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The Present Status of Flavin and Flavocoenzyme Chemistry

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Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Abstract

The term “flavin” stands for the yellow redox-active subgroup of the first coenzyme ever to be elucidated in terms of molecular structure. The “heroic” period of redox-enzymology of the early thirties ended in Hugo Theroell’s (172–175) description of the first enzyme ever to be split reversibly to yield coenzyme and apoprotein. This was the NADPH-oxidizing “Old Yellow Enzyme” from yeast, whose biological function is still unknown even nowadays. The structure of the coenzyme has been shown to be riboflavin-5’-phosphate, viz. a phosphate derivative of vitamin B2, which had been synthesized somewhat earlier by Karrer’s group (83), who based this work upon even more important chemical precursor studies of Kuhn and coworkers (102, 100) and on the biochemical work of Warburg and Christian (188).

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  1. Fachbereich Biologie, Universität Konstanz, Federal Republic of Germany

    P. Hemmerich

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    G. W. Kirby

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Hemmerich, P. (1976). The Present Status of Flavin and Flavocoenzyme Chemistry. In: Herz, W., Grisebach, H., Kirby, G.W. (eds) Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 33. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3262-3_5

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