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Bridging Innate and Adaptive Immunity in African Trypanosomiasis

  • John M. MansfieldEmail author
  • Donna M. Paulnock
  • Gina M. Hedberg
Chapter

Abstract

Infection of man and domestic animals with Brucei group African trypanosomes results in a fatal disease. The immunobiological events that underlie temporal host resistance and susceptibility during an infection are complex but informative, because the parasites activate and engage nearly every element of the host innate and adaptive immune system. The ability of trypanosomes to undergo extensive antigenic variation provides a means to escape adaptive immunity, but these protozoan pathogens also activate and regulate many elements of the host immune response to their own end. This chapter highlights the trypanosome elements that bridge innate and adaptive immune responses in the infected mammalian host: the pathogen-associated molecular patterns (PAMPs) that trigger the innate immune response; the associated pattern recognition receptors (PRRs) on innate immune cells and subcellular signaling events that are activated; the resulting pattern of pro-inflammatory gene expression that shapes the nascent adaptive immune response; and, the downstream elements that ultimately cause host resistance to fail. The chapter concludes with promising new approaches, informed by recent studies of immunological memory, aimed at protecting trypanosome infected hosts against a broad range of antigenic variants.

Keywords

Innate Immune System Host Resistance Innate Immune Cell Trypanosome Infection African Trypanosome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • John M. Mansfield
    • 1
    • 2
    Email author
  • Donna M. Paulnock
    • 1
    • 2
  • Gina M. Hedberg
    • 1
    • 2
  1. 1.Department of BacteriologyUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.Department of Medical Microbiology and ImmunologyUniversity of Wisconsin-MadisonMadisonUSA

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