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Lipase-Catalyzed Synthesis of Carboxylic

Amides: Nitrogen Nucleophiles as Acyl Acceptor

  • Chapter
Biocatalysis

Abstract

The lipase-catalyzed aminolysis of carboxylic esters is a fairly general reaction that has been performed with a wide range of esters and amines, generally in anhydrous organic media to avoid undesirable hydrolysis of the ester. Alternatively, carboxylic amides can be synthesized by lipase mediated condensation of carboxylic acids and amines if an excess of either reactant is avoided.

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Authors and Affiliations

  1. Laboratory of Organic Chemistry and Catalysis, Delft University of Technology, NL-2628 BL Delft, The Netherlands

    Fred van Rantwijk, A. P. J. Michiel Hacking & Roger A. Sheldon

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  1. Fred van Rantwijk
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  2. A. P. J. Michiel Hacking
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  3. Roger A. Sheldon
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  1. Institute of Organic Chemistry, Technical University of Graz, Austria

    Herfried Griengl

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van Rantwijk, F., Hacking, A.P.J.M., Sheldon, R.A. (2000). Lipase-Catalyzed Synthesis of Carboxylic. In: Griengl, H. (eds) Biocatalysis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6310-8_2

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  • DOI: https://doi.org/10.1007/978-3-7091-6310-8_2

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