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Kognition

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Zusammenfassung

Defizite in der kognitiven Leistungsfähigkeit zählen zu den Schlüsselsymptomen der Multiplen Sklerose (MS). Prävalenzraten werden je nach Studienlage mit 43 % (Rao et al. 1991a) bis 60 % (Benedict et al. 2006) angegeben. Somit leidet jeder zweite MS-Patient unter Einbußen in der kognitiven Kapazität. Die Defizite können bereits früh im Krankheitsgeschehen auftreten, sind, unabhängig vom Behinderungsgrad, auch bei einer benignen Verlaufsform präsent (Amato et al. 2006) und wirken sich negativ auf die Lebensqualität der Betroffenen aus. Anders als bei demenziellen Erkrankungen ist die Progression der kognitiven Defizite bei MS als eher langsam einzustufen (Amato et al. 2001). Eine möglichst frühzeitige differenzierte und zuverlässige neuropsychologische Diagnostik der sogenannten Kerndefizite unter Mitberücksichtigung möglicher kovariierender Faktoren, wie Fatigue, Depression und Angststörungen, ist von großer klinischer Relevanz.

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  1. Institut für Psychologie, Universität Basel, Missionsstraße 62A, 4055, Basel, Schweiz

    Iris-Katharina Penner PD Dr.

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  1. Medizinische Universität Innsbruck Universitätsklinik für Neurologie, Innsbruck, Austria

    Thomas Berger

  2. Leitender Arzt Klinik für Neurologie, Universitätsspital Zürich, Zürich, Switzerland

    Michael Linnebank

  3. Klinik für Allgemeine Neurologie, Universitätsklinikum Münster, Münster, Germany

    Heinz Wiendl

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Penner, IK. (2013). Kognition. In: Berger, T., Linnebank, M., Wiendl, H. (eds) Betaferon®. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1766-8_10

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