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Use of Novel Biomaterial Design and Stem Cell Therapy in Cutaneous Wound Healing

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Book cover Dermal Replacements in General, Burn, and Plastic Surgery

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Abstract

The spontaneous regenerative capacity of skin is dependent on the depth and area of cutaneous damage. This is the case as it dictates the extent of destruction of reparative basal and stem cell populations. Minor epidermal injury, where basement membrane and basal keratinocyte populations remain intact, results in rapid and complete cutaneous regeneration. However, partial-thickness (papillary dermal damage) and particularly full-thickness (papillary and reticular dermal damage) defects often heal through debilitating scar formation and contraction. Indeed, without surgical intervention the damage to physiological homeostasis resulting from large full-thickness wounds can be so acute that death may result. The rapid closure of such wounds is essential to restore the barrier functions of the skin and reduce scar formation (Cubison et al. 2006).

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Authors and Affiliations

  1. Plastic and Reconstructive Surgery Research, Dermatological Sciences, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK

    T. Hodgkinson BSc (Hons), MSc & Ardeshir Bayat BSc (Hons), MBBS, MRCS, PhD

  2. School of Chemical Engineering and Analytical Science, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess St, Manchester, UK

    T. Hodgkinson BSc (Hons), MSc

  3. Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Foundation Trust, Manchester, UK

    Ardeshir Bayat BSc (Hons), MBBS, MRCS, PhD

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  1. T. Hodgkinson BSc (Hons), MSc
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  2. Ardeshir Bayat BSc (Hons), MBBS, MRCS, PhD
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Correspondence to Ardeshir Bayat BSc (Hons), MBBS, MRCS, PhD .

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  1. , Department of Surgery, Medical University of Graz, Auenbruggerplatz 29, Graz, 8036, Austria

    Lars-Peter Kamolz

  2. , Department of Surgery, Medical University of Graz, Auenbruggerplatz 29, Graz, 8036, Austria

    David Benjamin Lumenta

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Hodgkinson, T., Bayat, A. (2013). Use of Novel Biomaterial Design and Stem Cell Therapy in Cutaneous Wound Healing. In: Kamolz, LP., Lumenta, D. (eds) Dermal Replacements in General, Burn, and Plastic Surgery. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1586-2_3

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