Skip to main content
SpringerLink
Log in

Biologische Untersuchungen in der Differentialdiagnostik kognitiver und depressiver Störungen im Alter

  • Chapter
Depression und Demenz im Alter

  • 227 Accesses

Zusammenfassung

Die Differentialdiagnose von Depression und Demenz gestaltet sich im klinischen Alltag der Gerontopsychiatrie häufig als besonders schwierig, denn gerade bei älteren Patienten kommt es oft zu einer Überlappung von Krankheitssymptomen, die mit einer Alzheimer Demenz [AD], bzw. einer Depression einhergehen (Lauter and Dame, 1992; Kötter et al., 1996). Dabei kann es sich sowohl um die krankheits-charakterisierenden kognitiven und depressiven Kernsymptome als auch um begleitende Symptome handeln, wie beispielsweise psychovegetative Störungen oder Störungen des Antriebes sowie des Sozialverhaltens.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Alavi A, Newberg AN, Souder E, Berlin JA (1993) Quantitative analysis of PET and MRI data in normal aging and Alzheimer’s disease: atrophy weighted total brain metabolism and absolute whole brain metabolism as reliable discriminators. J Nucl Med 34: 1681–1687

    PubMed  CAS  Google Scholar 

  • Amar K, Wilcock G (1996) Vascular dementia. BMJ 312 (7025): 227–231

    Article  PubMed  CAS  Google Scholar 

  • American Psychiatric Association (1987) Diagnostic and statistical manual of mental Disorders 3. überarb. Aufl. Washington DC,spivn pp 97–163

    Google Scholar 

  • American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders. 4. überarb. Aufl. Washington DC

    Google Scholar 

  • Andreasen NC, Rice J, Endicott J, Coryell W, Grove WM, Reich TH (1987) Familial rates of affective disorder. A report from the National Institute of Mental Health Collaborative Study. Arch Gen Psychiatry 44: 461–469

    Article  PubMed  CAS  Google Scholar 

  • Arnold SE, Hyman BT, Flory J, Damasio AR, Van Hoesen GW (1991) The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer’s disease. Cerebral Cortex 1: 103–116

    Article  PubMed  CAS  Google Scholar 

  • Arriagada P, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology 42: 631–639

    Article  PubMed  CAS  Google Scholar 

  • Aylward EH, Roberts-Twillie JV, Barta PE et al (1994) Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder. Am J Psychiatry 151 (5): 687–693

    PubMed  CAS  Google Scholar 

  • Ball MJ, Hachinski V, Fox A (1985) A new definition of Alzheimer’s disease: a hippocampal dementia. Lancet 82: 4531–4534

    Google Scholar 

  • Berrios CE (1985) Pseudodementia or melancholic dementia: a nineteenth century view. J Neurol Neurosurg Psychiatry 48: 393–400

    Article  PubMed  CAS  Google Scholar 

  • Bliwise DL (1989) REM latency in Alzheimer’s disease. Biol Psychiatry 25: 320–328

    Article  PubMed  CAS  Google Scholar 

  • Brenner R, Ulrich RF, Spiker DG, Scalabassi RJ, Reynolds CF (1986) Computerized EEG spectral analysis in elderly normal, demented and depressed subjects. Electroencephalography Clin Neurophys 75: 148–154

    Google Scholar 

  • Broeckhoven CV (1995) Presenilin and Alzheimer disease. Nature Genet 11: 230–232

    Article  PubMed  Google Scholar 

  • Buch K, Riemenschneider M, Bartenstein P, Willoch F, Müller U, Schmolke M, Nolde T, Steinmann C, Guder WG, Kurz A (1996) Tau-Protein — Ein potentieller biologischer Indikator zur Früherkennung der Alzheimer-Krankheit. Nervenarzt 69: 379–385

    Article  Google Scholar 

  • Burns A (1990) Psychiatric phenomena in Alzheimer’s disease: disorders of mood. Br J Psychiatry 157: 81–86

    Article  PubMed  CAS  Google Scholar 

  • Cassens G, Wolfu L, Zola M (1990) The Neuropsychology of depressions. J Neuropsychiatry Clin Neurosci 2(2): 202–213

    PubMed  CAS  Google Scholar 

  • Chui H C, Teng E L, Henderson V W, Moy A C (1985) Clinical subtypes of dementia of the Alzheimer type. Neurology 35: 1544–1550

    Article  PubMed  CAS  Google Scholar 

  • Coben La, Danziger W, Storandt M (1985) A longitudinal EEG study of mild senile dementia of Alzheimer’type: changes at 1 year and at 2.5 years. Electroencepohalography Clin Neurophys 61: 101–112

    Article  Google Scholar 

  • Coben LA Chi D, Snyder AZ, Storandt M (1990) Replication of a study of frequency analysis of the resting awake EEG in mild probabale Alzheimer’s disease. Electroencephalography Clin Neurophys 75: 148–154

    Article  Google Scholar 

  • Cohen RM (1982) Effort and cognition in depression. Arch Gen Psychiatry 39: 593–597

    Article  PubMed  CAS  Google Scholar 

  • Convit A, DeLeon M J, Tarshish C, DeSanti S, Tsui W, Rusinek H, George A (1997) Specific hippocampal volume reductions in individuals at risk for Alzheimer’s disease. Neurobiol Aging 18: 131–138

    Article  PubMed  CAS  Google Scholar 

  • Cuénod C-A, Denys A, Michot J-L, Jehenson P, Forette F, Kaplan D, Syrota A, Boller F (1993) Amygdala atrophy in Alzheimer’s disease Cummings JL (1983) Treatable dementias. Adv Neurol 38: 165–183

    Google Scholar 

  • Davis B M, Mohs R C, Greenwald B S, Mathe A A, Johns C A, Horvath T B, Davis K L (1985) Clinical studies of the cholinergic deficit in Alzheimer’s disease. Neurochemical and neuroendocrine studies. J Am Geriatr Soc 33: 741–748

    PubMed  CAS  Google Scholar 

  • de Leon MJ, Golomb J, George AE, Convit A, Tarshish CY, McRae T, De Santi S, Smith G, Ferris SH, Noz M, Rusinek H (1993) The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation. Am J Neuroradiol 14: 897–906

    PubMed  CAS  Google Scholar 

  • De Souza E B, Whitehouse P J, Price D L, Vale WW (1987) Abnormalities in corticotropin-releasing hormone (CRH) in Alzheimer’s disease and other human disorders. Ann N Y Acad Sci 512: 237–247

    Article  PubMed  CAS  Google Scholar 

  • DeCarli C, Murphy DGM, Mcintosh AR, Teichberg D, Schapiro MB, Horwitz B (1995) Discriminant analysis of MRI measures as a method to determine the presence of dementia of the Alzheimer type. Psychiatr Res 57: 119–130

    Article  CAS  Google Scholar 

  • Decker M W, McGaugh J L (1991) The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 7: 151–68

    Article  PubMed  CAS  Google Scholar 

  • Desmond PM, O’Brien JT, Tress BM, Ames DJ, Clement JG, Clement P, Schweitzer I, Tuckwell V, Robinson GS (1994) Volumetric and visual assessment of the mesial temporal sructures in Alzheimer’s disease. Aust NZ J Med 24: 547–553

    Article  CAS  Google Scholar 

  • Emery VO and Oxman TE (1992) Update on the dementia spectrum of depression. Am J Psychiatry 149: 305–317

    PubMed  CAS  Google Scholar 

  • Folstein MF, McHugh PR (1978) The dementia syndrome of depression. In: Katzman R, Terry RD, Bick KL (Hrsg) Alzheimer’s disease: senile dementia and related disorders (aging, vol. 7), Raven Press, New York

    Google Scholar 

  • Förstl H, Besthorn C, Hentschel F, Geiger-Kabisch C, Sattel H (1996) Frontal lobe degeneration and Alzheimer’s disease: a controlled study on clinical findings, volumetric brain changes and quantitative electroencephalography data. Dementia 7: 27–34

    PubMed  Google Scholar 

  • Frackowiak R, Pozzilli C, Legg N et al. (1981) Regional cerebral oxygen supply and utilization in dementia: a clinical and physiological study with oxygen-15 and positron tomography. Brain 104: 753–778

    Article  PubMed  CAS  Google Scholar 

  • Fukuda H, Nakamura S, Hara K, Udaka F, Kameyama M (1989) Study on the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in the lumbar cerebrospinal fluid (CSF) in neurological diseases. Rinsho Shinkeigaku 29: 1192–1194

    PubMed  CAS  Google Scholar 

  • George SM, Ketter RA, Post RM (1993) SPECT and PET imaging in mood disorders. J Clin Psychiatry (54) 11: 6–13

    Google Scholar 

  • Giacobini E (1990) The cholinergic system in Alzheimer’s disease. Prog Brain Res 84, 321–322

    Article  PubMed  CAS  Google Scholar 

  • Hampel H, Kötter HU (1997) Liquordiagnostik. Handbuch Morbus Alzheimer. Neurobiologie, Diagnose und Therapie. In: Weiss S, Weber J (Hrsg) Beltz Psychologie Verlags Union, S 689–753

    Google Scholar 

  • Hampel H, Müller N (1995) Inflammatory mechanisms in Alzheimer’s disease. Drug News Perspectives 8 (10): 599–608

    Google Scholar 

  • Hampel H, Berger C, Müller N (1996) A case of Ganser’s state presenting as a dementia syndrome. Psychopathology 29: 236–241

    Article  PubMed  CAS  Google Scholar 

  • Hampel H, Kötter HU, Müller-Spahn F (1997a) Blood-Cerebrospinal-Fluid-Barrier dysfunction for high molecular weight proteins in Alzheimer’s disease and major depression: indication for disease subsets. Alzheimer’s Dis Ass Disord 11(2): 78–87

    Article  Google Scholar 

  • Hampel H, Schoen D, Schwarz MJ, Kötter HU, Schneider C, Sunderland T, Dukoff R, Levy J, Padberg F, Stübner S, Buch K, Müller N, Möller HJ (1997b) Interleukin-6 CSF-levels are not altered in patients at risk and Alzheimer’s disease. Neuroscien Lett 228: 143–146

    Article  Google Scholar 

  • Hampel H, Teipel SJ, Kötter HU, Horwitz B, Pfluger Th, Mager T, Möller HJ, Müller-Spahn F (1997c) Strukturelle Magnet Resonanz Tomographie in Diagnostik und Erforschung der Demenz vom Alzheimer Typ. Nervenarzt 68(5): 365–378

    Article  Google Scholar 

  • Hampel H, Sunderland T, Kötter HU, Schneider C, Dukoff R, Levy J, Möller HJ (1998) Decreased soluble interleukin-6 receptor in CSF of patients with Alzheimer’s disease. Brain Res 780(2): 351–354

    Article  Google Scholar 

  • Hampel H, Teipel S J, Alexander G E, Horwitz B, Teichberg D, Schapiro M B, Rapoport S I (1998b) Corpus callosum atrophy is a possible indicator for region and cell type specific neuronal degeneration in Alzheimer disease: an MRI analysis. Arch Neurol 55: 193–198

    Article  Google Scholar 

  • Hampel H, Kötter HU, Padberg F, Körschenhausen D, Möller HJ (1999) Oligoclonal IgG bands and blood-cerebrospinal-fluid-barrier dysfunction in a subset of patients with Alzheimer’s disease: comparison with vascular dementia, major depression, and multiple sclerosis. Alzheimer’s Dis Ass Disord 13(1): 9–19

    Article  CAS  Google Scholar 

  • Hampel H, Teipel SJ, Padberg F, Haslinger A, Riemenschneider M, Schwarz MJ, Kötter HU, Scheloske M, Buch K, Stübner S, Dukoff R, Lasser R, Müller N, Sunderland T, Rapoport SI, Möller HJ (1999) Discriminant power of combined cerebrospinal fluid tau protein and soluble gp130 in the diagnosis of Alzheimer’s disease. Brain Res 823(1–2): 104–112

    Article  PubMed  CAS  Google Scholar 

  • Hansen L A, Armstrong D M, Terry D (1987) An immunohistochemical quantification of fribrous astrocytes in the aging human cerebral cortex. Neuribiol Aging 8: 1–6

    Article  CAS  Google Scholar 

  • Haass C (1996) Preseniline because of presenilin: the presenilin genes and early onset Alzheimer’s disease. Curr Opin Neurol 254–259

    Google Scholar 

  • Haxby JV, Duara R, Grady CL et al (1985) Relations between neuropsychological and cerebral metabolic asymmetries in early Alzheimer’s disease. J Cereb Blood Flow Metab 5: 193–200

    Article  PubMed  CAS  Google Scholar 

  • Hegerl U, Frodl-Bauch T (1997) Dipole source analysis of auditory evoked P300: a

    Google Scholar 

  • methodological advance? Psychiatry Res Neuroimaging 74: 109–118

    Google Scholar 

  • Hegerl U, Möller HJ (1997) EEG as a diagnostic instrument in dementia: review and perspectives. Int Psychogeriat 9 [Suppl] 1: 37–46

    Google Scholar 

  • Holsboer F, Liebl R, Hofschuster E (1982) Repeated dexamethasone suppression test during depressive illness. Normalisation of test result compared with clinical improvement. J Affective Disord 4(2): 93–101

    Article  CAS  Google Scholar 

  • Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL (1984) Alzheimer’s disease: cell specific pathology isolates the hippocampal formation. Science 225: 1168–1170

    Article  PubMed  CAS  Google Scholar 

  • Ikeda M, Tanabe H, Nakagawa Y, Kazui H, Oi H, Yamazaki H, Harada K, Nishimura T (1994) MRI-based quantitative assesment of the hippocampal region in very mild to moderate Alzheimer’s disease. Neuroradiology 36: 7–10

    Article  PubMed  CAS  Google Scholar 

  • Ito J, Yamao S, Fukuda H, Mimori Y, Nakamura S (1990) The P300 event-related potentials in dementia of the Alzheimer type. Correlations between P300 and monoamine metabolites. Electroencephalogr Clin Neurophysiol 77: 174–178

    Article  PubMed  CAS  Google Scholar 

  • Jack CR, Petersen RC, O’Brien PC, Tangalos EG (1992) MR-based hippocampal volumetry in the diagnosis of Alzheimer’s disease. Neurology 42: 183–188

    Article  PubMed  Google Scholar 

  • Jenike M, Albert MS (1984) The dexamethasone suppressiontest in patients with presenile and senile dementia of the Alzheimer’s type. J Am Geriatr Soc 32: 441–444

    PubMed  CAS  Google Scholar 

  • Jobst KA, Smith AD, Szatmari M, Esiri MM, Jaskowski A, Hindley N, McDonald B, Molyneux A (1994) Rapidly progressing atrophy of medial temporal lobe in Alzheimer’s disease. Lancet 343: 829–830

    Article  PubMed  CAS  Google Scholar 

  • Kamboh MI, Narambir D, Sanghera K, Ferrell R, DeKosky S (1995) APOE4-associated Alzheimer’ disease risk modified by a1-antichymotrypsin polymorphism. Nature Genet 10: 486–488

    Article  PubMed  CAS  Google Scholar 

  • Kawakatsu S, Morinobu S, Shinohara M, Totsuka S, Kobashi K (1990) Acetylcholinesterase activities and monoamine metabolite levels in the cerebrospinal fluid of patients with Alzheimer’s disease. Biol Psychiatry 28: 387–400

    Article  PubMed  CAS  Google Scholar 

  • Kesslak PJ, Nalcioglu O, Cotman CW (1991) Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer’s disease. Neurology 41: 51–54

    Article  PubMed  CAS  Google Scholar 

  • Kötter HU, Hampel H, Möller HJ (1996) Dementia or Depression? Differential diagnosis when symptoms overlap. Alzheimer Insights 2: 5–9

    Google Scholar 

  • Kral VA, Emery OB (1989) Long-term follow-up of depressive pseudodementia of the aged. Can J Psychiatry 34(5): 445–446

    PubMed  CAS  Google Scholar 

  • Krasuski J S, Alexander G E, Horwitz B, Daly E M, Murphy D G M, Rapoport S I, Schapiro M B (1998) Volumes of medial temporal lobe structures in patients with Alzheimer’s disease and mild cognitive impairment (and in healthy controls). Biol Psychiatry 43: 60–68

    Article  PubMed  CAS  Google Scholar 

  • Krishnan KRR (1993) Neuroanatomic substrates of depression in the elderly. J Geriatr Psychiatry Neurol. 1: 39–58

    Google Scholar 

  • Laakso MP, Soininen H, Partanen K, Helkala E-L, Hartikainen P, Vainio P, Hallikainen M, Hänninen T, Riekinnen Sr PJ (1995) Volumes of hippocampus, amygdala and frontal lobes in MRI-based diagnosis of early Alzheimer’s disease: correlation with memory functions. J Neural Transm 9: 73–86

    Article  CAS  Google Scholar 

  • Lauter H, Dame S (1992) Depressive disorders and dementia: the clinical view. Acta Psychiatr Scand 366: 40–46

    Google Scholar 

  • Lee S, Chiba T, Kitahama T, Kaieda R, Hagiwara M, Nagazumi A, Terashi A (1990) CSF beta-endorphin, HVA and 5-HIAA of dementia of the Alzheimer type and Binswanger’s disease in the elderly. J Neural Transm [Suppl] 30: 45–55

    CAS  Google Scholar 

  • Lehéricy S, Baulac M, Chiras J, Piérot L, Martin N, Pillon B, Deweer B, Dubois B, Marsault C (1994) Amygdalohippocampal MR volume measurements in the early stages of Alzheimer’s disease. Am J Neuroradiol 15: 927–937

    Google Scholar 

  • Leuchter AF, Spar JE, Walter DO, Weiner H (1987) Electroencephalographic spectra and coherence in the diagnosis of Alzheimer’s-type and multi-infarct dementia. Arch Gen Psychiatry 44: 993–998

    Article  PubMed  CAS  Google Scholar 

  • McGeer PL, kamo H, Harrop R, Li DK, Tuokko H, McGeer EG, Adam MJ, Ammann W, Beattie BL, Calme DB (1986) Positron emission tomography in patients with clinically diagnosed Alzheimer’s disease. Can Med Assoc J 134: 597–601

    CAS  Google Scholar 

  • McKhann G, Drachman G, Folstein M, Katzman R, Price D, Standlan EM (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS/ADRDA workgroup under the auspices of the Department of Health and and human services task force on Alzheimer’s disease. Neurology 34: 939–944

    Article  PubMed  CAS  Google Scholar 

  • Miller WR (1975) Psychological deficit in depression. Psychol Bull 82: 238–260

    Article  PubMed  CAS  Google Scholar 

  • Moe KE, Larsen LH, Prinz PN, Vitiello (1993) Major unipolar depression and mild Alzheimer’s disease: differentiation by quantitative tonic REM EEG. EEG Clin Neurophysiol 86: 238–246

    Article  CAS  Google Scholar 

  • Nagy Z, Jobst K A, Esiri M M, Morris J H, King E M-F, MacDonald B, Litchfield S, Barnetson L, Smith A D (1996) Hippocampal pathology reflects memory deficit and brain imaging meaurements in Alzheimer’s disease: clinicopathological correlations using three sets of pathologic diagnostic criteria. Dementia 7: 76–81

    PubMed  CAS  Google Scholar 

  • Nappi G, Facchinetti F, Martignoni E, Petraglia F, Sinforiani E, Bono G, Genazzani A R (1988) N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia. Acta Neurol Scand 78: 146–151

    Article  PubMed  CAS  Google Scholar 

  • Palmer A M, Sims N R, Bowen D M, Neary D, Palo J, Wikstrom J, Davison A N (1984) Monoamine metabolite concentrations in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer’s dementia. J Neurol Neurosurg Psychiatry 47: 481–484

    Article  PubMed  CAS  Google Scholar 

  • Pantel J, Schröder J, Schmitt R, Schad LR, Knopp MV, Geissler M, Uhde WH, Blüml S, Friedlinger M, Klemenz M, Essig M, Sauer H (1996) Quantitative Magnetresonanztomographie und Schweregrad der Defizite bei der Demenz vom Alzheimer-Typ. Nervenarzt 67: 46–52

    PubMed  CAS  Google Scholar 

  • Parnetti L, Reboldi G P, Santucci C, Santucci A, Gaiti A, Brunetti M, Cecchetti R, Senin U (1994) Platelet MAO-B activity as a marker of behavioural characteristics in dementia disorders. Aging Milano 6: 201–207

    PubMed  CAS  Google Scholar 

  • Parnetti L, Lowenthal DT, Presciutti O, Pellicioli GP, Palumbo R, Gobbi G, Chiarini P, Palumbo B, Tarduci R, Senin U (1996) 1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age associated memory impairment, and probable Alzheimer’s disease. J Am Geriatr Soc 44: 133–138

    PubMed  CAS  Google Scholar 

  • Pearlson GD, Harris GJ, Powers RE, Barta PE, Camargo EE, Chase GA, Noga JT, Tune LE (1992) Quantitative changes in mesial temporal volume, regional cerebral blood flow, and cognition in Alzheimer’s disease. Arch Gen Psychiatry 49: 402–408

    Article  PubMed  CAS  Google Scholar 

  • Penttilä M, Partanen JV, Soininen H, Riekkinen PJ (1985) Quantitative analysis of occipital EEG in different stages of Alzheimer’s disease. Electroencephalography and clinical Neurophysiology 60: 1–6

    Article  PubMed  Google Scholar 

  • Petit D, Montplaisir D, Lorrain D, Gauthier S (1992) Spectral analysis of the rapid eye movement sleep electroencephalogram in right and left temporal regions: a biological marker of Alzheimer’s disease. Ann Neurol 32: 172–176

    Article  PubMed  CAS  Google Scholar 

  • Pietrini P, Dani A, Furey M L, Alexander G E, Freo U, Grady C L, Mentis M J, Mangot D, Simon E W, Horwitz B, Haxby J V, Schapiro M B (1997) Low glucose metabolism during brain stimulation in older Down’s syndrome subjects at risk for Alzheimer’s disease prior to dementia. Am J Psychiatry 154: 1063–1069

    PubMed  CAS  Google Scholar 

  • Prinz P N, Larsen L H, Moe K E, Vitiello M V (1992) EEG markers of early Alzheimer’s disease in computer selected tonic REM sleep. Electroencephalogr Clin Neurophysiol 83: 36–43

    Article  PubMed  CAS  Google Scholar 

  • Prior R, Monning U, Schreiter Gasser U, Weidemann A, Blennow K, Gottfries C G, Masters C L, Beyreuther K (1991) Quantitative changes in the amyloid beta A4 precursor protein in Alzheimer cerebrospinal fluid. Neurosci Lett 124: 69–73

    Article  PubMed  CAS  Google Scholar 

  • Reinikainen K J, Paljarvi L, Halonen T, Malminen O, Kosma V M, Laakso M, Riekkinen P J (1988) Dopaminergic system and monoamine oxidase-B activity in Alzheimer’s disease. Neurobiol Aging 9: 245–252

    Article  PubMed  CAS  Google Scholar 

  • Reischies FM, Hedde JP, Drochner R (1989) Clinical correlates of cerebral blood flow in depression. Psychiatry Res 29: 323–326

    Article  PubMed  CAS  Google Scholar 

  • Reynolds CF, Kupfer DJ, Taska LS, Hoch CC, Spiker DG (1985) EEG sleep in elderly depressed, demented and healthy subjects. Biol Psychiatry 20: 431–442

    Article  PubMed  Google Scholar 

  • Rosén I, Gustafson L, Risberg J (1993) Multichannel EEG frequency analysis and somatosensory-evoked potentials in patients with different types of organic dementia. Dementia 4: 43–49

    PubMed  Google Scholar 

  • Roy C, Sherrington C (1890) On the regulation of the blood supply of the brain. J Physiol 11: 85–108

    PubMed  CAS  Google Scholar 

  • Rusinek H, de Leon MJ, George AE, Stylopoulos LA, Chandra R, Smith G, Rand T, Mourino M, Kowalsky H (1991) Alzheimer disease: measuring loss of cerebral grey matter with MR imaging. Radiology 178: 109–114

    PubMed  CAS  Google Scholar 

  • Schlegel S, Aldenhoff JB, Eissner D, Lindner P, Nickel O (1989) Regional cerebral blood flow in depression: associations with psychopathology. J Affect Disord 17(3): 211–218

    Article  PubMed  CAS  Google Scholar 

  • Seab JP, Jagust WJ, Wong STS, Roos MS, Reed BR, Budinger TF (1988) Quantitative NMR measurements of hippocampal atrophy in Alzheimer’s disease. Magn Reson Med 8: 200–208

    Article  PubMed  CAS  Google Scholar 

  • Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C et al. (1995) Cloning of a gene bearing missense mutations in early onset familial Alzheimer’s disease. Nature 375: 754–760

    Article  PubMed  CAS  Google Scholar 

  • Signorino M, Pucci E, Belardinelli N, Nolfe G, Angeleri F (1995) EEG spectral analysis in vascular and Alzheimer dementia. Electroencephalogr Clin Neurophysiol 94: 313–325

    Article  PubMed  CAS  Google Scholar 

  • Soininen H, MacDonald E, Rekonen M, Riekkinen P J (1981) Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with senile dementia of Alzheimer type. Acta Neurol Scand 64: 101–107

    Article  PubMed  CAS  Google Scholar 

  • Soininen H, Partanen J, Paakonen A, Koivisto E, Riekkinen PJ (1991) Changes in absolute power values of EEG spectra in the follow-up of Alzheimer’s disease. Acta Neurol Scand 83: 133–136

    Article  PubMed  CAS  Google Scholar 

  • Soininen H, Reinikainen KJ, Partanen J, Helkala E-L, Paljärvi L, Riekkinen PJ (1992) Slowing of electroencephalogram and choline acetyltransferase activity in post mortem frontal cortex in definite Alzheimer’s disease. Neuroscience 49: 529–535

    Article  PubMed  CAS  Google Scholar 

  • Starkstein SE, Vazquez S, Migliorelli R (1995) A SPECT study of depression. Neuropsychiatry Neuropsychol Behav Neurol 8: 38–43

    Google Scholar 

  • Sternberg DE, Jarvik ME (1976) Memory functions in depression. Arch Gen Psychiatry 33: 219–224

    Article  PubMed  CAS  Google Scholar 

  • Stromgren LS (1977) The influence of depression on memory. Acta Psychiatr Scand 56: 109–128

    Article  PubMed  CAS  Google Scholar 

  • Stübner S, Volkl G, Soyka M (1998) Zur Differentialdiagnose der dissoziativen Identitätsstörung (multiple Persönlichkeitsstörung). Nervenarzt 69: 440–445

    Article  PubMed  Google Scholar 

  • Stübner S, Schön T, Padberg F, Teipel SJ, Schwarz MJ, Haslinger A, Buch K, Dukoff R, Lasser R, Müller N, Sunderland T, Rapoport SI, Möller HJ, Hampel H Interleukin-6 and the soluble IL-6 receptor are decreased un cerebrospnal flkuid of geriatric patiens with major depression: no alteration of soluble gp 130. Neurosci Lett (in press)

    Google Scholar 

  • Suemaru S, Suemaru K, Hashimoto K, Ogasa T, Hirasawa R, Makino S, Kageyama J (1993) Cerebrospinal fluid corticotropin-releasing hormone and ACTH, and peripherally circulating choline-containing phospholipid in senile dementia. Life Sci 53: 697–706

    Article  PubMed  CAS  Google Scholar 

  • Swaab D F, Raadsheer F C, Endert E, Hofman M A, Kamphorst W, Ravid R (1994) Increased Cortisol levels in aging and Alzheimer’s disease in postmortem cerebrospinal fluid. J Neuroendocrinol 6: 681–687

    Article  PubMed  CAS  Google Scholar 

  • Szelies B, Mielke R, Herholz K, Heiss WD (1994) Quantitative topographical EEG compared to FDG PET for classification of vascular and degenerative dementia. Electroencephalogr Clin Neurophys 91: 131–139

    Article  CAS  Google Scholar 

  • Tabaton M, Schenone A, Romagnoli P, Mancardi G L (1985) A quantitative and ultrastructural study of substantia nigra and nucleus centralis superior in Alzheimer’s disease. Acta Neuropathol Berl 68: 218–223

    Article  PubMed  CAS  Google Scholar 

  • Tanna NK, Kohn MI, Horwich DN, Jolles PR, Zimmermann RA, Alves WM, Alavi A (1991) Analysis of brain and cerebrospinal fluid volumes with MR imaging: impact on PET Data correction. Radiology 178: 123–130

    PubMed  CAS  Google Scholar 

  • Teipel S J, Hampel H, Alexander G E, Schapiro M B, Horwitz B, Teichberg D, Daley E, Möller H-J, Hippius H, Rapoport SI (1998) Dissociation between white matter pathology and corpus callosum atrophy in Alzheimer’s disease. Neurology 51: 1381–1385

    Article  PubMed  CAS  Google Scholar 

  • Teipel S J, Hampel H, Pietrini P, Alexander G E, Horwitz B, Daley E, Möller HJ, Schapiro M B, Rapoport S I (1999a) Region specific corpus callosum atrophy correlates with regional pattern of cortical glucose metabolism in Alzheimer’s disease. Arch Neurol 56 (im Druck)

    Google Scholar 

  • Teipel S J, Pietrini P, Möller H-J, Rapoport S I, Hampel H (1999b) Positron emission tomography and the effect of aging and neurodegeneration on brain function. Part II: PET in Alzheimer’s disease — from resting state to activation studies. Drug News Perspectiv (im Druck)

    Google Scholar 

  • Tohgi H, Ueno M, Abe T, Takahashi S, Nozaki Y (1992) Remarkable reduction in acetylcholine concentration in the cerebrospinal fluid from patients with Alzheimer type dementia. J Neural Transm Park Dis Dement Sect 4: 69–77

    Article  PubMed  CAS  Google Scholar 

  • Tohgi H, Abe T, Hashiguchi K, Saheki M, Takahashi S (1994) Remarkable reduction in acetylcholine concentration in the cerebrospinal fluid from patients with Alzheimer type dementia. Neurosci Lett 177: 139–142

    Article  PubMed  CAS  Google Scholar 

  • Whitehouse P J, Vale W W, Zweig R M, Singer H S, Mayeux R, Kuhar M J, Price D L, De Souza E B (1987) Reductions in corticotropin releasing factor-like immunoreactivity in cerebral cortex in Alzheimer’s disease, Parkinson’s disease, and progressive supra-nuclear palsy. Neurology 37: 905–909

    Article  PubMed  CAS  Google Scholar 

  • Wragg RE, Jeste DV (1989) Overview of depression and psychosis in Alzheimer’s disease. Am J Psychiatry 146: 577–587

    PubMed  CAS  Google Scholar 

  • Wragg M, Hutton M, Talbot C, The Alzheimer’s Disease Collaborative Group (1996) Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer’s disease. Lancet 347: 509–512

    Article  PubMed  CAS  Google Scholar 

  • Yamauchi H, Fukuyama H, Harada K, Nabatame H, Ogawa M, Ouchi Y, Kimura J, Konishi J (1993) Callosal atrophy parallels dicreased cortical oxygen metabolism and neuropsychological impairment in Alzheimer’s disease. Arch Neurol 50: 1070–1074

    Article  PubMed  CAS  Google Scholar 

  • Zubenko GS, Moosey J, Koop U (1990) Neurochemical correlates of major depression in primary dementia. Arch Neurol 47: 209–214

    Article  PubMed  CAS  Google Scholar 

  • Zweig R M, Ross C A, Hedreen J C, Steele C, Cardillo J E, Whitehouse P J, Folstein M F, Price D L (1988) The neuropathology of aminergic nuclei in Alzheimer’s disease. Ann Neurol 24: 233–242

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. H. U. Kötter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Stübner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. U. Hegerl
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Hampel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Ludwig-Maximilians Universität, München, Deutschland

    Ulrich Hegerl  & Hans-Jürgen Möller  & 

  2. Psychosomatische Klinik, Windach, Deutschland

    Michael Zaudig

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Wien

About this chapter

Cite this chapter

Kötter, H.U., Stübner, S., Hegerl, U., Hampel, H. (2001). Biologische Untersuchungen in der Differentialdiagnostik kognitiver und depressiver Störungen im Alter. In: Hegerl, U., Zaudig, M., Möller, HJ. (eds) Depression und Demenz im Alter. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6253-8_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6253-8_5

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7259-9

  • Online ISBN: 978-3-7091-6253-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation