Skip to main content

Antioxidant systemic effect of short-term Cerebrolysin® administration

  • Conference paper
Ageing and Dementia

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURAL SUPPL,volume 53))

Summary

Levels of catalase (CAT) and Superoxide dismutase (SOD) activity were determinate in serum of intact rats (INT) and those with septohippocampal pathway lesion (SHPL), which recieved Cerebrolysin® (CRB) or saline solution (SAL) for a week. We found that Cerebrolysin® induces a decrease on the CAT and SOD levels. Decrease of CAT levels (19.1) in the group of SHPL-CRB was higher than the values obtained (57.3) in SHPL-SAL group. The lowest CAT levels were detected in the INT-CER group (16.7). The SOD levels obtained in SHPL-CER group (9.84) were also smaller than those obtained in the SHPL-SAL group (14.9) which showed the highest levels of SOD, while the INT animals showed the lowest levels (7.6). In addition, the SHPL animals mortality was of 18% for the CER group against 43% for SAL group. We suggest the Cerebrolysin® effect on CAT and SOD activity is related with a beneficial antioxidative role which may have potential application on brain injury.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Aebi H (1984) Catalase in vitro. Methods Enzymol 105: 121–126

    Article  PubMed  CAS  Google Scholar 

  • Akai F, Hiruma S, Sato T, Iwamoto N, Ioku M, Hashimoto S (1992) Neurotrophic factor — like effect of FPF1070 on septal cholinergic neurons after transections of fimbria-fornix in the rat brain. Histol Histophaol 7: 213–221

    CAS  Google Scholar 

  • Benzi G, Moretti (1995) Age and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system. Free Radic Biol Med 19: 77–101

    Article  PubMed  CAS  Google Scholar 

  • Benzi G, Moretti A (1995) Are reactive oxygen species involve in Alzheimer disease? Neurobiol Aging 16: 661–674

    Article  PubMed  CAS  Google Scholar 

  • Ceballos-Picot I, Trivier JM, Nicole A, Sinet PM, Thevenin M (1992) Age correlated modifications of Copper-Zinc Superoxide dismutase and glutathione-related enzyme activities in human erythrocytes. Clin Chem 38: 66–70

    PubMed  CAS  Google Scholar 

  • Choi BH (1995) Oxidative stress and Alzheimer’s disease. Neurobiol Aging 16: 675–678

    Article  PubMed  CAS  Google Scholar 

  • Colton C, Wilt S, Gilber D, Chernyshev O, Snell, Dubois-Dalq M (1996) Species differences in the generation of reactive oxigen species by microglia. Mol Chem Neuropathol 28: 15–20

    Article  PubMed  CAS  Google Scholar 

  • De Haan JB, Cristiano F, Iannello RC, Kola I (1995) Cu/Zn Superoxide dismutase and gluthathione peroxidase during aging. Biochem Mol Biol Int 35: 1281–1297

    PubMed  Google Scholar 

  • Durusoy M, Diril N, Bozcuk N (1995) Age-related activity of catalase in different genotypes of drosophila melanogaster. Exp Gerontol 30: 77–86

    Article  PubMed  CAS  Google Scholar 

  • Ebewe pharmaceuticals (1992) Cerebrolysin for the modern effective theraphy of disturbed cerebral functions. Ebewe Arzneimittel Ges.m.b.H., A-4866 Unterach, Austria, p 84

    Google Scholar 

  • Marklund J (1992) Involvement of the Superoxide anion radical in autoxidation of pirogallol as a convenient assay for Superoxide dismutase. Eur J Biochem 47: 469–474

    Article  Google Scholar 

  • Matson MP, Furukawa K (1996) Progarmed cell life: anti-apoptotic signaling and therapeutic for neurodegenerative disorders. Restorat Neurol Neurosci 9: 191–205

    Google Scholar 

  • Mo JQ, Horn DG, Andersen JK (1995) Decreases in protective enzymes correlates with increased oxidative damage in the aging mouse brain. Mech Ageing Dev 81: 73–82

    Article  PubMed  CAS  Google Scholar 

  • Moreno S, Mugnaini E, Cerú P (1995) Inmunohistochemical localization of catalase in the central nervous system of the rat. J Histochem Cytochem 43: 1253–1267

    Article  PubMed  CAS  Google Scholar 

  • Olanow CW (1992) An introduction to the free radical hypothesis in Parkinson’s disease. Ann Neurol 32: 2–9

    Article  Google Scholar 

  • Racagni G, Brunello N, Langer SZ (1994) Recent advances in the treatment of neurodegenerative disorders and cognitive dysfunction. In: Int Acad Biomed Drug Res, vol 7. Karger, Basel, p 327

    Google Scholar 

  • Singh A (1989) Chemical and biochemical aspects of activated oxygen: singlet oxygen, Superoxide anion, and related species. In: Handbook of free radicals and antioxidants in biomedicine, vol 1. Press, Iloride, pp 177–182

    Google Scholar 

  • Sugita Y, Kondo T, Kanazawa A, Itou T, Mixuno Y (1993) Protective effect of FPF 1070 (cerebrolysin) on delayed neuronal death in the gerbil: detection of hydroxyl radical with salisylic acid. No To Shinkei 45: 325–331

    PubMed  CAS  Google Scholar 

  • Zhang P, Damier P, Hirsch EC, Agyd Y, Ceballos-Picot I, Sinet PM, Nicole A, Laurent M, Javoy-Agyd F (1993) Preferential expression of Superoxide dismutase messenger RNA in melanized neurons in human mesencephalom. Neuroscience 55: 167–175

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Wien

About this paper

Cite this paper

González, M.E., Francis, L., Castellano, O. (1998). Antioxidant systemic effect of short-term Cerebrolysin® administration. In: Jellinger, K., Fazekas, F., Windisch, M. (eds) Ageing and Dementia. Journal of Neural Transmission. Supplementa, vol 53. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6467-9_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6467-9_29

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83114-4

  • Online ISBN: 978-3-7091-6467-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics