Pancreas Cryosurgery

  • Nikolai N. Korpan


The incidence of pancreatic cancer is increasing nationally as well as worldwide. The linear trend shows an increase of 3% to 15.1 per 100,000 (WHO standard 7.9 per 100,000). In contrast to other malignancies, in about 42% of all cases of pancreatic cancer the patient presents in a disseminated stage at the time of first diagnosis. Early diagnosis is difficult, because pancreas cancers develop relatively slowly and without clinical signs until the tumor has grown to a large size. Unfortunately the results of curative as well as of palliative treatment are not satisfactory to date.


Pancreatic Cancer Acute Pancreatitis Chronic Pancreatitis Pancreatic Fistula Cyst Wall 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Cooper IS. Cryogenic surgery: a new method of destruction or extirpation of benign or malignant tissues. N Engl J Med 1963; 268: 743–749.CrossRefGoogle Scholar
  2. 2.
    Gage AA, Baust J. Mechanisms of tissue injury in cryosurgery. Cryobiology 1998; 37 (3): 171–186.PubMedCrossRefGoogle Scholar
  3. 3.
    Korpan NN, Zemskov VS, Skiba W. Cryomethods in General Surgery. Medizinskii Referativnii Zhurnal 1984; Kiev/Moscow, 77: 93–98.Google Scholar
  4. 4.
    Korpan NN. Möglichkeiten und Grenzen der modernen Kryochirurgie. In: Neugebauer H. (Ed.) Was gibt es Neues in der Medizin. 1996; Medizinisches Jahrbuch, Dr. Peter Miiller Verlag-Wien, 207–213Google Scholar
  5. 5.
    Korpan NN. Hepatic Cryosurgery for Liver Metastases. Long-Term Follow-Up. Ann. Surg 1997; 225 (2): 193–201.PubMedCrossRefGoogle Scholar
  6. 6.
    Korpan NN. Pancreas Cryosurgery. An Animal Study. 2000; 1st European Congress of Cryosurgery (San Sebastian, Spain, March 29-April 2, 2000), Abstract Book, 7.Google Scholar
  7. 7.
    Korpan NN, Hochwarter G. Pancreatic cryosurgery — a new surgical procedure for pancreatic cancer. Europ J Clin Invest 1997; 27 (Suppl 1): A33.Google Scholar
  8. 8.
    Korpan NN, Hochwarter G, Sellner F, Zharkov JV. Pancreatic cryosurgery-a new surgical strategy for pancreatic cancer. 1997; 37th World Congress of Surgery, International Surgical Week ISW97 (Acapulco, Mexico, August 24–30, 1997), Abstract Book, 156.Google Scholar
  9. 9.
    Korpan NN, Muskin JN, Zemskov VS, Skiba VV. Abdomen Cryosurgery. Vestnik Surg 1985; 9: 141–145.Google Scholar
  10. 10.
    Korpan NN, Zharkov JV, Sacher R. A morphological study of cooling rate response in normal animal liver tissue: Cryosurgical Implications. Eur J Clin Invest 1999; 29 (Suppl 1): 22.Google Scholar
  11. 11.
    Rabin Y, Steif PS, Taylor MJ, Julian TB, Wolmark N. An experimental study of the mechanical response of frozen biological tissues at cryogenic temperatures. Cryobiology, 1996; 33 (4): 472–482.PubMedCrossRefGoogle Scholar
  12. 1.
    Aldrette JS, Jimens H, Halpern N. Evaluation and treatment of acute and chronic pancreatitis. A review of 380 Cases. Ann Surg 1980; 191 (6): 664–671.CrossRefGoogle Scholar
  13. 2.
    Lasson A, Laurel AB, Ohlsoon K. Correlation Among Complement Activation Protease Inhibitors and Clinical Course in Acute Pancreatitis in Man. Scand J Gastroenterol 1988; 20 (3): 335–345.CrossRefGoogle Scholar
  14. 3.
    Miller BJ, Henderson A. Necrotizing Pancreatitis: Operating to Life. International Surgery Week. Hong-Kong 1993; 239.Google Scholar
  15. 4.
    Ronson JH. The Role of Surgery in the Management of Acute Pancreatitis. Ann Surg 1990; 4: 382–392.CrossRefGoogle Scholar
  16. 5.
    Savelev VS. Late results of conservative and surgical treatment of pancreonecrosis. Surgery 1983; 7: 11–12.Google Scholar
  17. 6.
    Shalimov AA, Lifshits HZ, Kozhara SP. New approach to surgical treatment of patients with necrotic pancreatitic abscesses. International Surgery Week.Hong-Kong 1993; 245.Google Scholar
  18. 7.
    Shabalin VN. Immune therapy for destructive pancreatitis complicated by hepatic insufficiency. Surgery 1989; 7: 76–79.Google Scholar
  19. 1.
    Becker V. Pathological Anatomy and Pathogenesis of Acute Pancreatitis. World J Surg 1981; 5 (3): 303–309.PubMedCrossRefGoogle Scholar
  20. 2.
    Bellows JG. Cryosurgical Instruments. Theoretical and clinical consideration. Surgery 1967; 47 (5): 416–424.Google Scholar
  21. 3.
    Cooper J. Principles and rationale of cryogenic Surgery. Med Bull 1962; 1 (5): 10.Google Scholar
  22. 4.
    Cooper J. Cryogenic Surgery for Cancer. Fed Proc 1965; 24: 237–240.Google Scholar
  23. 5.
    Fay T, Henney GC. Correlation of body segmental temperature and its relation to the location of carcinomatous metastasis. Surg Gynecol Obstet 1938; 5: 512–524.Google Scholar
  24. 6.
    Hess W. Partielle and totale Pancreatektomien bei chronischer Pankreatitis. Helv Chir Acta 1967; 34 (1–2): 99–102.PubMedGoogle Scholar
  25. 7.
    Hiraoka T, Watanabe E, Katch T. A new surgical approach for control of pain in chronic pancreatitis complete denervation of the pancreas. Am J Surg 1986; 152 (5): 549–551.PubMedCrossRefGoogle Scholar
  26. 8.
    Mallet-Guy P. Surgical treatment of chronic relapsing pancreatitis. Arch Surg 1955; 70 (4): 609–610.Google Scholar
  27. 9.
    Myers RS, Hammond WC, Kemcham AS. Cryosurgical necrosis of the head of the pancreas. Ann Surg 1970; 171 (3): 413–418.PubMedCrossRefGoogle Scholar
  28. 10.
    Puchalski L, Ladny JR, Piotrowski Z, Rog I. Surgical management of chronic pancreatitis: indication and procedures. Int Surg Week. Hong-Kong. 1993; 820.Google Scholar
  29. 1.
    Andersson R. Acute pancreatitis — management of complicating pseudocysts. International Surgery Week. Hong-Kong 1993; 814.Google Scholar
  30. 2.
    Brazhnikova NA. Clinics of Opistorchosus pancreatitis. In: Abstract book: Diagnostics and treatment of hepatic and pancreatic diseases, Russia, 1990; 251–253.Google Scholar
  31. 3.
    Fedorov VD. Pancreatic cysts. International conference, Moscow, Russia, 1993; 37–38.Google Scholar
  32. 4.
    Galeev MA. Diagnostics and surgical treatment of pancreatic cysts. Scientific conference, Novosibirsk, Russia, 1992; 201.Google Scholar
  33. 5.
    Lanckich P, Happe-Lohr A, Peiper M. Operative treatment of pancreatic pseudocysts in chronic pancreatitis. International Surgery Week. Hong-Kong 1993; 808.Google Scholar
  34. 6.
    Nevell KA, Aranka GV, Prinz RA. Are Cystgastrostomy and Cystjejunostomy Equivalent Operations for Pancreatic Pseudocysts? Surgery 1990; 108 (4): 635–640.Google Scholar
  35. 7.
    Sulkowsky U, Meyer J, Kauts G, Bunte H. Argumente fur ein abgewandeltes Konzept in der Therapie der akuten Pankreatitis zur Indikation konservativer und chirurgischer Verfahren. Chirurg 1989; 60 (4): 246–250.Google Scholar
  36. 8.
    Svikluc AV. Surgical treatment for pancreatic tumors. International scientific conference, Kiev, Ukraine, 1988; 130–131.Google Scholar

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© Springer-Verlag Wien 2001

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  • Nikolai N. Korpan

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