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Immune modulation by proteins secreted from cells infected by vaccinia virus

  • Chapter
100 Years of Virology

Part of the book series: Archives of Virology. Supplementa ((ARCHIVES SUPPL,volume 15))

Summary

Vaccinia virus comprises the live vaccine that was used for vaccination against smallpox. Following the eradication of smallpox, vaccinia virus was developed as an expression vector that is now used widely in biological research and vaccine development. In recent years vaccinia virus and other p oxviruses have been found to express a collection of proteins that block parts of the host response to infection. Some of these proteins are secreted from the infected cell where they bind and neutralise host cytokines, chemokines and interferons (IFN). In this paper three such proteins that bind interleukin (IL)-1β, type I IFNs and CC chemokines are described. The study of these immunomodulatory molecules is enhancing our understanding of virus pathogenesis, yielding fundamental information about the immune system, and providing new molecules that have potential application for the treatment of immunological disorders or infectious diseases.

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Author notes

  1. A. Alcamí

    Present address: Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK

Authors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    Prof. G. L. Smith, J. A. Symons & A. Alcamí

Authors
  1. Prof. G. L. Smith
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  2. J. A. Symons
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  3. A. Alcamí
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Editors and Affiliations

  1. Arthropod-borne and Infectious Diseases Laboratory, Colorado State University, Fort Collins, Colorado, USA

    Charles H. Calisher

  2. Department of Infectious Diseases and Immunology, Institute of Virology, State University of Utrecht, Utrecht, Netherlands

    M. C. Horzinek

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© 1999 Springer-Verlag Wien

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Smith, G.L., Symons, J.A., Alcamí, A. (1999). Immune modulation by proteins secreted from cells infected by vaccinia virus. In: Calisher, C.H., Horzinek, M.C. (eds) 100 Years of Virology. Archives of Virology. Supplementa, vol 15. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6425-9_8

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  • DOI: https://doi.org/10.1007/978-3-7091-6425-9_8

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83360-5

  • Online ISBN: 978-3-7091-6425-9

  • eBook Packages: Springer Book Archive

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