Summary
We have cloned, expressed, and raised antibodies against a novel member of the TGF-ß superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-ß superfamily and does not belong to one of the known TGF-(3 subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.
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Strelau, J. et al. (2000). GDF-15/MIC-1 a novel member of the TGF-ß superfamily. In: Riederer, P., et al. Advances in Research on Neurodegeneration. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6301-6_18
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DOI: https://doi.org/10.1007/978-3-7091-6301-6_18
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83537-1
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