Abstract
During development, the lymphatic and the blood vascular system form highly branched networks that show extensive architectural similarities with the peripheral nervous system. Increasing evidence suggests that the vascular and the nervous systems share signaling pathways to overcome common challenges such as guidance of growth and patterning. Semaphorins, a large group of proteins originally identified as axon guidance molecules with repelling function, and their receptors, neuropilins and plexins, have recently also been implicated in vascular development. Here, we summarize the role of semaphorins and their receptors in angiogenesis and lymphangiogenesis, with an emphasis on neuropilin-1/semaphorin 3A interactions in lymphatic vessel maturation and valve formation. Understanding the basic principles of lymphatic vessel development and maturation might facilitate the development of therapies for the treatment of human diseases associated with lymphedema.
* Equally contributing authors. The authors declare no conflicts of interest.
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Acknowledgements
Work in the authors’ laboratory has been supported by National Institutes of Health grant CA69184, Swiss National Science Foundation grants 3100A0_108207, 31003A_130627, and 310030B_147087, Commission of the European Communities grant LSHC-CT-2005-518178, Advanced European Research Council grant LYVICAM, the Leducq Foundation Transatlantic Network of Excellence grant Lymph Vessels in Obesity and Cardiovascular Disease, Oncosuisse, and Krebsliga Zurich.
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Ochsenbein, A.M., Karaman, S., Jurisic, G., Detmar, M. (2014). The Role of Neuropilin-1/Semaphorin 3A Signaling in Lymphatic Vessel Development and Maturation. In: Kiefer, F., Schulte-Merker, S. (eds) Developmental Aspects of the Lymphatic Vascular System. Advances in Anatomy, Embryology and Cell Biology, vol 214. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1646-3_11
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