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Die Karzinomkrankheit

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Handbuch der Internistischen Geriatrie

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Zusammenfassung

Die Krebserkrankungen nehmen in der westlichen Welt insgesamt gering zu, auch wenn es einzelne Karzinome gibt, deren Inzidenz eine rückläufige Tendenz aufweist. So wird z.B. der Rückgang des Magen- oder des Zervixkarzinoms durch den weiteren Anstieg des Bronchuskarzinoms in einer Globalstatistik maskiert (Austoker 1994a, Travis 1995) (Tabelle 121).

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Literatur

  • Agrez MV, Coory M, Cockburn J (1998) Population screening for colorectal carcinom with fecal-occult blood testing. Cancer 81: 1803–1807

    Article  Google Scholar 

  • Austoker J (1994a) Cancerprevention: setting the scene. Br Med J 308: 1415–1420

    Article  CAS  Google Scholar 

  • Austoker J (1994b) Screening for ovarian, prostatic, and testicular cancers. Br Med J 309: 315–320

    Article  CAS  Google Scholar 

  • Beart RW, Curlee F (1978) Intestinal Stomas: managing the „unmentionable“. Geriatrics 33/11: 45–50

    PubMed  Google Scholar 

  • Berger HG, Gögler H, Kraas E, Schulz E, Bittner R (1979) Ergebnisse der chirurgischen Therapie des Dickdarmkarzinoms beim über 70jährigen Patienten. In: Rehn J (Hrsg) Der alte Mensch in der Chirurgie. Springer, Berlin Heidelberg New York, S 174–176

    Chapter  Google Scholar 

  • Berlin JD, Propert KJ, Trump D, Wilding G, Hudes G, Glick J, Burch P, Keller A, Loehrer P (1998) 5-Fluorouracil and leucovorin therapy in patients with hormone refractory prostate cancer: an Eastern Cooperative Oncology Group Phase II Study (E 1889). Am J Clin Oncol 21: 171–176

    Article  PubMed  CAS  Google Scholar 

  • Bernabei R, Gambassi G, Lapane K, Landi F, Gatsonis C, Dunlop R, Lipsitz L, Mor V, for the SAGE Study Group (1998) Management of pain in elderly patients with cancer. J Am Med Assoc 279: 1877–1882

    Article  CAS  Google Scholar 

  • Blackledge G (1998) New developments in cancer treatment with the novel thymidylate synthase inhibitor raltitrexed („Tomudex“). Br J Cancer 77 [Suppl 2]: 29–37

    Article  PubMed  CAS  Google Scholar 

  • Bonadonna G, Valagussa P (1981) Dose-response effect of adjuvant chemotherapy in breast cancer. N Engl J Med 304: 10–15

    Article  PubMed  CAS  Google Scholar 

  • Burke W, Petersen G, Lynch P, Botkin J, Daly M, Garber J, Kahn MJE, McTiernan A, Offit K, Thomson E, Varricchio C, for the Cancer Genetics Studies Consortium (1997) Recommensations for follow-up care of individuals with an inherited predisposition to cancer. I. Hereditary nonpolyposis colon cancer. J Am Med Assoc 277: 915–919

    Article  CAS  Google Scholar 

  • Butler AN (1992) Screening mammography for older women: a case of mixed messages. Arch Intern Med 152: 922–925

    Article  Google Scholar 

  • Canellos GP, Hellman S (1982) The management of early breast cancer. N Engl J Med 306: 1430–1432

    Article  PubMed  CAS  Google Scholar 

  • Catalona WJ, Smith DS, Ornstein DK (1997) Prostate cancer detection in men with serum PSA concentrations of 2,6 to 4,0 ng/ml and benign prostate examination. J Am Med Assoc 277: 1452–1455

    Article  CAS  Google Scholar 

  • Cleeland CS (1998) Undertreatment of cancer pain in elderly patients. J Am Med Assoc 279: 1914–1915

    Article  CAS  Google Scholar 

  • Colditz GA (1994) Oral contraceptive use and mortality during 12 years of follow-up: The Nurses Health Study. Ann Intern Med 120: 821–826

    PubMed  CAS  Google Scholar 

  • Council on Scientific Affairs (1984) Early detection of breast cancer. JAMA 252: 3008–3011

    Article  Google Scholar 

  • Crawford ED, Eisenberger MA, McLeod DG, Spaulding JT, Benson R, Dorr FA, Blumenstein BA, Davis MA, Goodman PJ (1989) A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med 321: 419–424

    Article  PubMed  CAS  Google Scholar 

  • Curless R, French JM, Williams GV, James OF (1994) Colorectal carcinoma: do elderly patients present differently? Age Ageing 23: 102–107

    Article  PubMed  CAS  Google Scholar 

  • de Graaf H, Willemse PHB, Sleijfer DT (1994) Review: breast cancer in elderly patients. Age Ageing 23: 424–427

    Google Scholar 

  • Delendi M, Gardison D. Ribol E, Sasco AJ (1989) Latent colorectal cancer found at necropsy. Lancet ii: 1331–1332

    Article  Google Scholar 

  • Dodd GD (1992) American Cancer Society guidelines on screening for breast cancer: an overview. Cancer 69: 177–180

    Google Scholar 

  • Dukes CE, Bussey HJR (1958) The spread of rectal cancer and its effect on prognosis. Br J Cancer 12: 1860–1864

    Article  Google Scholar 

  • Dunlop M, Campbell H (1997a) Screening for people with a family history of colorectal cancer. Br Med J 314: 1779–1780

    Article  CAS  Google Scholar 

  • Dunlop MG (1997b) Colorectal cancer. Br Med J 314: 1882–1885

    Article  CAS  Google Scholar 

  • Early Breast Cancer Trialists Collaborative Group (1998) Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 351: 1451–1467

    Article  Google Scholar 

  • Fentiman IS, Tirelli U, Monfardini S, Schneider M, Festen J, Cognetti F, Aapro MS (1990) Cancer in the elderly: why so badly treated? Lancet 335: 1020–1022

    Article  PubMed  CAS  Google Scholar 

  • Fielding LP, Phillips RKS, Hittinger R (1989) Factors influencing mortality after curative resection for large bowel cancer in elderly patients. Lancet i: 595–597

    Article  Google Scholar 

  • Finlay IG, Meek DR, Gray HW, Duncan JG, McArdle CS (1982) Incidence and detection of occult hepatic metastases on colorectal carcinoma. Br Med J 284: 803–805

    Article  CAS  Google Scholar 

  • Ford D, Easton DF, Bishop DT, Narod SA, Goldgar DE (1994) Risk of cancer in BRCA1-mutation carriers. Lancet 343: 692–695

    Article  PubMed  CAS  Google Scholar 

  • Gibbons RP, Correa RJ, Bannen GE, Weissman RM (1989) Total prostatectomy for clinically localised prostatic cancer: long-term results. J Urol 141: 564–566

    PubMed  CAS  Google Scholar 

  • Gomez ER, Rosenthal D (1984) Management of a subcutaneous colostomy perforation. Dis Col Rect 27: 651–653

    Article  CAS  Google Scholar 

  • Greenwald P, Nasca PC, Lawrence CE, Horton J, McGarrah RP, Gabriele T, Carlton K (1978) Estimated effect of breast self-examination and routine pyhsician examinations on breast cancer mortality. N Engl J Med 299: 271–273

    Article  PubMed  CAS  Google Scholar 

  • Howell A, Dowsett M (1997) Recent advances in endocrine therapy of breast cancer. Br Med J 315: 863–866

    Article  CAS  Google Scholar 

  • Hubay CA, Pearson OH, Marshall JS, Rhodes RS, DeBanne SM, Rosenblatt J, Mansour EG, Hermann RE, Jones JC, Flynn WJ, Eckert C, McGuire WL (1980) Adjuvant chemotherapy, antiestrogen therapy and immunotherapy for stage II breast cancer: 45-month follow-up of a prospective, randomized clinical trial. Cancer 46: 2805–2808

    Article  PubMed  CAS  Google Scholar 

  • Hunter DJ, Spiegelman D, Adami HO, Beeson L, Van den Brandt P, Folsom AR, Fraser GE, Goldbohm RA, Graham S, Howe GR, Kushi LH, Marshall JR, McDermott A, Miller AB, Speizer FE, Wolk A, Yaun SS, Willett W (1996) Cohort studies of fat intake and the risk of breast cancer — pooled analysis. N Engl J Med 334: 356–361

    Article  PubMed  CAS  Google Scholar 

  • Irvin TT (1988) Prognosis of colorectal cancer in the elderly. Br J Surg 75: 419–421

    Article  PubMed  CAS  Google Scholar 

  • Jack CI, Lye M, Lesley F, Wilson G, Donnelly RJ, Hind CR (1997) Surgery for lung cancer: age alone is not a contraindication. Int J Clin Pract 51: 423–426

    PubMed  CAS  Google Scholar 

  • Jensen J, Kewenter J, Haglind E, Lycke G, Svensson C, Ahren C (1986) Diagnostic accuracy of double contrast enema and rectosigmoidoscopy in connection with faecal occult blood testing of rectosigmoid neoplasms. Br J Surg 73: 961–964

    Article  PubMed  CAS  Google Scholar 

  • Johansson JE, Adami HO, Andersson SO, Bergström R, Krusemo UB, Kraaz W (1989) Natural history of localised prostatic cancer. Lancet i: 799–803

    Article  Google Scholar 

  • Kemppainen M, Räihha I, Rajala T, Sourander L (1993) Delay in diagnosis of colorectal cancer in elderly patients. Age Ageing 22: 260–264

    Article  PubMed  CAS  Google Scholar 

  • Kerlikowske K, Grady D, Barclay J, Sickles EA, Eaton A, Ernster V (1993) Positive predictive value of screening mammography by age and family history of breast cancer. J Am Med Assoc 270: 2444–2450

    Article  CAS  Google Scholar 

  • Klein LA (1979) Prostatic carcinoma. N Engl J Med 300: 824–833

    Article  PubMed  CAS  Google Scholar 

  • Klurfeld DM (1992) Dietary fiber-mediated mechanism in carcinogenesis. Cancer Res 52 [Suppl]: 2055S–2059S

    PubMed  CAS  Google Scholar 

  • Kobayashi T, Kawakubo T (1994) Prospective investigation of tumor markers and risk assessment in early cancer screening. Cancer 73: 1946–1953

    Article  PubMed  CAS  Google Scholar 

  • Kronborg O, Fenger C, Olsen J, Jorgensen OD, Sondergaard O (1996) Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet 348: 1467–1471

    Article  PubMed  CAS  Google Scholar 

  • Lamas AM, Horwitz RI, Peck D (1984) Usefulness of mammography in the diagnosis and management of breast disease in postmenopausal women. JAMA 252: 2999–3002

    Article  PubMed  CAS  Google Scholar 

  • Landrigan PJ (1998) Asbestons — still a carcinogen. N Engl J Med 338: 1618–1619

    Article  PubMed  CAS  Google Scholar 

  • Lilienfeld AM (1963) The epidemiology of breast cancer. Cancer Res 23: 1503–1513

    PubMed  CAS  Google Scholar 

  • Mandel JS, Bond JH, Church TR, Snover DC, Bradley GM, Schuman LM, Ederer F, for the Minnesota Colon Cancer Control Study (1993) Reducing mortality from colorectal cancer by screening for fecal occult blood. N Engl J Med 328: 1365–1371

    Article  PubMed  CAS  Google Scholar 

  • Margreiter R (1980) Die Bedeutung der Hormonrezeptor-Analyse für die Therapie des Mammakarzinoms. Berichte Öst Ges Klin Chemie 3: 80–85

    Google Scholar 

  • Miller AB, Bulbrook RD (1982) Screening, detection, and diagnosis of breast cancer. Lancet i: 1109–1111

    Article  Google Scholar 

  • Moon TD, Sloane BB (1989) Prostatic adenocarcinoma. J Am Geriatr Soc 37: 55–64

    PubMed  CAS  Google Scholar 

  • Moon TD (1992) Prostate cancer. J Am Geriatr Soc 40: 622–627

    PubMed  CAS  Google Scholar 

  • Mushlin AI (1985) Diagnostic tests in breast cancer. Ann Intern Med 103: 79–85

    PubMed  CAS  Google Scholar 

  • Nemunaitis J, Klemow S, Tong A, Courtney A, Johnston W, Mack M, Taylor W, Solano M, Stone M, Mallams J, Mues G (1998) Prognostic value of K-ras mutations, ras oncoprotein, and c-erb B2 oncoprotein expression in adenocarcinoma of the lung. Am J Clin Oncol 21: 155–160

    Article  PubMed  CAS  Google Scholar 

  • Nobile MT, Barzacch MC, Sanguineti O, Gozza A, Vincenti M, Lavarello A, Cognein P, Lionetto R, Oercivale PL, Bertoglio S, Murolo C, Esposiot M, Vannozzi MO, Rosso R (1998) Activity of high dose 24 hour 5-fluorouracil infusion plus l-leucovorin in advanced colorectal cancer. Anticancer Res 18: 517–521

    PubMed  CAS  Google Scholar 

  • Oesterling JE (1991) Prostate-specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J Urol 145: 907–923

    PubMed  CAS  Google Scholar 

  • Oesterling JE, Jacobsen SJ, Chute CG, Guess HA, Girman CJ, Panser LA, Lieber MM (1993) Serum prostate-specific antigen in an community-based population of healthy men. J Am Med Assoc 270: 860–864

    Article  CAS  Google Scholar 

  • Papatestas AE, Mulvihill M, Josi C, Ioannivich J, Lesnick G, Aufses AH (1980) Parity and prognosis in breast cancer. Cancer 45: 191–194

    Article  PubMed  CAS  Google Scholar 

  • Parshad R (1997) Adjuvant therapy in colorectal cancer. Trop Gastroenterol 18: 139–144

    PubMed  CAS  Google Scholar 

  • Patterson WB (1989) Surgical issues in geriatric oncology. Semin Oncol 16: 57–65

    PubMed  CAS  Google Scholar 

  • Patterson WB (1992) Cancer in old people: an overview. In: Evans JG, Williams TF (eds) Oxford textbook of geriatric medicine. Oxford University Press, Oxford New York Tokyo

    Google Scholar 

  • Paulson DF, Moul JW, Walther PJ (1990) Radical prostatectomy for clinical stage T1-2N0M0 prostatic adenocarcinoma: long-term results. J Urol 144: 1180–1184

    PubMed  CAS  Google Scholar 

  • Pelger RC, Hamdy NA, Zwinderman AH, Lycklama A, Nijholt AA, Papapoulos SE (1998) Effects of the bisphosphonatc olpadronate in patients with carcinoma of the prostate metastatic to the skeleton. Bone 22: 403–408

    Article  PubMed  Google Scholar 

  • Prager E (1984) The continent colostomy. Dis Col Rect 27: 235–237

    Article  CAS  Google Scholar 

  • Prandoni P, Lensing AWA, Büller HR, Cogo A, Prins MH, Cattelan AM, Cuppinie S, Noventa F, ten Cate JW (1992) Deept-vein thrombosis and the incidence of subsequent symptomatic cancer. N Engl J Med 327: 1128–1133

    Article  PubMed  CAS  Google Scholar 

  • Rosell R, Gomez-Codina J, Camps C, Maestre J, Padille J, Canto A, Mate JL, Li S, Roig J, Olazabal A, Canela M. Ariza A, Skacel Z, Morera-Prat J, Abad A (1994) A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-smallcell lung cancer. N Engl J Med 330: 153–158

    Article  PubMed  CAS  Google Scholar 

  • Scalliet P (1991) Radiotherapy in the elderly. Eur J Cancer 27: 3–5

    Article  PubMed  CAS  Google Scholar 

  • Smith IE (1996) Prophylactic cranial irradiation for small-cell lung cancer. Lancet 348: 350

    Article  PubMed  CAS  Google Scholar 

  • Stamey TA, Yang N, Hay AR, McNeal JE, Freiha FS, Redwine E (1987) Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 317: 909–916

    Article  PubMed  CAS  Google Scholar 

  • Steinberg KK, Thacker WD, Smith SJ, Stroup DF, Zack MM, Flanders WD, Berkelman RL (1991) A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer. J Am Med Assoc 265: 1985–1990

    Article  CAS  Google Scholar 

  • Stjernsward J (1998) WHO cancer pain relief program. Cancer Surv 7: 195–208

    Google Scholar 

  • Stolley PD (1983) Lung cancer in women — five years later, situation worse. N Engl J Med 309: 428–429

    Article  PubMed  CAS  Google Scholar 

  • Swedish Rectal Cancer Trial (1997) Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 336: 980–987

    Article  Google Scholar 

  • Travis WD, Travis LB, Devesa SS (1995) Lung cancer. Cancer Suppl 75: 191–202

    CAS  Google Scholar 

  • Vähäkangas KH, Samet JM, Metcalf RA, Welch JA, Bennett WP, Lane DP (1992) Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Lancet 339: 576–580

    Article  PubMed  Google Scholar 

  • Van den Brandt PA, Goldbohm RA, Van Veer P (1995) Alcohol and breast cancer: results from the Netherlands Cohort Study. Am J Epidemiol 141: 907–915

    PubMed  Google Scholar 

  • Walsh SJ, Begg CB, Carbone CC (1989) Cancer chemotherapy in the elderly. Semin Oncol 16: 66–75

    PubMed  CAS  Google Scholar 

  • Warmuth MA, Sutton LM, Winer EP (1997) A review of hereditary breast cancer: from screening to risk factor modification. Am J Med 102: 107–115

    Google Scholar 

  • Westeel V, Murray N, Gelmon K, Shah A, Sheehan F, McKenzie M, Wong F, Morris J, Grafton C, Tsang V, Goddard K, Murphy K. Parsons C, Amy R, Page R (1998) New combination of the old drugs for elderly patients with small-cell lung cancer: a phase II study of the PAVE regimen. J Clin Oncol 16: 1940–1947

    PubMed  CAS  Google Scholar 

  • Willers H, Wurschmidt F, Bunemann H, Heilmann HP (1998) High-dose radiation therapy alone for inoperable non-small cell lung cancer — experience with prolonged overall treatment times. Acta Oncol 37: 101–105

    Article  PubMed  CAS  Google Scholar 

  • Willett WC, Stampfer MJ, Colditz GA, Rosner BA, Speizer FE (1990) Relation of meat and fiber intake to the risk of colon cancer in a prospec-tive study among women. N Engl J Med 323: 1664–1672

    Article  PubMed  CAS  Google Scholar 

  • Zachariah B, Casey L, Balducci L (1995) Radiotherapy of the oldest old cancer patients: a study of effectiveness and toxicity. J Am Geriatr Soc 43: 793–795

    PubMed  CAS  Google Scholar 

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  1. I. Medizinischen Abteilung, Donauspitals, Wien, Österreich

    Univ.-Prof. Dr. Karl Heinz Tragl (Vorstand, Ärztlicher Leiter, Leiter)

  2. Ludwig-Boltzmann-Institutes für Altersforschung, Donauspital, Langobardenstraße 122, A-1220, Wien, Österreich

    Univ.-Prof. Dr. Karl Heinz Tragl (Vorstand, Ärztlicher Leiter, Leiter)

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© 1999 Springer-Verlag Wien

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Tragl, K.H. (1999). Die Karzinomkrankheit. In: Handbuch der Internistischen Geriatrie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6409-9_15

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