The Biology of Tsetse–Trypanosome Interactions

  • Guy CaljonEmail author
  • Linda De Vooght
  • Jan Van Den AbbeeleEmail author


Human African trypanosomiasis (HAT) or sleeping sickness is a disease caused by human-pathogenic protozoan parasites of the Trypanosoma brucei species. These parasites are transmitted by the tsetse fly vector in which parasites have to surmount several natural bottlenecks to eventually reach the insect salivary glands and to differentiate into a final stage that is infective for a new vertebrate host. During the development in tsetse flies, trypanosomes change their surface properties, traverse physical barriers and achieve colonization of various tissues while going through complex cellular proliferation and differentiation programs. The general tsetse fly physiology and immunology, the blood feeding machinery and symbiotic relationships are important parameters that affect the parasite transmissibility.


Salivary Gland Human African Trypanosomiasis Sterile Insect Technique Trypanosome Infection Peritrophic Matrix 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Wien 2014

Authors and Affiliations

  1. 1.Veterinary Protozoology UnitInstitute of Tropical MedicineAntwerpBelgium

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