Zusammenfassung
Die Spinalanästhesie ist ein gängiges Verfahren bei der Kaiserschnittentbindung und gewinnt auch an Bedeutung für die Analgesie zur Wehenschmerzbehandlung. Sie wird durch die reversible Blockade der Nervenleitung der Spinalganglien, Spinalnerven und des Rückenmarks hervorgerufen. Die sachgerechte Durchführung und Aufrechterhaltung der rückenmarksnahen Leitungsanästhesie setzt eine gründliche Kenntnis der Faktoren, welche die Verteilung, Gewebsaufnahme und die Elimination von Lokalanästhetika beeinflussen, voraus. Im Folgenden wird daher die Verteilung neuraxial verabreichter Pharmaka im Subarachnoidalraum, der Einfluß von Barizität, Konzentration und Dosis auf die Pharmakokinetik der Lokalanästhetika und die Elimination von Lokalanästhetika beschrieben.
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Frölich, M.A. (2000). Pharmakokinetik der neuraxialen Leitungsblockaden. In: Geburtshilfliche Anästhesie und Intensivmedizin. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6317-7_9
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DOI: https://doi.org/10.1007/978-3-7091-6317-7_9
Publisher Name: Springer, Vienna
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