Skip to main content

Triple H Therapy after Aneurysmal Subarachnoid Hemorrhage. A Review

  • Conference paper
Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 77))

Abstract

Outcome in patients with aneurysmal subarachnoid hemorrhage (SAH) have improved over the past two decades with advances in neurosurgery and neurocritical care, including an emphasis on early aneurysm clipping to prevent rebleeding. However, cerebral ischemia related to vasospasm remains an important cause of morbidity and mortality, despite the beneficial effects of the calcium channel blocker nimodipine.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Awad IA, Carter LP, Spetzler RF, Medina M, Williams Jr FC (1987) Clinical vasospasm after subarachnoid hemorrhage: response to hypervolemic hemodilution and arterial hypertension. Stroke 18: 365–372

    Article  PubMed  CAS  Google Scholar 

  2. Darby JM, Yonas H, Marks EC, Durham S, Snyder RW, Nemoto EM (1994) Acute cerebral blood flow response to dopamine-induced hypertension after subarachnoid hemorrhage. J Neurosurg 80: 857–864

    Article  PubMed  CAS  Google Scholar 

  3. Dearden NM (1998) Triple H therapy in the management of cerebral vasospasm. Eur J Anaesthesiol 15 [Suppl] 17: 70–79

    Article  Google Scholar 

  4. Egge A, Sjoholm H, Solberg T, Ingebrigtsen T, Romner B (2000) Triple-H therapy in aneurysmal SAH. A clinical randomized study. 7th International Conference on Cerebral Vasospasm, Interlaken, Switzerland (abstract)

    Google Scholar 

  5. Haley EC, Kassell NF, Torner JC (1993) A randomised controlled trial of high dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage: a report of the co-operative aneurysm Study. J Neurosurg 78: 537–547

    Article  PubMed  Google Scholar 

  6. Heros RC, Korosue K (1989) Hemodilution for cerebral ischemia. Stroke 20: 423–427

    Article  PubMed  CAS  Google Scholar 

  7. Kasell NF, Peerless SJ, Durward QJ, Beck DW, Drake CG, Adams Jr HP (1982) Treatment of ischemic deficits from vasospasm with intravascular volume expansion and induced arterial hypertension. Neurosurgery 11: 337–343

    Article  Google Scholar 

  8. Korosue K, Ishida K, Matsuoka H, Nagao T, Tamaki N, Matsumoto S (1988) Clinical, hemodynamic, and hemorheological effects of isovolemic hemodilution in acute cerebral infarction. Neurosurgery 23: 148–153

    Article  PubMed  CAS  Google Scholar 

  9. Lennihan L, Mayer SA, Fink ME, Beckford A, Paik MC, Zhang H, Wu YC, Klebanoff LM, Raps EC, Solomon RA (2000) Effect of hypervolemic therapy on cerebral blood flow after subarachnoid hemorrhage: a randomized controlled trial. Stroke 31: 383–391

    Article  PubMed  CAS  Google Scholar 

  10. Levy M, Gianotta S (1991) Cardiac performance indices during hypervolemic therapy for cerebral vasospasm. J Neurosurg 75: 27–31

    Article  PubMed  CAS  Google Scholar 

  11. Mayberg MR, Batjer HH, Dacey R, Diringer M, Haley EC, Heros RC, Sternau LL, Torner J, Adams Jr HP, Feinberg W, Thies W (1994) Guidelines for the management of aneurysmal subarachnoid hemorrhage. A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke 25: 2315–28

    Article  PubMed  CAS  Google Scholar 

  12. Mayer SA, Solomon RA, Fink ME, Lennihan L, Stern L, Beckford A, Thomas CE, Klebanoff LM (1998) Effect of 5% albumin solution on sodium balance and blood volume after subarachnoid hemorrhage. Neurosurgery 42: 759–768

    Article  PubMed  CAS  Google Scholar 

  13. Messeter K, Brandt L, Ljunggren B, Svendgaard NA, Algotsson L, Romer B, Ryding E (1987) Prediction and prevention of delayed ischemic dysfunction after aneurysmal subarachnoid hemorrhage and early operation. Neurosurgery 20: 548–553

    Article  PubMed  CAS  Google Scholar 

  14. Mori K, Arai H, Nakajima K, Tajima A, Maeda M (1995) Hemorheological and hemodynamic analysis of hypervolemic hemodilution therapy for cerebral therapy for cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 26: 1620–1626

    Article  PubMed  CAS  Google Scholar 

  15. Muizelaar JP, Becker DP (1986) Induced hypertension for the treatment of cerebral ischemia after subarachnoid hemorrhage: direct effect on cerebral blood flow. Surg Neurol 25: 317–325

    Article  PubMed  CAS  Google Scholar 

  16. Ohtaki M., Tramner BI (1993) Hyperdynamic therapy for focal cerebral ischemia of rats: use of colloidal volume expansion and dobutamine. Surg Neurol 40: 131–137

    Article  PubMed  CAS  Google Scholar 

  17. Origitano TC, Wascher TM, Reichman OH, Anderson DE (1990) Sustained increased cerebral blood flow with prophylactic hypertensive hypervolemic hemodilution (“triple-H” therapy) after subarachnoid hemorrhage. Neurosurgery 27: 729–739

    Article  PubMed  CAS  Google Scholar 

  18. Pritz MB, Giannotta SL, Kindt GW, McGillicuddy JE, Prager RL (1978) Treatment of patients with neurological deficits associated with cerebral vasospasm by intravascular volume expansion. Neurosurgery 3: 364–368

    Article  PubMed  CAS  Google Scholar 

  19. Pritz MB (1997) Treatment of cerebral vasospasm due to aneurysmal hemorrhage: past, present, and future of hyperdynamic therapy. Neurosurg Qu 7: 273–285

    Article  Google Scholar 

  20. Solomon RA, Fink ME, Lennihan L (1988) Early aneurysm surgery and prophylactic hypervolemic hypertensive therapy for the treatment of aneurysmal subarachnoid hemorrhage. Neurosurgery 23: 699–704

    Article  PubMed  CAS  Google Scholar 

  21. Solomon RA, Fink ME, Lennihan L (1988) Prophylactic volume expansion therapy for the prevention of delayed cerebral ischemia after early aneurysm surgery. Arch Neurol 45: 325–332

    PubMed  CAS  Google Scholar 

  22. Shimoda M, Oda S, Tsugane R, Sato O (1993) Intracranial complications of hypervolemic therapy in patients with a delayed ischemic deficit attributed to vasospasm. J Neurosurg 78: 423–429

    Article  PubMed  CAS  Google Scholar 

  23. Tu Y-K, Kuo MF, Liu H-M (1997) Cerebral oxygen transport and metabolism during graded isovolemic hemodilution in experimental global ischemia. J Neural Sci 150: 115–122

    Article  CAS  Google Scholar 

  24. Wood JH, Simeone FA, Kron RE, Snyder LL (1984) Experimental hypervolemic hemodilution: physiological correlations of cortical blood flow, cardiac output, and intracranial pressure with fresh blood viscosity and plasma volume. Neurosurgery 14: 709–723

    Article  PubMed  CAS  Google Scholar 

  25. Yamakami I, Isobe K, Yamaura A (1987) Effects of intravascular volume expansion on cerebral blood flow in patients with ruptured cerebral aneurysms. Neurosurgery 21: 303–309

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag

About this paper

Cite this paper

Romner, B., Reinstrup, P. (2001). Triple H Therapy after Aneurysmal Subarachnoid Hemorrhage. A Review. In: Seiler, R.W., Steiger, HJ. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 77. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6232-3_51

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6232-3_51

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83650-7

  • Online ISBN: 978-3-7091-6232-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics