The Normal and Aberrant Development of Synaptic Structures Between Parallel Fibers and Purkinje Cell Dendritic Spines

  • A. Hirano
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 18)


Under normal circumstances the dendritic spines of the cerebellar Purkinje cell differentiate in association with the parallel fibers formed by the descending granule cells. In the adult these elements form the most frequent synapse of the cerebellar cortex. In certain conditions, however, the granule cells are destroyed before they form the parallel fibers. Nevertheless, unattached dendritic spines are found which are complete with submembranous densities. Their cytochemical reactions and their morphology in both thin section and after freeze fracture are indistinguishable from normal spines except for the fact that they are unattached to any presynaptic elements. Examples of the formation of unattached presynaptic endings have also been observed. We conclude, therefore, that at least in some instances, pre- and postsynaptic terminals may form without benefit of the direct one-to-one influence of their synaptic mates.


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  1. Hanna, R. B., Hirano, A., Pappas, G. D.: Membrane specializations of dendritic spines and glia in the weaver mouse cerebellum. A freeze-fracture study. J. Cell Biol. 68, 403–410 (1976).CrossRefPubMedGoogle Scholar
  2. Hayes, B. P., Roberts, A.: The distribution of synapses along the spinal cord of an amphibian embryo: An electronmicroscopic study of junctional development. Cell Tiss. Res. 153, 227–244 (1974).Google Scholar
  3. Herndon, R. M., Margolis, G., Kilham, L.: The synaptic organization of the malformed cerebellum induced by perinatal infection with the feline panleukopenia virus (PLV) in the Purkinje cell and its afferents. J. Neuropathol. Exp. Neurol. 30, 557–570 (1971).CrossRefPubMedGoogle Scholar
  4. Hirano, A.: On the independent development of the pre- and postsynaptic terminals. In: Progress in Neuropathology, pp. 79–99. New York: Raven Press. 1979.Google Scholar
  5. Hirano, A., Dembitzer, H. M.: Cerebellar alterations in the weaver mouse. J. Cell Biol. 56, 478–486 (1973).CrossRefPubMedCentralPubMedGoogle Scholar
  6. Hirano, A., Dembitzer, H. M., Jones, M.: An electron microscopic study of cycasin-induced cerebellar alterations. J. Neuropathol. Exp. Neurol. 31, 113–125 (1972).CrossRefPubMedGoogle Scholar
  7. Hirano, A., Dembitzer, H. M., Yoon, C. H.: Development of Purkinje cell somatic spines in the weaver mouse. Acta Neuropathol. (Berl.) 40, 85–90 (1977).Google Scholar
  8. Hirano, A., Shin, W.-Y: Unattached presynaptic terminals in a cerebellar neuroblastoma in the human. J. Neuropathol. Appl. Neurobiol. 5, 63–70 (1979).CrossRefGoogle Scholar
  9. Larramendi, L. M. H.: Analysis of synaptogenesis in cerebellum of the mouse. In: Neurobiology of Cerebellar Evolution and Development, pp. 803–843. Chicago: American Medical Association/Education and Research Foundation. 1969.Google Scholar
  10. Palay, S. L., Chan-Palay, V.: Cerebellar Cortex. Berlin-Heidelberg-New York: Springer. 1974.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1983

Authors and Affiliations

  • A. Hirano
    • 1
  1. 1.Division of Neuropathology, Department of PathologyMontefiore Hospital and Medical Center, Albert Einstein College of MedicineBronxUSA

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