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Varicella-zoster virus with a lost gE epitope: evidence for immunological pressure by the human antibody response

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Immunity to and Prevention of Herpes Zoster

Summary

The varicella-zoster virus (VZV) genome contains about 70 open reading frames (ORF). ORF 68 codes for glycoprotein gE, formerly called gp1, which is the predominant VZV glycoprotein; gE is a typical type 1 transmembrane protein with 623 amino acids. Recently, a variant virus was discovered which has a mutation in gE codon 150; this mutation converts an aspartic acid into an asparagine residue.

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Author information

Authors and Affiliations

  1. Departments of Microbiology & Pediatrics, University of Iowa, Iowa City, Iowa, USA

    J. A. Padilla & C. Grose

  2. Department of Pediatrics, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA, 52242, USA

    J. A. Padilla

Authors
  1. J. A. Padilla
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  2. C. Grose
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, USA

    Anne A. Gershon

  2. Department of Microbiology and Immunology, Stanford University, Stanford, USA

    Ann M. Arvin

  3. Arthropod-borne and Infectious Diseases Laboratory, Colorado State University, Fort Collins, USA

    Charles H. Calisher

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© 2001 Springer-Verlag Wien

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Padilla, J.A., Grose, C. (2001). Varicella-zoster virus with a lost gE epitope: evidence for immunological pressure by the human antibody response. In: Gershon, A.A., Arvin, A.M., Calisher, C.H. (eds) Immunity to and Prevention of Herpes Zoster. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6259-0_4

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  • DOI: https://doi.org/10.1007/978-3-7091-6259-0_4

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83555-5

  • Online ISBN: 978-3-7091-6259-0

  • eBook Packages: Springer Book Archive

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