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Immunity to and Prevention of Herpes Zoster pp 71–79Cite as

Interactions among structural proteins of varicella zoster virus

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Summary

Varicella zoster virus tegument components include the regulatory proteins 1E4, 1E62, 1E63 and the ORF10 protein, a protein kinase (ORF47) and an abundant protein encoded in ORF9 which is the homolog of HSV VP22. The kinase is able to phosphorylate 1E62 and the ORF9 protein specifically in viral particles. We show that interactions among these proteins are, at least in part, dependent on the presence or absence of phosphate groups and we suggest models for tegument formation and for its dissolution in the infected cell.

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Author information

Authors and Affiliations

  1. Department of Microbiology and Witebsky Center for Microbial Pathogenesis and Immunology, State University of New York at Buffalo, Buffalo, New York, USA

    M. Spengler, N. Niesen, W. T. Ruyechan & J. Hay

  2. Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA

    C. Grose

  3. Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    M. Spengler

  4. Department of Microbiology and Witebsky Center for Microbial Pathogenesis and Immunology, State University of New York at Buffalo, Buffalo, NY, 14214, USA

    J. Hay

Authors
  1. M. Spengler
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  2. N. Niesen
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  3. C. Grose
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  4. W. T. Ruyechan
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  5. J. Hay
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, USA

    Anne A. Gershon

  2. Department of Microbiology and Immunology, Stanford University, Stanford, USA

    Ann M. Arvin

  3. Arthropod-borne and Infectious Diseases Laboratory, Colorado State University, Fort Collins, USA

    Charles H. Calisher

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© 2001 Springer-Verlag Wien

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Spengler, M., Niesen, N., Grose, C., Ruyechan, W.T., Hay, J. (2001). Interactions among structural proteins of varicella zoster virus. In: Gershon, A.A., Arvin, A.M., Calisher, C.H. (eds) Immunity to and Prevention of Herpes Zoster. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6259-0_8

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  • DOI: https://doi.org/10.1007/978-3-7091-6259-0_8

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83555-5

  • Online ISBN: 978-3-7091-6259-0

  • eBook Packages: Springer Book Archive

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