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Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics

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Advances in Research on Neurodegeneration

Summary

Our attempts to explain the serendipitous observations made on the neuroprotective action of a-phenyl-tert-butyl-nitrone (PBN) several years ago provided a challenge, which lead us to postulate the occurrence of neuroinflammatory processes in the stroked and the aging brain to help explain the results. Surprising observations made earlier by other investigators also forced them to conclude that enhanced neuro-inflammatory processes occur in the Alzheimer’s Disease (AD) brain. Observations we made recently, combined with the early seminal findings and the many others made since, overwhelmingly support the notion that neuro-inflammatory processes occur in the AD brain. Results obtained in our attempts to explain the mechanistic basis of the neuroprotective action of PBN provide strong support for the notion that this compound acts, not by trapping free radicals in a mass-action

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Authors and Affiliations

  1. Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    R. A. Floyd

  2. Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    R. A. Floyd, K. Hensley & G. Bing

Authors
  1. R. A. Floyd
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  2. K. Hensley
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  3. G. Bing
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of WĂĽrzburg, Federal Republic of Germany

    P. Riederer

  2. Neurodegenerative Disorders Centre, Faculty of Medicine, University Hospital, Vancouver, B.C., Canada

    D. B. Calne

  3. Schering AG Berlin, Berlin, Federal Republic of Germany

    R. Horowski

  4. Department of Neurology, Juntendo University, Tokyo, Japan

    Y. Mizuno

  5. Department of Neurology, Mount Sinai Medical Center, New York, New York, USA

    C. W. Olanow

  6. Department of Neurology, University of Innsbruck, Innsbruck, Austria

    W. Poewe

  7. Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel

    M. B. H. Youdim

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© 2000 Springer-Verlag Wien

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Floyd, R.A., Hensley, K., Bing, G. (2000). Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics. In: Riederer, P., et al. Advances in Research on Neurodegeneration. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6301-6_28

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  • DOI: https://doi.org/10.1007/978-3-7091-6301-6_28

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83537-1

  • Online ISBN: 978-3-7091-6301-6

  • eBook Packages: Springer Book Archive

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