Lessons from studies of antigen-specific T cell responses in Multiple Sclerosis

  • R. Martin
  • B. Bielekova
  • B. Gran
  • H. F. McFarland
Conference paper


Multiple Sclerosis (MS) is considered a T cell-mediated autoimmune disease of central nervous system myelin. Based on elegant experiments in an animal model of MS, experimental allergic encephalomyelitis (EAE), a number of myelin proteins and peptides derived from these can induce inflammatory demyelinating lesions. Recent studies with transgenic mice expressing human HLA-DR molecules and a myelin basic protein (MBP)specific T cell receptor as well as data from a phase II clinical trial with an altered peptide ligand based on MBP peptide (83-99) provide convincing evidence that the pathogenetic concepts which largely stem from the above EAE studies are valid in MS, too.


Multiple Sclerosis Experimental Autoimmune Encephalomyelitis Multiple Sclerosis Patient Myelin Basic Protein Experimental Allergic Encephalomyelitis 
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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • R. Martin
    • 1
  • B. Bielekova
    • 2
  • B. Gran
    • 2
  • H. F. McFarland
    • 2
  1. 1.Neuroimmunology BranchNINDS, National Institutes of HealthBethesdaUSA
  2. 2.Neuroimmunology BranchNINDS, National Institutes of HealthBethesdaUSA

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