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Kardiologie

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Gender Medizin

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Zusammenfassung

Kardiovaskuläre Erkrankungen sind die wichtigste Todesursache in den industrialisierten Ländern. Dies gilt für Männer und für Frauen, wobei bei Frauen — im Gegensatz zu den Männern — durch das um etwa 15 Jahre spätere Auftreten der koronaren Herzkrankheit der Anstieg an kardiovaskulären und im besonderen koronaren Todesfällen nach dem 75. Lebensjahr viel ausgeprägter ist.

Nach einer langen Phase, in der Frauen nicht in kardiologische Studien eingeschlossen wurden, konnten in den letzten zwei bis drei Jahrzehnten bedeutsame Erkenntnisse über Geschlechtsunterschiede in Präsentation, Diagnostik, Prognose sowie medikamentöse, interventionelle und chirurgische Behandlung von Herzerkrankungen gewonnen werden. Die vorliegende Übersicht befasst sich aufgrund der Bedeutung für die Praxis zu einem großen Teil mit der koronaren Herzkrankheit (KHK) und ihren zahlreichen Aspekten (Epidemiologie, Risikofaktoren, Klinik, einzelne Krankheitsbilder, Untersuchungstechniken, kathetergestützte und chirurgische Revaskularisierung sowie medikamentöse Therapie), weitere Kapitel umfassen das Syndrom Herzinsuffizienz (Hl) sowie ausgewählte Bereiche der Rhythmologie.

Einen raschen Überblick über Geschlechtsunterschiede in der Kardiologie gibt Tabelle 1.

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Literatur

  1. Aaronson KD et al. (1995) Sex differences in patient acceptance of cardiac transplantation candidacy. Circulation 91:2753–2761

    Article  PubMed  CAS  Google Scholar 

  2. Abildstrom SZ et al. (2002) Impact of age and sex on sudden cardiovascular death following myocardial infarction. Heart 88:573–578

    Article  PubMed  CAS  Google Scholar 

  3. Albert CM et al. (2003) Prospective study of sudden cardiac death among women in the United States. Circulation 107:2096–2101

    Article  PubMed  Google Scholar 

  4. Aidea GS et al. (1999) Effect of gender on postoperative outcomes and hospital stays after coronary artery bypass grafting. Ann Thorac Surg 67:1097–1103

    Article  Google Scholar 

  5. Allen JK, Blumenthal RS (1998) Risk factors in the offspring of women with premature coronary heart disease. Am Heart J 135:428–434

    Article  PubMed  CAS  Google Scholar 

  6. Amanullah AM et al. (1998) Incremental prognostic value of adenosine myocardial perfusion single-photon emission computed tomography in women with suspected coronary artery disease. Am J Cardiol 82:725–730

    Article  PubMed  CAS  Google Scholar 

  7. American Heart Association (2002) Heart disease and stroke statistics — 2003 Update. Dallas, Texas

    Google Scholar 

  8. Anonymus (1980) W.H.O. cooperative trial on primary prevention of ischaemic heart disease using Clofibrate to lower serum cholesterol: mortality follow-up. Report of the Committee of Principal Investigators. Lancet 2:379–385

    Google Scholar 

  9. Anonymus (1995) First-year results of CABRI (Coronary Angioplasty versus Bypass Revascularisation Investigation). CABRI trial participants. Lancet 346:1179–1184

    Google Scholar 

  10. Anonymous (1998) Missed opportunities in preventive counseling for cardiovascular disease: United States 1995. Morb Mortal Wkly Rep 47:91–95

    Google Scholar 

  11. Arbogast A, Sechtem U (2002) Geschlechtsunterschiede im Aussagewert der Diagnostik der KHK. In: Brachmann J, Medau HJ (Hrsg) Die koronare Herzkrankheit der Frau. Steinkopff Verlag, Darmstadt. S 137–147

    Chapter  Google Scholar 

  12. Arnold AM et al. (1994) Gender differendes for coronary angioplasty. Am J Cardiol 74:18–21

    Article  PubMed  CAS  Google Scholar 

  13. Arora RR et al. (1990) Restenosis after transluminal coronary angioplasty: a risk factor analysis. Cathet Cardiovasc Diagn 19:17–22

    Article  PubMed  CAS  Google Scholar 

  14. Ascherio A et al. (2001) Blood donations and risk of coronary heart disease in men. Circulation 103:52–57

    Article  PubMed  CAS  Google Scholar 

  15. Atrial Fibrillation Investigators (1994) Riskfactors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials. Ann Intern Med 154: 1449–1457

    Article  Google Scholar 

  16. Ayanian JZ, Epstein AM (1991) Differences in the use of procedures between women and men hospitalized for coronary heart disease. N Engl J Med 325:221–225

    Article  PubMed  CAS  Google Scholar 

  17. Bankier B, Littman AB (2002) Psychiatric disorders and coronary heart disease in women — a still neglected topic: review of the literature from 1971 to 2000. Psychother Psychosom 71:133–140

    Article  PubMed  Google Scholar 

  18. Barakat K et al. (2000) Acute Myocardial Infarction in Women: Contribution of Treatment Variables to Adverse Outcome. Am Heart J 140:740–746

    Article  PubMed  CAS  Google Scholar 

  19. Barrett-Connor E (1998) Hormone replacement therapy. Brit Med J 317:457–461

    Article  PubMed  CAS  Google Scholar 

  20. Bartlett C et al. (2003) Women, older persons, and ethnic minorities: factors associated with their inclusion in randomised trials of statins 1990 to 2001. Heart 89:327–328

    Article  PubMed  CAS  Google Scholar 

  21. Bearden D et al. (1994) Age, race, and gender variation in the utilization of coronary artery bypass surgery and angioplasty in SHEP Cooperative Research Group: Systolic Hypertension in the Elderly Program. J Am Geriatr Soc 42:1143–1149

    PubMed  CAS  Google Scholar 

  22. Becker A et al. (2003) Cardiovascular events in type 2 diabetes: comparison with nondiabetic individuals without and with prior cardiovascular disease. Eur Heart J 24:1406–1413

    Article  PubMed  Google Scholar 

  23. Bell MR et al. (1993) The changing in-hospital mortality of women undergoing percutaneous transluminal coronary angioplasty. J Am Med Ass 269: 2091–2095

    Article  CAS  Google Scholar 

  24. Bell MR et al. (1995 a) Referral for coronary artery revascularization procedures after dignostic coronary angiography: evidence for gender bias ? J Am Coll Cardiol 25:1650–1655

    Article  PubMed  CAS  Google Scholar 

  25. Bell MR et al. (1995 b) Long-term outcome of women compared with men after successful coronary angioplasty. Circulation 91:2876–2881

    Article  PubMed  CAS  Google Scholar 

  26. Bengtsson C et al. (1993) Associations of serum lipid concentrations and obesity with mortality in women: 20 year follow up of participants in prospective population study in Gothenburg, Sweden. Brit Med J 307:1385–1388

    Article  PubMed  CAS  Google Scholar 

  27. Benjamin J et al. (1994) Independent riskfactors for atrial fibrillation in a population-based cohort: the Framingham Heart Study. J Am Med Assoc 271: 840–844

    Article  CAS  Google Scholar 

  28. Bickell NA et al. (1992) Referral patterns for coronary artery disease treatment: gender bias or good clinical judgment? Ann Intern Med 116:791–797

    Article  PubMed  CAS  Google Scholar 

  29. BIP study group (2000) Secondary prevention by raising HDL-Cholesterol and reducing triglycerides in patients with coronary artery disease. Circulation 102:21–27

    Article  Google Scholar 

  30. Birdwell BG et al. (1993) Evaluating chest pain. Arch Intern Med 153:1991–1995

    Article  PubMed  CAS  Google Scholar 

  31. Bittner V, Oparil S (1993) Hypertension. In: Douglas PS (ed) Cardiovascular health and disease in women. W.B. Saunders, Philadelphia, pp 63–104

    Google Scholar 

  32. Bittner V et al. (2000) Correlates of high HDL cholesterol among women with coronary heart disease. Am Heart J 139:288–296

    PubMed  CAS  Google Scholar 

  33. Blair SN et al. (1989) Physical fitness and all-cause mortality: a prospective study of healthy men and women. J Am Med Assoc 262:2395–2401

    Article  CAS  Google Scholar 

  34. Bobbio M et al. (1991) Restenosis rate after percutaneous transluminal coronary angioplasty: a literature overview. J Invas Cardiol 3:214–224

    CAS  Google Scholar 

  35. Boersma E et al. (2002) Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a metaanalysis of all major randomised clinical trials. Lancet 359:189–198

    Article  PubMed  CAS  Google Scholar 

  36. Bourassa MG et al. (1993) Natural history and current practices in heart failure. J Am Coll Cardiol 22(SupplA):14A–19A

    Article  PubMed  CAS  Google Scholar 

  37. Braunwald E et al. (2002) ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction-summary article. J Am Coll Cardiol 40:1366–1374

    Article  PubMed  Google Scholar 

  38. Brochier ML, Arwidson P (1998) Coronary heart disease risk factors in women. Eur Heart J 1998 (SupplA):A45–A52

    Google Scholar 

  39. Bullemer F et al. (1995) Gender-related differences in riskfactors of young patients with symptomatic coronary artery disease. J Am Coll Cardiol (Special Issue): 267A

    Google Scholar 

  40. Buring JE et al. (1995) The primary prevention of coronary heart disease in women. N Engl J Med 332:1758–1766

    Article  PubMed  Google Scholar 

  41. Burns RB et al. (1997) Outcomes for older men and women with congestive heart failure. J Am Geriatr Soc 45:276–280

    PubMed  CAS  Google Scholar 

  42. Cabin H et al. (1990) Riskfor systemic embolization of atrial fibrillation without mitral stenosis. Am J Cardiol 65:1112–1116

    Article  PubMed  CAS  Google Scholar 

  43. Califf RM et al. (1991) Restenosis after coronary angioplasty: an overview. J Am Coll Cardiol 17:2B-13B

    Article  PubMed  CAS  Google Scholar 

  44. Campeau L et al. (1999) Aggressive cholesterol lowering delays saphenous vein graft atherosclerosis in women, the elderly, and patients with associated riskfactors. NHLBI Post Coronary Artery Bypass Graft Clinical Trial. Circulation 99:3241–3247

    Article  PubMed  CAS  Google Scholar 

  45. Cannon RO III et al. (1992) Pathophysiological dilemma of syndrome X. Circulation 85:883–892

    Article  PubMed  Google Scholar 

  46. Cerqueira MD (1995) Diagnostic testing strategies for coronary artery disease: special issues related to gender. Am J Cardiol 75:52D–60D

    Article  PubMed  CAS  Google Scholar 

  47. Chae SC et al. (1993) Identification of extensive coronary artery disease in women by exercise singlephoton emission computed tomographic (SPECT) thallium imaging. J Am Coll Cardiol 21:1305–1311

    Article  PubMed  CAS  Google Scholar 

  48. Choi W et al. (2002) Iron deficiency anemia increases nitric oxide production in healthy adolescents. Ann Hematol 81:1–6

    Article  PubMed  CAS  Google Scholar 

  49. Chronos NAF et al. (1997) Percutaneous transluminal coronary angioplasty in women. In: Julian DG, Wenger NK (eds): Women and heart disease. Martin Dunitz, London

    Google Scholar 

  50. CIBIS-II Investigators and Committees (1999) The Cardiac Insufficiency Bisoprolol Study II (CIBIS II). Lancet 353:9–13

    Article  Google Scholar 

  51. Clarke KW et al. (1994) Evidence of inadequate investigation and treatment of patients with heart failure. Br Heart J 71:584–587

    Article  PubMed  CAS  Google Scholar 

  52. Clarke SC et al. (2002) A study of hormone replacement therapy in postmenopausal women with ischaemic heart disease: the Papworth HRT atherosclerosis study. Br J Obstet Gynaecol 109:1056–1062

    Article  CAS  Google Scholar 

  53. Colditz GA et al. (1987) Menopause and the risk of coronary heart disease in women. N Engl J Med 316:1105–1110

    Article  PubMed  CAS  Google Scholar 

  54. Conlan MG et al. (1993) Associations of Factor VIII and von Willebrand factor with age, race, sex and risk factors for atherosclerosis. Thrombosis and Haemostasis 70:380–385

    PubMed  CAS  Google Scholar 

  55. Cooper G, Sandler DP (1998) Age at natural menopause and mortality. Ann Epidemiol 8:229–235

    Article  PubMed  CAS  Google Scholar 

  56. Cowley MT et al. (1985) Sex differences in early and long term results of coronary angioplasty in the NHLBI PTCA registry. Circulation 71:90–97

    Article  PubMed  CAS  Google Scholar 

  57. Crook D et al. (1992) Comparison of transdermal and oral estrogen-progestin replacement therapy: effects on serum lipids and lipoproteins. Am J Obstet Gynecol 166:950–955

    Article  PubMed  CAS  Google Scholar 

  58. Cubo E et al. (1998) Risk factors of stroke after percutaneous transluminal coronary angioplasty. Eur J Neurol 5:459–462

    Article  PubMed  Google Scholar 

  59. Dahlof B et al. (1991) Morbidity and mortality in the Swedish trial in older patients with hypertension (STOP-Hypertension). Lancet 338:1281–1285

    Article  PubMed  CAS  Google Scholar 

  60. Davie AP et al. (1997) The prevalence of left ventricular diastolicfilling abnormalities in patients with suspected heart failure. Eur Heart J 18:981–984

    Article  PubMed  CAS  Google Scholar 

  61. De Maria R et al. (1993) Comparison of the clinical findings in idiopathic dilated cardiomyopathy in women versus men. Am J Cardiol 72:580–585

    Article  PubMed  Google Scholar 

  62. DePuey EG, Rozanski A (1995) Using gated tech-netium-99m-sestamibi SPECT to characterize fixed myocardial defects as infarct or artifact. J Nucl Med 36:952–955

    PubMed  CAS  Google Scholar 

  63. DeSanctis RW (1993) Clinical manifestations of coronary artery disease: chest pain in women. In: Wenger NK, Speroff L, Packard B (eds) Cardiovascular health and disease in women. Le Jacq Communications, Greenwich, Conn, pp 67–72

    Google Scholar 

  64. DeWilde S et al. (2003) Evolution of statin prescribing 1994–2001: a case of agism but not of sexism? Heart 89:417–421

    Article  PubMed  CAS  Google Scholar 

  65. Digitalis Investigation Group (1997) The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 336:525–533

    Article  Google Scholar 

  66. Diver DJ et al. (1994) Clinical and arteriographic characterization of patients with unstable angina without critical coronary arterial narrowing (from the TIMI-IIIA trial). Am J Cardiol 74:531–537

    Article  PubMed  CAS  Google Scholar 

  67. Do K-A et al. (2000) Longitudinal study of risk factors for coronary heart disease across the menopausal transition. Am J Epidemiol 151:584–593

    Article  PubMed  CAS  Google Scholar 

  68. Douglas PS (1993) Cardiovascular health and disease in women. W.B. Saunders, Philadelphia London New York St. Louis Sydney Toronto

    Google Scholar 

  69. Douglas PS, Ginsburg GS (1996) The evaluation of chest pain in women. N Engl J Med 334:1311–1313

    Article  PubMed  CAS  Google Scholar 

  70. Douglas PS (2001) Coronary artery disease in women. In: Braunwald E, Zipes DP, Libby P (eds) Heart Disease, 6th ed. W.B. Saunders, Philadelphia London New York St. Louis Sydney Toronto

    Google Scholar 

  71. Downs JR et al. (1998) Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels results of AFCAPS/ TexCAPS. J Am Med Assoc 279:1615–1622

    Article  CAS  Google Scholar 

  72. Eagle KA et al. (1999) ACC/AHA guidelines for coronary artery bypass graft surgery: executive summary and recommendation: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation 100:1464–1480

    Article  PubMed  CAS  Google Scholar 

  73. Ebert SN et al. (1998) Gender-based therapeutics: female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence. J Women’s Health 7:547–557

    Article  CAS  Google Scholar 

  74. Echeverria HH et al. (1983) Congestive heart failure: Echocardiographic insights. Am J Med 75:750–755

    Article  PubMed  CAS  Google Scholar 

  75. Elhendy A et al. (1997) Gender differences in the accuracy of dobutamine stress echocardiography for the diagnosis of coronary artery disease. Am J Cardiol 80:1414–1418

    Article  PubMed  CAS  Google Scholar 

  76. Ellis S (1990) Elective coronary angioplasty: techniques and complications. In: Topol E (ed) Textbook of interventional cardiology. WB Saunders, Philadelphia London New York St. Louis Sydney Toronto, pp 199–222

    Google Scholar 

  77. Ericsson CG et al. (1996) Angiographic assessment of effects of bezafi brate on progression of corona ry artery disease in young male postinfarction patients. Lancet 347:849–853

    Article  PubMed  CAS  Google Scholar 

  78. Eriksson M et al. (1999) Relationship between plasma fibrinogen and coronary heart disease in women. Arterioscler Thromb Vase Biol 19:67–72

    Article  CAS  Google Scholar 

  79. Ernst E, Resch KL (1993) Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature. Ann Intern Med 118:956–963

    Article  PubMed  CAS  Google Scholar 

  80. ESPRIT team (2002) Oestrogen therapy for prevention of reinfarction in postmenopausal women: a randomised placebo controlled trial. Lancet 360: 2001–2008

    Article  Google Scholar 

  81. Feinberg WM et al. (1995) Prevalence, age distribution, and gender of patients with atrial fibrillation: analysis and implications. Arch Intern Med 155:469–473

    Article  PubMed  CAS  Google Scholar 

  82. Fox KAA et al. (2002) Interventional versus conservative treatment for patients with unstable angina or non ST-elevation myocardial infarction: the British heart foundation RITA-3 randomized trial. Lancet 360:743–751

    Article  PubMed  CAS  Google Scholar 

  83. Francis CM et al. (1995) Open access echocardiography in management of heart failure in the community. Brit Med J 310:634–636

    Article  PubMed  CAS  Google Scholar 

  84. Freyssinges C, Ducrocq MB (1996) Simvastatin and pregnancy. Therapie 51:537–542

    PubMed  CAS  Google Scholar 

  85. Frick MH et al. (1987) Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 317:1237–1245

    Article  PubMed  CAS  Google Scholar 

  86. Frick MH et al. (1997) Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lopid Coronary Angiography Trial (LOCAT) Study Group. Circulation 96:2137–2143

    Article  PubMed  CAS  Google Scholar 

  87. Friedman TD et al. (1982) Exercise thallium-201 myocardial scintigraphy in women: correlation with coronary arteriography. Am J Cardiol 49: 1632–1637

    Article  PubMed  CAS  Google Scholar 

  88. Garavaglia GE et al. (1989) Sex differences in cardiac adaptation to essential hypertension. Eur Heart J 10:1110–1114

    PubMed  CAS  Google Scholar 

  89. Garg R et al. (1995) Overview of randomized trials of angiotensin converting enzyme inhibitors on mortality and morbidity in heart failure. J Am Med Assoc 273:1450–1456

    Article  CAS  Google Scholar 

  90. Ghali JK et al. (2002) Metoprolol CR/XL in female patients with heart failure: analysis of the experience in MERIT-HF. Circulation 105:1585–1591

    Article  PubMed  CAS  Google Scholar 

  91. Gilligan DM et al. (1994) Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation 89:2545–2551

    Article  PubMed  CAS  Google Scholar 

  92. Glaser R et al. (2002) Benefit of an early invasive management strategy in women with acute coronary syndromes. J Am Med Assoc 288:3124–3129

    Article  Google Scholar 

  93. Gohlke-Bärwolf C (2002) Hormontherapie der KHK bei Frauen: Kardioprotektion oder Risiko? In: Brachmann J, Medau HJ (Hrsg) Die koronare Herzkrankheit der Frau. Steinkopff, Darmstadt

    Google Scholar 

  94. Gordon DJ et al. (1989) High-density lipoprotein cholesterol and cardiovascular disease: Four prospective American studies. Circulation 79:8–15

    Article  PubMed  CAS  Google Scholar 

  95. Green LA, Ruffin MT IV (1994) A closer examination of sex bias in the treatment of ischemic cardiac disease. J Fam Pract 39:331–336

    PubMed  CAS  Google Scholar 

  96. Greenberg MA, Mueller HS (1993) Why the excess mortality in women after PTCA? Circulation 87:1030–1032

    Article  PubMed  CAS  Google Scholar 

  97. Greenland P et al. (1991) In-hospital and 1-year mortality in 1524 women after myocardial infarction: comparison with 4315 men. Circulation 83:484–491

    Article  PubMed  CAS  Google Scholar 

  98. Grodstein F et al. (1996) Prospective study of exogenous hormones and risk of pulmonary embolism in women. Lancet 348:983–987

    Article  PubMed  CAS  Google Scholar 

  99. Grodstein F et al. (2000) A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med 133:933–941

    Article  PubMed  CAS  Google Scholar 

  100. Grodstein F, Stampfer MJ (2002) The epidemiology of postmenopausal hormone therapy and cardiovascular disease. In: Goldhaber SZ, Ridker PM (eds) Thrombosis and thromboembolism. Marcel Dekker, New York

    Google Scholar 

  101. Groh WJ et al. (2002) What’s bad for the gender…women and sudden cardiac death. Heart 88:553–554

    Article  PubMed  CAS  Google Scholar 

  102. Grundy SM et al. (1999) Assessment of cardiovascular risk by use of multiple risk-factor assessment equations: A statement for healthcare professionals from the American Heart Association and the American College of Cardiology. J Am Coll Cardiol 34:1348–1359

    Article  PubMed  CAS  Google Scholar 

  103. Grundy SM et al. (2002) Third Report of the National Cholesterol Education Program (NCEP) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) National Institutes of Health NIH Publication No. 02–5215, September 2002

    Google Scholar 

  104. Hague W et al. (2003) Effect of pravastatin on cardiovascular events and mortality in 1516 women with coronary heart disease: results from the long-term intervention with pravastatin in ischemic disease (LIPID) study. Am Heart J 145:643–651

    Article  PubMed  CAS  Google Scholar 

  105. Haldeman GA et al. (1998) Changes in mortality from heart failure — United States, 1980–1995. J Am Med Assoc 280:874–875

    Article  Google Scholar 

  106. Healy B (1991) The Yentl syndrome. N Engl J Med 325:274–276

    Article  PubMed  CAS  Google Scholar 

  107. Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360:7–22

    Article  Google Scholar 

  108. Heintzen MP et al. (1997) Incidence and therapy of peripheral arterial vascular complications after heart catheter examinations. Z Kardiol 86:264–272

    Article  PubMed  CAS  Google Scholar 

  109. Hemminki E, McPherson K (1997) Impact of postmenopausal hormone therapy on cardiovascular events and cancer: pooled data from clinical trials. BMJ315:149–153

    Google Scholar 

  110. Hermanson B et al. (1988) Beneficial six-year outcome of smoking cessation in older men and women with coronary artery disease: Results from CASS registry. N Engl J Med 319:1365–1369

    Article  PubMed  CAS  Google Scholar 

  111. Herrington DM et al. (2000) Effects of estrogen replacement on the progression of coronary-artery atherosclerosis. N Eng J Med 343:522–529

    Article  CAS  Google Scholar 

  112. Herrington DM et al. (2002) Statin therapy, cardiovascular events, and total mortality in the heart and estrrogen/progestin replacement study (HERS). Circulation 105:2962–2967

    Article  PubMed  CAS  Google Scholar 

  113. Hinkle L, Thaler HT (1982) Clinical classification of cardiac deaths. Circulation 65:457–464

    Article  PubMed  Google Scholar 

  114. Hippisley-Cox J et al. (2001) Sex inequalities in ischemic heart disease in general practice: cross sectional survey. Brit Med J 322:832–834

    Article  PubMed  CAS  Google Scholar 

  115. Hnatkova K et al. (1998) Age and gender influences on rate and duration of paroxysmal atrial fibrillation. Pacing Clin Electrophysiol 21:2455–2458

    Article  PubMed  CAS  Google Scholar 

  116. Ho KKL et al. (1993 a) The epidemiology of heart failure: the Framingham study. J Am Coll Cardiol. 22:6A-13A

    Article  PubMed  CAS  Google Scholar 

  117. Ho KKL et al. (1993 b) Survival after the onset of congestive cardiac failure in the Framingham Heart Study. Circulation. 88:107–115

    Article  PubMed  CAS  Google Scholar 

  118. Hochleitner M, Bader A (2003) Geschlechtsunterschiede in der Kardiologie. Acta Med Austriaca 3: 69–71

    Google Scholar 

  119. Hochman JS et al. (1997) Outcome and profile of women and men presenting with acute coronary syndromes: a report from TIMI NIB. Thrombolysis In Myocardial Infarction. J Am Coll Cardiol 30:141–148

    Article  PubMed  CAS  Google Scholar 

  120. Hochman JS et al. (1999) Sex, clinical presentation, and outcome in patients with acute coronary syndromes. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes lib Investigators. N Engl J Med 341:226–232

    Article  PubMed  CAS  Google Scholar 

  121. Hochman JS, Tamis-Holland JE (2002) Acute coronary syndromes: Does sex matter? J Am Med Assoc 288:3161–3164

    Article  Google Scholar 

  122. Hoffman RM et al. (1994) Modifiable risk factors for incident heart failure in the Coronary Artery Surgery Study. Arch Intern Med. 154:417–423

    Article  PubMed  CAS  Google Scholar 

  123. Hollman B et al. (1989) Risk factors for recurrent stenosis following successful coronary angioplasty. Cleve Clin J Med 56:517–523

    Article  PubMed  CAS  Google Scholar 

  124. Horwitz RI et al. (1990) Treatment adherence and risk of death after a myocardial infarction. Lancet 336:542–545

    Article  PubMed  CAS  Google Scholar 

  125. Hu FB et al. (2000) Trends in the incidence of coronary heart disease and changes in diet and lifestyle in women. N Engl J Med 343:530–537

    Article  PubMed  CAS  Google Scholar 

  126. Hulley S et al. (1998) Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. J Am Med Assoc 280:605–613

    Article  CAS  Google Scholar 

  127. Humphries KH et al. (2001) New-onset atrial fibrillation: sex differences in presentation, treatment, and outcome. Circulation 103:2365–2370

    Article  PubMed  CAS  Google Scholar 

  128. Hung J et al. (1984) Noninvasive diagnostic test choices for the evaluation of coronary artery disease in women: a multivariate comparison of cardiac flouroscopy, exercise echocardiography and exercise thallium myocardial perfusion scintigraphy. Am J Cardiol 4:8–16

    Article  CAS  Google Scholar 

  129. Hussain KMA et al. (1997) Trends in success rate after percutaneous transluminal coronary angioplasty in men and women with coronary artery disease. Am Heart J134:719–727

    Article  Google Scholar 

  130. Jacobs D et al. (1992) Report of the conference on low blood cholesterol: mortality associations. Circulation 86:1046–1067

    Article  PubMed  CAS  Google Scholar 

  131. Jacobs AK et al. (1998) Better outcome for women compared with men undergoing coronary revascularization: a report from the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 98:1279–1285

    Article  PubMed  CAS  Google Scholar 

  132. Johansson S et al. (1984) Sex differences in cardio-angiographic findings after myocardial infarction. Eur Heart J 5:374–381

    PubMed  CAS  Google Scholar 

  133. Johnstone D et al. (1992) Clinical characteristics of patients in the Studies of Left Ventricular Dysfunction. Am J Cardiol 70:894–900

    Article  PubMed  CAS  Google Scholar 

  134. Kahn JK et al. (1992) Comparison of procedural results and risks of coronary angioplasty in men and women for conditions other than acute myocardial infarction. Am J Cardiol 69:1241–1242

    Article  PubMed  CAS  Google Scholar 

  135. Kanaya AM et al. (2003) Glycemic effects of postmenopausal hormone therapy: the heart and estro-gen/progestin replacement study. Ann Intern Med 138:1–9

    Article  PubMed  CAS  Google Scholar 

  136. Kane JP et al. (1990) Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens. J Am Med Assoc 264:3007–3012

    Article  CAS  Google Scholar 

  137. Kannel WB (1989) Epidemiological aspects of heart failure. Cardiol Clin 7:1–9

    PubMed  CAS  Google Scholar 

  138. Kannel WB, Belanger AJ (1991) Epidemiology of heart failure. Am Heart J 121:951–957

    Article  PubMed  CAS  Google Scholar 

  139. Kannel WB, Pinsky J (1991) Trends in cardiac failure: incidence and causes over three decades in the Framingham Study. J Am Coll Cardiol 17(suppl 2): 87A

    Article  Google Scholar 

  140. Kannel WB et al. (1998) Sudden coronary death in women. Am Heart J 136:205–212

    Article  PubMed  CAS  Google Scholar 

  141. Kaplan NM (1989) The deadly quartet: upper-body obesity, glucose intolerance,hypertriglyceridemia, and hypertension. Arch Intern Med 149:1514–1520

    Article  PubMed  CAS  Google Scholar 

  142. Karrillon GJ et al. (1996) Intracoronary stent implantation without ultrasound guidance and with replacement of conventional anticoagulation by antiplatelet therapy. 30-day clinical outcome of the French multicenter registry. Circulation 94: 1519–1527

    Article  PubMed  CAS  Google Scholar 

  143. Kaye MP (1994) The Registry of the International Society for Heart and Lung Transplantation: 10th official report. J Heart Lung Transplant 13:561–570

    Google Scholar 

  144. Keelan ET et al. (1997) Comparison of immediate and long-term outcome of coronary angioplasty performed for unstable angina and rest pain in men and women. Mayo Clin Proc 72:5–12

    Article  PubMed  CAS  Google Scholar 

  145. Kelsey S et al. (1993) Results of percutaneous transluminal coronary angioplasty in women. Circulation 87:720–727

    Article  PubMed  CAS  Google Scholar 

  146. Kenchaiah S et al. (2002) Obesity and the risk of heart failure. N Engl J Med 347:305–313

    Article  PubMed  Google Scholar 

  147. Khan SS et al. (1990) Increased mortality of women in coronary artery bypass graft surgery: evidence for referral bias. Ann Intern Med 112:561–567

    Article  PubMed  CAS  Google Scholar 

  148. Khaw KT (1993) Where are the women in studies of coronary heart disease ? Br Med J 306:1145–1146

    Article  CAS  Google Scholar 

  149. Kim C et al. (2001) Out-of-hospital cardiac arrest in men and women. Circulation 104:2699–2703

    Article  PubMed  CAS  Google Scholar 

  150. King SB III et al. (1995) Emory Angioplasty versus Surgery Trial (EAST):design, recruitment and baseline description of patients. Am J Cardiol 75:42C-59C

    Article  PubMed  Google Scholar 

  151. Kjekshus J (1996) Lipid-lowering therapy for patients with and at risk of coronary disease. Curr Opin Cardiol 11:418–427

    Article  PubMed  CAS  Google Scholar 

  152. Knopp RH et al. (1993) Exaggerated lipoprotein abnormalities in diabetic women as compared with diabetic men: Possible significance for atherosclerosis. In: Wenger NK, Speroff L, Packard B (eds) Cardiovascular health and disease in women. LeJacq Communications, Greenwich, pp 131–138

    Google Scholar 

  153. Knopp RH et al. (1994) Sex hormones and lipid interactions: Implications for cardiovascular disease in women. Endocrinologist 4:286–301

    Article  Google Scholar 

  154. Kolettis TM et al. (1990) Coronary angioplasty in patients with prior coronary artery bypass grafting. Int J Cardiol 28:333–340

    Article  PubMed  CAS  Google Scholar 

  155. Koyanagi S et al. (1982) Effects of chronic hypertension and left ventricular hypertrophy on the incidence of sudden cardiac death after coronary artery occlusion in conscious dogs. Circulation 65: 1192–1197

    Article  PubMed  CAS  Google Scholar 

  156. Krumholz HM et al. (1992) Selection of patients for coronary angiography and coronary revascularization early after myocardial infarction: Is there evidence for a gender bias ? Ann Int Med 116:785–790

    Article  PubMed  CAS  Google Scholar 

  157. Krumholz HM et al. (1993) Effect of ramipril on mortality and morbidity on survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 342:821–828

    Google Scholar 

  158. Kwok Y et al. (1999) Meta-analysis of exercise testing to detect coronary artery disease in women. Am J Cardiol 83:660–666

    Article  PubMed  CAS  Google Scholar 

  159. Lagerqvist B et al. (2001) Is early invasive treatment of unstable coronary artery disease equally effective for both women and men? J Am Coll Cardiol 38: 41–48

    Article  PubMed  CAS  Google Scholar 

  160. LaRosa JC (1997) Triglycerides and coronary risk in women and the elderly. Arch Intern Med 157:961–968

    Article  PubMed  CAS  Google Scholar 

  161. LaRosa JC et al. (1999) Effect of statins on risk of coronary disease. A meta-analysis of randomized controlled trials. J Am Med Assoc 282:2340–2346

    Article  CAS  Google Scholar 

  162. Laskey WK (1992) Gender differences in the management of coronary artery disease: bias or good clinical judgment? Ann Intern Med 116:869–871

    Article  PubMed  CAS  Google Scholar 

  163. Lee PY et al. (2001) Representation of elderly persons and women in published randomized trials of acute coronary syndromes. J Am Med Assoc 286: 708–713

    Article  CAS  Google Scholar 

  164. Lee W, Cotton DB (1989) Peripartum cardiomyopathy: current concepts and clinical management. Clin Obstet Gynecol. 32:54–67

    Article  PubMed  CAS  Google Scholar 

  165. Lerner DJ, Kannel WB (1986) Patterns of coronary heart disease morbidity and mortality in the sexes: 26-year follow-up of the Framingham population. Am Heart J 111:383–390

    Article  PubMed  CAS  Google Scholar 

  166. Levy D et al. (1996). The progression from hypertension to heart failure. J Am Coll Cardiol 275:1557–1562

    CAS  Google Scholar 

  167. Levy S (1998) Epidemiology and classification of atrial fibrillation. J Cardiovasc Electrophysiol 9: S78-S82

    PubMed  CAS  Google Scholar 

  168. Lewis SJ et al. (1998) Effect of pravastatin on cardiovascular events in women after myocardial infarction: The cholesterol and recurrent events trial. J Am Coll Cardiol 32:140–146

    Article  PubMed  CAS  Google Scholar 

  169. Lincoff AM et al. (1993) Thrombolytic therapy for women with myocardial infarction: is there a gender gap? J Am Coll Cardiol 22:1780–1787

    Article  PubMed  CAS  Google Scholar 

  170. LIPID study group (1998) Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 339:1349–1357

    Article  Google Scholar 

  171. Lippert TH et al. (1999) Klinisch-pharmakologische Besonderheiten der konjugierten equinen Estrogene. Arzneimitteltherapie 17:362–364

    Google Scholar 

  172. Malacrida R et al. (1998) A comparison of the early outcome of acute myocardial infarction in women and men. N Engl J Med 338:8–14

    Article  PubMed  CAS  Google Scholar 

  173. Mandak JS et al. (1998) Modifiable risk factors for vascular access site complications in the IMPACT II trial of angioplasty with versus without eptifiba-tide. J Am Coll Cardiol 31:1518–1524

    Article  PubMed  CAS  Google Scholar 

  174. Manolio TA et al. (1992) Cholesterol and heart disease in older persons and women: review of an NHLBI workshop. Ann Epidemiol 2:161–176

    Article  PubMed  CAS  Google Scholar 

  175. Manson JE et al. (1990) A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med 322:882–889

    Article  PubMed  CAS  Google Scholar 

  176. Manson JE, Speisberg A (1996) Risk modification in the diabetic patient. In: Manson JE, Ridker PM, Gazi-ano JM, Hennekens CH (eds) Prevention of Myocardial Infarction. Oxford University Press, New York, pp 241–273

    Google Scholar 

  177. Manson JE et al. (1999) A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. N Engl J Med 341:650–658

    Article  PubMed  CAS  Google Scholar 

  178. Manson JE, Martin KA (2001) Clinical practice. Postmenopausal hormone-replacement therapy. N Engl J Med 345:34–40

    Article  PubMed  CAS  Google Scholar 

  179. Mark DB et al. (1994) Absence of sex bias in the referral of patients for cardiac catheterization. N Engl J Med 330:1101–1106

    Article  PubMed  CAS  Google Scholar 

  180. Marwick TH (1995) Current status of stress echocardiography in the diagnosis of coronary artery disease. Cleve Clin J Med 62:227–234

    Article  PubMed  CAS  Google Scholar 

  181. Marwick TH et al. (1995) Exercise echocardiography is an accurate and cost-efficient technique for detection of coronary artery disease in women. J Am Coll Cardiol 26:335–341

    Article  PubMed  CAS  Google Scholar 

  182. McDonagh TA et al. (1997) Symptomatic and asymptomatic left ventricular systolic dysfunction. Lancet 350:829–833

    Article  PubMed  CAS  Google Scholar 

  183. McEniery PT et al. (1987) Comparative safety and efficacy of percutaneous transluminal coronary angioplasty in men and in women. Cathet Cardiovasc Diagn 13:364–371

    Article  PubMed  CAS  Google Scholar 

  184. Mehilli J et al. (2003) Gender and restenosis after coronary artery stenting. Eur Heart J 24: 1523–1530

    Article  PubMed  Google Scholar 

  185. Melin JA et al. (1985) Alternative diagnostic strategies for coronary artery disease in women: demonstration of the usefulness and efficiency of probability analysis. Circulation 71:535–542

    Article  PubMed  CAS  Google Scholar 

  186. Menon V et al. (2001) New heparin dosing recommendations for patients with acute coronary syndromes. Am J Med 110:641–650

    Article  PubMed  CAS  Google Scholar 

  187. Mesa A et al. (1999) Long-term prognosis in women with normal dobutamine stress echocardiography. Am J Cardiol 83:1127–1129

    Article  PubMed  CAS  Google Scholar 

  188. Meschia M et al. (1998) Effects of oral and transdermal hormone replacement therapy on lipoprotein(A) and lipids: a randomized controlled trial. Menopause 5:157–162

    PubMed  CAS  Google Scholar 

  189. Michels KB, Manson JE (2003) Postmenopausal hormone therapy. A reversal of fortune. Circulation 107:1830–1833

    Article  PubMed  Google Scholar 

  190. Miettinen TA et al. (1997) Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris. Findings from the Scandinavian Simvastatin Survival Study (4S). Circulation 96:4211–4218

    Article  PubMed  CAS  Google Scholar 

  191. Mikkola TS, Clarkson TB (2002) Estrogen replacement therapy, atherosclerosis, and vascular function. Cardiovasc Res 53:605–619

    Article  PubMed  CAS  Google Scholar 

  192. Morise AP, Beto R (1997) The specificity of exercise electrocardiography in women grouped by estrogen status. Int J Cardiol 60:55–65

    Article  PubMed  CAS  Google Scholar 

  193. Mosca L et al. (1997) Cardiovascular disease in women. A statement for healthcare professionals from the American Heart Association. Circulation 96: 2468–2482

    Article  PubMed  CAS  Google Scholar 

  194. Mosca L et al. (2001) Hormone replacement therapy and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 104:499–503

    Article  PubMed  CAS  Google Scholar 

  195. Moscucci M et al. (1994) Peripheral vascular complications of directional coronary atherectomy and stenting: predictors, management and outcome. Am J Cardiol 74:448–453

    Article  PubMed  CAS  Google Scholar 

  196. Moscucci M et al. (1998) Frequency, predictors,and appropriateness of blood transfusions after percutaneous coronary interventions. Am J Cardiol 81 (6): 702–707

    Article  PubMed  CAS  Google Scholar 

  197. Moulton A et al. (1991) Risk factors for stroke in patients with nonrheumatic atrial fibrillation: a case-control study. Am J Med 91:156–161

    Article  PubMed  CAS  Google Scholar 

  198. Myerburg RJ et al. (1992) Sudden cardiac death. Structure, function, and time-dependence of risk. Circulation 85:12–10

    Google Scholar 

  199. Nanchahal K et al. (2000) Association between blood pressure, the treatment of hypertension, and cardiovascular riskfactors in women. J Hyper-tens 18:833–841

    Article  CAS  Google Scholar 

  200. North American Menopause Society (2003) Hormone Therapy. Menopause 10:6–12

    Google Scholar 

  201. Orth-Gomer K et al. (1997) Lipoprotein(a) as a determinant of coronary heart disease in young women. Circulation 95:329–334

    Article  PubMed  CAS  Google Scholar 

  202. Orth-Gomer K et al. (2000) Marital stress worsens prognosis in women with coronary heart disease: the Stockholm female coronary risk study. J Am Med Assoc 284:3008–3014

    Article  CAS  Google Scholar 

  203. Österreichisches Statistisches Zentralamt (1998) Statistisches Jahrbuch für die Republik Österreich. XLIX. Jahrgang

    Google Scholar 

  204. Packer M et al. (2001) Effect of Carvedilol on survival in severe chronic heart failure. N Engl J Med 344: 1651–1658

    Article  PubMed  CAS  Google Scholar 

  205. Parrish HM et al. (1967) Time interval from castration in premenopausal women to development of excessive coronary atherosclerosis. Am J Obstet Gynecol 99:155–162

    PubMed  CAS  Google Scholar 

  206. Pepine CJ et al. (1994) Characteristics of a contemporary population with angina pectoris. Am J Cardiol 74:226–231

    Article  PubMed  CAS  Google Scholar 

  207. Petrie M et al. (1999) Failure of Women’s Hearts. Circulation 99:2334–2341

    Article  PubMed  CAS  Google Scholar 

  208. Philbin EF, DiSalvo TG (1998) Influence of race and gender on care process, resource use, and outcomes in congestive heart failure. Am J Cardiol 82: 76–81

    Article  PubMed  CAS  Google Scholar 

  209. Pilote L (1995) Attitudes of women toward hormone therapy and prevention of heart disease. Am Heart J 129:1237–1238

    Article  PubMed  CAS  Google Scholar 

  210. Pilote L, Hlatky MA (1996) Determinants of the use of coronary angiography and revascularization after thrombolysis for acute myocardial infarction. N Engl J Med 335:1198–2005

    Article  PubMed  CAS  Google Scholar 

  211. Piovaccari G et al. (1991) Percutaneous transluminal coronary angioplasty in women: immediate results and follow up. Coronary Artery Disease 2: 1057–1060

    Google Scholar 

  212. Punnonen R et al. (1987) Premenopausal hysterectomy and risk of cardiovascular disease. Lancet 1:1139

    Article  PubMed  CAS  Google Scholar 

  213. Rahimtoola SH et al. (1993) Survival at 15 to 18 years after coronary artery bypass surgery for angina in women. Circulation 88(part 2): 71–78

    Google Scholar 

  214. Rathore SS et al. (2000) Race, sex, poverty, and the medical treatment of acute myocardial infarction in the elderly. Circulation 102:642–648

    Article  PubMed  CAS  Google Scholar 

  215. Rathore SS et al. (2002) Sex-based differences in th effect of digoxin for the treatment of heart failure. N Engl J Med 347:1403–1411

    Article  PubMed  CAS  Google Scholar 

  216. Reitsma JB et al. (1996) Increase in hospital admission rates for heart failure in the Netherlands 1980–1993. Heart 76:388–392

    Article  PubMed  CAS  Google Scholar 

  217. Remme WJ, Swedberg Karl (2001) Task Force Report: Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J 22:1527–1560

    Article  PubMed  CAS  Google Scholar 

  218. Rich-Edwards JW et al. (1995) The primary prevention of coronary heart disease in women. N Engl J Med 332:1758–1766

    Article  PubMed  CAS  Google Scholar 

  219. Ridker PM et al. (1998) Prospective study of C-reac-tive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 98:731–733

    Article  PubMed  CAS  Google Scholar 

  220. Ridker PM et al. (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342: 836–843

    Article  PubMed  CAS  Google Scholar 

  221. Robertson T et al. (1997) Influence of gender on in-hospital clinical and angiographic outcomes and on one-year follow-up in the New Approaches to Coronary Intervention (NACI) registry. Am J Cardiol 80(10A):26K-39K

    Article  PubMed  CAS  Google Scholar 

  222. Rosano GM et al. (1993) Beneficial effect of oestrogen on exercise-induced myocardial ischemia in women with coronary artery disease. Lancet 342: 133–136

    Article  PubMed  CAS  Google Scholar 

  223. Rossouw JE (1999) What we still need to learn about hormone replacement therapy. Infert Reprod Med Clin North Am 10:189–209

    Google Scholar 

  224. Sacks FM et al. (1996) The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 335:1001–1009

    Article  PubMed  CAS  Google Scholar 

  225. Safstrom K et al. (1998) Unstable coronary artery disease in post-menopausal women: identifying patients with significant coronary artery disease by basic clinical parameters and exercise test. IRIS Study Group. Eur Heart J 19:899–907

    Article  PubMed  CAS  Google Scholar 

  226. Sawada SG et al. (1989) Exercise echocardiographic detection of coronary artery disease in women. J Am Coll Cardiol 14:1440–1447

    Article  PubMed  CAS  Google Scholar 

  227. Say AE et al. (2002) Impact of body iron status on myocardial perfusion, left ventricular function, and angiographic morphologic features in patients with hypercholesterolemia. Am Heart J 143:257–264

    Article  PubMed  Google Scholar 

  228. Scandinavian Simvastatin Survival Study group (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344:1383–1389

    Google Scholar 

  229. Schocken DD et al. (1992) Prevalence and mortality rate of congestive heart failure in the United States. J Am Coll Cardiol 20:301–306

    Article  PubMed  CAS  Google Scholar 

  230. Schrott HG et al. (1997) Adherence to National Cholesterol Education Program treatment goals in postmenopausal women with heart disease: the Heart and Estrogen/progestin Replacement Study (HERS): the HERS Research Group. J Am Med Assoc 277: 1281–1286

    Article  CAS  Google Scholar 

  231. Secknus MA, Marwick TH (1997) Influence of gender on physiologic response and accuracy of dobu-tamine echocardiography. Am J Cardiol 80: 721–724

    Article  PubMed  CAS  Google Scholar 

  232. Shaw LJ et al. (1994) Gender differences in the noninvasive evaluation and management of patients with suspected coronary artery disease. Ann Intern Med 120:559–566

    Article  PubMed  CAS  Google Scholar 

  233. Shekelle PG et al. (2003) Efficacy of angiotensin-converting enzyme inhibitors and beta-blockers in the management of left ventricular systolic dysfunction according to race, gender and diabetic status. J Am Coll Cardiol 41:1529–1538

    Article  PubMed  CAS  Google Scholar 

  234. SHEP cooperative research group, (1991) Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). J Am Med Assoc 265: 3255–3264

    Article  Google Scholar 

  235. Sizemore C, Lewis JF (1999) Clinical relevance of chest pain during dobutamine stress echocardiography in women. Clin Cardiol 22:715–718

    Article  PubMed  CAS  Google Scholar 

  236. Smart SC et al. (2000) Dobutamine-atropine stress echocardiography and dipyridamol sestamibi scintigraphy for the detection of coronary artery disease: limitations and concordance. J Am Coll Cardiol 36:1265–1273

    Article  PubMed  CAS  Google Scholar 

  237. SOLVD Investigators (1996) Adverse effects of ena-lapril in the Studies of Left Ventricular Dysfunction. Am Heart J. 131:350–355

    Article  Google Scholar 

  238. Sotelo MM, Johnson SR (1997) The effects of hormone replacement therapy on coronary heart disease. Endocrinol Metab Clin North Am 26:313–328

    Article  PubMed  CAS  Google Scholar 

  239. Staessen JA et al. (1999) Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) trial investigators. Lancet 350:757–764

    Article  Google Scholar 

  240. Steering Committee of the Physicians Health Study Research Group (1989) Final report on the aspirin component of the ongoing physician’s health study. N Engl J Med 321:129–135

    Article  Google Scholar 

  241. Stegnar M, Pentek M (1993) Fibrinolytic response to venous occlusion in healthy subjects: relationship to age,gender,body weight,blood lipids and insulin. Thromb Res 69:81–92

    Article  PubMed  CAS  Google Scholar 

  242. Steingart RM et al. (1991) Sex differences in the management of coronary artery disease. N Engl J Med 325:226–230

    Article  PubMed  CAS  Google Scholar 

  243. Stone GW et al. (1995) A comparison of in-hospital outcome in men versus women treated by either thrombolytic therapy or primary coronary angioplasty for acute myocardial infarction. Am J Cardiol 75:987–992

    Article  PubMed  CAS  Google Scholar 

  244. Stone PH et al. (1996) Influence of race, sex, and age on management of unstable angina and non-Q-wave myo-cardial infarction: the TIMI III registry. J Am Med Ass 275:1104–1112

    Article  CAS  Google Scholar 

  245. Sullivan AK et al. (1994) Chest pain in women: clinical, investigative, and prognostic features. Brit Med J 308:883–886

    Article  PubMed  CAS  Google Scholar 

  246. Sullivan JL (1989) The iron paradigm of ischemic heart disease. Am Heart J 117:1177–1188

    Article  PubMed  CAS  Google Scholar 

  247. Sullivan JL (2003) Are menstruating women protected from heart disease because of, or in spite of, estrogen? Relevance of the iron hypothesis. Am Heart J145:190–194

    Article  Google Scholar 

  248. Suttorp M et al. (1993) Recurrence of paroxysmal atrial fibrillation or flutter after successful cardioversion in patients with normal left ventricular function. Am J Cardiol 71:710–713

    Article  PubMed  CAS  Google Scholar 

  249. Taillefer R et al. (1997) Comparative diagnostic accuracy of TI-201 and Tc-99m-sestamibi SPECT imaging (perfusion and ECG-gated SPECT) in detecting coronary artery disease in women. J Am Coll Cardiol 29:69–77

    Article  PubMed  CAS  Google Scholar 

  250. Tobin JN et al. (1987) Sex bias in considering coronary bypass surgery. Ann Intern Med 107:19–25

    Article  PubMed  CAS  Google Scholar 

  251. Tofler GH et al. (1987) Effects of gender and race on prognosis after myocardial infarction: adverse prognosis for women, particularly black women. J Am Coll Cardiol 9:473–82

    Article  PubMed  CAS  Google Scholar 

  252. Topol EJ et al. (1985) Hypertrophic hypertensive cardiomyopathy of the elderly. N Engl J Med 312: 277–283

    Article  PubMed  CAS  Google Scholar 

  253. Tracy RP et al. (1992) The distribution of coagulation factors VII and VIII and fibrinogen in adults over 65 years: results from the Cardiovascular Health Study. Ann Epidemiol 2:509–519

    Article  PubMed  CAS  Google Scholar 

  254. Tunstall-Pedoe H et al. (1996) Sex differences in myocardial infarction and coronary deaths in the Scottish MONICA population of Glasgow 1985–1991: presentation, diagnosis, treatment, and 28-day case fatality of 3991 events in men and 1551 events in women. Circulation 93:1981–1992

    Article  PubMed  CAS  Google Scholar 

  255. Vehkavaara S et al. (2000) Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women. Circulation 102:2687–2693

    Article  PubMed  CAS  Google Scholar 

  256. Von der Lohe E (2003) Coronary heart disease in women. Springer, Berlin, Heidelberg, New York, Hong Kong, London, Milan, Paris,Tokyo

    Book  Google Scholar 

  257. Vongpatanasin W et al. (2003). Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women. J Am Coll Cardiol 41:1358–1363

    Article  PubMed  CAS  Google Scholar 

  258. Waksman R et al. (1995) Predictors of groin complications after balloon and new-device coronary intervention. Am J Cardiol 75:886–889

    Article  PubMed  CAS  Google Scholar 

  259. Walsh BW et al. (1991) Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 325:1196–2004

    Article  PubMed  CAS  Google Scholar 

  260. Walsh BW et al. (1994) Effects of postmenopausal hormone replacement with oral and transdermal estrogen on high density lipoprotein metabolism. J Lipid Res 35:2083–2093

    PubMed  CAS  Google Scholar 

  261. Wamala SP et al. (2000) Job stress and the occupational gradient in coronary heart disease in women: The Stockholm female coronary risk study. Soc Sci Med 51:481–489

    Article  PubMed  CAS  Google Scholar 

  262. Wang XL et al. (1994) Determinants of severity of coronary artery disease in Australian men and women. Circulation 89:1974–1981

    Article  PubMed  CAS  Google Scholar 

  263. Waters D et al. (1995) Effects of cholesterol lowering on the progression of coronary atherosclerosis in women. A Canadian Coronary Atherosclerosis Intervention Trial (CCAIT) Substudy. Circulation 92: 2404–2410

    Article  PubMed  CAS  Google Scholar 

  264. Waters DD et al. (2002) Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women. J Am Med Assoc 288:2432–2440

    Article  CAS  Google Scholar 

  265. Weaver WD et al. (1996) Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy. J Am Med Ass 275:777–782

    Article  CAS  Google Scholar 

  266. Webb JG et al. (1990) Coronary angioplasty after coronary bypass surgery: initial results and late outcome in 422 patients. J Am Coll Cardiol 16:812–820

    Article  PubMed  CAS  Google Scholar 

  267. Weber T et al. (1999) Klinische Präsentation und koronarangiographische Befunde bei instabiler Angina pectoris. Acta Med Austriaca 26:12–16

    PubMed  CAS  Google Scholar 

  268. Weiner DA et al. (1979) Exercise stress testing: correlations among history of angina,ST-segment response and prevalence of coronary- artery disease in the Coronary Artery Surgery Study (CASS). N Engl J Med 301:230–235

    Article  PubMed  CAS  Google Scholar 

  269. Weintraub WS et al. (1994) Percutaneous transluminal coronary angioplasty in women compared with men. J Am Coll Cardiol 1994; 24:81–90

    Article  Google Scholar 

  270. Weintraub WS et al. (1998) Changing clinical characteristics of coronary surgery patients: differences between men and women. Circulation 98:1279–1285

    Article  Google Scholar 

  271. Welch CC et al. (1975) Coronary angiographic find-ingsin 1000women under age 50. Am J Cardiol 35: 211–215

    Article  PubMed  CAS  Google Scholar 

  272. Welty FK et al. (1994) Similar results of percutaneous transluminal coronary angioplasty for women and men with postmyocardial infarction ischemia. J Am Coll Cardiol 23:35–39

    Article  PubMed  CAS  Google Scholar 

  273. Wenger NK (1990) Gender, coronary artery disease, and bypass surgery. Ann Intern Med 112:557–558

    Article  PubMed  CAS  Google Scholar 

  274. Wenger NK (1992) Exclusion of the elderly and women from coronary trials: is their quality of care compromised? J Am Med Assoc 268:1460–1461

    Article  CAS  Google Scholar 

  275. Wheeldon NM et al. (1993) Echocardiography in chronic heart failure in the community. Q J Med 86: 17–22

    PubMed  CAS  Google Scholar 

  276. WHI Steering Committee and Writing Group (2002) Response. J Am Med Assoc 288:2823–2825

    Google Scholar 

  277. White R et al. (1999) Major bleeding after hospitalization for deep-vein thrombosis. Am J Med 107: 517–518

    Article  Google Scholar 

  278. White HD et al. (1993) After correcting for worse baseline characteristics,women treated with thrombolytic therapy for acute myocardial infarction have the same mortality and morbidity as men except for a higher incidence of hemorrhagic stroke. Circulation 88:2097–2103

    Article  PubMed  CAS  Google Scholar 

  279. Willen WC et al. (1987) Relative and absolute excess risks of coronary heart disease among women who smoke cigarettes. N Engl J Med 317:1303–1309

    Article  Google Scholar 

  280. Willett WC et al. (1995) Weight, weight change, and coronary heart disease in women. J Am Med Assoc 273:461–465

    Article  CAS  Google Scholar 

  281. Williams DG, Olsen EGJ (1985) Prevalence of dilated cardiomyopathy in two regions of England. Br Heart J 54:153–155

    Article  PubMed  CAS  Google Scholar 

  282. Wilson PWF et al. (1998) Prediction of coronary heart disease using riskfactor categories. Circulation 97: 1837–1847

    Article  PubMed  CAS  Google Scholar 

  283. Wittes J et al. (1999) Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 341:410–418

    Article  PubMed  Google Scholar 

  284. Writing group for the PEPI Trial (1995) Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. J Am Med Assoc 273:199–208

    Article  Google Scholar 

  285. Writing group for the Women’s Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Woman’s Health Initiative randomized controlled trial. J Am Med Assoc 288: 321–333

    Article  Google Scholar 

  286. Zheng ZJ et al. (2001) Sudden cardiac death in the United States, 1989 to 1998. Circulation 104:2158–2163

    Article  PubMed  CAS  Google Scholar 

  287. Zipes DP, Wellens HJ (1998) Sudden cardiac death. Circulation 98:2334–2351

    Article  PubMed  CAS  Google Scholar 

  288. Zuanetti G et al. (1993) Influence of diabetes on mortality in acute myocardial infarction: data from the GISSI- 2 study. J Am Coll Cardiol 22:1788–1794

    Article  PubMed  CAS  Google Scholar 

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  5. B. Eber
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  1. Institut für Sozialmedizin, Medizinische Universität Wien, Österreich

    Anita Rieder

  2. Abteilung für Geschichte, Ethik und Philosophie der Medizin, Medizinische Hochschule Hannover, Deutschland

    Brigitte Lohff

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© 2004 Springer-Verlag Wien

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Weber, T., Auer, J., Berent, R., Lassnig, E., Eber, B. (2004). Kardiologie. In: Rieder, A., Lohff, B. (eds) Gender Medizin. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3766-6_15

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  • DOI: https://doi.org/10.1007/978-3-7091-3766-6_15

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-3767-3

  • Online ISBN: 978-3-7091-3766-6

  • eBook Packages: Springer Book Archive

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