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Molecular Pathways and Animal Models of Coronary Artery Anomalies

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Congenital Heart Diseases: The Broken Heart

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Abstract

The coronary vascular system is a sophisticated, highly patterned anatomical entity, and therefore a wide range of congenital malformations of the coronary vasculature has been described. Despite the clinical interest of congenital coronary artery anomalies (CCA), very few attempts have been made to relate specific embryonic developmental mechanisms to the congenital anomalies of these blood vessels. This is so because developmental data about the morphogenesis of the coronary vascular system is derived from complex studies carried out in animals (mostly transgenic mice) and may not be noted by the clinicians who take the care of these patients. We will try to offer embryological explanations for a variety of CCA based on the analysis of multiple animal models for the study of cardiac embryogenesis, and suggest to the reader developmental mechanistic explanations for the pathogenesis of these anomalies.

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Authors and Affiliations

  1. Department of Animal Biology, Faculty of Sciences, University of Málaga, Málaga, Spain

    Juan A. Guadix & José M. Pérez-Pomares

  2. Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Campanillas (Málaga), Spain

    Juan A. Guadix & José M. Pérez-Pomares

  3. Instituto de Biomedicina de Málaga (IBIMA)-Hospital Carlos de Haya, Málaga, Spain

    Juan A. Guadix & José M. Pérez-Pomares

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  1. Juan A. Guadix
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  2. José M. Pérez-Pomares
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Correspondence to José M. Pérez-Pomares .

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Editors and Affiliations

  1. Cardiovascular Genetics, Charité - Universitätsmedizin Berlin , Berlin, Germany

    Silke Rickert-Sperling

  2. Developmental Biology, Inst. of Marseilles, Aix-Marseille Univ. , Marseille, France

    Robert G. Kelly

  3. Dpt. of Pediatrics Div.of Pediatric Card, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

    David J. Driscoll

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Guadix, J.A., Pérez-Pomares, J.M. (2016). Molecular Pathways and Animal Models of Coronary Artery Anomalies. In: Rickert-Sperling, S., Kelly, R., Driscoll, D. (eds) Congenital Heart Diseases: The Broken Heart. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1883-2_45

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