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Apolipoprotein E genotype, atherosclerosis, and cognitive decline: the Rotterdam study

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Ageing and Dementia

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURAL SUPPL,volume 53))

Summary

The apolipoprotein E4 allele (APOEɛ4) and atherosclerosis are risk factors for cognitive decline. We investigated whether the effects of APOEɛ4 and atherosclerosis on cognitive decline are independent. A population-based follow-up study was performed on 838 subjects who were non-demented at baseline. The Mini Mental State Examination (MMSE) score at follow-up was studied as a function of APOEɛ4 and atherosclerosis. Mild, non-significant effects on the MMSE score were found for atherosclerosis in the absence of APOEɛ4 and for APOEɛ4 in the absence of atherosclerosis. APOEɛ4 carriers with two or more indicators of atherosclerosis positive, had a significantly lower MMSE score at follow-up (mean difference −0.7 points; 95% confidence interval −1.1 to −0.2) relative to non-APOEɛ4 carriers with no evidence of atherosclerosis. Our findings suggest that the consequences of APOEɛ4 and atherosclerosis are not independent, and that particularly APOEɛ4 carriers with atherosclerosis are at increased risk of cognitive decline.

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Author information

Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, Erasmus University Medical School, PO Box 1738, 3000 DR, Rotterdam, The Netherlands

    A. J. C. Slooter, C. M. van Duijn, M. L. Bots, A. Ott, M. B. Breteler, D. E. Grobbee & A. Hofman

  2. Neurogenetics Laboratory, Flemish Institute of Biotechnology, Born-Bunge Foundation, University of Antwerp (UIA), Antwerp, Belgium

    J. De Voecht, A. Wehnert & C. Van Broeckhoven

  3. TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands

    P. de Knijff & L. M. Havekes

  4. MGC Department of Human Genetics, Leiden University, Leiden, The Netherlands

    P. de Knijff

Authors
  1. A. J. C. Slooter
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  2. C. M. van Duijn
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  3. M. L. Bots
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  4. A. Ott
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  5. M. B. Breteler
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  6. J. De Voecht
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  7. A. Wehnert
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  8. P. de Knijff
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  9. L. M. Havekes
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  10. D. E. Grobbee
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  11. C. Van Broeckhoven
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  12. A. Hofman
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Editor information

Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für Klinische Neurobiologie, Wien, Österreich, Austria

    K. Jellinger (Prof. Dr.) (Prof. Dr.)

  2. Universitätsklinik für Neurologie, Graz, Österreich, Austria

    F. Fazekas (Prof. Dr.) (Prof. Dr.)

  3. Institut für Experimentelle Pharmakologie, Forschungsinitiative EBEWE, Graz, Österreich, Austria

    M. Windisch (Dr.) (Dr.)

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© 1998 Springer-Verlag Wien

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Slooter, A.J.C. et al. (1998). Apolipoprotein E genotype, atherosclerosis, and cognitive decline: the Rotterdam study. In: Jellinger, K., Fazekas, F., Windisch, M. (eds) Ageing and Dementia. Journal of Neural Transmission. Supplementa, vol 53. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6467-9_3

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  • DOI: https://doi.org/10.1007/978-3-7091-6467-9_3

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83114-4

  • Online ISBN: 978-3-7091-6467-9

  • eBook Packages: Springer Book Archive

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