Abstract
Multiple sclerosis (MS) is associated with a wide array of behavioral disorders that may be grouped into two broad categories, namely, those affecting cognition on the one hand and mood and affect on the other. Very little research has been specifically devoted to how gender may impact these conditions. When gender is discussed, it is largely in passing, as just one more variable in a lengthy list of factors that may, or may not, be associated with a particular disorder that is the focus of the researchers’ attention. The fact that gender has been largely bypassed in this fashion, however, should not obscure its potential importance, primarily as a modifier of psychopathology and cognition. This chapter will therefore provide an overview of disorders of cognition, mood, and affect in people with MS and, where relevant, highlight their associations with gender.
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References
WHO. Gender disparities in mental health world. Ment Heal Minist Round Tables 54th World Heal Assem. 2001;48(5):1–25.
Feinstein A. Multiple sclerosis and depression. Mult Scler. 2011;17(11):1276–81.
Patten S, Beck C, Williams J, Barbui C, Metz L. Major depression in multiple sclerosis: a population-based perspective. Neurology. 2003;61(11):1524–7.
Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.
Amato M, Ponziani G, Rossi F, Liedl C, Stefanile C, Rossi L. Quality of life in multiple sclerosis: the impact of depression, fatigue and disability. Mult Scler. 2001;7(5):340–4.
Arnett P, Higginson C, Voss W, Bender W, Wurst J, Tippin J. Depression in multiple sclerosis: relationship to working memory capacity. Neuropsychology. 1999;13(4):546–56.
Stenager EN, Stenager E, Koch-Henriksen N, Brønnum-Hansen H, Hyllested K, Jensen K, et al. Suicide and multiple sclerosis: an epidemiological investigation. J Neurol Neurosurg Psychiatry. 1992;55(7):542–5.
Feinstein A, Roy P, Lobaugh N, Feinstein K, O’Connor P, Black S. Structural brain abnormalities in multiple sclerosis patients with major depression. Neurology. 2004;62(4):586–90.
Akbar N, Lobaugh NJ, O’Connor P, Moradzadeh L, Scott CJM, Feinstein A. Diffusion tensor imaging abnormalities in cognitively impaired multiple sclerosis patients. Can J Neurol Sci. 2010;37(5):608–14.
Lynch SG, Kroencke DC, Denney DR. The relationship between disability and depression in multiple sclerosis: the role of uncertainty, coping, and hope. Mult Scler. 2001;7(6):411–6.
Minden SL, Feinstein A, Kalb RC, Miller D, Mohr DC, Patten SB, et al. Evidence-based guideline: assessment and management of psychiatric disorders in individuals with MS report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2014;82(2):174–81.
Koch MW, Glazenborg A, Uyttenboogaart M, Mostert J, De Keyser J. Pharmacologic treatment of depression in multiple sclerosis. Cochrane Database Syst Rev. 2011;(2):CD007295.
Dahl O-P, Stordal E, Lydersen S, Midgard R. Anxiety and depression in multiple sclerosis. A comparative population-based study in Nord-Trøndelag County, Norway. Mult Scler. 2009;15(12):1495–501.
Beiske A, Svensson E, Sandanger I, Czujko B, Pedersen E, Aarseth J, et al. Depression and anxiety amongst multiple sclerosis patients. Eur J Neurol. 2008;15(3):239–45.
Chwastiak L, Ehde DM, Gibbons LE, Sullivan M, Bowen JD, Kraft GH. Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample. Am J Psychiatry. 2002;159(11):1862–8.
Galeazzi GM, Ferrari S, Giaroli G, Mackinnon A, Merelli E, Motti L, et al. Psychiatric disorders and depression in multiple sclerosis outpatients: impact of disability and interferon beta therapy. Neurol Sci. 2005;26(4):255–62.
Zorzon M, de Masi R, Nasuelli D, Ukmar M, Mucelli RP, Cazzato G, et al. Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects. J Neurol. 2001;248(5):416–21.
Montel SR, Bungener C. Coping and quality of life in one hundred and thirty five subjects with multiple sclerosis. Mult Scler. 2007;13(3):393–401.
D’Alisa S, Miscio G, Baudo S, Simone A, Tesio L, Mauro A. Depression is the main determinant of quality of life in multiple sclerosis: a classification-regression (CART) study. Disabil Rehabil. 2006;28(5):307–14.
Théaudin M, Romero K, and Feinstein A. “In multiple sclerosis anxiety, not depression, is related to gender.” Multiple Sclerosis Journal. 2016;22(2):239–244.
Nagels G, Geentjens L, Kos D, Vleugels L, D’hooghe MB, Van Asch P, et al. Paced visual serial addition test in multiple sclerosis. Clin Neurol Neurosurg. 2005;107:218–22.
Da Silva AM, Vilhena E, Lopes A, Santos E, Gonçalves MA, Pinto C, et al. Depression and anxiety in a Portuguese MS population: associations with physical disability and severity of disease. J Neurol Sci. 2011;306(1–2):66–70.
Brown RF, Valpiani EM, Tennant CC, Dunn SM, Sharrock M, Hodgkinson S, et al. Longitudinal assessment of anxiety, depression, and fatigue in people with multiple sclerosis. Psychol Psychother. 2009;82(Pt 1):41–56.
Jones K, Ford D, Jones P, John A, Middleton R, Lockhart-Jones H, et al. A large-scale study of anxiety and depression in people with multiple sclerosis: a survey via the web portal of the UK MS register. PLoS One. 2012;7(7):1–10.
Korostil M, Feinstein A. Anxiety disorders and their clinical correlates in multiple sclerosis patients. Mult Scler. 2007;13(1):67–72.
Poder K, Ghatavi K, Fisk JD, Campbell TL, Kisely S, Sarty I, et al. Social anxiety in a multiple sclerosis clinic population. Mult Scler. 2008;15(3):393–8.
Feinstein A, O’Connor P, Gray T, Feinstein K. The effects of anxiety on psychiatric morbidity in patients with multiple sclerosis. Mult Scler. 1999;5(5):323–6.
Quesnel S, Feinstein A. Multiple sclerosis and alcohol: a study of problem drinking. Mult Scler. 2004;10(2):197–201.
Pozzilli C, Tomassini V, Marinelli F, Paolillo A, Gasperini C, Bastianello S. “Gender gap” in multiple sclerosis: magnetic resonance imaging evidence. Eur J Neurol. 2003;10(1):95–7.
Koenig K, Lowe M, Lin J, Sakaie K, Stone L, Bermel R, et al. Sex differences in resting-state functional connectivity in multiple sclerosis. AJNR Am J Neuroradiol. 2013;34(12):2304–11.
Fraser C, Polito S. A comparative study of self‐efficacy in men and women with multiple sclerosis. J Neurosci Nurs. 2007;39(2):102–6.
Jensen MP, Smith AE, Bombardier CH, Yorkston KM, Miró J, Molton IR. Social support, depression, and physical disability: age and diagnostic group effects. Disabil Health J. 2014;7(2):164–72.
Schiffer RB, Wineman N, Weitkamp L. Association between bipolar affective disorder and multiple sclerosis. Am J Psychiatry. 1986;143:94–5.
Schiffer RB, Weitkamp LR, Wineman NM, Guttormsen S. Multiple sclerosis and affective disorder: family history, sex, and HLA-DR antigens. Arch Neurol. 1988;45(12):1345–8.
Feinstein A, Feinstein K, Gray T, O’Connor P. Prevalence and neurobehavioral correlates of pathological laughing and crying in multiple sclerosis. Arch Neurol. 1997;54(9):1116–21.
Schiffer RB, Herndon RM, Rudick RA. Treatment of pathologic laughing and weeping with amitriptyline. N Engl J Med. 1985;312(23):1480–2.
Seliger GM, Hornstein A, Flax J, Herbert J, Schroeder K. Fluoxetine improves emotional incontinence. Brain Inj. 1992;6(3):267–70.
Panitch HS, Thisted RA, Smith RA, Wynn DR, Wymer JP, Achiron A, et al. Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis. Ann Neurol. 2006;59(5):780–7.
Fishman I, Benedict RHB, Bakshi R, Priore R, Weinstock-Guttman B. Construct validity and frequency of euphoria sclerotica in multiple sclerosis. J Neuropsychiatry Clin Neurosci. 2004;16(3):350–6.
Rabins PV, Brooks BR, O’donnell P, Pearlson GD, Moberg P, Jubelt B, et al. Structural brain correlates of emotional disorder in multiple sclerosis. Brain. 1986;109(4):585–97.
Miller A, Dishon S. Health-related quality of life in multiple sclerosis: the impact of disability, gender and employment status. Qual Life Res. 2006;15(2):259–71.
Casetta I, Riise T, Wamme Nortvedt M, Economou NT, De Gennaro R, Fazio P, et al. Gender differences in health-related quality of life in multiple sclerosis. Mult Scler. 2009;15(11):1339–46.
Lobentanz IS, Asenbaum S, Vass K, Sauter C, Klösch G, Kollegger H, et al. Factors influencing quality of life in multiple sclerosis patients: disability, depressive mood, fatigue and sleep quality. Acta Neurol Scand. 2004;110(1):6–13.
Chiaravalloti ND, Genova HM, DeLuca J. Cognitive rehabilitation in multiple sclerosis: the role of plasticity. Front Neurol. 2015;6:67.
De Giglio L, De Luca F, Prosperini L, Borriello G, Bianchi V, Pantano P, et al. A low-cost cognitive rehabilitation with a commercial video game improves sustained attention and executive functions in multiple sclerosis a pilot study. Neurorehabil Neural Repair. 2015;29(5):453–61.
Beatty WW, Aupperle RL. Sex differences in cognitive impairment in multiple sclerosis. Clin Neuropsychol. 2002;16(4):472–80.
Schoonheim MM, Hulst HE, Landi D, Ciccarelli O, Roosendaal SD, Sanz-Arigita EJ, et al. Gender-related differences in functional connectivity in multiple sclerosis. Mult Scler. 2012;18(2):164–73.
Schoonheim MM, Popescu V, Lopes FCR, Wiebenga OT, Vrenken H, Douw L, et al. Subcortical atrophy and cognition Sex effects in multiple sclerosis. Neurology. 2012;79(17):1754–1761.
Schoonheim MM, Vigeveno RM, Lopes FCR, Pouwels PJW, Polman CH, Barkhof F, et al. Sex-specific extent and severity of white matter damage in multiple sclerosis: Implications for cognitive decline. Hum Brain Mapp. 2014;35(5):2348–2358.
Savettieri G, Messina D, Andreoli V, Bonavita S, Caltagirone C, Cittadella R, et al. Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. J Neurol. 2004;251(10):1208–14.
Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG. Multiple sclerosis. N Engl J Med. 2000;343(13):938–52.
Whitacre CC, Reingold SC, O’Looney PA. A gender gap in autoimmunity. Science. 1999;283(5406):1277.
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Feinstein, A., Pavisian, B. (2017). Multiple Sclerosis, Gender, and Disorders of Behavior. In: Houtchens, M., Sadovnick, A. (eds) Health Issues in Women with Multiple Sclerosis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-4858-7_9
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DOI: https://doi.org/10.1007/978-3-7091-4858-7_9
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