Summary: Circulating Tryptophan, Brain Tryptophan, and Psychiatric Disease
This symposium has addressed four important questions related to circulating tryptophan and the brain. These are: (1) What controls the uptake of circulating tryptophan into the brain? (2) What compounds can be measured in human blood that provide reliable indices of brain tryptophan uptake and utilization? (3) Might the metabolism of tryptophan, or its uptake into or utilization by the brain, be altered in psychiatric diseases? and, (4) Are tryptophan supplements useful in the treatment of depression and other psychiatric disorders—either by themselves or as adjuncts to drug therapy? Our views concerning these questions are summarized below. We hope that they also represent consensus opinions.
KeywordsPlasma NEFA Large Neutral Amino Acid Plasma Tryptophan Free Tryptophan Plasma Amino Acid Concentration
Unable to display preview. Download preview PDF.
- Pardridge, W. M.: Regulation of amino acid availability to the brain. In: Nutrition and the Brain (Wurtman, R. J., Wurtman, J. J., eds.), pp. 141 to 200. New York: Raven Press. 1977 a.Google Scholar
- Scally, M. C., Ulus, I., Wurtman, R. J.: Brain tyrosine level controls striatal dopamine synthesis in haloperidol-treated rats. Brain Res. 41, 1–6 (1977).Google Scholar
- Wurtman, R. J.: Diurnal rhythms in mammalian protein metabolism. In: Mammalian Protein Metabolism (Munro, H. N., ed.). New York: Academic Press. 1970.Google Scholar