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Neurosurgical Re-Engineering of the Damaged Brain and Spinal Cord pp 163–168Cite as

Effect of subthalamic lesion with kainic acid on the neuronal activities of the basal ganglia of rat Parkinsonian models with 6-hydroxydopamine

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Part of the Acta Neurochirurgica Supplements book series (NEUROCHIRURGICA,volume 87)

Summary

The aim of the present study was to investigate the alteration of neuronal activities in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), after ipsilateral STN lesioning by kainic acid in the rat hemi-parkinsonian 6-hydroxydopamine (6-OHDA) model. In various rat parkinson’s disease (PD) models, an increase in the SNpr firing rate was observed, despite the occurrence of bursting patterns, and subthalamic lesion was found to reduce the mean firing rates and the percentage of bursting neurons in the SNpr. However, the relative proportion of bursting neurons, among all GP neurons, was slightly increased as a result of the subthalamic lesion. The significance of bursting activity in the SNpr and GP remains obscure. Further study is necessary to elucidate the pathophysiological mechanism behind parkinson’s disease.

Keyword

  • 6-hydroxydopamine
  • Parkinson’s disease
  • subthalamus
  • basal ganglia

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  • DOI: 10.1007/978-3-7091-6081-7_34
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Abbreviations

PD :

Parkinson’s disease

6-OHDA :

6-hydroxydopamine

STN :

subthalamic nucleus

MFB :

medial forebrain bundle

SN :

substantia nigra

L-DOPA :

L-3,4-dihydroxyphenylalanine

DA :

dopamine

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Authors and Affiliations

  1. Department of Neurosurgery, Medical Research Center, Brain Korea 21 project for Medical Science & Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea

    Jin Woo Chang M.D., M. F. Jeon, B. H. Lee & S. S. Chung

  2. Graduate School of East-West Science, Kyung Hee University, Seoul, Korea

    J. S. Yang

Authors
  1. Jin Woo Chang M.D.
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  2. J. S. Yang
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  3. M. F. Jeon
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  4. B. H. Lee
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  5. S. S. Chung
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Corresponding author

Correspondence to Jin Woo Chang M.D. .

Editor information

Editors and Affiliations

  1. Department of Neurological Surgery, Nihon University, School of Medicine, Tokyo, Japan

    Prof. Y. Katayama

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© 2003 Springer-Verlag Wien

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Chang, J.W., Yang, J.S., Jeon, M.F., Lee, B.H., Chung, S.S. (2003). Effect of subthalamic lesion with kainic acid on the neuronal activities of the basal ganglia of rat Parkinsonian models with 6-hydroxydopamine. In: Katayama, Y. (eds) Neurosurgical Re-Engineering of the Damaged Brain and Spinal Cord. Acta Neurochirurgica Supplements, vol 87. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6081-7_34

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  • DOI: https://doi.org/10.1007/978-3-7091-6081-7_34

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