Abstract
There are three isoforms of endothelin (ET) such as ET-1, ET-2, and ET-3, and the vascular endothelium expresses only ET-1 binding to ET receptor type A of adjacent vascular smooth muscle cells of the vessel wall and causes a potent and sustained contraction [1, 5, 7, 8]. Cerebral vasospasm after subarachnoid hemorrhage (SAH) remains one of the major decisive factors in the clinical course of SAH patients and ET-1 has been identified as one of the causative substances [5, 8].
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References
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© 2001 Springer-Verlag
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Mima, T., Mostafa, M.G. (2001). Inhibition of Overexpression of Endothelin-1 by an RNA Synthesis Inhibitor, Doxorubicin, in the Rat Vasospasm Model. In: Seiler, R.W., Steiger, HJ. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 77. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6232-3_47
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DOI: https://doi.org/10.1007/978-3-7091-6232-3_47
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