschung — Ein Überblick. Fischer, Stuttgart, S 123–144
Bogerts B (1997) The temporolimbic system theory of positive schizophrenic symptoms. Schizophr Bull 23: 423–435
Bogerts B, Lieberman J (1993) Neuropathology in the study of psychiatric disease. In: Costa e Silva ACJ, Nadelson CC (eds) International review of psychiatry, vol 1. American Psychiatric Press, Washington, pp 515–555
Cannon TD, Mednick SA, Parnas J, Schulsinger F, Praestholm J, Vestergaard A (1993) Developmental brain abnormalities in the offspring of schizophrenic mothers. I. Contribution of genetic and perinatal factors. Arch Gen Psychiatry 50: 551–564
Chakos MH, Lieberman JA, Bilder RM, Borenstein M, Lerner G, Bogerts B, Wu H, Kinon B, Ashtari M (1994) Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs. Am J Psychiatry 151: 1430–1436
Crow TJ (1990) Temporal lobe asymmetries as the key to the etiology of schizophrenia. Schizophr Bull 16(3): 434–443
Crow TJ (1993) Schizophrenia as an anomaly of cerebral asymmetry. In: Maurer K (ed) Imaging of the brain in psychiatry and related fields. Springer, Berlin Heidelberg New York Tokyo, pp 2–17
Degreef G, Bogerts B, Falkai P, Greve B, Lantos G, Ashtari M, Lieberman J (1992a) Increased prevalence of the cavum septum pellucidum in MRI scans and postmortem brains of schizophrenic patients. Psychiatry Res Neuroimaging 45: 1–13
Degreef G, Ashtari M, Bogerts B, Bilder RM, Jody DN, Alvir JMJ, Lieberman JA (1992b) Volumes of ventricular system subdivisions measured from magnetic resonance images in first episode schizophrenic patients. Arch Gen Psychiatry 49: 531–537
Falkai P, Bogerts B, Rozumek M (1988a) Cell loss and volume reduction in the entorhinal cortex of schizophrenics. Biol Psychiatry 24: 515–521
Falkai P, Bogerts B, Roberts GW, Crow TJ (1988b) Measurement of the alpha-cell-migration in the entorhinal region: a marker for developmental disturbances in schizophrenia? Schizophr Res 1: 157–158
Falkai P, Schneider T, Greve B, Klieser E, Bogerts B (1995) Reduced frontal and occipital lobe asymmetry on CT-scans of schizophrenic patiens. Its specifity and clinical significance. J Neural Transm [GenSect] 99: 63–77
Geddes JR, Lawrie S (1995) Obstetric complications and schizophrenia. A meta-analysis. Br J Psychiatry 167: 786–793
Goldman-Rakic P (1994) Cerebral cortical mechanisms in schizophrenia. Neuropsycho-pharmacol 10[Suppl 3]: 22–27
Harvey I, Ron MA, Du Boulay G, Wicks SW, Lewis SW, Murray RM (1993) Reduction of cortical volume in schizophrenia on magnetic resonance imaging. Psychol Med 23: 591–604
Heinsen H, Gössmann E, Rüb U, Eisenmenger W, Bauer M, Ulmar G, Bethke B, Schüler M, Schmitt HP, Götz M, Lockemann U, Püshel K (1996) Variability in the human entorhinal region may confound neuropsychiatric diagnoses. Acta Anat 157: 226–237
Jakob J, Beckmann H (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm 65: 303–326
Jönsson SA, Luts A, Guldberg-Kjaer N, Brun A (1997) Hippocampal pyramidal cell disarray correlates negatively to cell number: implications for the pathogenesis of schizophrenia. Eur Arch Psychiatry Clin Neurosci 247: 120–127
Katsetos CD, Hyde TM, Herman MM (1997) Neuropathology of the cerebellum in schizophrenia — an update: 1996 and future directions. Biol Psychiatry 42: 213–224
Lieberman J, Bogerts B, Degreef G, Ashtari M, Alvir J (1992) Qualitative assessment of brain morphology in acute and chronic schizophrenia. Am J Psychiatry 149: 784–791
Marsh L, Suddath RL, Higgins N, Weinberger DR (1994) Medial temporal lobe structures in schizophrenia: relationship of size to duration of illness. Schizophr Res 11: 225–238
McCarley RW, Hsiao JK, Freedman R, Pfefferbaum A, Donchin E (1996) Neuroimaging and the cognitive neuroscience of schizophrenia. Schizophr Bull 22: 703–725
Pakkenberg B (1990) Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Arch Gen Psychiatry 47: 1023–1028
Raz S (1993) Structural cerebral pathology in schizophrenia: regional or diffuse? J Abnorm Psychol 102: 445–452
Schlaepfer TE, Harris GJ, Tien AY, Peng LW, Lee S, Federman EB, Chase GA, Barta PE, Pearlson GD (1994) Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry 151: 842–848
Selemon LD, Rajkowska PS, Goldman-Rakic PS (1995) Abnormally high neuronal density in the schizophrenic cortex. A morphometric anaysis of prefrontal area 9 and occipital area 17. Arch Gen Psychiatry 52: 805–818
Shapiro RM (1993) Regional neuropathology in schizophrenia: where are we? Where are we going? Schizophr Res 10: 187–239
Travis MJ, Kerwin R (1997) Schizophrenia — Neuroimaging. Curr Opin Psychiatry 10: 16–25
Van Os J, Fahy A, Jones P, Harvey I, Lewis S, Williams M, Toone B, Murray R (1995) Increased intracerebral cerebrospinal fluid spaces predict unemployment and negative symptoms in psychotic illness — a prospective study. Br J Psychiatry 166: 750–758
Weinberger DR (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44: 660–669
Zipurski RB, Marsh L, Lim KO, Dement S, Shear PK, Sullivan EV, Murphy GM, Csernansky JG, Pfefferbaum A (1994) Volumetric assessment of temporal lobe structures in schizophrenia. Biol Psychiatr 35: 501–516
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Wien
About this paper
Cite this paper
Bogerts, B. (1998). Befunde der neueren neuroanatomischen Schizophrenie-Forschung und deren Interpretation. In: Möller, HJ., Müller, N. (eds) Schizophrenie — Moderne Konzepte zu Diagnostik, Pathogenese und Therapie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6471-6_15
Download citation
DOI: https://doi.org/10.1007/978-3-7091-6471-6_15
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83086-4
Online ISBN: 978-3-7091-6471-6
eBook Packages: Springer Book Archive