D2-Protein and D3-Protein as Markers for Synaptic Turnover and Concentration

  • O. S. Jørgensen
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 18)


The D2-protein is in the brain present on the external surface of neurones, especially in newly formed processes and in synapses. In olfactory bulb, where synaptogenesis occur at a high rate, the concentration is twice the concentration in rat forebrain. D2-protein is probably involved in inter-neuronal adhesion during neuronal migration and synaptogenesis. The D3-protein is mainly present in mature synapses. Both proteins were studied in density gradient fractionated microsomes and osmotically shocked synaptosomes. It is suggested that the concentration of these proteins may be used as an index for synaptic turnover and density in both rodent and human brain.


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Copyright information

© Springer-Verlag Wien 1983

Authors and Affiliations

  • O. S. Jørgensen
    • 1
    • 2
  1. 1.Psychochemistry InstituteUniversity of CopenhagenDenmark
  2. 2.Psychochemistry InstituteKøbenhavn ØDenmark

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