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Exkurs: Multisystematrophie

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Neuro-Psychopharmaka Ein Therapie-Handbuch

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Zusammenfassung

Die Multisystematrophie (MSA) ist eine sporadische, progredient verlaufende neurodegenerative Erkrankung mit Beginn zwischen dem 40. und 70. Lebensjahr, welche klinisch in 90% der Fälle mit einem Parkinson-Syndrom einhergeht und neuropathologisch durch oligodendrogliale Einschlußkörperchen („glial cytoplasmic inclusions“ GCIs, erstmals 1989 beschrieben durch Papp et al.) vor allem in Basalganglien und motorischem Kortex charakterisiert ist (PAPP und Lantos 1994). Vor allem Putamen und Substantia nigra pars compacta sind von neuronalem Zellverlust, Astrogliose und Pigmentdeposition betroffen (Wenning et al. 1995). Jedoch finden sich degenerative Veränderungen variablen Ausmaßes auch in anderen neuronalen Kerngebieten des Zentralnervensystems wie untere Oliven, Pons, Cerebellum, präganglionäre Sympathikusneurone im Rückenmark sowie Onufscher Kern im Sakralmark (Daniel 1992).

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Authors
  1. G. K. Wenning
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  2. W. Poewe
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Editor information

Editors and Affiliations

  1. Klinische Neurochemie, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Würzburg, Bundesrepublik Deutschland

    Peter Riederer

  2. Bezirkskrankenhaus Gabersee, Wasserburg/Inn, Bundesrepublik Deutschland

    Gerd Laux

  3. Wien, Österreich

    Walter Pöldinger

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© 1999 Springer-Verlag Wien

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Wenning, G.K., Poewe, W. (1999). Exkurs: Multisystematrophie. In: Riederer, P., Laux, G., Pöldinger, W. (eds) Neuro-Psychopharmaka Ein Therapie-Handbuch. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6400-6_42

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  • DOI: https://doi.org/10.1007/978-3-7091-6400-6_42

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7315-2

  • Online ISBN: 978-3-7091-6400-6

  • eBook Packages: Springer Book Archive

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