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Sonstige Psychopharmaka

  • Chapter
Neuro-Psychopharmaka

Zusammenfassung

Clomethiazol ist chemisch ein Derivat des Thiazol-Anteils des Thiamins (Vitamin B1) mit

  • antikonvulsiven,

  • sedativen,

  • hypnotischen und auch

  • anxiolytischen

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Literatur

  • Athen D (1986) Comparative investigation of chlormethiazole and neuroleptic agents in the treatment of alcoholic delirium. Acta Psychiatr Scand 329 (73): 167–170

    Article  CAS  Google Scholar 

  • Athen D, Hippids H, Meyendorf R, Riemer CH, Steiner CH (1977) Ein Vergleich der Wirksamkeit von Neuroleptika und Chlormethiazol bei der Behandlung des Alkoholdelirs. Nervenarzt 48: 528–532

    PubMed  CAS  Google Scholar 

  • Bayer AJ, Bayer EM, Pathy MSJ, Stoker MJ (1986) A double-blind controlled study of chlormethia- zole and triazolam as hypnotics in the elderly. Acta Psychiatr Scand [Suppl 329] 73: 104–111

    Article  Google Scholar 

  • Beckmann H, Athen D (1978) Die Therapie des Delirium tremens. Dtsch Med Wochenschr 103: 1427–1428

    Article  PubMed  CAS  Google Scholar 

  • Bekanntgabe Der Arzneimittelkommission Der DeutSchen Ă„rzteschaft (1977) Strenge Indikationsstellung fĂĽr Clomethiazol. Dtsch Ă„rztebl 74: 1905

    Google Scholar 

  • Calverley PMA, Carmichael GLM, Scott DB (1984) The effect of chlormethiazole on the hypoxic drive to breathing in normal man. Br J Clin Pharmacol 18: 163–167

    Article  PubMed  CAS  Google Scholar 

  • Calverley PMA, Carmichael GLM, Scott DB (1987) Die Behandlung des Delirium tremens bei Alkoholentzug. Arzneimittelbrief. Berlin, Jahrgang 21 (125): 97–100

    Google Scholar 

  • Douglas NJ, White DP, Weil JV et al. (1982) Hypoxic ventilatory response decrease during sleep in normal man. Am Rev Resp Dis 1235: 286–289

    Google Scholar 

  • Evans J, Lewis SA, Tinker M (1972) Chlormethiazole, sleep and drug withdrawal. Psychol Med 2: 239–247

    Article  PubMed  CAS  Google Scholar 

  • Feuerlein W (1989) Aktuelle Beiträge zur Definition und Therapie der Alkoholkrankheit. Neuropsychiatrie 3: 7–12

    Google Scholar 

  • Fischer PA (1977) Intensivbehandlung des Alkoholentzugssyndroms. Diagnostik Intensivther 2: 9–11

    Google Scholar 

  • Geisler L, Herberg D (1967) Studies on the effect of some commonly used drugs on the excitability of the respiratory centre in man. Therapiewoche 47: 1941–1947

    Google Scholar 

  • Giacobini E, Salum I (1961) Treatment of delirium tremens. A comparative study of different therapeutic methods in 434 cases. Acta Psychiatr Scand 37: 198–208

    Article  PubMed  CAS  Google Scholar 

  • Gsell S et al. (1972) Atem-und Herzstillstand unter Distraneurin. Nervenarzt 43: 635

    PubMed  CAS  Google Scholar 

  • Helbig H (1962) Das tödliche Alkoholdelir. Nervenarzt 33: 221–226

    PubMed  CAS  Google Scholar 

  • Hoensch HP (1986) Effect of chlormethiazole on the hepatic monooxygenase enzyme system. Acta Psychiatr Scand [Suppl 329] 73: 66–68

    Article  Google Scholar 

  • Holzbach E, Boiler KE (1978) Die Behandlung des Delirium tremens mit Haldol. Nervenarzt 49: 405–409

    PubMed  CAS  Google Scholar 

  • Jostell KG (1987) Pharmacokinetics of chlormethiazole in man and influence of altered physiological conditions. Acta Univ Ups, Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 31. Graphic Systems, Stockholm

    Google Scholar 

  • Jostell KG et al. (1986) The bioavailability and pharmacodynamics of chlormethiazole in healthy young and elderly volunteers: praeliminary findings. Acta Psychiatr Scand [Suppl 329] 73: 32–33

    Article  Google Scholar 

  • Kalant H, Khanna JM (1986) Metabolic and functional aspects of tolerance to chlormethiazole and cross-tolerance to ethanol in the rat. Acta Psychiatr Scand [Suppl 329] 73: 45–53

    Article  Google Scholar 

  • Kalant H, Khanna JM, Llewellyn M, Rinkel GJE, Woodworth I (1986) Functional tolerance to chlormethiazole and crosstolerance to ethanol in the rat: importance of test and mode of drug administration. Acta Psychiatr Scand [Suppl 329] 73: 54–65

    Article  Google Scholar 

  • Keup W (1977) Das Abhängigkeitspotential des Clomethiazol (Distraneurin). Dtsch Arztebl 74: 1902–1905

    Google Scholar 

  • Klotz U, Avant GR, Hoyumpa A, Schenker S, Wilkin-Son GR (1975) The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J Clin Invest 55: 347–359

    Article  PubMed  CAS  Google Scholar 

  • Koo KW, Sax DS, Snider GL (1975) Arterial blood gases and pH during sleep in chronic obstructive pulmonary disease. Am J Med 58: 663–670

    Article  PubMed  CAS  Google Scholar 

  • Laborit H, Coirault R (1957) L’utilisation en clinique mĂ©dicale et psychiatrique de l’action hypogĂ©ne d’un dĂ©rivĂ© du noyau thiazolique de la Vitamine B1. Le S.C.T.Z. Sem Med (Paris) 33: 1704

    Google Scholar 

  • Laborit H, Coirault R, Damasio R, Guarjard R, Laborit G, Fabrizy P (1957) Sur un type nouveau d’anesthĂ©sie chirurgicale et sur e’emploi en thĂ©rapeutique d’un dĂ©presseur du cortex cĂ©rĂ©bral. ( S.C.T.Z. ). Anesth Analg 14: 384

    Google Scholar 

  • Liljenberg B et al. (1986) The effects of chlormethiazole in EEG recorded sleep in normal elderly volunteers. Acta Psychiatr Scand [Suppl 329] 73: 34–39

    Article  Google Scholar 

  • Majumdar SK (1978) The effect of chlormethiazole on hepatic microsomal enzymes. Pharmatherapeutica 2: 27–30 (reprint)

    Google Scholar 

  • Majumdar SK (1981) Effects on the endocrine system of drugs used in treating the ethanol withdrawal syndrome: a survey. Drug Alcohol Depend 7: 379–385

    Article  PubMed  CAS  Google Scholar 

  • Majumdar SK (1986) The influence of chlormethiazole on the neuroendocrine system in chronic alcoholics. Acta Psychiatr Scand [Suppl 329] 73: 69–72

    Article  Google Scholar 

  • Marion H, Schneider E (1970) Der EinfluĂź von Chlormethiazol ( Distraneurin) auf das SchlafElektroencephalogramm nach Alkoholdelir. Pharmakopsychiatr Neuro Psychopharm 3: 233–238

    Google Scholar 

  • Moore RG, Triggs EJ, Shanks CM, Thomas J (1975a) Pharmacokinetics of chlormethiazole in humans. Eur J Clin Pharmacol 8: 353–357

    Article  PubMed  CAS  Google Scholar 

  • Moore RG, Robertson AV, Smytm I MP, Thomas J, Vine J (1975b) Metabolism and urinary excretion of chlormethiazole in humans. Xenobiotica 5: 687–696

    Article  PubMed  CAS  Google Scholar 

  • Nies AS, Shand PG, Wilkinson GR (1976) Altered hepatic blood flow and drug disposition. Clin Pharmacokin 1: 135–155

    Article  CAS  Google Scholar 

  • Ogren SO (1986) Chlormethiazole-mode of action. Acta Psychiatr Scand [Suppl 329] 73: 13–27

    Article  Google Scholar 

  • Platz W (1981) Therapie medikamentös bedingter deliranter Syndrome, insbesondere bei Clomethiazol- Abhängigkeit. In: Keup W (Hrsg) Behandlung der Sucht und des MiĂźbrauchs chemischer Stoffe. 4. Wissenschaftliches Symposium der Deutschen Hauptstelle gegen die Suchtgefahren in Tutzing, 1980. Thieme, Stuttgart New York, S 65–73

    Google Scholar 

  • Platz W (1985) Medikamentöse Therapie bei gerontopsychiatrischen Notfällen. Med Klin 80: 511–513

    Google Scholar 

  • Pälsson A (1986) The efficacy of early chlormethiazole medication in the prevention of delirium tremens. A retrospective study of the outcome of different drug treatment strategies at the Helsingborg psychiatric clinics, 1975–1980. Acta Psychiatr Scand [Suppl 329] 73: 140–145

    Article  Google Scholar 

  • Schied HW, Mann K (1989) Die Behandlung des Delirium tremens und des Alkoholentzugssyndroms. In: Schied HW, Heimann H, Mayer K (Hrsg) Der chronische Alkoholismus. Fischer, Stuttgart New York, S 285–300

    Google Scholar 

  • Schmehling E (1967) Atemdepression nach Distraneurin? Nervenarzt 38: 266–269

    PubMed  CAS  Google Scholar 

  • Schmidt L (1986) Alkoholkrankheit AlkoholmiĂźbrauch. Kohlhammer, Stuttgart Berlin Köln Mainz

    Google Scholar 

  • Scott DB (1986) Circulatory and respiratory effects of chlormethiazole. Acta Psychiatr Scand [Suppl 329] 73: 28–31

    Article  Google Scholar 

  • Stille G (1986) Das Abhängigkeitspotential von Clomethiazol. In: Evans G, Feuerlein W, Glatt MM, Kanowski S, Scott DB (Hrsg) Clomethiazol. Verlag fĂĽr angewandte Wissenschaften, MĂĽnchen, S 103–109

    Google Scholar 

  • Who Expert Committee on Drug Dependence (1988) Twenty-fourth report. Technical Report Series 761. World Health Organization, Geneva, pp 11–13

    Google Scholar 

  • Ahrens R (1991) Androcur (Cyproteronacetat) bei Sexualdelinquenz — Nachuntersuchung von untergebrachten psychiatrischen Patienten. Schweiz Arch Neurol Psychiatr 142: 171–188

    PubMed  CAS  Google Scholar 

  • Bancroft J, Tennent G, Loucas K, Cass J (1974) The control of deviant sexual behaviour by drugs. Br J Psychiatry 125: 310–315

    Article  PubMed  CAS  Google Scholar 

  • Bhargava AS, Soeger A, GĂĽnzel P (1977) Isolation und identification of 15-beta-hydroxy cyproterone acetats as a new metabolite of cyproterone acetate in dog, monkey and man. Steroids 30: 407

    Article  PubMed  CAS  Google Scholar 

  • Binder S, Roters G, Schultka H (1971) Klinische und experimentell-psychologische Untersuchungen zur Wirkung des Antiandrogens Cyproteronazetat bei erheblich vermindert zurechnungsfähigen und zurechnungsunfähigen Sexualdelinquenten. Nervenarzt 42: 26

    PubMed  CAS  Google Scholar 

  • Cooper AJ, Ismail AAA, Phanjoo AL, Lone DL (1972) Anti-androgen therapy in deviant hypersexuality. Br J Psychiatry 102: 59

    Article  Google Scholar 

  • Dorfmann RI (1970) Serum assays and anti-androgens. Biological activity on antiandrogens. Br J Dermatol 82 [Suppl 61: 3–8

    Article  Google Scholar 

  • Fähndrich E (1974) Cyproteronacetat in der Behandlung von Sexualdeviationen bei Männern. Dtsch Med Wochenschr 99: 234

    Article  PubMed  Google Scholar 

  • Herrmann WM, Beach RC (1978) Experimental and clinical data indicating the psychotropic properties of progestogens. Postgraduate Med J 54 [Suppl 2]: 82–87

    CAS  Google Scholar 

  • Hoffet H (1968) Die medizinischen Behandlungsmöglichkeiten von Sexualdelinquenten. Schweiz Z Strafrecht 84: 377

    Google Scholar 

  • Hoffet H (1969) Neue Wege in der Behandlung von Sexualdelinquenten. Kriminalistik 23: 405

    Google Scholar 

  • Hoffet H (1980) Die klinische Anwendung von Antiandrogenen in der Psychiatrie. Gynäkologe 13: 33–43

    PubMed  CAS  Google Scholar 

  • Horn HJ (1971) Der Leidensdruck als Indikationskriterium. Bemerkungen zur “medikamentösen Kastration”. Nervenarzt 42: 312

    PubMed  CAS  Google Scholar 

  • Itil TM, Cora R, Akpinar S, Herrmann WM, Patter-Son CI (1974) Psychotropic action of sex hormones. Curr Ther Res 16. 11: 1147

    Google Scholar 

  • Kockott G (1983) Die Behandlung sexueller Delinquenz mit Antiandrogenen. Psychiat Prax 10: 158–164

    CAS  Google Scholar 

  • Laschet U (1970) Ergebnisse neuer medikamentöser Behandlungsmethoden bei Sexualdelinquenten. Kriminolog Gegenwartsfragen 9: 174–179

    Google Scholar 

  • Laschet U (1988) Die Behandlung männlicher Sexualdeviationen. 20 Jahre Erfahrungen mit Androcur. Vorlesungsreihe Schering, Heft 20

    Google Scholar 

  • Laschet U, Laschet L (1971) Psychopharmacotherapy of sex offenders with cyproterone acetate. Pharmakopsychiatr Neuro Psychopharmakol 4: 99–104

    Article  Google Scholar 

  • Laschet U, Laschet L (1978) Ten years cyproterone acetate for the modification of sexual behaviour in men. bga-Berichte 3: 91–96

    Google Scholar 

  • Menghini P, Ernst K (1991) Die Antiandrogenbehandlung im rĂĽckblickenden Urteil von 19 Sexualstraftätern. Nervenarzt 62: 303–307

    PubMed  CAS  Google Scholar 

  • Micheroli R, Battegay R (1985) Ambulante Behandlung von Sexualdelinquenten mit Cyproteronacetat ( Androcur ). Schweiz Arch Neurol Neurochir Psychiatr 136: 37–58

    Google Scholar 

  • Mothes C, Lehnert J, Samimi F, Ufer J (1973) Klinische PrĂĽfung von Cyproteronacetat ( Androcur) bei Sexualdeviationen - Gesamtauswertung. Med Mitteilungen 2: 26–39

    Google Scholar 

  • Neumann F (1977) Normale und gestörte Sexualdifferenzierung. Medizin in unserer Zeit 1: 98–108

    Google Scholar 

  • Neumann F (1978) Chemie, Biochemie und pharmakologische Grundlagen der Antiandrogene. Dtsch Ă„rztebl 75: 1633–1640

    Google Scholar 

  • Neumann F (1986) Pharmacology and clinical uses of cyproteron-acetate. In: Furr BJA, Wakeling AE (eds) Pharmacology and clinical uses of inhibitors of hormone secretion and action. BailliĂ©re Tindall, London Philadelphia Toronto Mexico City Sydney Tokyo Hong Kong, pp 132–159

    Google Scholar 

  • Neumann F (1989) Möglichkeiten der pharmakodynamischen Beeinflussung des Sexualverhaltens. Symposium Sexualmedizin, Heidelberg

    Google Scholar 

  • Neumann F, Elger W (1966) Permanent changes in gonadal function and sexual behaviour as a result of early feminization of male rats by treatment with an antiandrogenic steroid. Endokrinologie 50: 209–225

    PubMed  CAS  Google Scholar 

  • Neumann F, Wiechert R (1984) Die Geschichte von Cyproteronacetat. MPS, Med Pharmazeut Studienges e.V., Mainz. Berichte aus der PharmaForschung, Bd I II

    Google Scholar 

  • Neumann F, Wiechert R (1988) Das Antiandrogen Cyproteron-acetat. Pharmazie in unserer Zeit 17: 33–50

    Article  PubMed  CAS  Google Scholar 

  • Neumann F, Elger W, Steinbeck H (1970) Antiandrogens and reproductive development. Phil Trans Roy Soc Lond B 259: 179–184

    Article  CAS  Google Scholar 

  • Neumann F, Schleusener A, Albring M (1978) Pharmacology of antiandrogens. IN: Hammerstein J, Lachnit-Fixson U, Neumann F, Plewig G (eds) Androgenization in women–acne, seborrhoea, androgenetic alopecia and hirsutism. Excerpta Medica, Amsterdam Oxford Princeton, pp 147–192

    Google Scholar 

  • Neumann F, Schleusener A, Humpel M (1979) Antiandrogene. Gynäkologe 12: 228–242

    Google Scholar 

  • Ott F, Hoffet H (1968) Beeinflussung von Libido, Potenz und Hodenfunktion durch Antiandrogene. Schweiz Med Wochenschr 98: 1812–1815

    Google Scholar 

  • Rasch W (1978) Sexuelle Devianz und strafrechtliche Sanktion. In: FĂĽllgraff G, Barbey I (Hrsg) AbschluĂźbericht der Kommission beim Bundesgesundheitsamt: Stereotaktische Hirnoperationen bei abweichendem Sexualverhalten (bga-Berichte 3 ). D Reimer, Berlin, S 111–114

    Google Scholar 

  • Rasch W (1986) Forensische Psychiatrie. Kohlhammer, Stuttgart Berlin Köln Mainz

    Google Scholar 

  • RaspĂ© G (ed) (1972) Schering Symposium ĂĽber Sexualdeviationen und ihre medikamentöse Behandlung. Life Science Monographs 2. Pergamon Press. Vieweg, Oxford Edinburgh New York Toronto Sydney Braunschweig

    Google Scholar 

  • Schacher A, el Etreby MF, Neumann F (1984) EinfluĂź von Cyproteronacetat, Flutamid und Spironolacton auf die Achse Hypothalamus-Hypophyse-Hoden bei Ratten. Akt Urol 15: 218

    Google Scholar 

  • Sigusch V (1979) Die Behandlung mit Antiandrogenen. Sexualmedizin 8: 13–19

    Google Scholar 

  • Wiechert R, Neumann F (1965) Gestagene Wirksamkeit von 1-Methyl-und 1,2a-Methylen-Steroiden. Arzneimittelforschung 15: 244–246

    CAS  Google Scholar 

  • Azrin NH, Sisson RW, Meyer SR, Godley M (1982) Alcoholism treatment by disulfiram and com- munity reinforcement therapy. J Behav Ther Exp Psychiatry 13: 105–112

    Article  PubMed  CAS  Google Scholar 

  • Bartmann U, Fautsch J (1991) Eine Chance fĂĽr die ambulante Therapie. Psycho 17: 192–202

    Google Scholar 

  • Bartonicek V, Teisinger J (1962) Effect of tetraethyl thiuram disulphide (disulfiram) on metabolism of trichloro-ethylene in man. Br J Industr Med 19: 216–221

    CAS  Google Scholar 

  • Bilbao JM, Briggs SJ, Gray TA (1984) Filamentous axonopathy in disulfiram neuropathy. Ultrastruct Pathol 7: 295–300

    Article  PubMed  CAS  Google Scholar 

  • Chick J, Gough K, Falkowski W, Kershaw P, Hore B, Mehta B, Ritson B, Ropner R, Torley D (1992) Disulfiram treatment of alcoholism. Br J Psychiatry 161: 84–89

    Article  PubMed  CAS  Google Scholar 

  • Christensen JK, Ronsted P, Vaag VH (1984) Side effects after disulfiram. Acta Psychiatr Scand 69: 265–273

    Article  PubMed  CAS  Google Scholar 

  • Ciraulo DA, Barnhill J, Boxenbaum H (1985) Pharmacokinetic interaction of disulfiram and an- tidepressants. Am J Psychiatry 142: 1373–1374

    PubMed  CAS  Google Scholar 

  • Coger RW, Dymond AM, Serafetinides EA et al. (1976) Averaged visual evoked response amplitude-intensity slope and symmetry in withdrawal. Biol Psychiatry 11: 435–443

    PubMed  CAS  Google Scholar 

  • Cushmann P (1986) Sedative drug interactions of clinical importance. In: Galanter M (ed) Alcoholism, vol 4. Plenum Press, New York London

    Google Scholar 

  • Feuerlein W (1989) Alkoholismus — MiĂźbrauch und Abhängigkeit, 4. Aufl. G Thieme, Stuttgart

    Google Scholar 

  • Fischer I (1945) Säregen svampförgiftining. Sv Läk-Tidn 42: 2513–2515

    Google Scholar 

  • Fuller RK (1988) Disulfiram treatment of alcoholism. In: ROSE RM, BARRET JE (eds) Alcoholism: origins and outcome. Raven Press, New York, pp 237–244

    Google Scholar 

  • Fuller RK, Roth HP (1979) Disulfiram for the treatment of alcoholism: an evaluation in 128 men. Ann Intern Med 90: 901–904

    PubMed  CAS  Google Scholar 

  • Fuller RK, Williford WO (1980) Life-table analysis of abstinence in a study evaluating the efficacy of disulfiram. Alcohol Clin Exp Res 4: 298–301

    Article  PubMed  CAS  Google Scholar 

  • Gill K, Amit Z (1989) Serotonin uptake blockers and voluntary alcohol consumption. A review of recent studies. In: Galanter M (ed) Alcoholism, vol 7. Plenum Press, New York London, pp 225–248

    Google Scholar 

  • Halo E, Jacobson I (1948) A drug sensitising the organism to ethylalcohol. Lancet 11: 1001–1003

    Google Scholar 

  • Haubroe K (1980) What we know today about “Antabuse® (Disulfiram)”. Manedsskrift for praktisk Laegegerning 58: 30–40

    Google Scholar 

  • Iber FL, Lee K, Lacoursiere R, Fuller R (1987) Liver toxicity encoutered in the Veterans Administration trial of disulfiram in alcoholics. Alcohol Clin Res 11: 301–304

    Article  CAS  Google Scholar 

  • Jacobsen E (1967a) Neues ĂĽber die theoretische Grundlage der Disulfiram-Wirkung. Med Welt 18 (N.F.): 2169–2173

    Google Scholar 

  • Jacobsen E (1967b) Die Verwendung von Disulfiram (Antabus®). Med Welt 18 (N.F.): 2230–2234

    Google Scholar 

  • Jaffe JH, Ciraulo DA (1985) Drugs used in the treatment of alcoholism. In: Mendelson JH, Mello NK (eds) The diagnosis and treatment of alcoholism, 2nd ed. McGraw-Hill, New York

    Google Scholar 

  • Jensen E (1984) A proper use of Antabuse, the Danish model of treatment. Br J Clin Pract [Suppl 36] 38: 2–4

    Google Scholar 

  • Kitson TM (1977) The disulfiram-ethanol reaction. J Studies Alcohol 38: 96–113

    CAS  Google Scholar 

  • Koelsch F (1914) Ăśber neuartige gewerbliche Erkrankungen in Kalkstickstoffbetrieben. MĂĽnch Med Wochenschr 35: 1869–1870

    Google Scholar 

  • Koivusalo M (1956) Studies on the metabolism of methanol and formaldehyde in the animal organism. Acta Physiol Scand 39 [Suppl 131]

    Google Scholar 

  • KĂĽfner H, Feuerlein W (1989) In-patient treatment for alcoholism. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Lenz H (1957) Zur Ursache der fehlenden Antabus-Alkohol-Reaktion. Wien Klin Wochenschr 38 /39: 743

    Google Scholar 

  • Lindros KO, Stowell A, Pikkarainen P, Salaspuro M (1981) The disulfiram (Antabuse) alcohol reaction in male alcoholics: its efficient management by 4-methylpyrazole. Alcohol Clin Exp Res 5: 528–530

    Article  PubMed  CAS  Google Scholar 

  • Macleod SM, Sellers EM, Giles HG, Billings BJ, Martin PR, Greenblatt DJ, Marshman JA (1978) Interaction of disulfiram with benzodiazepines. Clin Pharmacol Ther 24: 583–589

    PubMed  CAS  Google Scholar 

  • Mccrady B (1989) Outcomes of family-involved alcoholism treatment. In: Galanter M (ed) Alcoholism, vol 7. Plenum Press, New York London, pp 165–182

    Google Scholar 

  • Nutt D, Adinoff B, Limoila M (1989) Benzodiazepines in the treatment of alcoholism. In: Galanter M (ed) Alcoholism, vol 7. Plenum Press, New York London, pp 283–313

    Google Scholar 

  • Pattison EM (1985) The selection of treatment modalities for the alcoholic patient. In: Mendelson JH, Mello NK (eds) The diagnosis and treatment of alcoholism, 2nd ed. McGraw-Hill, New York

    Google Scholar 

  • Peeke SC, Prael AR, Herning RI et al. (1979) Effect of disulfiram on cognition, subjective response, and cortical event-related alcoholic in nonalcoholic subjects. Alcohol Clin Exp Res 3: 223–229

    Article  PubMed  CAS  Google Scholar 

  • Perman ES (1962) Effect of ethanol on oxygen uptake and on blood glucose concentration in anesthetized rabbits. Acta Physiol Scand 55: 189–202

    Article  PubMed  CAS  Google Scholar 

  • Platz WE (1992) Alkoholkriminalität (in Vorbereitung)

    Google Scholar 

  • Rainey JM (1977) Disulfiram toxicity and carbon disulfide poisoning. Am J Psychiatry 134: 371–378

    PubMed  CAS  Google Scholar 

  • Robichaud C, Strickler D, Bigelow G, Liebson I (1979) Disulfiram maintenance employee alcoholism treatment: a three-phase evaluation. Behav Ther 14: 618–621

    Google Scholar 

  • Schmidt L (1986) Alkoholkrankheit and AlkoholmiĂźbrauch. Kohlhammer, Stuttgart

    Google Scholar 

  • Schuckit MA (1981) Disulfiram (Antabuse) and the treatment of alcoholic men. Adv Alcohol 11: 1–4

    Google Scholar 

  • Schuckit MA (1985a) Treatment of alcoholism in offices and outpatient settings. In: Mendelson JH, Mello NK (eds) The diagnosis and treatment of alcoholism, 2nd ed. McGraw-Hill, New York

    Google Scholar 

  • Schuckit MA (1985b) A one-year follow-up of men alcoholics given disulfiram. J Stud Alcohol 46: 191–195

    PubMed  CAS  Google Scholar 

  • Schuckit MA ( 1985 c) Inpatient and residential approaches to the treatment of alcoholism. In: Mendelson JH, Mello NK (eds) The diagnosis and treatment of alcoholism, 2nd ed. McGraw-Hill, New York

    Google Scholar 

  • Schuckit MA (1989) Drug and alcohol abuse. Plenum, New York London

    Google Scholar 

  • Sellers EM, Naranjo CA, Peachey JE (1981) Drugs to decrease alcohol consumtion. N Engl J Med 305: 1255–1262

    Article  PubMed  CAS  Google Scholar 

  • Staub H (1955) Beiträge zum Antabuse-Problem. Helv Physiol Acta 13: 121–140

    CAS  Google Scholar 

  • Strömme JH, Eldjarn L (1966) Distribution and chemical forms of diethyldithiocarbamate and tetraethylthiuram disulphide ( Disulfiram) in mice in relation to radioprotection. Biochem Pharmacol 15: 287–297

    Google Scholar 

  • Truitt EB, Duritz G, Morgan AM, Prouty RW (1962) Disulfiram-like actions produced by hypoglycemic sulfonylurea compounds. Q J Stud Alcohol 23: 197–207

    PubMed  CAS  Google Scholar 

  • Usdin GL, Rond PC, Hinchcliffe JA, Ross WD (1952) The meaning of disulfiram to alcoholics in group psychotherapy. Q J Stud Alcohol 13: 590–599

    PubMed  CAS  Google Scholar 

  • Williams EE (1937) Effects of alcohol on workers with carbon disulfide. JAMA 109: 1472–1473

    Article  Google Scholar 

  • Apter A, Van Praag HM, Plutchik R, Sevy S, Korn M, Brown SL (1990) Interrelationships among anxiety, aggression, impulsivity, and mood: a serotonergically linked cluster? Psychiatry Res 32: 191–199

    Article  PubMed  CAS  Google Scholar 

  • Ball JC, Ross A (1991) (eds) The effectiveness of methadone maintenance treatment. Springer, Berlin Heidelberg New York Tokyo

    Book  Google Scholar 

  • Balldin JK, Berggren UC, Lindstedt G (1992) Neuroendocrine evidence for reduced dopamine receptor sensitivity in alcoholism. Alcoholism Clin Exp Res 16: 71–74

    Article  CAS  Google Scholar 

  • Barnes DM (1988) The biological triangle of drug addiction. Science 241: 415–417

    Article  PubMed  CAS  Google Scholar 

  • Baumgarten HG (1991) Neuroanatomie und Neurophysiologie des zentralen 5-HT-Systems. In: Heinrich K, Hippius H, Poldinger W (Hrsg) Serotonin–ein funktioneller Ansatz fĂĽr die psychiatrische Diagnose und Therapie? Springer, Berlin Heidelberg New York Tokyo, S 17–44

    Google Scholar 

  • Bergmark A, Oscarsson L (1987) The concept of control and alcoholism. Br J Addict 82: 1203–1212

    Article  PubMed  CAS  Google Scholar 

  • Bloom FE (1987) Future directions and goals in basic psychopharmacology. In: Meltzer HY (ed) Psychopharmacology. The third generation of progress. Raven Press, New York, pp 1685–1689

    Google Scholar 

  • Blum K, Briggs AH, Trachtenberg M (1989) Ethanol ingestive behaviour as a function of central neurotransmission. Experientia 45: 444–452

    Article  PubMed  CAS  Google Scholar 

  • Boning J (1989) Anxiety and dependence–reason or consequence? Psychiat Fen [Suppl] 20: 83–90

    Google Scholar 

  • Boning J (1991) Zur Neurobiologie und Psychopathologie sĂĽchtigen Verhaltens. In: Wanke K, Behringer G (Hrsg) Grundstörungen der Sucht.Springer, Berlin Heidelberg New York Tokyo, S 1–27

    Google Scholar 

  • Brahen LS, Capone TJ, Capone DM (1988) Naltrexon: lack of effect on liver enzymes. J Clin Pharmacol 28: 64–70

    PubMed  CAS  Google Scholar 

  • Breese GR, Criswell HE, Mueller RA (1990) Evidence that lack of brain dopamine during development can increase the susceptibility for aggression and self-injurious behaviour by influencing D1-dopamine receptor function. Prog Neuro Psychopharmacol Biol Psychiatry 14: S 65–80

    Article  Google Scholar 

  • Brewer C, Rezae H, Bailey C (1988) Opioid withdrawal and naltrexone induction in 48–72 hours with minimal dropout, using a modification of the naltrexone-clonidine technique. Br J Psychiatry 153: 340–343

    Article  PubMed  CAS  Google Scholar 

  • Bronisch F (1990) Alcoholism and depression. Prog Alcohol Res 2: 69–99

    Google Scholar 

  • Bruno F (1989) Buspirone in the treatment of alcoholic patients. Psychopathology 22: 49–59

    Article  PubMed  Google Scholar 

  • Buydens-Branchey L, Branchey MH, Noumair D (1989) Age of alcoholism onset. I. Relationship to psychopathology. II. Relationship to susceptibility to serotonin precursor availability. Arch Gen Psychiatry 46: 225–230, 231–236

    Google Scholar 

  • Cadoret RJ, Troughton E, Bagford J, Woodworth G (1990) Genetic and environmental factors in adoptee antisocial personality. Eur Arch Psychiatr Neurol Sci 239: 231–240

    Article  CAS  Google Scholar 

  • Cloninger CR (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236: 410–416

    Article  PubMed  CAS  Google Scholar 

  • Cloninger CR, Sigvardsson S, Bohman M (1988) Childhood personality predicts alcohol abuse in young adults. Alcoholism Clin Exp Res 12: 494–505

    Article  CAS  Google Scholar 

  • Collingridge GL, Davies SN (1989) NMDA receptors and long-term potentiation in the hippocampus. In: Watkins JC, Collingridge GL (eds) The Nmda receptor. IRL Press, Oxford, pp 123–136

    Google Scholar 

  • Costall B, Jones BJ, Kelly ME, Naylor RJ, Onaivi ES, Tyres MB (1990) Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuse. Pharmacol Biochem Behav 36: 339–344

    Article  PubMed  CAS  Google Scholar 

  • Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. PNAS 85: 5274–5278

    Article  PubMed  Google Scholar 

  • Dongier M, Vachon L, Schwartz G (1991) Bromocriptine in the treatment of alcohol dependence. Alcoholism Clin Exp Res 15: 970–977

    Article  CAS  Google Scholar 

  • Dorus W, Ostrow DG, Anton R et al. (1989) Lithium therapy of depressed and nondepressed alcoholics. JAMA 262: 1646–1652

    Article  PubMed  CAS  Google Scholar 

  • Fawcett J, Clark DC, Aagesen CA, Pisani VD, Tilkin JM, Sellers D, Mcguire M, Gibbons RD (1987) A double-blind, placebo-controlled trial of lithium carbonate therapy for alcoholism. Arch Gen Psychiatry 44: 248–256

    Article  PubMed  CAS  Google Scholar 

  • Finlay JM, Damsma G, Fibiger HC (1992) Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration. Psychopharmacology 106: 202–208

    Article  PubMed  CAS  Google Scholar 

  • Friessem DH, Täschner KL (1991) Codein and Dihydrocodein als Ausweich-and Ersatzdrogen. Fortschr Neurol Psychiat 59: 164–169

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Alonso F, Gutierrez M, San L et al. (1989) A multicenter study to introduce naltrexone for opiate dependence in Spain. Drug Alcohol Depend 23: 117–121

    Article  PubMed  CAS  Google Scholar 

  • Gawin FH, Kleber HD (1984) Cocaine abuse treatment: open pilot trial with desipramine and lithium carbonate. Arch Gen Psychiatry 42: 903–910

    Article  Google Scholar 

  • Gawin FH, Allen D, Humblestone B (1989) Outpatient treatment of “crack” cocaine smoking flupentixol decanoate a preliminary report. Arch Gen Psychiatry 46: 322–325

    Article  PubMed  CAS  Google Scholar 

  • George DT, Adinoff B, Ravitz B, Nutt DJ, Dejong J, Berrettini W, Mefford IN, Costa E, Linnoila M (1990a) A cerebrospinal fluid study of the pathophysiology of panic disorder associated with alcoholism. Acta Psychiatr Scand 82: 1–7

    Article  PubMed  CAS  Google Scholar 

  • George DT, Nun DJ, Dwyer BA, Linnoila M (1990b) Alcoholism and panic disorder: is the comorbidity more than coincidence? Acta Psychiatr Scand 81: 97–107

    Article  PubMed  CAS  Google Scholar 

  • Ginzburg HM (1986) Naltrexone: its clinical utility. Adv Alcohol Subst Abuse 5: 83–101

    Article  Google Scholar 

  • Goldstein A (1989) (ed) Molecular and cellular aspects of the drug addictions. Springer, Berlin Heidelberg New York Tokyo

    Book  Google Scholar 

  • Graeff FL (1986) 5-Hydroxytryptamine, aversion, and anxiety. Behav Brain Sci 9: 339–340

    Google Scholar 

  • Gronbladh L, Ohlund LS, Gunne LM (1990) Mortality in heroin addiction: impact of methadone treatment. Acta Psychiatr Scand 82: 223–227

    Article  PubMed  CAS  Google Scholar 

  • Hartmann F, Poirier MF, Bourdel MC, Loo H, Le-Comte JM, Schwartz JC (1991) Comparison of acetorphan with clonidine for opiate withdrawal symptoms. Am J Psychiatry 148: 627–629

    PubMed  CAS  Google Scholar 

  • Havemann-Reinecke U (1991) Sucht–zur neuro-biologischen Grundlagenforschung in der Bundesrepublik. In: Materialien zur Gesundheitsforschung. Schriftreihe zum Programm der Bundesregierung Forschung und Entwicklung im Dienste der Gesundheit (Hrsg) Suchtforschung: Bestandsaufnahme und Analyse des Forschungsbedarfs. Bonn (Bd 19 ), S 33–49

    Google Scholar 

  • Hawkes CH (1992) Endorphins: the basis of pleasure? J Neurol Neurosurg Psychiatry 55: 247–250

    Article  PubMed  CAS  Google Scholar 

  • Herz A, Shippenberg TS (1989) Neurochemical aspects of addiction: opioids and other drugs of abuse. In: Goldstein A (ed) Molecular and cellular aspects of the drug addiction. Springer, Berlin Heidelberg New York Tokyo, pp 111–142

    Chapter  Google Scholar 

  • Hubbard RL, Rachal JV, Craddock SG, Cavanaugh ER (1984) Treatment outcome prospective study (TOPS): client characteristics and behaviours before, during, and after treatment. In: TIMs FM, Ludford JP (eds) Drug abuse treatment evaluation: strategies, progress and prospects. NIDA, Rockville, MD, pp 42–68 (Monograph series 51 )

    Google Scholar 

  • Hutson PH, Bristow LJ, Thorn L, Tricklebank MD (1991) R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. Br J Pharmacol 103: 2037–2044

    Article  PubMed  CAS  Google Scholar 

  • Irwin M, Schuckit M, Smith TL (1990) Clinical importance of age at onset in type 1 and type 2 primary alcoholics. Arch Gen Psychiatry 47: 320–324

    Article  PubMed  CAS  Google Scholar 

  • Johnston AL, Thevos AK, Randall CL, Anton RF (1991) Increased severity of alcohol withdrawal in in-patient alcoholics with a co-existing anxiety diagnosis. Br J Addict 86: 719–725

    Article  PubMed  CAS  Google Scholar 

  • Kahn RS, Wetzler S (1991) m-chlorophenylpiperazine as a probe of serotonin function. Biol Psychiatry 30: 1139–1166

    Google Scholar 

  • Kalant H (1989) The nature of addiction: an analysis of the problem. In: Goldstein A (ed) Molecular and cellular aspects of the drug addictions. Springer, Berlin Heidelberg New York Tokyo, pp 1–28

    Chapter  Google Scholar 

  • Keup W (1990) Eignung fĂĽr Methadon-Erhaltungs-programme in einer Zufallsstichprobe von Drogenabhängigen. Suchtgefahren 36: 243–249

    Google Scholar 

  • Keup W (1991) Naltrexon–Einsatz fĂĽr Opiatab- hängige. Arzneimitteltherapie 5: 129–132

    Google Scholar 

  • Knorring AL V, Bohman M, Knorring L V, Oreland L (1985) Platelet MAO activity as a biological marker in subgroups of alcoholism. Acta Psychiatr Scand 72: 51–58

    Article  Google Scholar 

  • Knorring AL V, Hallman J, Knorring L v, Oreland L (1991) Platelet monoamine oxidase activity in type I and type 2 alcoholism. Alcohol Alcoholism 26: 409–416

    Google Scholar 

  • Knorring L V, Knorring AL v, Smigan L, Lindberg Y, Edholm M (1987) Personality traits in subtypes of alcoholics. J Stud Alcohol 48: 523–527

    Google Scholar 

  • Kosten TA, Kosten TR (1991) Pharmacological blocking agents for treating substance abuse. J Nerv Ment Dis 179: 583–592

    Article  PubMed  CAS  Google Scholar 

  • Kosten TR, Kleber HD, Morgan C (1989) Role of opioid antagonists in treating intravenous cocain abuse. Life Sci 44: 887–892

    Article  PubMed  CAS  Google Scholar 

  • Kosten TR, Morgan C, Kleber HD (1991) Treatment of heroin addicts using buprenorphine. Am J Drug Alcohol Abuse 17: 119–128

    Article  PubMed  CAS  Google Scholar 

  • Kryspin-Exner K (1983) Psychopharmakotherpie bei Abhängigkeitsprozessen von Alkohol, Medikamenten und Drogen. In: Langer G, Hei-Mann H (Hrsg) Psychopharmaka. Grundlagen und Therapie. Springer, Wien New York, S 491–514

    Google Scholar 

  • Krystal JH, Leaf PJ, Bruce ML, Charney DS (1992) Effects of age and alcoholism on the prevalence of panic disorder. Acta Psychiatr Scand 85: 77–82

    Article  PubMed  CAS  Google Scholar 

  • Kuschinsky K (1981) Psychic dependence on opioids: mediated by dopaminergic mechanisms in the striatum? TINS 11: 287–289

    Google Scholar 

  • Kushner MG, Kenneth MA, Sher J, Beitman BD (1990) The relation between alcohol problems and the anxiety disorders. Am J Psychiatry 147: 685–695

    PubMed  CAS  Google Scholar 

  • Lee MA, Meltzer HY (1991) Neuroendocrine responses to serotonergic agents in alcoholics. Biol Psychiatry 30: 1017–1030

    Article  PubMed  CAS  Google Scholar 

  • Lesch OM, Walter H, Bonte W, Grunberger J, Mu-Salek M, Sprung R (1991) Etiology of subgroups in chronic alcoholism and different mechanisms in transmitter systems. In: Palmer TN (ed) Alcoholism–a molecular perspective. Nato, Life Sciences 206: 137–152

    Google Scholar 

  • Limson R, Goldman D, Roy A, Lamparski D, Ravitz B, Adinoff B, Linnoila M (1991) Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Arch Gen Psychiatry 48: 437–441

    Article  PubMed  CAS  Google Scholar 

  • Linnoila M, Eckardt M, Durcan M, Lister R, Martin P (1987) Interactions of serotonin with ethanol: clinical and animal studies. Psychopharmacol Bull 23: 452–457

    PubMed  CAS  Google Scholar 

  • Liskow BI, Goodwin DW (1987) Pharmacological treatment of alcohol intoxication, withdrawal and dependence: a critical review. J Stud Alcohol 48: 356–370

    PubMed  CAS  Google Scholar 

  • Loimer N, Lenz K, Schmid R, Presslich O (1991) Technique for greatly shortening the transition form methadone to naltrexone maintenance of patients addicted to opiates. Am J Psychiatry 148: 933–935

    PubMed  CAS  Google Scholar 

  • Malka R, Loo H, Ganry H, Souche A, Marey C, Kamoun A (1992) Long-term administration of tianeptine in depressed patients after alcohol withdrawal. Br J Psychiatry 160: 66–71

    Google Scholar 

  • Mason BJ, Kocsis JH (1991) Desipramine treatment of alcoholism. Psychopharmacol Bull 27: 155–161

    PubMed  CAS  Google Scholar 

  • Meert TF, Janssen PAJ (1991) Ritanserin, a new therapeutic approach for drug abuse. Part 1. Effects on alcohol. Drug Dev Res 24: 235–249

    Google Scholar 

  • Meert TF, Janssen PAJ (1992a) Ritanserin, a new therapeutic approach for drug abuse. Part 2. Effects on cocaine. Drug Dev Res 25: 39–53

    Google Scholar 

  • Meert TF, Janssen PAJ (1992b) Ritanserin, a new therapeutic approach for drug abuse. Part 3. Effects on fentanyl and sucrose. Drug Dev Res 25: 55–66

    Google Scholar 

  • Meyer RE (1989) Prospects for a rational pharmacotherapy of alcoholism. J Clin Psychiatry 50: 403–412

    PubMed  CAS  Google Scholar 

  • Meyers R, Beil H (1989) Ambulante Behandlung von Alkohol-and Drogenabhängigen. Munch Med Wochenschr 131: 489–493

    Google Scholar 

  • Meltzer HY (1991) The mechanism of action of novel antipsychotic drugs. Schizophr Bull 17: 263–287

    Article  PubMed  CAS  Google Scholar 

  • Miller FT, Busch F, Hertz-Tanenbaum J (1989) Drug abuse in schizophrenia and bipolar disorder. Am J Drug Alcohol Abuse 15: 291–295

    Article  PubMed  CAS  Google Scholar 

  • Miller NS, Ries RK (1991) Drug and alcohol dependence and psychiatric populations: the need for diagnosis, intervention and training. Compr Psychiatry 32: 268–276

    Article  PubMed  CAS  Google Scholar 

  • Möller HG, Nowak K, Kuschinsky K (1987) Conditioning of pre-and postsynaptic behavioural responses to the dopamine receptor agonist apomorphine in rats. Psychopharmacology 91: 50–55

    Article  PubMed  Google Scholar 

  • Moody CA, Spear LP (1992) Ontogenetic differences in the psychopharmacological responses to separate and combined stimulation of D, and D2 dopamine receptors during the neonatal to weanling age period. Psychopharmacology 106: 161–168

    Article  PubMed  CAS  Google Scholar 

  • Morris RGM, Davis S, Butcher SP (1989) The role of NMDA receptors In learning and memory. In: Watkins JC, Collingridge GL (eds) The NMDA receptor. IRL Press, Oxford New York Tokyo, pp 137–152

    Google Scholar 

  • Myers RD (1989) Isoquinolines, (3-carbolines and alcohol drinking: involvement of opioid and dopaminergic mechanisms. Experientia 45: 436–443

    Article  PubMed  CAS  Google Scholar 

  • Nace EP, Davis GW, Gaspari JP (1991) Axis II comorbidity in substance abusers. Am J Psychiatry 148: 118–120

    PubMed  CAS  Google Scholar 

  • Noble EP, Blum K, Ritchie T, Montgomery A, Sheri-Dan PJ (1991) Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 48: 648–654

    Article  PubMed  CAS  Google Scholar 

  • Ollat H, Parvez H, Parvez S (1988) Alcohol and central neurotransmission. Neurochem Int 13: 275–300

    Article  PubMed  CAS  Google Scholar 

  • Olivier B, Mos J, Rasmussen D (1990) Behavioural pharmacology of the serenic, eltoprazine. Drug Metab Drug Interact 8: 31–83

    CAS  Google Scholar 

  • Parsian A, Todd RD, Devor EJ, O’malley KL, Suarez BK, Reich T, Cloninger RC (1991) Alcoholism and alleles of the human D2 dopamine receptor locus. Arch Gen Psychiatry 48: 655–663

    Article  PubMed  CAS  Google Scholar 

  • Peralta V, Cuesta MJ (1992) Influence of cannabis abuse on schizophrenic psychopathology. Acta Psychiatr Scand 85: 127–130

    Article  PubMed  CAS  Google Scholar 

  • Pfeiffer A, Brantl V, Herz A, Emrich HM (1986) Psychotomimesis mediatet by K opiate receptors. Science 233: 774–776

    Article  PubMed  CAS  Google Scholar 

  • Pietraszek MH, Urano T, Sumioshi K, Serizawa K, Takahashi S, Takada Y, Takada A (1991) Alcohol-induced depression: involvement of serotonin. Alcohol Aloholism 26: 155–159

    CAS  Google Scholar 

  • Post RM, Susan R, Weiss B (1992) Sensitization, kindling, and carbamazepine: an update on their implications for the course of affective illness. Pharmacopsychiatry 25: 41–43

    Article  PubMed  CAS  Google Scholar 

  • Presslich O, Loimer N, Aschauer G, Fodor G, Pfersmann D, MĂĽller K, Pakesch G, Lieber A (1989) Fraktionierter Opiatentzug mit Tiaprid and Naloxon, ein neuer Therapieansatz. Psychiat Prax 16: 179–181

    CAS  Google Scholar 

  • Regier LDA, Farmer ME, Rae DS et al. (1990) Co-morbidity of mental disorders with alcohol and other drug abuse: results from the epidemiologic catchment area ( ECA) study. JAMA 264: 2511–2518

    Google Scholar 

  • Resnick RB, Resnick E, Galanter M (1991) Buprenorphine responders: a diagnostic subgroup of heroin addicts? Prog Neuro Psychopharmacol Biol Psychiatry 15: 531–538

    Article  CAS  Google Scholar 

  • Rezvani AH, Grady DR, Janowsky DS (1991) Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys. Alcohol Alcoholism 26: 161–167

    CAS  Google Scholar 

  • Robbins SJ, Ehrman RN (1992) Designing studies of drug conditioning in humans. Psychopharmacology 106: 143–153

    Article  PubMed  CAS  Google Scholar 

  • Ross HE, Glaser FB, Stiasny S (1988) Sex differences in the prevalence of psychiatric disorders in patients with alcohol and drug problems. Br J Addict 83: 1179–1192

    Article  PubMed  CAS  Google Scholar 

  • Rou Renberg O (1988) Das Belohnungssystem des Gehirn. In: Gehirn und Nervensystem. Spektrum der Wissenschaft. Verlagsgemeinschaft Weinheim, S 161–167

    Google Scholar 

  • Roy A, Virkkunen M, Linnoila M (1987) Reduced central serotonin turnover in a subgroup of alcoholism. Prog Neuro Psychopharmacol Biol Psychiatry 11: 173–177

    Article  CAS  Google Scholar 

  • Roy A, Dejong J, Lamparski D, George T, Linnoila M (1991) Depression among alcoholics. Arch Gen Psychiatry 48: 428–432

    Article  PubMed  CAS  Google Scholar 

  • San L, Pomarol G, Peri JM, Olle JM, Cami J (1991) Follow-up after a six-month maintenance period on naltrexone versus placebo in heroin addicts. Br J Addict 86: 983–990

    Article  PubMed  CAS  Google Scholar 

  • Scherbaum N, Gastpar M (1991) Die Substitution mit Methadon als Therapieansatz in der Behandlung Opiatabhängiger. Nervenarzt 62: 529–535

    PubMed  CAS  Google Scholar 

  • Schmidt LG, Rommelspacher H (1990) Biologische Marker des Alkoholismus. Nervenarzt 61: 140–147

    PubMed  CAS  Google Scholar 

  • Schrappe O (1980) Toxikomanie. In: Peters UH (Hrsg) Die Psychologie des 20. Jahrhunderts, Bd X. Ergebnisse fĂĽr die Medizin ( 2 ). Psychiatrie. Kindler, ZĂĽrich, S 849–868

    Google Scholar 

  • Schuckit MA (1986) Genetic and clinical implications of alcoholism and affective disorder. Am J Psychiatry 143: 140–147

    PubMed  CAS  Google Scholar 

  • Schuckit MA (1987) Biology of risk for alcoholism. In: Meltzer HY (ed) Psychopharmacology. The third generation of progress. Raven Press, New York, pp 1527–1533

    Google Scholar 

  • Schuckit MA (1989) Drug and alcohol abuse. A clinical guide to diagnosis and treatment. Plenum, New York

    Google Scholar 

  • Segest E, Mygind O (1990) The influence of prolonged stable methadone maintenance treatment on mortality and employment: an 8-year follow-up. Int J Addict 25: 53–63

    PubMed  CAS  Google Scholar 

  • Sellis SB (1981) Follow-up and treatment outcome. In: Lo’inson JH, Ruiz P (eds) Substance abuse: clinical problems and perspectives. Williams and Wilkins, Baltimore London, pp 783–800

    Google Scholar 

  • Shaw GK, Majumdar SK, Waller S, Macgarvie J, Dunn G (1987) Tiapride in the long-term ma- nagement of alcoholics of anxious or depres- sive temperament. Br J Pschiatry 150: 164–168

    Article  CAS  Google Scholar 

  • Shippenberg TS, Bals-Kubik R, Huber A, Herz A (1991) Neuroanatomical substrates mediating the aversive effects of D1—dopamine receptor antagonists. Psychopharmacology 103: 209–214

    Article  PubMed  CAS  Google Scholar 

  • Snyder SH (1987) Molecular strategies in neuropsychopharmacology: old and new. In: Meltzer HY (ed) Psychopharmacology. The third generation of progress. Raven Press, New York, pp 17–21

    Google Scholar 

  • Stastny D, Potter M (1991) Alcohol abuse by patients undergoing methadone treatment programm. Br J Addict 86: 307–310

    Article  PubMed  CAS  Google Scholar 

  • Steketee JD, Sorg BA, Kalivas PW (1992) The role of the nucleus accumbens in sensitization to drugs of abuse. Neuro Psychopharmacol Biol Psychiatry 16: 237–246

    Article  CAS  Google Scholar 

  • Strian F, Zieglgänzberger W, Holsboer F (1991) Neurobiologische Forschungsstrategien zur Alkoholkrankheit. In: Materialien zur Gesundheitsforschung. Schriftreihe zum Programm der Bundesregierung Forschung und Entwicklung im dienste der Gesundheit (Hrsg) Suchtforschung: Bestandsaufnahme und Analyse des Forschungsbedarfs. Bonn (Bd 19 ), S 50–64

    Google Scholar 

  • Sullivan JL, Baenziger JC, Wagner DL, Rauscher FP, Nurnbrger JI, Holmes JS (1990) Platelet MAO in subtypes of alcoholism. Biol Psychiatry 27: 911–922

    Article  PubMed  CAS  Google Scholar 

  • Szmigielski A, Zalewska-Kaszubska J (1991) Cooperation between D,— and D2—dopamine receptors in the nucleus accumbens. Neuropharmacology 30: 259–266

    Article  PubMed  CAS  Google Scholar 

  • Taschner KL (1991) Brauchen wir Methadonsubstitutionsprogramme? Nervenarzt: 62: 524–528

    PubMed  CAS  Google Scholar 

  • Tollefson GD (1989) Serotonin and alcohol: interrelationships. Psychopathology 22 [Suppl]: 37–48

    Article  PubMed  Google Scholar 

  • Tollefson GD, Lancaster SP, Montague-Clouse J (1991) The association of buspirone and its metabolite 1—pyrimidinylpiperazine in the remission of comorbid anxiety with depressive features and alcohol dependency. Psychopharmacol Bull 27: 163–170

    PubMed  CAS  Google Scholar 

  • Topel H (1990) Perspektiven der Alkoholismus-Forschung der 90er Jahre. Suchtgefahren 36: 91–96

    Google Scholar 

  • Turner E, Ewing J, Shilling P, Smith TL, Irwin M, Schuckit M, Kelsoe JR (1992) Lack of association between an RFLP near the D2dopamine receptor gene and severe alcoholism. Biol Psychiatry 31: 285–290

    Article  PubMed  CAS  Google Scholar 

  • Trudeau LE, Aragon CMG, Amit Z (1991) Involvement of endogenous opioid mechanisms in the interaction between stress and ethanol. Psychopharmacology 103: 425–429

    Article  PubMed  CAS  Google Scholar 

  • Udego L, Grenhoff J, Svensson TH (1989) Ritanserin, a 5—HT, receptor antagonist, activates mid-brain dopamine neurons by blocking serotonergic inhibition. Psychopharmacology 98: 45–50

    Article  Google Scholar 

  • Vining E, Kosten TR, Kleber HD (1988) Clinical utility of rapid clonidine-naltrexone detoxification for opioid abusers. Br J Addict 83: 567–575

    Article  PubMed  CAS  Google Scholar 

  • Vogel WH, Netter P (1989) Effect of ethanol and stress on plasma catecholamines and their relation to changes in emotional state and performance. Alcoholism Clin Exp Res 13: 284–290

    Article  CAS  Google Scholar 

  • Watson SJ, Trujillo KA, Herman JP, AKIL H (1989) Neuroanatomical and neurochemical substrates of drug-seeking behaviour: overview and future directions. In: Goldstein A (ed) Molecular and cellular aspects of the drug addictions. Springer, Berlin Heidelberg New York Tokyo, pp 29–91

    Chapter  Google Scholar 

  • Weddington WW, Brown BS, Haertzen CA, Hess JM, Mahaffey JR, Kolar AF, Jaffe JH (1991) Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence. Am J Drug Alcohol Abuse 17: 137–152

    Article  PubMed  Google Scholar 

  • Weiss RD, Mirin SM (1989) Tricyclic antidepressants in the treatment of alcoholism and drug abuse. J Clin Psychiatry 50: 4–9

    PubMed  Google Scholar 

  • Wikler A (ed) (1980) Opioid dependence. Mechanisms and treatment. Plenum Press, New York London

    Google Scholar 

  • Wise RA (1987) The role of reward pathways in the development of drug dependence. Pharmacol Ther 35: 227–263

    Article  PubMed  CAS  Google Scholar 

  • Wittchen HU, Hand I, Hecht H (1989) Prävalenz, Komorbidität und Schweregrad von Angststörungen. Ergebnisse der MĂĽnchner Followup-Studie ( MFS ). Z KIM Psychol 18: 117–133

    Google Scholar 

  • Birmanns B, Clarenbach P (1989) Effect of serotonin receptor antagonists on sleep and sleep related release of HGH, prolactin and cortisol. In: Wauquier A et al. (eds) Slow wave sleep: physiological, pathophysiological and functional aspects. Raven, New York, pp 235–242

    Google Scholar 

  • Campbell M, Adams P, Small AM, Curren EL, Overall JE, Anderson LT, Lynch N, Perry R (1988) Efficacy and safety of fenfluramine in autistic children. J Am Acad Child Adolesc Psychiatry 4: 434–439

    Article  Google Scholar 

  • Ceulemans DLS, Hoppenbrouwers MLJA, Gelders YG, Ryntjens AJM (1985) The influence of ritanse- rin, a serotonin antagonist, in anxiety disorders: a double-blind placebo-controlled study versus lorazepam. Pharmacopsychiatry 18: 303–305

    Article  PubMed  CAS  Google Scholar 

  • Cook EH JR, Leventhal BL, Freedman DX (1988) Free serotonin plasma: autistic children and their first-degree relatives. Biol Psychiatry 24: 488–491

    Article  PubMed  Google Scholar 

  • Curzon G (1988) Serotonergic mechanism of depression. Clin Neuropharmacol 11 [Suppl 2]: 11–20

    Google Scholar 

  • Den Boer JA (1989) Serotonergic mechanism in anxiety disorders. An inquiry into serotonergic function in panic disorder. Pharmaceutisch Weekblad Scientific edition 11: 103–104

    Article  Google Scholar 

  • Doerish CT (1987) Brain 5-HT, receptors and anxiety. In: DouxisH CT et al. (eds) Brain 5-HT„ receptors. Ellis Howard, Chichester, pp 261–277

    Google Scholar 

  • Gelders Y (1989) Ritanserin: an original thymosthenic, 4th ed. Janssen Research Foundation, Beerse

    Google Scholar 

  • Gelernter J, Kammen DP (1988) Schizophrenia: instability in norepinephrine, serotonin, and gamma-aminobutyric acid systems. Int Rev Neurobiol 29: 309–347

    Article  PubMed  CAS  Google Scholar 

  • Glennon RA (1990) Serotonin receptors: clinical implications. Neurosci Biobehav Rev 14: 35–47

    Article  PubMed  CAS  Google Scholar 

  • Janssen PAJ (1987) Does ritanserin, a potent serotonin S2-antagonist, restore energetic functions during the night? J R Soc Med 80: 409–4413

    PubMed  CAS  Google Scholar 

  • Leibowitz SF, Weiss GF, Shor-Posner G (1988) Hypothalamic serotonin: pharmacological, biochemical, and behavioral analyses of its feeding-suppressive action. Clin Neuropharmacol 11 [Suppl 11: 51–71

    Google Scholar 

  • Leonard BE (1988) Pharmacological effects of serotonin reuptake inhibitors. J Clin Psychiatry 49: 12–17

    PubMed  Google Scholar 

  • Leysen JE, Van Gompel P, Gommeren W, Woesten-Borghs R, Janssen PAJ (1986) Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with serotonin-S2 antagonists: ritanserin and setoperone. Psychopharmacology 88: 434 444

    Google Scholar 

  • Marfk GJ, Li A, Seiden LS (1989) Selective 5hydroxytryptamine2 antagonists have antidepressant-like effects on differential-reinforcement of low rate 72-S schedule. J Pharmacol Exp Ther 250: 52–59

    Google Scholar 

  • Mcbride PA, Anderson GM, Hertzig ME, Sweeny JA (1989) Serotonergic responsivity in male young adults with autistic disorder. Arch Gen Psychiatry 46: 213–221

    Article  PubMed  CAS  Google Scholar 

  • Mita T, Hanada S, Nishino N, Kuno T, Nakai H, Yamadori T, Mizol Y, Tanaka C (1986) Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics. Biol Psychiatry 21: 1407–1414

    Article  PubMed  CAS  Google Scholar 

  • Paiva T, Arriaga F, Wauquier A, Lara E, Largo R, Leitao JN (1989) Changes in sleep disturbances of dysthymic patients induced by ritanserin. In: Wauquier A et al. (eds) Slow wave sleep: physiological, pathophysiological and functional aspects. Raven, New York, pp 217–234

    Google Scholar 

  • Pastel RH (1988) Effects of LY53857, a selective 5-HT2 antagonist, on sleep in the rat. Soc Neurosci Abstr 14: 1307

    Google Scholar 

  • Realmuto GM, August GJ, Garfinkel BD (1989) Clinical effect of buspirone in autistic children. J Clin Psychopharmacol 9: 122–125

    Article  PubMed  CAS  Google Scholar 

  • Reynolds GP, Arnold L, Rossor MN, Iversen LL, Mountjoy CQ, Roth M (1984) Reduced binding of (3H)ketanserin to cortical 5-HT2 receptors in senile dementia of the Alzheimer type. Neurosci Lett 44: 47–51

    Article  PubMed  CAS  Google Scholar 

  • Sanders-Bush E, Breeding M, Roznoski M (1987) 5HT2 binding sites after mianserin: comparison of loss of sites and brain levels of drug. Eur J Pharmacol 133: 199–204

    Google Scholar 

  • Silver H, Blacker M, Weller MPI, Lerer B (1989) Treatment of chronic schizophrenia with cyproheptadine. Biol Psychiatry 25: 502–504

    Article  PubMed  CAS  Google Scholar 

  • Stanley M, Mann JJ (1983) Increased serotonin-2 binding sites in the frontal cortex of suicide victims. Lancet is 214–216

    Google Scholar 

  • Tricklebank MD (1989) Interactions between dopamine and 5-HT3 receptors suggest new treatments for psychosis and drug addiction. Trends Pharmacol Sci 10: 129

    Article  Google Scholar 

  • Ugedo L, Grenhoff J, Svensson TH (1989) Ritanserin, a 5-HT2 receptor antagonist, activates mid-brain dopamine neurons by blocking serotonergic inhibition. Psychopharmacology 98: 45–50

    Article  PubMed  CAS  Google Scholar 

  • Watling KJ (1989) 5-HT3 receptor agonists and antagonists. Neurotransmission 5: 1–4

    Google Scholar 

  • Akerman KEO, Heinonen E (1983) Qualitative measurement of cytosolic calciumion concentration within isolated guinea-pig nerve endings using entrapped arsenazo. Biochem Biophys Acta 732: 111–121

    Google Scholar 

  • Allen GS, Goss CJ, French LA, Chou SN (1976) Cerebral arterial spasm. Part 5. In vitro contractile activity of vasoactive agents including human cerebrospinal fluid on human basilar and anterior cerebral arteries. J Neurosurg 6: 63–70

    Google Scholar 

  • Allen GS, Ahn HS, Preziosi TJ et al. (1983) Cerebral arterial spasm–a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med 308: 619–624

    Article  PubMed  CAS  Google Scholar 

  • Alps BJ, Calder C, Wilson A (1983) The beneficial effect of nicardipine compared with nifedipine and verapamil in limiting myocardial infarct size in baboons. Arzneimittelforschung 33: 868–876

    PubMed  CAS  Google Scholar 

  • Amery WK, Cares LI, Aerts WJL (1985) Flunarizine, a calcium entry blocker in migraine prophylaxis. Headache 25: 249–254

    Article  PubMed  CAS  Google Scholar 

  • Ames A III, Wright RL, Kowada M, Thurston JM, Majno G (1968) Cerebral ischemia. II. The noreflow phenomenon. Am J Pathol 52: 437–453

    Google Scholar 

  • Anthony M, Hinterberger H, Lance JW (1968) Studies of serotonin metabolism in migraine. Proc Austr Assoc Neurol 5: 109–112

    CAS  Google Scholar 

  • Asplund K, Eriksson S (1987) Scandinavian Stroke Study Group: multicenter trial of hemodilution in acute ischemic stroke. In: Hartmann A, Kuschinsky W (eds) Cerebral ischemia and hemorheology. Springer, Berlin Heidelberg New York Tokyo, pp 472–486

    Chapter  Google Scholar 

  • Astrup J, Siesjö BK, Symon L (1981) Thresholds in cerebral ischemia: the ischemic penumbra. Stroke 12: 723–725

    Article  PubMed  CAS  Google Scholar 

  • Auer LM (1981) Pial arterial vasodilatation by intravenous nimodipine in cats. Drug Res 31: 1423–1425

    CAS  Google Scholar 

  • Auer ML (1983) Cerebrovascular activity of the calcium antagonist nimodipine. In: Reivich M, Hurtig S (eds) Cerebrovascular diseases. Raven Press, New York, pp 375–384

    Google Scholar 

  • Ban TA, Morey L, Aguglia E, Azzarelli O, Balsano F, Marigliano V, Caglieris N, Steriicchio M, Capurso A, Tomasi NA, Crepaldi G, Volpe D, Palmieri G, Ambrosi G, Polli E, Cortellaro M, Zanussi C, Froldi M (1990) Nimodipine in the treatment of old age dementias. Prog Neuro Psychopharmacol Biol Psychiatry 14: 525–551

    Article  CAS  Google Scholar 

  • Barrett JN, Magelby KL, Pallotta BS (1982) Properties of single calcium activated potassium channels in cultured rat muscle. J Physiol 331: 211–230

    PubMed  CAS  Google Scholar 

  • Blass JP, Zemcov A (1984) Alzheimer disease: a metabolic systems degeneration. Neurochem Pathol 2: 103–114

    Article  PubMed  CAS  Google Scholar 

  • Blaustein MP (1974) Interrelationship between sodium and calcium fluxes across cell membranes. Rev Physiol Biochem Pharmacol 70: 33–82

    Article  PubMed  CAS  Google Scholar 

  • Böker DK, Solymosi L, Wassmann H (1985) Immediate postangiographic intraarterial treatment of cerebral vasospasm after subarachnoid hemorrhage with nimodipine. Neurochirurgi-ca 28: 118–120

    Google Scholar 

  • Boni G, Manzioni GC, Matrucci N, Baldrati A, Farina S, Cassabgi F, Decarolis P, Nappi G Flunarizine in common migraine: Italian cooperative trial. II. Long-term follow-up. Cephalalgia 2: 155–158

    Google Scholar 

  • Bourke RS, Kimelberg HG (1975) The effect of HCO3 on the swelling and ion uptake of monkey cerebral cortex under conditions of raised extracellular potassium. J Neurochem 25: 323–328

    Article  PubMed  CAS  Google Scholar 

  • Brandt L, Anderson KE, Edvinsson L, Ljunggren B (1981) Effects of extracellular calcium and of calcium antagonists on the contractile responses of isolated human pial and mesenteric arteries. J Cereb Blood Flow Metab I: 339–347

    Google Scholar 

  • Branston NM, Strong AJ, Symon L (1977) Extracellular potassium activity, evoked potential and tissue blood flow: relationships during progressive ischaemia in baboon cerebral cortex. J Neurol Sci 32: 305–321

    Article  PubMed  CAS  Google Scholar 

  • Brody IA (1969) Muscle contracture induced by exercise. N Engl J Med 281: 187–192

    Article  PubMed  CAS  Google Scholar 

  • Campbell AK (1983) Intracellular calcium: its universal role as regulator. Wiley, New York

    Google Scholar 

  • Carbone E, Lux HD (1984) A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones. Nature 310: 501–502

    Google Scholar 

  • Castillo J Del, Katz B (1954) Quantal components of the end plat potential. J Physiol 124: 560–573

    Google Scholar 

  • Cheung WY (1982) Calmodulin: an overview. Fed Proc 41: 2253–2257

    PubMed  CAS  Google Scholar 

  • Caongdon PJ, Forsrre WI (1979) Migraine in childhood: a study of 300 children. Dev Med Child Neurol 21: 209–216

    Article  Google Scholar 

  • Cortes R, Supavilai P, Karobath M, Palacios JM (1984) Calcium antagonist binding sites in the rat brain: quantitative autoradiographic mapping using the 1,4—dihydropyridines (3H)PN 200–110 and (3H)PY 108–068. J Neural Transm 60: 169–197

    Article  PubMed  CAS  Google Scholar 

  • Crompton MR (1964) The pathogenesis of cerebral infarction following the rupture of cerebral berry aneurysms. Brain 87: 491–510

    Article  PubMed  CAS  Google Scholar 

  • Danon MJ, Karpati G, Charuk J, Holland P (1988) Sarcoplasmatic reticulum adenosine triphos- phate deficiency with probably autosomal dominant inheritance. Neurology 38: 812–814

    Article  PubMed  CAS  Google Scholar 

  • Delorenzo RJ (1983) Caclium-calmodulin protein phosphorylation in neuronal transmission: a molecular approach to neuronal excitability and anticonvulsant drug action. Adv Neurol 34: 311–323

    Google Scholar 

  • Demopoulos HB, Flamm ES, Pietronigro DD, Selig-Man ML (1980) The free radical pathology and the microcirculation in the major central ner- vous disorders. Acta Physiol Scand 492: 91–119

    CAS  Google Scholar 

  • Deshmukh SV, Meyer JS (1977) Cyclic change in platelet dynamics and the pathogenesis and prophylaxis of migraine. Headache 17: 101–108

    Article  PubMed  CAS  Google Scholar 

  • Dick DJ, Gardner-Medwin D, Gates PG, Gibson M, Walls TJ (1986) A trial of flunarizine in the treatment of Duchenne muscular dystrophy. Muscle Nerve 9: 349–354

    Article  PubMed  CAS  Google Scholar 

  • Dunlap K, Fischbach GD (1981) Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones. J Physiol 317: 519–535

    PubMed  CAS  Google Scholar 

  • Eckert R, Chad JE (1984) Inactivation of Ca chan- nels. Prog Biophys Mol Bio144: 215–267

    Google Scholar 

  • Elbaz P, Haguenauer JP, Muler H, Portmann M (1986) Activite therapeutique d’un inhibiteur de la surcharge calcique, la flunarizine, dans les troubles vestibulaires: etude a double insu contra placebo. ORL 35: 301–308

    Google Scholar 

  • Ell J, Gresty M (1983) The effects of the “vestibular sedative” drug flunarizine upon the vestibular and oculomotor systems. J Neurol Neurosurg Psychiatry 46: 716–724

    Article  PubMed  CAS  Google Scholar 

  • Eppich C, Barnes CA, Baldwin J (1985) 3,4-Dia-minopyridine improves spatial working me- mory but not spatial reference memory in aged rats. Soc Neurosci Abstr 11: 724

    Google Scholar 

  • Fisher CM, Robertson GH, Olemann G (1984) Cerebral vasospasm with ruptured saccular aneurysm — the clinical manifestation. Neurosurgery 1: 245–248

    Article  Google Scholar 

  • Flaim SF (1982) Comparative pharmacology of calciumblockers based on studies of vascular smooth muscle. In: Flaim SF, Zeus R (eds) Calcium blockers: mechanism of action and clinical applications. Urban & Schwarzenberg, Baltimore, pp 155–178

    Google Scholar 

  • Fleckenstein A (1977) Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. Ann Rev Pharmacol Toxicol 17: 149–166

    Article  CAS  Google Scholar 

  • Fraser RAR, Stein MM, Barrett RE, Pool JL (1970) Noradrenergic mediation of experimental cerebrovascular spasm. Stroke 1: 356–362

    Article  PubMed  CAS  Google Scholar 

  • Freedman SB, Dawson G, Villereal ML, Miller RJ (1984) Identification and characterization of voltage-sensitive calcium channels in neuronal clonal cell lines. J Neurosci 4: 1453–1467

    PubMed  CAS  Google Scholar 

  • Freeman GB, Gibson GE (1986) Selective alteration of neurotransmitter release with aging. Soc Neurosci Abstr 12: 271

    Google Scholar 

  • Frenken CWGM, Nuijten STM (1984) Flunarizine, a new preventive approach in migraine. Clin Neurol Neurosurg 86: 17–20

    Article  PubMed  CAS  Google Scholar 

  • Fijisawa A, Matdsumoto M, Matsltyama T, Ueda H, Wanaka W, Yoneda S, Kimura K, Kamada T (1986) The effect of the calcium antagonist nimodipine on the gerbil model of experimental cerebral ischemia. Stroke 17: 748–752

    Article  Google Scholar 

  • Gaab RM, Rode C-P, Schakel EH, Haubitz I, Bock-Horn J, Brawanski A (1985) Zum EinfluĂź des Ca-Antagonisten Nimodipin auf die globale and regionale Hirndurchblutung. Klin Wochenschr 83: 8–15

    Article  Google Scholar 

  • Garb MR, Hollerhage HG, Zumkeller M, Trost HA (1987) The effect of the Ca antagonist nimodipine on cerebral blood flow autoregulation. J Cereb Blood Flow Metab 7: 170

    Google Scholar 

  • Gallant EM, Foldes FF, Rempel WE, Gronert GA (1985) Verapamil is not a therapeutic adjunct to dantrolene in porcine malignant hyperthermia. Anaesth Anal 64: 601–606

    CAS  Google Scholar 

  • Gardos G (1958) The function of calcium in the potassium permeability of human erythrocytes. Biochem Biophys Acta 30: 653–654

    Article  PubMed  CAS  Google Scholar 

  • Garruto RM, Fukatsu R, Yanagihara R, Gajdusek DC, Hook G, Fiori CE (1984) Imaging of calcium and aluminium in neurofibrillary tangle-bearing neurons in Parkinsonism-dementia of Guam. Proc Natl Acad Sci USA 81: 1875–1879

    Article  PubMed  CAS  Google Scholar 

  • Gelmers HJ (1982) Effect of nimodipine (Bay-9736) on postischaemic cerebrovascular reactivity, as revealed by measuring regional cerebral blood flow (rCBF). Acta Neurochir (Wien) 63: 283–290

    Article  CAS  Google Scholar 

  • Gelmers HJ (1983) Nimodipine, a new calcium antagonist, in the prophylactic treatment of migraine. Headache 23: 106–109

    Article  PubMed  CAS  Google Scholar 

  • Gelmers HJ, Gorter K, De Weerdt CJ, Wiezer HJ (1988) A controlled trial of nimodipine in acu- te ischemic stroke. N Engl J Med 318: 203–207

    Article  PubMed  CAS  Google Scholar 

  • Ginsberg MD, Mela L, Wrobel Kuhl K, Reivich M (1977) Mitochondrial metabolism following bilateral cerebral ischemia in the gerbil. Ann Neurol 1: 519–527

    Article  PubMed  CAS  Google Scholar 

  • Goldensohn ES, Purpura DP (1963) Intracellular potentials of cortical neurons during focal epileptogenic discharges. Science 139: 840–842

    Article  PubMed  CAS  Google Scholar 

  • Gould RJ, Murphy KMM, Snyder SH (1982) Autoradiographic visualization of (3H)-nitrendipine binding sites in rat brain: localization to synaptic zones. Eur J Pharmacol 82: 517–519

    Google Scholar 

  • Gould RJ, Murphy KMM, Reynolds U, Snyder SH (1984) Calcium channel blockade: possible explanation for thioridazine’s peripheral side effects. Am J Psychiatry 141: 352–357

    PubMed  CAS  Google Scholar 

  • Greenberg DA, Carpenter CL, Cooper EC (1985) Stimulation of calcium uptake in PC12 cells by the dihydropyridine agonist BAY K 8644. J Neurochem 45: 990–993

    Article  PubMed  CAS  Google Scholar 

  • Gronert GA, Mou J, Lee J (1988) Aetiology of malignant hyperthermia. Anaesth 60: 253–267

    Article  CAS  Google Scholar 

  • Grubb RL, Raichle ME, Eichlin JO, Gado MH (1977) Effect of subarachnoid hemorrhage on cere- bral blood volume, blood flow and oxygen utilisation in humans. J Neurosurg 46: 446–453

    Article  PubMed  Google Scholar 

  • Guerrero JR, Martin SS (1984) Verapamil: full spectrum calcium channel blocking agent: an overview. Med Res Rev 4: 87–109

    Article  PubMed  CAS  Google Scholar 

  • Harper AM, Braigen L, Karda S (1981) Effect of the calcium antagonist, nimodipine, in cerebral blood flow and metabolism in the primate. J Cereb Blood Flow Metab 1: 349–356

    Article  PubMed  CAS  Google Scholar 

  • Harris RJ, Symon L, Branston NM, Bayan M (1981) Changes in extracellular calcium activity in cerebral ischaemia. J Cereb Blood Flow Me-tab 1: 203–209

    Article  CAS  Google Scholar 

  • Harris RJ, Branston MM, Symon L, Bayhan M, Wat-Son A (1982) The effect of a calcium antagonist, nimodipine, upon physiological responses of the cerebral vasculature and its possible influence upon focal cerebral ischemia. Stroke 13: 759–766

    Article  PubMed  CAS  Google Scholar 

  • Hartmann A (1987) Die Bedeutung der Rheologie fĂĽr zerebrale Durchblutungsstörungen. Akt Neurol 14: 35–41

    Article  Google Scholar 

  • Hartmann A (1987) Die Hämodilution beim zerebralen Insult. Akt Neurol 14: 42–49

    Article  Google Scholar 

  • Hartmann A (1988) Die Gehirndurchblutung bei der Migräne. In: Soyka D (Hrsg) Klinische Kopfschmerzsyndrome. Fischer, Stuttgart New York, S 33–44

    Google Scholar 

  • Havanka-Kanniainen H, Hokkanen E, Myllyka VV (1985) Efficacy of nimodipine in the prophylaxis of migraine. Cephalgia 5: 39–43

    Article  CAS  Google Scholar 

  • Heffez DS, Passoneau JV (1985) Effect of nimodipine on cerebral metabolism during ischemia and recirculation in the mongolian gerbil. J Cereb Blood Flow Metab 5: 523–528

    Article  PubMed  CAS  Google Scholar 

  • Heiss WD (1983) Flow thresholds of functional and morphological damage of brain tissue. Stroke 14: 329–331

    Article  PubMed  CAS  Google Scholar 

  • Hess P, Landsman JB, Tsien RW (1984) Different modes of Ca channel gating behavior favoured by dihydropyridine Ca agonist and antagonists. Nature 311: 538–544

    Article  PubMed  CAS  Google Scholar 

  • Hilles B (1984) Ionic channels of excitable membranes. Sinauer Associates, Sunderland Mass

    Google Scholar 

  • Hofferberth B (1986) Calcium entry blockers in the treatment of vertebro-basilar insufficiency. Eur Neurol 25: 80–85

    Article  PubMed  Google Scholar 

  • Holmes B, Brogden RN, Heel C, Speight TM, AVERY GS (1984) Flunarizine: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use. Drugs 27: 6 44

    Google Scholar 

  • Hossman KA, Paschen W, Csiby L (1983) Relation-ship between calcium accumulation and re- covery of cat brain after prolonged cerebral ischemia. J Cereb Blood Flow Metab 3: 346–353

    Article  Google Scholar 

  • Jacoss MB (1983) Diltiazem and akathisia. Ann Intern Med 99: 794–795

    Google Scholar 

  • Kahan A, Weber S, Amor B, Guerin F, Degeorges M (1983) Nifedipine in the treatment of migraine in patients with Raynaud’s phenomenon. N Engl J Med 308: 1102–1103

    PubMed  CAS  Google Scholar 

  • Kalls P (1977) Uptake and release of calcium in rabbit vagus nerve. PflĂĽgers Arch 326: 1–14

    Google Scholar 

  • Karpati G, Charuk J, Carpenter S, Jablecki C, Hol-Land P (1986) Myopathy caused by a deficiency of Ca“ ATPase in sarcoplasmatic reticulum ( Brody’s disease ). Ann Neurol 20: 38–49

    Google Scholar 

  • Kassell NF, Sasaki T, Colohan ART, Nayar G (1985) Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 16: 562–572

    Article  PubMed  CAS  Google Scholar 

  • Kazda S, Garthoff B, Krause HP, Schlossmann K (1982) Cerebral vascular effects of the calcium antagonistic dihydropyridine derivative nimodipine in animal experiments. Arzneimittelforschung 2: 331–338

    Google Scholar 

  • Kimball RW, Goodmann MA (1961) Effects of reserpine on amino acid excretion in patients with vascular headaches. Neurology (Minneapolis) 11: 116

    Article  CAS  Google Scholar 

  • Kur A, Elder B, Ruiz-Funes HP, Buchwald M, Grin-Stein (1985) The free cytoplasmatic Ca“-levels in Duchenne muscular dystrophy lymphocytes. Muscle Nerve 8: 317–320

    Google Scholar 

  • Koos WT, Pernezky A, Auer LM, Böker DB, Gaab MR, Jaschke H, Kostron H, Meinig G, Muizellar JP, Van Der Werft AJM, Seibert HK, Ulrich F, Sprung C (1985) Nimodipine treatment of ischemic neurological deficits due in cerebral vasospasms after subarachnoid hemorrhage. Neurochirurgica 28: 114–117

    Google Scholar 

  • Lauritzen M, Olsen J (1984) Regional cerebral blood flow during migraine attacks by Xenon-133 inhalation and emission tomography. Brain 107: 447–461

    Article  PubMed  Google Scholar 

  • Lauritzen M, Skyhoj Olsen T, Lassen NA, Paulson OB (1983) Changes in regional cerebral blood flow during the course of classical migraine attacks. Ann Neurol 13: 633–641

    Article  PubMed  CAS  Google Scholar 

  • Lead AAP (1944) Spreading depression of activity in cerebral cortex. J Neurophysiol 7: 359–390

    Google Scholar 

  • Lee KS, Tsien RW (1986) Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature 302: 790–794

    Article  Google Scholar 

  • Lee JA, Watson A, Boothby G (1986) Calcium antagonists in the prevention of motion sickness. Aviat Space Environ Med 57: 45–48

    PubMed  CAS  Google Scholar 

  • LehmenkĂĽhler A (1979) Interrelationship between CD potentials, potassium activity, pO2 and pCO2 in the cerebral cortex of the rat. In: Speckmann EJ, Caspers H (eds) Origin of cerebral field potentials. Thieme, Stuttgart, pp 49–59

    Google Scholar 

  • Lewis JG (1983) Adverse reactions to calcium antagonists. Drugs 25: 196–222

    Article  PubMed  CAS  Google Scholar 

  • Li CL, Van Buren JM (1972) Micro-electrode recordings in the brain of man with particular reference to epilepsy and dyskinesia. In: Somjen GG (ed) Neurophysiology studied in man. Excerpta Medica, Amsterdam, pp 49–63

    Google Scholar 

  • Ljunggren B, Brandt L, Saeveland H, Nilsson PE et al. (1984) Outcome in 60 consecutive patients treated with early aneurysm operation and intravenous nimodipine. J Neurosurg 67: 864 873

    Google Scholar 

  • Lopez JR, Allen PD, Alamo L, Jones D, Sreter FA (1988) Myoplasmic free Ca“ during a malignant hypertheramia episode in swine. Muscle Nerve 11: 82–88

    Article  PubMed  CAS  Google Scholar 

  • Louis P (1981) A double-blind placebo-controlled prophylactic study of flunarizine (Sibelium) in migraine. Headache 21: 235–239

    Article  PubMed  CAS  Google Scholar 

  • Louis P, Sperings ELH (1982) Comparison of flunarizine (Sibelium) and pizotifen (Sandomigran) in migraine treatment: a double-blind study. Cephalgia 2: 197–203

    Article  CAS  Google Scholar 

  • LĂĽllmann H, Peters TH (1977) Plasmalemmal calcium in cardiac excitation-contradiction coupling. Clin Exp Pharmacol Physiol 4: 49–57

    Article  PubMed  Google Scholar 

  • LĂĽllmann H, Peters TH, Preuner J (1983) Role of the plasmalemma for calcium homeostasis and for excitation-contraction coupling in cardiac musle. In: Drake N, Holland S, Noble M (eds) Cardiac metabolism. Wiley, Chichester, pp 1–18

    Google Scholar 

  • Lux HD, Hofmeier G (1982) Properties of calcium-and voltage-activated potassium current in helix pomatia neurons. PflĂĽgers Arch 394: 61–59

    Article  PubMed  CAS  Google Scholar 

  • Markley HG, Cheronis JCD, Piepho RW (1984) Verapamil in prophylactic therapy of migraine. Neurology 34: 973–976

    Article  PubMed  CAS  Google Scholar 

  • Matsumuto H, Ajmone Marsan C (1964) Cortical cellular phenomena in experimental epilepsy: interictal manifestations. Exp Neurol 9: 286–304

    Article  Google Scholar 

  • Matthews EK (1986) Calcium and membrane permeability. Br Med Bull 42: 391–397

    PubMed  CAS  Google Scholar 

  • Meech RW (1978) Calcium-dependent potassium activation in nervous tissues. Ann Rev Biophys Bioeng 7: 1–18

    Article  CAS  Google Scholar 

  • Mendenopoulos G, Manafi T, Logothesis 1, Bostant-Joroulou S (1985) Flunarizine in the prevention of classical migraine. A placebo controlled evaluation. Cephalalgia 5: 31–37

    Google Scholar 

  • Meyer EM, Baker SP, Crews FT, Larsen K (1985) Aging and acetylcholine-release from cortical synaptosomal and atrial minces. Soc Neurosci Abstr 11: 980

    Google Scholar 

  • Meyer FB, Anderson RE, Sundt TM Jr, Yaksh TL (1986) Intracellular brain pH, indicator tissue perfusion, electroencephalography, and histology in severe and moderate focal cortical ischemia in the rabbit. J Cereb Blood Flow Metab 1: 190–191

    Google Scholar 

  • Meyer FB, Anderson RE, Sund TM Jr, Sharbrough FW (1986) Selective central nervous system calcium channel blockers–a new class of anticonvulsive agents. Mayo Clin Press 61: 239–247

    Article  CAS  Google Scholar 

  • Meyer JS, Hardenberg J (1983) Clinical effectiveness of calcium entry blockers in prophylactic treatment of migraine and cluster headache. Headache 23: 266–277

    Article  PubMed  CAS  Google Scholar 

  • Micieli O, Trucco M, Agostinis C, Macuso A, Papalia F, Sinforiani E (1985) Nimodipine vs. pizotifen in common migraine: results of a double blind cross-over trial. Cephalagia 5: 532–533

    Google Scholar 

  • Miller RJ (1985) How many types of calcium channels exist in neurones? Trends Neurosci 8: 45–47

    Article  CAS  Google Scholar 

  • Miller JR (1987) Multiple calcium channels and neuronal function. Science 235: 46–52

    Article  PubMed  CAS  Google Scholar 

  • Mohamed AA, Gotch O, Graham DI, Osborne KA, Mcculloch J, Mendelow AD, Teasdale GM, Harper AM (1985) Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion. Ann Neurol 18: 705–711

    Article  PubMed  CAS  Google Scholar 

  • Mongini T, Ghigo D, Doriguzzi C, Bussolino F, Pascarmona G, Pollo B, Schiffer D, Bosia A (1988) Free cytoplasmatic Ca“ at rest and after cholinergic stimulus is increased in cultured muscle cells from Duchenne muscular dystrophy patients. Neurology 38: 476–480

    Article  PubMed  CAS  Google Scholar 

  • Moxley RT, Brooke MH, Fenichel GM, Mendell JR, Griggs RC, Miller JP, Province MA, Patterson V (1987) Clinical investigation in Duchenne dystrophy. VI. Double-blind controlled trial of nifedipine Muscle Nerve 10: 22–33

    Google Scholar 

  • Murphy KMM, Gould RJ, Largent BL, Snyder SH (1983) A unitary mechanism of calcium antagonist drug action. Proc Natl Acad Sci USA 80: 860–864

    Article  PubMed  CAS  Google Scholar 

  • Murphy SN, Miller RJ (1988) A glutamate receptor regulates Cat+ mobilization in hippocampal neurons. Proc Natl Acad Sci USA 85: 8737–8741

    Article  PubMed  CAS  Google Scholar 

  • Newberg LA, Steen PA, Milde JH, Michenfelder JD (1984) Failure of flunarizine to improve cerebral blood flow or neurologic recovery in a canine model of complete cerebral ischemia. Stroke 13: 666–671

    Article  Google Scholar 

  • Nishizuka Y (1984) Turnover of inositol phospholipide and signal transduction. Science 225: 1365–1370

    Article  PubMed  CAS  Google Scholar 

  • Nowycky MC, Fox AP, Tsien RW (1985) Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 316: 440–443

    Article  PubMed  CAS  Google Scholar 

  • Olesen J, Larsen B, Lauritzen M (1981) Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 9: 344–352

    Article  PubMed  CAS  Google Scholar 

  • Oosterveld D (1982) Flunarizine in vertigo. A double-blind placebo-controlled crossover evaluation of a constant-dose schedule. ORL 44: 72–80

    Article  PubMed  CAS  Google Scholar 

  • Oosterveld WJ (1974) Vestibular pharmacology of flunarizine compared to that of cinnarizine. ORL 36: 157–164

    Article  PubMed  CAS  Google Scholar 

  • Overweg J, Ashton D, DE Beukelaar F, Binnie Wau-Quier A (1986) Add-on therapy in epilepsy with calcium entry blockers. Eur Neurol 25: 93–101

    Article  PubMed  Google Scholar 

  • Paskin NH (1981) Pharmacology of migraine. Ann Rev Pharmacol Toxicol 21: 463–478

    Article  Google Scholar 

  • Peerless SJ, Kassell NF, Komatsu K, Hunter IG (1980) Cerebral vasospasm: acute proliferative vasculopathy? II. Morphology. In: WILKINS RH (ed) Cerebral arterial spasm. Williams & Wilkins, Baltimore, pp 88–96

    Google Scholar 

  • Pelletieri L, Carlson CA, Lindholm L (1981) Is the vasospasm following subarachnoid hemorrhage an immunoreactive disease? Experientia 15: 1170–1171

    Article  Google Scholar 

  • Pennefather K, Lancaster B, Adams PR, Nicoll RA (1986) Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells. Proc Natl Acad Sci USA 82: 3040–3044

    Article  Google Scholar 

  • Peroutka SJ, Allen GS (1983) Calcium-channel antagonist binding sited labeled by 3H-nimodipine in human brain. J Neurosurg 59: 933–937

    Article  PubMed  CAS  Google Scholar 

  • Peterson C, Gibson GE (1983) Aging and 3,4—diaminopyridine alter synaptosomal calcium uptake. J Biol Chem 258: 11482–11485

    PubMed  CAS  Google Scholar 

  • Peterson C, Goldman JE (1986) Alterations in calcium content and biochemical processses during aging and Alzheimer disease. Proc Natl Acad Sci USA 83: 2758–2762

    Article  PubMed  CAS  Google Scholar 

  • Peterson C, Ratan RR, Shelanski ML, Goldman JE (1986) Cytosolic free calcium and cell spreading decreases in fibroblasts from aged and Alzheimer donors. Proc Natl Acad Sci USA 83: 7999–8001

    Article  PubMed  CAS  Google Scholar 

  • Prentki M, Biden TJ, Janjic D, Irvine RF, Berridge MJ, Wdllheim CB (1984) Rapid mobilization of Ca“’ from rat insulinoma microsomes by ionositol-1,4,5—triphosphate. Nature 309: 562–564

    Article  PubMed  CAS  Google Scholar 

  • Rascol A, Montastruc JL, Rascol O (1985) Flunarizine versus pizotifen: a double blind study in the prophylaxes of migraine. Cephalalgia 5: 542

    Google Scholar 

  • Rasmussen H, Waismann DM (1983) Modulation of cell function in the calcium messenger system. Rev Physiol Biochem Pharmacol 95: 111–148

    Article  CAS  Google Scholar 

  • Reynolds IL Gould RJ, Snyder SH (1984) Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects. J Pharmacol Exp Ther 231: 628–632

    Google Scholar 

  • Roy MW, Dempsey RJ, Meyer KL, Donaldson DL, Tibbs PA, Young AB (1985) Effects of verapamil and diltiazem on acute stroke in cats. J Neurosurg 63: 929–936

    Article  PubMed  CAS  Google Scholar 

  • Ryan US (1983) Endothelial cells and inflammation. Clin Lab Med 3: 577–599

    PubMed  CAS  Google Scholar 

  • Sakai F, Meyer JS (1978) Regional cerebral hemodynamics during migraine and cluster headaches measured by the 133—Xe inhalation method. Headache 18: 122–132

    Article  PubMed  CAS  Google Scholar 

  • Scherer H, Schmidtmayer E, Hirche H (1978) Die Wirkung von Bencyclan, Flunarizin and Naftridrofuryl auf den Nystagmus eines kalorischen Dauerreizes. Laryngol Rhinol Otol 57: 773–798

    Google Scholar 

  • Schwartz AC (1985) Neurological recovery after cardiac arrest: clinical feasibility trial of calcium blockers. Am J Emerg Med 3: 1–10

    Article  PubMed  CAS  Google Scholar 

  • Seiler R, Grolimund P, Weber M (1988) Effect of nimodipine on the CO2 reactivity of patients with aneurysmatil subarachnoid hemorrhage. International Workshop: Cerebral Ischemia and Calcium. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Shader RI, Dimascio A (1970) Psychotropic drug side effects: clinical and theoretical perspectives. Williams & Wilkins, Baltimore

    Google Scholar 

  • Sharbrough FW, Messick JM JR, Sundt TM Jr (1973) Correlation of continuous electroencephalograms with cerebral blood flow measurements during carotid endarterectomy. Stroke 4: 674–683

    Article  PubMed  CAS  Google Scholar 

  • Shearman GT (1989) Effect of NMDA antagonist MK-801 in animal models of focal and global cerebral ischemia. In: Ginsberg MD, Dietrich WD (eds) Cerebrovascular diseases. 16th Princetone Conference. Raven Press, New York, pp 73–78

    Google Scholar 

  • Siesjö BK (1982) Lactic acidosis in the brain: occurrence, triggering mechanisms and pathophysiological importance. Ciba Found Symp 87: 77–100

    PubMed  Google Scholar 

  • Siesjö BK (1984) Cerebral circulation and metabolism. J Neurosurg 60: 883–908

    Article  PubMed  Google Scholar 

  • Siesjö BK, Wieloch T (1985) Molecular mechanisms of ischemic brain damage: Cat..-related events. In: Plum P, Pulsinelli L (eds) Cerebro-vascular disease. 13th Research Conference, Princetone. Raven Press, New York, pp 187–197

    Google Scholar 

  • Skinho JE (1973) Hemodynamic studies within the brain during migraine. Arch Neurol (Chicago) 29: 95–98

    Article  Google Scholar 

  • Smith R, Schwartz A (1984) Diltiazem prophylaxis in refractory migraine. N Engl J Med 310: 1327–1328

    Article  PubMed  CAS  Google Scholar 

  • Solaro RJ (1982) The role of calcium in the concentration of the heart. In: Flaim SF, Zelis R (eds) Calcium blockers. Urban & Schwarzenberg, Baltimore, pp 21–36

    Google Scholar 

  • Solomon GD, Steel JG, Spaccavento LJ (1983) Verapamil prophylaxes of migraine: a double-blind, placebocontrolled study. JAMA 250: 2500–2502

    Article  PubMed  CAS  Google Scholar 

  • Somlyo AV, Bond M, Somlyo AP, Scarpa A (1985) Inositol triphosphate-induced calcium relea- se and contraction in vascular smooth muscle. Proc Natl Acad Sci USA 82: 5231–5235

    Article  PubMed  CAS  Google Scholar 

  • Sorge F, Desimone R, Marano E, Orefice G, Carrieri P (1985) Efficacy of flunarizine in the pro- phylaxis of migraine in children. Cephalalgia 5: 172

    Google Scholar 

  • Staessen AJ (1977) Treatment of circulatory disturbances with flunarizine and cinnarizine. VASA 6: 59–71

    PubMed  CAS  Google Scholar 

  • Stanfield PR (1986) Voltage-dependent calcium-channels of escitable membranes. Br Med Bull 42: 359–367

    PubMed  CAS  Google Scholar 

  • Steen PA, Newberg LA, Milde JH, Michenfelder JD (1983) Nimodipine improves cerebral blood flow and neurologic recovery after complete cerebral ischemia in the dog. J Cereb Blood Flow Metab 3: 38–43

    Article  PubMed  CAS  Google Scholar 

  • Strong AJ, Tomlinson BE, Venables GS, Gibson G, Hardy JA (1983) The cortical ischaemic penumbra associated wirth occlusion of the middle cerebral artery in the cat. 2. Studies of histopathology, water content, and in vivo neurotransmitter uptake. J Cereb Blood Flow Metab 3: 97–108

    Google Scholar 

  • Summers WK, Majovski LV, Marsh GM, Takichi K, Kling A (1986) Oral tetrahydroaminoacridine in long term treatment of senile dementia, Alzheimer type. N Engl J Med 315: 1241–1245

    Google Scholar 

  • Suzuki J, Kodama N, Yosjimoto, Mizoi K (1982) Ultraearly surgery of intracranial aneurysms. Acta Neurochir 83: 186–191

    Google Scholar 

  • Symon L, Ackermann R, Bull JWD et al. (1972) The use of the xenon clearance method in subarachnoid hemorrhage. Post-operative studies with clinical and angiography correlation. Eur Neurol 8: 8–14

    Google Scholar 

  • Symon L, Branston NM, Strong AJ, Hope TD (1977) The concept of thresholds of ischaemia in relation to brain structure and function. J Clin Pathol 30: 149–154

    Article  Google Scholar 

  • Taneda M (1982) Effect of early operation for ruptured aneurysms on prevention of delayed ischemic symptoms. J Neurosurg 57: 622–627

    Article  PubMed  CAS  Google Scholar 

  • Teasdale G, Pickard J, Shaw D, Illingworth R (1989) Treatment of subarachnoid hemorrhage with calcium-antagonist: large randomized controlled trial. In: Hartmann A, Kuschinski W (eds) Cerebral ischemia and calcium. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Thesleff S (1981) Aminopyridines and synaptic transmission. Neuroscience 5: 1413–1419

    Article  Google Scholar 

  • Theunissen EJJM, Huvgen PLM, Nicolasen MGM (1986) Flunarizine treatment in dizzy patients with vestibular hyperactivity and hyperventilation. ORL 48: 203–208

    Article  PubMed  CAS  Google Scholar 

  • Turner JS (1977) The dizzy patient: diagnosis and treatments. Drugs 13: 382–387

    Article  PubMed  Google Scholar 

  • Vanhouite PM, Paoletti R (1987) The Who classification of calcium antagonists. TIPS 8: 4–5

    Google Scholar 

  • Vermeulen M, Lindsy KW, Murray GD, Gheahf, Hijdra A, Muizelaar JP, Schannong M, Teasdale GM, Van Grevel H, Van Gijn J (1984) Antifibrinolytic treatment in subarachnoid hemorrhage. N Engl J Med 311: 432–437

    Article  PubMed  CAS  Google Scholar 

  • Voldby B, Peterson OF, Buhl M, Jakobsen P, Oster-Gaard R (1984) Reversal of cerebral arterial spasm by intrathecal administration of a calcium antagonist (nimodipine). Acta Neurochir (Wien) 70: 243–254

    Article  CAS  Google Scholar 

  • Weir BA (1980) The incidence and onset of vasospasm after subarachnoid hemorrhage from ruptured aneurysm. In: Wilkins RH (ed) Cerebral arterial spasm. Williams & Wilkins, Baltimore, pp 302–305

    Google Scholar 

  • Welsh FA, O’connor MJ, Marcy VR, Spatacco AJ, Johns RL (1982) Factors limiting regeneration of ATP following temporary ischemia in cat brain. Stroke 13: 234–242

    Article  PubMed  CAS  Google Scholar 

  • Wesseling H, Agoston S, Van Dam GB, Pasma J, De Wrr DJ, Havinga H (1984) Effects of 4-aminopyridine in elderly patients with Alzheimer’s disease. N Engl J Med 310: 988–989

    Article  PubMed  CAS  Google Scholar 

  • White BC, Gadzinski DS, Hoehner PJ, Krone C, Hoener T, White DJ, Trombley JH (1982) Effect of flunarizine on canine cerebral cortical blood flow and vascular resistance post cardiac arrest. Ann Emerg Med 11: 119–126

    Article  PubMed  CAS  Google Scholar 

  • White RP (1979) Multiple origins of cerebral vasospasm. In: Price TR, Nelson E (eds) Cerebro-vascular diseases. Raven Press, New York, pp 307–319

    Google Scholar 

  • Wieloch T, Siesjö BK (1982) Ischemic brain injury: the importance of calcium, lipolytic activities, and free fatty acids. Pathol Biol (Paris) 30: 269–277

    CAS  Google Scholar 

  • Wiernsperger N, Gyax P, Hofmann A (1984) A calcium antagonist PY 108–068: demonstration of its efficacy in various types of experimental brain ischemia. Stroke 15: 670–683

    Article  Google Scholar 

  • Wiill, OW, Walden J, Speckmann EJ, Elger CE (1983) Reduction of penicillin-induced paroxysmal depolarization shifts of rat cerebral cortex by intracellular injection of calcium channel blokker. Neurosci Lett 14: 405–407

    Google Scholar 

  • Wolff GH (1983) Headache and other head pain. Oxford University Press, New York

    Google Scholar 

  • Zahlmann F, Perloff JK, Durant NN, Campion DS (1983) Acute respiratory failure following intravenous verapamil in Duchenne muscular dystrophy. Am Heart J 3: 104–105

    Google Scholar 

  • Acevedo AG, Smith JK (1988) Adverse reaction to caffeine in ECT. Am J Psychiatry 145: 529–530

    PubMed  CAS  Google Scholar 

  • Acevedo AMA (1986) Drug evaluations. Saunders, Philadelphia, pp 324–325

    Google Scholar 

  • Aranda JV, Gorman W, Bergsteinsson H, Gunn T (1977) Efficacy of caffeine in treatment of apnea in the low — birth weight infant. J Pediatr 90: 467–472

    Article  PubMed  CAS  Google Scholar 

  • Arnold LE, Christopher J, Huestis R, Smeltzer DJ (1978) Methylphenidate vs dextroamphetamine vs caffeine in minimal brain dysfunction. Am J Psychiatry 35: 463–473

    CAS  Google Scholar 

  • Barone JJ, Roberts HR (1984) Human consumption of caffeine. In: Dews P (ed) Caffeine. Springer, Berlin Heidelberg New York, pp 59–73

    Chapter  Google Scholar 

  • Beach CA, Mays DC, Guiler RC, Jacober CH, Ger-Ber N (1986) Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics. Clin Pharmacol Ther 39: 265–270

    Article  PubMed  CAS  Google Scholar 

  • Becker AB, Simons KJ, Gillespie CA, Simons FER (1984) The bronchodilator effects and pharmakokinetics of caffeine in asthma. N Engl J Med 310: 743–746

    Article  PubMed  CAS  Google Scholar 

  • Berkowitz BA, Spector S, Wool W (1971) The interaction of caffeine, theophylline and theobromine with monoaminoxidase inhibitors. Eur J Pharmacol 16: 315

    Article  PubMed  CAS  Google Scholar 

  • Blanchard J, Sawers SJA (1983) The absolute bio-availability of caffeine in man. Eur J Clin Pharmacol 24: 93–98

    Article  PubMed  CAS  Google Scholar 

  • Bonati M, Garattini S (1984) Interspecies comparison of caffeine disposition. In: Dews P (ed) Caffeine. Springer, Berlin Heidelberg New York, pp 48–56

    Chapter  Google Scholar 

  • Boulenger JP, Salem N, Marangos PJ, Uhde TW (1987) Plasma adenosine levels: measurement in humans and relationship to the anxiogenic effects of caffeine. Psychiatr Res 21: 247–255

    Article  CAS  Google Scholar 

  • Curatolo PW, Robertson D (1983) The health consequences of caffeine. Ann Intern Med 98: 641–653

    PubMed  CAS  Google Scholar 

  • Debas HT, Cohen MM, Holubitsky IB, Harrison RC (1971) Caffeine-stimulated gastric acid and pepsin secretion: dose-response studies. Scand J Gastroenterol 6: 453–457

    Article  PubMed  CAS  Google Scholar 

  • Deckert J, Gleiter CH (1989) Adenosinergic psychopharmaceuticals. TIPS 10: 99–100

    PubMed  CAS  Google Scholar 

  • Deckert J, Gleiter CH (1990) Adenosinergic psychopharmaceuticals: just an extra cup of coffee? J Psychopharmacol 4: 183–187

    Article  PubMed  CAS  Google Scholar 

  • Defreitas B, Schwartz G (1979) Effects of caffeine in chronic psychiatric patients. Am J Psychiatry 136: 1337–1338

    CAS  Google Scholar 

  • Dobmeyer DJ, Stine RA, Leier CV, Greenberg R, Schaal SF (1983) The arrhythmogenic effects of caffeine in human beings. N Engl J Med 308: 814–816

    Article  PubMed  CAS  Google Scholar 

  • Eichler O (1976) Atmung und Atemwege. In: Eichler O (Hrsg) Kaffee und Coffein. Springer, Berlin Heidelberg New York, S 171–173

    Google Scholar 

  • Ellinwood EH, Rockwell WJK (1988) Central nervous system stimulants and anorectic agents. In: Dukes Mng (ed) Meyler’s side effects of drugs. Elsevier, Amsterdam, pp 1–3

    Google Scholar 

  • Estler CJ (1982) Caffeine. In: Hoffmeister F, Stille G (eds) Handbook of experimental pharma- cology, vol 55/III. Psychotropic agents. Sprin- ger, Berlin Heidelberg New York, pp 369–389

    Chapter  Google Scholar 

  • Estler FDA (1977) Over-the-counter drugs: establishment of monograph for OTC internal analgesic, antipyretic and antirheumatic products. Federal Register 42: 35439–35487

    Google Scholar 

  • File SE, Bond AJ, Lister RG (1982) Interaction between effects of caffeine and lorazepam in performance tests and self-ratings. J Clin Psychopharmacol 2: 102–106

    Article  PubMed  CAS  Google Scholar 

  • Fulgraf G (1976) Niere und Nierenfunktion. In: Eichler O (Hrsg) Kaffee und Coffein. Springer, Berlin Heidelberg New York, S 171–173

    Google Scholar 

  • Gleiter CH, Deckert J, Nurr DJ (1988) Changes in caffeine seizure threshold after electroconvulsive shock. Psychopharmacology 95: 544–545

    PubMed  CAS  Google Scholar 

  • Gleiter CH, Deckert J, Nuit DJ, Marangos PJ (1989) Electroconvulsive shock ( ECS) and the adenosine neuromodulatory system. J Neurochem 52: 641–646

    Google Scholar 

  • Goldstein A, Kaizer S, Warren R (1965) Psychotropic effects of caffeine in man. II. Alertness, psychomotor coordination and mood. J Pharmacol Exp Ther 150: 146–151

    Google Scholar 

  • Greden JF (1981) Caffeinism and caffeine withdrawal. In: Lowinson JH, Ruiz P (eds) Substance abuse. Williams & Wilkins, Baltimore, pp 274–286

    Google Scholar 

  • Griffiths RR, Woodson PP (1988) Caffeine physical dependence: a review of human and laboratory animal studies. Psychopharmacology 94: 437–451

    Article  PubMed  CAS  Google Scholar 

  • Haas S, Beckmann H (1983) Psychopharmakotherapie bei (psychotischen) Erregungszuständen. In: Langer G, Heimann H (Hrsg) Psychopharmaka. Springer, Wien New York, S 437–446

    Google Scholar 

  • Hinkle PE, Coffey CE, Weiner RD, Cress RN, Chri Stison C (1987) Use of caffeine to lengthen seizures in ECT. Am J Psychiatry 144: 1143–1148

    Google Scholar 

  • Hoeldtke RD, Stephen TC, Hughes JD, Polansky M (1986) Treatment of orthostatic hypotension with dihydroergotamine and caffeine. Ann Intern Med 105: 168–172

    PubMed  CAS  Google Scholar 

  • Kalow W (1985) Variabilty of caffeine metabolism in humans. Arzneimittelforschung/Drug Res 35: 319–324

    CAS  Google Scholar 

  • Karacan I, Thornby JI, Anch AM, Booth GH, Wil-Liams RL, Salis MA (1976) Dose related sleep disturbances induce by coffee and caffeine. Clin Pharmacol Ther 20: 682–689

    PubMed  CAS  Google Scholar 

  • Klinz C, Biesold KH (1990) Familiäre paroxysmale dystone Choreoathetose. Nervenarzt 61: 507–509

    PubMed  CAS  Google Scholar 

  • Laska EM, Sunshine A, MĂĽller F, Elvers WB, Siegel C, Rubin A (1984) Caffeine as an analgesic adjuvant. J Am Med Assoc 251: 1711–1733

    Article  CAS  Google Scholar 

  • Lee MA, Flegel P, Greden JF, Cameron OG (1988) Anxiogenic effects of caffeine on panic and depressed patients. Am J Psychiatry 145: 632–635

    PubMed  CAS  Google Scholar 

  • Lucas PB, Pickar D, Kelsoe J, Rapaport M, Pato C, Hommer D (1990) Effects of the acute administration of caffeine in patients with schizophrenia. Biol Psychiatry 28: 35–40

    Article  PubMed  CAS  Google Scholar 

  • Nagesh RV, Murphy KA (1988) Caffeine poisening treated by hemoperfusion. Am J Kidney Dis 12: 316–318

    PubMed  CAS  Google Scholar 

  • Onrot J, Goldberg MR, Biaggoni I, Hollister AS, Kincaid D, Robertson D (1985) Hemodynamic and humoral effects of caffeine in autonomic failure. N Engl J Med 313: 549–555

    Article  PubMed  CAS  Google Scholar 

  • Onrot J, Shaheen O, Biaggioni I, Goldberg MR, Feely J, Wilkinson GR, Hollister AS, Robertson D (1986) Reduction of liver plasma flow by caffeine and theophylline. Clin Pharmacol Ther 40: 506–510

    Article  PubMed  CAS  Google Scholar 

  • Price KR, Fligner DJ (1990) Treatment of caffeine toxicity with esmolol. Ann Emerg Med 19: 44 46

    Google Scholar 

  • Rall TW (1990) Drugs used in the treatment of asthma. In: Goodman Gilman A, Rall TW, Nies AS, Taylor P (eds) Goodman and Gilman’s the pharmacological basis of therapeutics, 8th ed. Pergamon, New York, pp 618–637

    Google Scholar 

  • Reynolds JEF (ed) (1989) Martindale, the extra pharmacopeia, 29th ed. The Pharmaceutical Press, London, pp 1522–1524

    Google Scholar 

  • Robertson D, Frölich JC, Carr RK, Watson JT, Hollifield JW, Shand DG, Oates JA (1978) Effects of caffeine on plasma renin activity, catecholamines and blood pressure. N Engl J Med 298: 181–186

    Article  PubMed  CAS  Google Scholar 

  • Schingnitz G, KĂĽfner-MĂĽhl U, Ensinger H, Lehr E (1991) A novel xanthine derivative for treatment of cognitive deficits. Biol Psychiatry 29: 6945

    Google Scholar 

  • Schnackenberg RC (1973) Caffeine as a substitute for schedule II stimulants in hyperkinetic children. Am J Psychiatry 130: 796–798

    PubMed  CAS  Google Scholar 

  • Schroder-Rosenstock K (1990) Kaffeekonsum —Ein medizinisches Problem? MĂĽnch Med Wochenschr 132: 158–159

    Google Scholar 

  • Sechzer PH, Abel L (1978) Postspinal anesthesia headache treated with coffeine. Curr Ther Res 24: 307–312

    Google Scholar 

  • Shapira B, Lerer B, Gilboa B, Drexler H, Kugelmass S, Calev A (1987) Facilitation of ECT by caffeine pretreatment. Am J Psychiatry 144: 1199–1202

    PubMed  CAS  Google Scholar 

  • Snyder SH (1984) Adenosine as a mediator of the behavioral effects of caffeine. In: DEWS PB (ed) Caffeine. Springer, Berlin Heidelberg New York Tokyo, pp 129–141

    Chapter  Google Scholar 

  • Sobotka TJ (1989) Neurobehavioral effects of prenatal caffeine. Ann NY Acad Sci 562: 327–339

    Article  PubMed  CAS  Google Scholar 

  • Somani SM, Gupta P (1988) Caffeine: a new look at an age-old drug. Int J Clin Pharmacol Toxicol 26: 521–533

    CAS  Google Scholar 

  • Strubelt O (1976) Endokrines System. In: Eichler O (Hrsg) Kaffee und Coffein. Springer, Berlin Heidelberg New York, S 287–296

    Google Scholar 

  • Strubelt O (1986) Kaffee und Coffein. Dtsch Apotheker Z 38: 2025–2032

    Google Scholar 

  • Weidner K (1961) Schlaflosigkeit: Versuch mit Kaffee. Selecta 3: 10

    Google Scholar 

  • Weir RL, Hruska RE (1983) Interaction between methylxanthines and the benzodiazepine receptor. Arch Int Pharmacodyn 254: 42–48

    Google Scholar 

  • Zenglein R (1975) Behandlung der Migräne. Dtsch Med Wochenschr 100: 557–559

    Article  PubMed  CAS  Google Scholar 

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Platz, W.E. et al. (1992). Sonstige Psychopharmaka. In: Riederer, P., Laux, G., Pöldinger, W. (eds) Neuro-Psychopharmaka. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3793-2_5

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